G Bu

Summary

Publications

  1. ncbi ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP)
    G Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Sci 110:65-73. 1997
  2. pmc 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein
    G Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 14:2269-80. 1995
  3. ncbi The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein
    C X Liu
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 276:28889-96. 2001
  4. pmc Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis
    Y Li
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 21:1185-95. 2001
  5. ncbi High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs
    L Melman
    Department of Pediatrics Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:29338-46. 2001
  6. ncbi Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein
    L M Obermoeller-McCormick
    Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 114:899-908. 2001
  7. ncbi The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor
    R Savonen
    Departments of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:25877-82. 1999
  8. ncbi Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation
    M Zhuo
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 20:542-9. 2000
  9. ncbi Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein
    G Bu
    Edward Mallinkrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:22218-24. 1996
  10. ncbi Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein
    G Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 273:13359-65. 1998

Collaborators

Detail Information

Publications21

  1. ncbi ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP)
    G Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Sci 110:65-73. 1997
    ..Taken together, our results thus demonstrate that ERD2 proteins are capable of retaining the novel ER retention signal associated with RAP...
  2. pmc 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein
    G Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 14:2269-80. 1995
    ..Taken together, our results thus suggest that RAP functions intracellularly as a molecular chaperone for LRP and regulates its ligand binding activity along the secretory pathway...
  3. ncbi The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein
    C X Liu
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 276:28889-96. 2001
    ..In addition, tissue expression analysis reveals that the LRP1B gene is expressed in brain, thyroid, and salivary gland. These studies thus extend the physiological roles of members of the LDL receptor family...
  4. pmc Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis
    Y Li
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 21:1185-95. 2001
    ..Thus, the role of PKA phosphorylation of LRP in receptor-mediated endocytosis may provide a mechanism by which the endocytic function of LRP can be regulated by external signals...
  5. ncbi High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs
    L Melman
    Department of Pediatrics Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:29338-46. 2001
    ....
  6. ncbi Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein
    L M Obermoeller-McCormick
    Department of Pediatrics, St Louis Children's Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 114:899-908. 2001
    ..We conclude that while domains II and IV of LRP share many ligand-binding properties, each of the putative ligand-binding domains of LRP is unique in its contribution to ligand binding...
  7. ncbi The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor
    R Savonen
    Departments of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:25877-82. 1999
    ..Thus, our present study demonstrates that RAP serves as a folding and trafficking chaperone for the VLDL receptor via interactions of its carboxyl-terminal repeat with the three amino-terminal ligand-binding repeats of the VLDL receptor...
  8. ncbi Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation
    M Zhuo
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 20:542-9. 2000
    ..Taken together, our results demonstrate that interactions between tPA and cell surface LRP are important for hippocampal L-LTP...
  9. ncbi Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein
    G Bu
    Edward Mallinkrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:22218-24. 1996
    ..Thus, our results strongly suggest that, in addition to the prevention of premature binding of ligands to LRP, RAP also plays an important role in receptor folding...
  10. ncbi Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein
    G Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 273:13359-65. 1998
    ..Both rapid and long term induction of LRP expression were also detected in peripheral nervous system-derived PC12 cells following NGF treatment. Taken together, our results demonstrate that NGF regulates LRP expression in neuronal cells...
  11. ncbi Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells
    G Bu
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 269:29874-82. 1994
    ..Our results thus strongly suggest several potential roles for LRP in brain protein and lipoprotein metabolism, as well as control of extracellular protease activity...
  12. ncbi Low-density lipoprotein receptor family: endocytosis and signal transduction
    Y Li
    Department of Pediatrics, Washington University School of Medicine, and St Louis Children's Hospital, MO 63110, USA
    Mol Neurobiol 23:53-67. 2001
    ..The relationship of these functions to the development of the neuronal system and in the pathogenesis of Alzheimer's disease is specifically discussed...
  13. ncbi The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein
    Y Li
    Departments of Pediatrics, and Cell Biology and Physiology, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 275:17187-94. 2000
    ..In addition, we show that LRP minireceptor mutants defective in endocytosis signal(s) accumulate at the cell surface and are less efficient in delivery of ligand for degradation...
  14. ncbi The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family
    G Bu
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Int Rev Cytol 209:79-116. 2001
    ....
  15. pmc The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo
    I Warshawsky
    Edward Mallinckrodt Department of Pediatrics, Jewish Hospital, St Louis, Missouri 63110, USA
    J Clin Invest 95:1773-81. 1995
    ..Together our findings demonstrate that the carboxy-terminal region(s) distal to amino acid 160 of TFPI mediates TFPI binding to hepatoma cells both in vitro and in vivo...
  16. ncbi Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts
    M M Hardy
    Department of Cell Culture and Biochemistry, Monsanto Company, St Louis, Missouri 63167, USA
    J Biol Chem 272:6812-7. 1997
    ..These results demonstrate that cellular modulation of t-PA expression in HCF involves LRP receptor-mediated clearance of t-PA. This LRP receptor-mediated event results in down-regulation of t-PA expression at the mRNA level...
  17. ncbi Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates
    Y Li
    Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri 63110, USA
    J Biol Chem 276:18000-6. 2001
    ..These results thus suggest that the endocytic functions of members of the LDLR family are distinct and that certain receptors in this family may play their main roles in areas other than receptor-mediated endocytosis...
  18. pmc Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo
    M Narita
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 96:1164-8. 1995
    ..Our results clearly demonstrate that two independent receptor systems, LRP and the mannose receptor, are involved in the hepatic clearance of t-PA...
  19. pmc Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis
    J Zhang
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Oncogene 29:539-49. 2010
    ..Our results suggest that Wnt signaling activation at the cell-surface receptor level can contribute to breast cancer tumorigenesis...
  20. ncbi Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide
    K L Moulder
    Department of Neurology and Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 72:1069-80. 1999
    ..Furthermore, these results indicate that the toxic effect may occur independently of members of the low-density lipoprotein receptor gene family...
  21. pmc Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins
    P van Kerkhof
    Department of Cell Biology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Mol Biol Cell 12:2556-66. 2001
    ..The data suggest that the ubiquitin-proteasome pathway is involved in an endosomal sorting step of selected membrane proteins to lysosomes, thereby providing a mechanism for regulated degradation...