Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancerAngelika M Burger
Laboratory of Molecular Pathology, Department of Anatomic Pathology and Division of Molecular and Cellular Biology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ont, Canada
Eur J Cancer 41:1515-27. 2005
..In this review, we have examined the roles of IGFBP-3 and IGFBP-rP1 in breast cancer, and discuss the potential impact of these two proteins in mammary carcinoma risk assessment and the development of treatments for breast cancer...
- A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer
Angelika M Burger
Laboratories of Molecular Pathology, Department of Anatomic Pathology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Cancer Res 65:10401-12. 2005
..Its association with clinical measures and its effects on cell growth indicate that BCA2 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth...
The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomeraseMark Schrader
Department of Urology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
BMC Cancer 2:32. 2002
..Here we investigate the correlation of telomerase activity and hTERT gene expression and the differentiation status of primary testicular germ cell tumors (TGCT)...
- The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications
Angelika M Burger
Laboratory of Molecular Pathology, Department of Anatomic Pathology, Division of Molecular and Cellular Biology, Sunnybrook and Women s College Health Sciences Centre, S 224, 2075 Bayview Avenue, Toronto, Ont, Canada M4N 3M5
Eur J Cancer 40:2217-29. 2004
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- The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases
Richard Kitching
Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
Biochim Biophys Acta 1639:104-12. 2003
..Our GST-pulldown and immunoprecipitation results indicate that RNF11 interacts with the E3 ligase AIP4 when coexpressed with RNF11 in mammalian cells...
- Gene expression profiling of ductal carcinomas in situ and invasive breast tumors
Arun Seth
Laboratory of Molecular Pathology, Department of Anatomic Pathology, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
Anticancer Res 23:2043-51. 2003
..CONCLUSION: The known and novel genes discussed here represent targets for molecular characterization during breast cancer development as well as for designing novel strategies for diagnosis and treatment...
- Analysis of the HER2/neu gene amplification in microdissected breast cancer tumour samples
Rishie M Seth
Department of Anatomic Pathology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Anticancer Res 26:927-31. 2006
..Our results indicated that LCM is a powerful technique for isolating pure populations of cells from paraffin-embedded tissue sections and that these cells can be used to study genomic alterations at the DNA level...
- The breast cancer-associated gene Di12 has oncogenic activity
Angelika M Burger
Molecular and Cell Biology Research, Laboratory of Molecular Pathology, Sunnybrook and Women's College Health Science Centre, University of Toronto, Toronto, Canada
Anticancer Res 23:2027-33. 2003
..Our data indicate that Di12 expression is oncogenic in in vitro transformation and in vivo tumorigenic assays...
- Highlights in experimental therapeutics
Angelika M Burger
Department of Pharmacology and Experimental Therapeutics, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Cancer Lett 245:11-21. 2007
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Characterisation of breast cancer cell lines and establishment of a novel isogenic subclone to study migration, invasion and tumourigenicityLinda Hughes
UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, Ireland
Clin Exp Metastasis 25:549-57. 2008
..The presence of a breast cancer stem cell population within the variant cell line may provide an explanation for the increased anchorage independent growth and tumourigenicity...
- KML001 cytotoxic activity is associated with its binding to telomeric sequences and telomere erosion in prostate cancer cells
Pornima Phatak
Department of Pharmacology, Cytogenetics Laboratory, University of Maryland, Baltimore, MD, USA
Clin Cancer Res 14:4593-602. 2008
..In this study, we elucidated the mode of action of KML001 and investigated its effects on telomerase and telomeres...
- Correlation of ErbB2 gene status, mRNA and protein expression in a panel of >100 human tumor xenografts of different origin
Simon Kuesters
Oncotest Institute for Experimental Oncology, Am Flughafen 12-14, 79108 Freiburg i.Br, Germany
Onkologie 29:249-56. 2006
..Correlation was found between ErbB2 mRNA and protein expression. CONCLUSION: Based on expression data, cervical, gastric and adenocarcinomas of the lung emerged as new potential indications for ErbB2-directed cancer therapies...
- Antitumor activity of bis-indole derivatives
Aldo Andreani
Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
J Med Chem 51:4563-70. 2008
..In conclusion we demonstrated that this approach was successful, since some of the compounds described are much more active than the numerous, so far prepared and tested 3-indolylmethylene-2-indolinones...
- Microarrays of 41 human tumor cell lines for the characterization of new molecular targets: expression patterns of cathepsin B and the transferrin receptor
Gregory J Wirth
Institute for Experimental Oncology, Oncotest GmbH, Freiburg, Germany
Oncology 71:86-94. 2006
..Western blotting confirmed the results obtained by immunohistochemistry. Using these cell line microarrays, cell lines overexpressing a target of interest can be selected for in vitro evaluation of specific inhibitors...
- Cancer stem cells and individualized therapy
Saranya Chumsri
Department of Medicine, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD 21201, USA
Cancer Genomics Proteomics 4:165-74. 2007
..Here, we provide a current overview of cancer stem cell biology and highlight possibilities for targeted intervention with existing and novel experimental anticancer agents...
- Inhibition of adenosine deaminase by analogues of adenosine and inosine, incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one
Ravi K Ujjinamatada
Laboratory for Drug Design and Synthesis, Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA
J Med Chem 51:694-8. 2008
..Also, 3 is not a substrate of ADA. Nucleosides 3 and 4 also exhibit moderate in vitro activity against breast cancer cell lines, while all four are only minimally or nontoxic to the normal cells...
- 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors
Thomas Beckers
ASTA Medica Oncology, D 60314 Frankfurt Main, Germany
Cancer Res 62:3113-9. 2002
..4 days at 400 mg/kg. Therefore, D-64131 and analogues have the potential to be developed for cancer therapy, replacing or supplementing standard therapy regimens with tubulin-targeting drugs from natural sources...
- Contributions of human tumor xenografts to anticancer drug development
Edward A Sausville
Marlene and Stewart Greenebaum Cancer Center, and Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
Cancer Res 66:3351-4, discussion 3354. 2006
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- Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in vitro: activity in human tumor cells correlates with telomere length and can be enhanced, or antagoni
Jennifer C Cookson
Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, United Kingdom
Mol Pharmacol 68:1551-8. 2005
..Our results support the combined use of certain classes of cytotoxic anticancer agents with RHPS4 to enhance potential clinical benefit...
- Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models
Victoria Smith
Tumor Biology Center at the University of Freiburg, Breisacherstr. 117, 79106, Freiburg, Germany
Cancer Chemother Pharmacol 56:126-37. 2005
..e. by modulating Hsp90 function. Since 17DMAG can be formulated in physiological aqueous solutions, the data reported here strongly support the development of 17DMAG as a more pharmaceutically practicable congener of 17AAG...
- Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression
Goran Landberg
Division of Pathology, Department of Laboratory Medicine, U MAS, Lund University, Malmo, Sweden
Breast Cancer Res Treat 89:313-6. 2005
..A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis...
- The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
Angelika M Burger
Institute for Experimental Oncology, Freiburg, Germany
Cancer Res 65:1489-96. 2005
..The in vitro and in vivo data presented here is consistent with the G-quadruplex binding ligand BRACO-19 producing an anticancer effect by inhibiting the capping and catalytic functions of telomerase...
- 17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models
Angelika M Burger
Tumor Biology Center, Albert Ludwigs University of Freiburg, Freiburg, Germany
Anticancer Drugs 15:377-87. 2004
..g. with tumor regressions) to 17-AAG may be associated with modulation of Hsp90 expression. The expression of this target should be followed in clinical studies with 17-AAG...
- Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization
Helge Prinz
Institute of Pharmaceutical and Medicinal Chemistry, Westphalian Wilhelms University, Hittorfstrasse 58 62, D 48149 Munster, Germany
J Med Chem 46:3382-94. 2003
..The novel benzylidene-9(10H)-anthracenones described in the present study constitute an interesting group of highly active and easily accessible antimitotic agents that inhibit tubulin polymerization...
- 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines
Geoffrey Wells
Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham, NG7 2RD, U.K
J Med Chem 46:532-41. 2003
..Analogue 7a also showed in vivo antitumor activity against human RXF 944XL renal xenografts in nude NMRI mice and is the focus of further study...
- Cancer stem cell targeted agents: therapeutic approaches and consequences
Saranya Chumsri
University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, North Hospital S9D10, 22 South Greene Street, Baltimore, MD 21201, USA
Curr Opin Mol Ther 10:323-33. 2008
..In addition, known inhibitors of these targets that could be utilized in the design of clinical protocols together with conventional cytotoxics as debulking agents are described...
