Javier S Burgos

Summary

Publications

  1. doi request reprint Zebrafish as a new model for herpes simplex virus type 1 infection
    Javier S Burgos
    Drug Discovery Unit, NEURON BioPharma, Edificio BIC, Avda Innovación 1, Armilla, Spain
    Zebrafish 5:323-33. 2008
  2. ncbi request reprint Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner
    Javier S Burgos
    NEURON BioPharma, Drug Discovery Unit, Edificio BIC, Armilla, Granada, Spain
    Aging Cell 6:841-2. 2007
  3. ncbi request reprint Changes in immunoglobulin levels related to herpes simplex virus type 1 brain infection in pregnant mice
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Spain
    J Neurovirol 13:233-41. 2007
  4. pmc Hematogenous vertical transmission of herpes simplex virus type 1 in mice
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biología Molecular, Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid, Spain
    J Virol 80:2823-31. 2006
  5. pmc Herpes simplex virus type 1 infection via the bloodstream with apolipoprotein E dependence in the gonads is influenced by gender
    Javier S Burgos
    Departamento de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Lab CX340, Cantoblanco, 28049 Madrid, Spain
    J Virol 79:1605-12. 2005
  6. pmc Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA
    Javier S Burgos
    Lab CX340, Centro de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 80:5383-7. 2006
  7. ncbi request reprint ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1
    Javier S Burgos
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Neuroreport 14:1825-7. 2003
  8. pmc Involvement of apolipoprotein E in the hematogenous route of herpes simplex virus type 1 to the central nervous system
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 76:12394-8. 2002
  9. doi request reprint Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death
    Saleta Sierra
    Biopharma Division, Neuron BPh, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Armilla, Granada, Spain
    J Alzheimers Dis 23:307-18. 2011
  10. ncbi request reprint Non-invasive bioluminescence imaging for monitoring herpes simplex virus type 1 hematogenous infection
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Spain
    Microbes Infect 8:1330-8. 2006

Collaborators

  • Fernando Valdivieso
  • Cristina Fillat
  • Saleta Sierra
  • Carlos Ramirez
  • Juan M Alfaro
  • Maria C Ramos
  • Fernando Guzman-Sanchez
  • Antonia Pineda
  • Inmaculada Tercero
  • Javier Velasco
  • Jose Antonio Vazquez
  • Jorge Ripoll-Gómez
  • Sonia Campoy
  • Sònia Sánchez
  • Pilar Molina
  • Cynthia Esteo
  • Tatiana Manrique
  • Amparo Prades
  • Eduardo Peris
  • Jose L Adrio
  • Beatriz Suarez
  • Macarena Poyatos
  • María Del Carmen Ramos

Detail Information

Publications22

  1. doi request reprint Zebrafish as a new model for herpes simplex virus type 1 infection
    Javier S Burgos
    Drug Discovery Unit, NEURON BioPharma, Edificio BIC, Avda Innovación 1, Armilla, Spain
    Zebrafish 5:323-33. 2008
    ..Viruses cleared from infected brains showed the ability to infect human neuroblastoma cells. This study is the first to demonstrate HSV-1 infection in the zebrafish and manifests the potential use of this species in herpesvirus studies...
  2. ncbi request reprint Apolipoprotein E genotype influences vertical transmission of herpes simplex virus type 1 in a gender specific manner
    Javier S Burgos
    NEURON BioPharma, Drug Discovery Unit, Edificio BIC, Armilla, Granada, Spain
    Aging Cell 6:841-2. 2007
    ..Here we show that the combination of inherited APOE genotype and vertical transmission of HSV-1 confers a differential risk of brain infection. These risk factors are known to be associated with AD...
  3. ncbi request reprint Changes in immunoglobulin levels related to herpes simplex virus type 1 brain infection in pregnant mice
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Spain
    J Neurovirol 13:233-41. 2007
    ..IgGs provided protection during the postnatal phase...
  4. pmc Hematogenous vertical transmission of herpes simplex virus type 1 in mice
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biología Molecular, Universidad Autonoma de Madrid, 28049 Cantoblanco, Madrid, Spain
    J Virol 80:2823-31. 2006
    ..Neonatal HSV-1 infection therefore appears to be mainly caused by hematogenous vertical transmission, and the viruses that colonize the offspring CNS are capable of molecular reactivation after a period of latency...
  5. pmc Herpes simplex virus type 1 infection via the bloodstream with apolipoprotein E dependence in the gonads is influenced by gender
    Javier S Burgos
    Departamento de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Lab CX340, Cantoblanco, 28049 Madrid, Spain
    J Virol 79:1605-12. 2005
    ..In male mice, HSV-1 was detected predominantly in the adrenal cortex. It was also found that apolipoprotein E promotes virus colonization of the ovaries, the APOE gene dose being directly related to viral invasiveness...
  6. pmc Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA
    Javier S Burgos
    Lab CX340, Centro de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 80:5383-7. 2006
    ..The APOE dosage correlated directly with the HSV-1 DNA concentration in the brain, strengthening the hypothesis that HSV-1, together with ApoE, might be involved in AD...
  7. ncbi request reprint ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1
    Javier S Burgos
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Neuroreport 14:1825-7. 2003
    ....
  8. pmc Involvement of apolipoprotein E in the hematogenous route of herpes simplex virus type 1 to the central nervous system
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 76:12394-8. 2002
    ..This study demonstrates the involvement of ApoE in the hematogenous route of HSV-1 to the CNS...
  9. doi request reprint Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death
    Saleta Sierra
    Biopharma Division, Neuron BPh, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Armilla, Granada, Spain
    J Alzheimers Dis 23:307-18. 2011
    ..Among the nine statins studied, simvastatin presented the best characteristics for preventing neurodegenerative conditions...
  10. ncbi request reprint Non-invasive bioluminescence imaging for monitoring herpes simplex virus type 1 hematogenous infection
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Spain
    Microbes Infect 8:1330-8. 2006
    ....
  11. doi request reprint Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish
    Saleta Sierra
    Neuron BIO, Biopharma Division, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Av Innovación 1, Armilla 18100, Granada, Spain
    Brain Res Bull 88:467-70. 2012
    ..These results show a neuroprotective benefit in zebrafish fed with DHA-enriched diet before birth and during the whole life...
  12. ncbi request reprint ICP47 mediates viral neuroinvasiveness by induction of TAP protein following intravenous inoculation of herpes simplex virus type 1 in mice
    Javier S Burgos
    Departamento de Biología Molecular and Centro de Biologí Molecular Severo Ochoa, C S I C U A M, Universidad Autonoma de Madrid, Madrid, Spain
    J Neurovirol 12:420-7. 2006
    ..These results suggest that ICP47 plays a role in infection, and that TAP1 production is regulated during viral challenge...
  13. doi request reprint How statins could be evaluated successfully in clinical trials for Alzheimer's disease?
    Javier S Burgos
    Biopharma Division, Neuron BIO, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain
    Am J Alzheimers Dis Other Demen 27:151-3. 2012
    ..We consider that there are a number of explanations for this failure that may provide guidance for selecting and clinically developing statins with therapeutic efficacy in AD...
  14. doi request reprint Kainate administered to adult zebrafish causes seizures similar to those in rodent models
    Juan M Alfaro
    Neuron BPh, Biopharma Division, Parque Tecnológico de Ciencias de la Salud, Edif BIC Granada, Av Innovación 1, Armilla 18100, Granada, Spain
    Eur J Neurosci 33:1252-5. 2011
    ..Kainate triggers seizures in adult zebrafish, and thus this species can be considered as a new model for studying seizures and subsequent excitotoxic brain injury...
  15. pmc ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage
    Carlos Ramirez
    Biopharma Division, Neuron BPh, Granada, Spain
    PLoS ONE 6:e22712. 2011
    ..These findings confirm hypercholesterolaemia as a key biomarker for monitoring mild cognitive impairment, and shows these transgenic mice can be used as a model for cognitive and psycho-motor decline...
  16. doi request reprint Simvastatin modulates the Alzheimer's disease-related gene seladin-1
    Maria C Ramos
    Neuron BIO, Biopharma Division, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Armilla, Granada, Spain
    J Alzheimers Dis 28:297-301. 2012
    ..Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies...
  17. doi request reprint Aging-related neurostructural, neuropathological, and behavioral changes associated with herpes simplex virus type 1 brain infection in mice
    Fernando Guzman-Sanchez
    Centro de Biologia Molecular Severo Ochoa, Departamento de Biologia Molecular, Universidad Autonoma de Madrid, Madrid, Spain
    J Alzheimers Dis 30:779-90. 2012
    ..Neuroinfection was associated with memory deficit and a reduction in metabolic indicators of CNS health...
  18. doi request reprint Biomedical properties of a series of ruthenium-N-heterocyclic carbene complexes based on oxidant activity in vitro and assessment in vivo of biosafety in zebrafish embryos
    Juan M Alfaro
    BioPharma Unit, Neuron BPh, Health Science Technology Park, Armilla, Spain
    Zebrafish 7:13-21. 2010
    ..Their characteristics as pro-oxidant and/or antioxidant agents together with their biosafety may point to their having biomedical applications as antitumoral or neuroprotective drugs...
  19. doi request reprint Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment
    Carlos Ramirez
    Neuron BPh, Biopharma Division, Parque Tecnológico de Ciencias de Salud, Edif BIC Granada, Armilla, Granada, Spain
    J Alzheimers Dis 24:161-74. 2011
    ..Our results suggest that both simvastatin and lovastatin (but especially simvastatin) may well have therapeutic potential in the treatment of neurodegenerative diseases involving excitotoxicity and memory impairment, including AD...
  20. ncbi request reprint Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis
    Javier S Burgos
    Centro de Biología Molecular Severo Ochoa C S I C, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Med Oncol 22:113-21. 2005
    ..Finally, p53 presented abnormalities only in a low percentage of samples. These results reinforce the role of the EBV in the NPC discussing several potential mechanisms of pathogenesis in this neoplasia...
  21. doi request reprint Semisynthesis of novel monacolin J derivatives: hypocholesterolemic and neuroprotective activities
    Sonia Campoy
    BioIndustrial Division, Neuron BPh, Granada, Spain
    J Antibiot (Tokyo) 63:499-505. 2010
    ..In vitro hypocholesterolemic and neuroprotection assays showed that one derivative (NST0037) had a very low 3-hydroxy-3-methylglutaryl CoA reductase IC(50) and high protection rate for oxidative-stress-induced neuron cell death...
  22. ncbi request reprint Absence of p53 alterations in nasopharyngeal carcinoma Spanish patients with Epstein-Barr virus infection
    Javier S Burgos
    Centro de Biología Molecular Severo Ochoa C S I C, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Virus Genes 27:263-8. 2003
    ..These results indicate that the p53 mutations are an infrequent event in NPC in Spanish patients needing exogenous factors as the EBV infection for the development of this malignancy...