David J Brusick

Summary

Publications

  1. doi request reprint A perspective on testing of existing pharmaceutical excipients for genotoxic impurities
    David J Brusick
    Regul Toxicol Pharmacol 55:200-4. 2009
  2. ncbi request reprint Critical assessment of the genetic toxicity of naphthalene
    David Brusick
    Regul Toxicol Pharmacol 51:S37-42. 2008
  3. doi request reprint Possible genotoxic modes of action for naphthalene
    David Brusick
    Department of Environmental Engineering, Carnegie Mellon University, USA
    Regul Toxicol Pharmacol 51:S43-50. 2008
  4. doi request reprint A critical review of the genetic toxicity of steviol and steviol glycosides
    D J Brusick
    Brusick Consultancy, 123 Moody Creek Road, Bumpass, VA 23024, United States
    Food Chem Toxicol 46:S83-91. 2008
  5. doi request reprint Expert panel report on a study of Splenda in male rats
    David Brusick
    Independent Consultant, 123 Moody Creek Rd, Bumpass, VA 23024, USA
    Regul Toxicol Pharmacol 55:6-12. 2009
  6. doi request reprint The absence of genotoxicity of sucralose
    D Brusick
    Toxicology Consultant, Bumpass, VA 23024, USA
    Food Chem Toxicol 48:3067-72. 2010
  7. ncbi request reprint Analysis of genotoxicity and the carcinogenic mode of action for ortho-phenylphenol
    David Brusick
    Covance Laboratories, Vienna, Virginia 22182, USA
    Environ Mol Mutagen 45:460-81. 2005
  8. ncbi request reprint A review of the genotoxicity of ethylbenzene
    Leigh Henderson
    Henderson Scientific Consultancy, Cuddington, Cheshire CW82UT, UK
    Mutat Res 635:81-9. 2007

Detail Information

Publications8

  1. doi request reprint A perspective on testing of existing pharmaceutical excipients for genotoxic impurities
    David J Brusick
    Regul Toxicol Pharmacol 55:200-4. 2009
    ..This report is an attempt to put such recommendations into the proper perspective regarding the likelihood of protecting or improving public health...
  2. ncbi request reprint Critical assessment of the genetic toxicity of naphthalene
    David Brusick
    Regul Toxicol Pharmacol 51:S37-42. 2008
    ..Based on the data reviewed in this report, it is not apparent that genetic lesions produced by naphthalene or any of its metabolites drive the tumorigenic activity...
  3. doi request reprint Possible genotoxic modes of action for naphthalene
    David Brusick
    Department of Environmental Engineering, Carnegie Mellon University, USA
    Regul Toxicol Pharmacol 51:S43-50. 2008
    ..The report also outlines a set of six studies that could resolve some of these key uncertainties...
  4. doi request reprint A critical review of the genetic toxicity of steviol and steviol glycosides
    D J Brusick
    Brusick Consultancy, 123 Moody Creek Road, Bumpass, VA 23024, United States
    Food Chem Toxicol 46:S83-91. 2008
    ..Application of a Weight-of-Evidence approach to assess the genetic toxicology database concludes that these substances do not pose a risk of genetic damage following human consumption...
  5. doi request reprint Expert panel report on a study of Splenda in male rats
    David Brusick
    Independent Consultant, 123 Moody Creek Rd, Bumpass, VA 23024, USA
    Regul Toxicol Pharmacol 55:6-12. 2009
    ..The study conclusions are not consistent with published literature and not supported by the data presented...
  6. doi request reprint The absence of genotoxicity of sucralose
    D Brusick
    Toxicology Consultant, Bumpass, VA 23024, USA
    Food Chem Toxicol 48:3067-72. 2010
    ..All results were evaluated as negative. These results support the overall conclusion by regulatory and heath agencies that sucralose is safe for its intended use...
  7. ncbi request reprint Analysis of genotoxicity and the carcinogenic mode of action for ortho-phenylphenol
    David Brusick
    Covance Laboratories, Vienna, Virginia 22182, USA
    Environ Mol Mutagen 45:460-81. 2005
    ..It is possible that this threshold-dependent clastogenicity could contribute to the carcinogenic mode of action for OPP or SOPP...
  8. ncbi request reprint A review of the genotoxicity of ethylbenzene
    Leigh Henderson
    Henderson Scientific Consultancy, Cuddington, Cheshire CW82UT, UK
    Mutat Res 635:81-9. 2007
    ..The available data from the standard battery of genotoxicity assays do not support a genotoxic mechanism for ethylbenzene-induced kidney, liver or lung tumors in rats and mice...