- Recombination in HIV: an important viral evolutionary strategy
D S Burke
Walter Reed Army Institute of Research, Rockville, MD 20850, USA
Emerg Infect Dis 3:253-9. 1997
..Certain features of HIV replication, such as syncytium formation and transactivation, may be best understood as components of a sexual reproductive cycle. Recombination may be an important HIV evolutionary strategy...
- Full-length sequence and mosaic structure of a human immunodeficiency virus type 1 isolate from Thailand
J K Carr
Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland 20850, USA
J Virol 70:5935-43. 1996
..The mosaic structure of a CM240 virion is suggestive of phenotypic differences which might have contributed to the emergence of this variant...
- Evolution and probable transmission of intersubtype recombinant human immunodeficiency virus type 1 in a Zambian couple
M O Salminen
Henry M Jackson Foundation and Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
J Virol 71:2647-55. 1997
..Intersubtype recombination apparently played a central role in the evolution of HIV-1 in this couple and may contribute substantially to the rapid emergence of HIV-1 variants whenever mixed-subtype HIV-1 infections occur...
- Human HIV vaccine trials: does antibody-dependent enhancement pose a genuine risk?
D S Burke
Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland 20850
Perspect Biol Med 35:511-30. 1992
..However, to date there is no direct clinical, experimental, or epidemiological evidence that HIV enhancement can be operative in vivo. Such evidence should be actively sought...
- The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon
J K Carr
Henry M Jackson Foundation, Rockville, Maryland 20850, USA
Virology 286:168-81. 2001
..This suggests that there was an ancestral AG recombinant that gave rise to CRF02 AG (IbNG), the successful circulating recombinant form, and to others that were less successful and are now rare...
- Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1
J H Kim
Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, MD, USA
Clin Exp Immunol 108:243-50. 1997
..Modification of restricted proliferative responses to Env by vaccination or cytokines in vitro suggests that strategies incorporating IL-7 or IL-12 as adjuvants may selectively boost cellular reactivity to HIV-1...