Mark R Burns

Summary

Publications

  1. pmc Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor
    Mark R Burns
    MediQuest Therapeutics, Inc, Bothell, Washington 98021, USA
    J Med Chem 52:1983-93. 2009
  2. ncbi request reprint Polycationic sulfonamides for the sequestration of endotoxin
    Mark R Burns
    MediQuest Therapeutics, Inc, 22322 20th Avenue SE, Bothell, Washington 98021, USA
    J Med Chem 50:877-88. 2007
  3. ncbi request reprint Structure-activity relationships in lipopolysaccharide neutralizers: design, synthesis, and biological evaluation of a 540-membered amphipathic bisamide library
    Mark R Burns
    MediQuest Therapeutics, Inc, Bothell, Washington 98021, USA
    J Comb Chem 8:32-43. 2006
  4. pmc Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs
    Mark R Burns
    MediQuest Therapeutics, Inc, 22322 20th Ave SE, Bothell, WA 98021, USA
    Bioorg Med Chem Lett 16:6209-12. 2006
  5. ncbi request reprint Lysine-spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants
    Mark R Burns
    MediQuest, Inc, 4101 Stone Way North, Suite 220, Seattle, WA 98103, USA
    Bioorg Med Chem 13:2523-36. 2005
  6. ncbi request reprint Induction of apoptosis by aryl-substituted diamines: role of aromatic group substituents and distance between nitrogens
    Mark R Burns
    MediQuest Therapeutics, Inc, 4010 Stone Way North, Seattle, WA 98103, USA
    Bioorg Med Chem Lett 12:1263-7. 2002

Detail Information

Publications6

  1. pmc Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor
    Mark R Burns
    MediQuest Therapeutics, Inc, Bothell, Washington 98021, USA
    J Med Chem 52:1983-93. 2009
    ..The availability of a potent polyamine transport inhibitor allows, for the first time, for a real test of the hypothesis that starving cells of polyamines will lead to objective clinical response...
  2. ncbi request reprint Polycationic sulfonamides for the sequestration of endotoxin
    Mark R Burns
    MediQuest Therapeutics, Inc, 22322 20th Avenue SE, Bothell, Washington 98021, USA
    J Med Chem 50:877-88. 2007
    ....
  3. ncbi request reprint Structure-activity relationships in lipopolysaccharide neutralizers: design, synthesis, and biological evaluation of a 540-membered amphipathic bisamide library
    Mark R Burns
    MediQuest Therapeutics, Inc, Bothell, Washington 98021, USA
    J Comb Chem 8:32-43. 2006
    ..These findings are of value in further iterations of design and development of specific and potent endotoxin sequestrants...
  4. pmc Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs
    Mark R Burns
    MediQuest Therapeutics, Inc, 22322 20th Ave SE, Bothell, WA 98021, USA
    Bioorg Med Chem Lett 16:6209-12. 2006
    ..The research discussed herein may be useful for the design of additional carbohydrate recognizing molecules and endotoxin-neutralizing drugs...
  5. ncbi request reprint Lysine-spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants
    Mark R Burns
    MediQuest, Inc, 4101 Stone Way North, Suite 220, Seattle, WA 98103, USA
    Bioorg Med Chem 13:2523-36. 2005
    ....
  6. ncbi request reprint Induction of apoptosis by aryl-substituted diamines: role of aromatic group substituents and distance between nitrogens
    Mark R Burns
    MediQuest Therapeutics, Inc, 4010 Stone Way North, Seattle, WA 98103, USA
    Bioorg Med Chem Lett 12:1263-7. 2002
    ..These compounds do not induce the enzyme SSAT or deplete intracellular polyamine levels, mechanisms demonstrated by other cytotoxic polyamine analogues...