Bruno Buisson

Summary

Publications

  1. doi Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy
    Thierry Bordet
    Trophos, Parc Scientifique de Luminy, Luminy Biotech Entreprises, Case 931, 13288 Marseille Cedex 9, France
    J Pharmacol Exp Ther 326:623-32. 2008
  2. ncbi Nicotine addiction: the possible role of functional upregulation
    Bruno Buisson
    Dept of Pharmacology and Toxicology, TROPHOS SA, Parc Scientifique de Luminy, Marseille, France
    Trends Pharmacol Sci 23:130-6. 2002
  3. ncbi Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
    Thierry Bordet
    Trophos, Parc Scientifique de Luminy, Marseille Cedex, France
    J Pharmacol Exp Ther 322:709-20. 2007
  4. doi TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition
    Sophie Schaller
    Trophos S A, Luminy Biotech Entreprises, Marseille, France
    J Pharmacol Exp Ther 333:696-706. 2010
  5. pmc Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism
    Yolanda F Vallejo
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:5563-72. 2005
  6. ncbi Potentiation of human alpha4beta2 neuronal nicotinic acetylcholine receptor by estradiol
    Logos Curtis
    Department of Physiology, Faculty of Medicine, Geneve, Switzerland
    Mol Pharmacol 61:127-35. 2002
  7. ncbi Strategies for nicotine replacement therapy
    Bruno Buisson
    Pharmacology Toxicology, Trophos, Case 931, Parc Luminy Biotech Entreprises, 13288 Marseille Cedex 9, France
    Drug Discov Today 8:778-9. 2003
  8. ncbi Allosteric modulation of ligand-gated ion channels
    Ron C Hogg
    Department of Neurosciences, Medical Faculty, CMU 1, rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Biochem Pharmacol 70:1267-76. 2005

Detail Information

Publications8

  1. doi Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy
    Thierry Bordet
    Trophos, Parc Scientifique de Luminy, Luminy Biotech Entreprises, Case 931, 13288 Marseille Cedex 9, France
    J Pharmacol Exp Ther 326:623-32. 2008
    ..These results support the potential use of TRO19622 to treat painful diabetic and chemotherapy-induced neuropathies...
  2. ncbi Nicotine addiction: the possible role of functional upregulation
    Bruno Buisson
    Dept of Pharmacology and Toxicology, TROPHOS SA, Parc Scientifique de Luminy, Marseille, France
    Trends Pharmacol Sci 23:130-6. 2002
    ..Moreover, we propose a new paradigm that describes the unusual behavior of these neuronal nAChRs and helps to explain the effects of nicotine in the CNS and the diffuse effects of ACh...
  3. ncbi Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
    Thierry Bordet
    Trophos, Parc Scientifique de Luminy, Marseille Cedex, France
    J Pharmacol Exp Ther 322:709-20. 2007
    ..TRO19622 may have therapeutic potential for ALS and other motor neuron and neurodegenerative diseases...
  4. doi TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition
    Sophie Schaller
    Trophos S A, Luminy Biotech Entreprises, Marseille, France
    J Pharmacol Exp Ther 333:696-706. 2010
    ..Its efficacy in an animal model of myocardial infarctions makes TRO40303 a promising new drug for the reduction of cardiac ischemia-reperfusion injury...
  5. pmc Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism
    Yolanda F Vallejo
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:5563-72. 2005
    ....
  6. ncbi Potentiation of human alpha4beta2 neuronal nicotinic acetylcholine receptor by estradiol
    Logos Curtis
    Department of Physiology, Faculty of Medicine, Geneve, Switzerland
    Mol Pharmacol 61:127-35. 2002
    ..These results suggest the presence of a specific site at the human nicotinic acetylcholine receptor alpha4 subunit through which estradiol can cause an allosteric potentiation of acetylcholine-evoked responses...
  7. ncbi Strategies for nicotine replacement therapy
    Bruno Buisson
    Pharmacology Toxicology, Trophos, Case 931, Parc Luminy Biotech Entreprises, 13288 Marseille Cedex 9, France
    Drug Discov Today 8:778-9. 2003
  8. ncbi Allosteric modulation of ligand-gated ion channels
    Ron C Hogg
    Department of Neurosciences, Medical Faculty, CMU 1, rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Biochem Pharmacol 70:1267-76. 2005
    ..Here we review the allosteric modulation of LGICs in light of the latest findings and discuss the suitability of this approach to the design of new therapeutic molecules...