immunohistochemical expression of survivin and γ-H2AX in vulvar intraepithelial neoplasia and low-stage squamous cell carcinomaHermann Brustmann
Department of Pathology, Landesklinikum Thermenregion Moedling, Sr Maria Restitutagasse 12, Moedling, Austria
Int J Gynecol Pathol 30:583-90. 2011
..Expression patterns were different for both factors, suggesting their involvement in different biologic mechanisms as an early event leading to resistance to apoptosis in vulvar carcinogenesis...
The accuracy of frozen section analysis in ultrasound- guided core needle biopsy of breast lesionsAndreas H Brunner
Department of Obstetrics and Gynecology, Division of Gynecology and Gynecologic Oncology, Landesklinikum Moedling Vienna, Austria
BMC Cancer 9:341. 2009
..Limited data are available to evaluate the accuracy of frozen section analysis and ultrasound- guided core needle biopsy of the breast...
Poly(ADP-ribose) polymerase (PARP) and DNA-fragmentation factor (DFF45): expression and correlation in normal, hyperplastic and neoplastic endometrial tissuesHermann Brustmann
Department of Pathology, Thermenklinikum, Sr Maria Restitutagasse 12, A 2340 Moedling, Vienna, Austria
Pathol Res Pract 203:65-72. 2007
..Immunoexpression of PARP and DFF45 is apparently altered in endometrial carcinomas as compared with non-neoplastic endometrial tissues, indicating impaired mechanisms of apoptosis in the former...
- Epidermal growth factor receptor is involved in the development of an invasive phenotype in vulvar squamous lesions, but is not related to MIB-1 immunoreactivity
Hermann Brustmann
Department of Pathology, Thermenklinikum Moedling Vienna, Austria
Int J Gynecol Pathol 26:481-9. 2007
..The lack of a relationship with PIs suggests that mechanisms other than proliferation are involved in this process...
- Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome
Hermann Brustmann
Department of Pathology, Thermenklinikum, Moedling Vienna, Austria
Int J Gynecol Pathol 26:147-53. 2007
..0196, log-rank test). This study indicates that PARP expression is frequently upregulated in ovarian serous carcinomas, related with MIB-1 LIs and p53 expression, and may serve as a marker of aggressive behavior with prognostic value...
- Paraganglioma of the vagina: report of a case
Hermann Brustmann
Department of Pathology, Thermenklinikum, Sr Maria Restitutagasse 12, A 2340 Moedling Vienna, Austria
Pathol Res Pract 203:189-92. 2007
..This case study reports on an endocrinologically inactive vaginal paraganglioma, emphasizing the morphological and immunohistochemical differential diagnoses...
- Nucleoporin 88 expression in normal and neoplastic squamous epithelia of the uterine cervix
Hermann Brustmann
Department of Pathology, Landesklinikum Thermenregion, A 2340 Moedling, Austria
Ann Diagn Pathol 13:303-7. 2009
..However, Nup88 evaluation is of limited value as a diagnostic marker in individual cases...
- Intestinal metastases in a squamous cell carcinoma arising in mature cystic teratoma of the ovary: a case report
Hermann Brustmann
Department of Pathology, Thermenklinikum, A 2340 Moedling Vienna, Austria
Ann Diagn Pathol 10:374-5. 2006
..In this unusual case, metastasizing SCC of the ovary arising in an MCT led to suppurative peritonitis and consequently to death of the patient. Follow-up procedures regarding intestinal spread could be useful in patients with SCC in MCT...
- DNA fragmentation factor (DFF45): expression and prognostic value in serous ovarian cancer
Hermann Brustmann
Department of Pathology, Thermenklinikum, Sr Maria Restitutagasse, 12A 2340 Moedling Vienna, Austria
Pathol Res Pract 202:713-20. 2006
..0187). Apoptotic bodies were consistently DFF45-negative. This study indicates that DFF45 expression is frequently upregulated in ovarian serous carcinomas and may serve as a marker of aggressive behavior with prognostic value...
- Myxoglobulosis of the appendix associated with a proximal carcinoid and a pseudodiverticulum
Hermann Brustmann
Department of Pathology, Thermenklinikum, Moedling, Vienna, Austria
Ann Diagn Pathol 10:166-8. 2006
..The latter may be an adjunct to the proximal partial obstruction of the appendiceal lumen by the carcinoid in the development of the spheroids of myxoglobulosis...
- Galectin-3 and CD1a-positive dendritic cells are involved in the development of an invasive phenotype in vulvar squamous lesions
Hermann Brustmann
Department of Pathology, Thermenklinikum, Moedling Vienna, Austria
Int J Gynecol Pathol 25:30-7. 2006
....
- Immunohistochemical detection of human telomerase reverse transcriptase (hTERT) and c-kit in serous ovarian carcinoma: a clinicopathologic study
Hermann Brustmann
Department of Pathology, Thermenklinikum, Sr Maria Restitutagasse 12, A 2340 Moedling Vienna, Austria
Gynecol Oncol 98:396-402. 2005
..This study investigated the expression of human telomerase reverse transcriptase (hTERT) and c-kit in a cohort of serous ovarian carcinomas by immunohistochemistry with regard to outcome and clinicopathologic variables...
- Immunohistochemical detection of human telomerase reverse transcriptase (hTERT), topoisomerase IIalpha expression, and apoptosis in endometrial adenocarcinoma and atypical hyperplasia
Hermann Brustmann
Department of Pathology, Thermenklinikum Moedling, Vienna, Austria
Int J Gynecol Pathol 24:184-92. 2005
..1956). These results suggest that hTERT expression is closely related to proliferation, apoptosis, and high grade in endometrial carcinomas, reflecting cell cycle deregulation in endometrial carcinogenesis...
- Vascular endothelial growth factor expression in serous ovarian carcinoma: relationship with topoisomerase II alpha and prognosis
Hermann Brustmann
Department of Pathology, Thermenklinikumm, A 2340 Moedling Vienna, Austria
Gynecol Oncol 95:16-22. 2004
....
- Expression of cellular apoptosis susceptibility protein in serous ovarian carcinoma: a clinicopathologic and immunohistochemical study
Hermann Brustmann
Department of Pathology, Thermenklinikum, Moedling Vienna, Austria
Gynecol Oncol 92:268-76. 2004
....
- Galectin-3 expression in normal, hyperplastic, and neoplastic endometrial tissues
Hermann Brustmann
Department of Pathology, Landeskrankenhaus, Moedling Vienna, Austria
Pathol Res Pract 199:151-8. 2003
..This study shows that galectin-3 expression increases from normal and hyperplastic to atypical hyperplastic and cancerous states of endometrial tissues, and provides further evidence of a relationship between AH and EC...
- Expression of phosphorylated histone H2AX (γ-H2AX) in normal and neoplastic squamous epithelia of the uterine cervix: an immunohistochemical study with epidermal growth factor receptor
Hermann Brustmann
Department of Pathology, Landesklinikum Thermenregion, Moedling, Austria
Int J Gynecol Pathol 30:76-83. 2011
....
- Epidermal growth factor receptor expression in serous ovarian carcinoma: an immunohistochemical study with galectin-3 and cyclin D1 and outcome
Hermann Brustmann
Department of Pathology, Landesklinikum Thermenregion, Moedling, Austria
Int J Gynecol Pathol 27:380-9. 2008
..6578 and P=0.0675, respectively). This study indicates that with regard to EGFR and cytoplasmic galectin-3 immunoexpression, multiple marker testing may be an adjunct in the identification of high-risk ovarian serous cancers...
- Vascular endothelial growth factor expression in serous ovarian carcinoma: relationship with high mitotic activity and high FIGO stage
Hermann Brustmann
Department of Pathology, Landeskrankenhaus, Moedling Vienna, A 2340, Austria
Gynecol Oncol 84:47-52. 2002
..The aim of this study was to investigate the expression of vascular endothelial growth factor (VEGF) by neoplastic cells in serous ovarian cystadenocarcinoma in relation to proliferation as determined by mitotic activity and to FIGO stage...
- Immunoexpression of PAX 8 in endometrial cancer: relation to high-grade carcinoma and p53
Andreas H Brunner
Department of Obstetrics and Gynecology, Landesklinikum Thermenregion Moedling Vienna Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Sr Maria Restitutag 12, Moedling Vienna, Austria
Int J Gynecol Pathol 30:569-75. 2011
..PAX 8 overexpression correlates with p53 expression and high-grade endometrial carcinomas but seems not to be useful as a prognostic parameter...
- Expression of topoisomerase IIalpha, Ki-67, proliferating cell nuclear antigen, p53, and argyrophilic nucleolar organizer regions in vulvar squamous lesions
Hermann Brustmann
Department of Pathology, Landeskrankenhaus, Moedling/Vienna, Austria
Gynecol Oncol 86:192-9. 2002
..CONCLUSIONS: This study presents topo IIalpha and Ki-67 as useful proliferation-associated markers of vulvar epithelia...
- Apoptotic bodies as a morphological feature in serous ovarian carcinoma: correlation with nuclear grade, Ki-67 and mitotic indices
Hermann Brustmann
Department of Pathology, Landeskrankenhaus, Moedling/Vienna, Austria
Pathol Res Pract 198:85-90. 2002
..The positive correlation between ABI and increasing nuclear grade, mitotic activity, and architectural growth pattern may indicate that apoptotic bodies are another variable for grading serous ovarian carcinomas...
- Expression of human telomerase reverse transcriptase in vulvar intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study with survivin and p53
Alfred Wellenhofer
Department of Obstetrics and Gynecology, Landesklinikum Thermenregion Baden, Moedling, Austria
Arch Pathol Lab Med 136:1359-65. 2012
..Human telomerase reverse transcriptase (hTERT), an enzyme that enables cells to overcome replicative senescence and to divide indefinitely, is overexpressed in many cancers and their precursor lesions...
- Expression of γ-H2AX in endometrial carcinomas: an immunohistochemical study with p53
Andreas H Brunner
Department of Obstetrics and Gynecology, Landesklinikum Thermenregion Moedling Vienna, Moedling Vienna, Austria
Gynecol Oncol 121:206-11. 2011
..Increasing expression levels of γ-H2AX are associated with unfavourable prognostic factors in type I and type II endometrial carcinomas...
- Heterotopic liver in the right cardiac auricle
Hermann Brustmann
Department of Pathology, , Vienna, Austria
Ann Diagn Pathol 6:248-9. 2002
..Another abnormal finding was a horseshoe kidney. To the best of the author's knowledge, this is the first report of heterotopic liver tissue in the cardiac auricles...
- Undifferentiated Endometrial Sarcoma of the Ovary: A Case Report with Review of Recent Literature and Discussion of Lacking Specificity of CD10 Immunoreactivity
Hermann Brustmann
Department of Pathology, Landesklinikum Thermenregion Mödling, Sr M Restitutagasse 12, Mödling A 2340, Austria
Patholog Res Int 2010:608519. 2010
..Morphological features, extensive sampling, and appropriate immunohistochemistry including markers for cytokeratins and myogenic differentiation are mandatory to arrive at the correct diagnosis...
