Natasja Bruin


Affiliation: Fraunhofer IME-TMP
Location: Frankfurt am Main, Duitsland


  1. request reprint
    de Bruin N, van Luijtelaar E, Cools A, Ellenbroek B. Dopamine characteristics in rat genotypes with distinct susceptibility to epileptic activity: apomorphine-induced stereotyped gnawing and novelty/amphetamine-induced locomotor stimulation. Behav Pharmacol. 2001;12:517-25 pubmed
    ..It is suggested that the functional dopaminergic mesolimbic dominance is an important factor in the susceptibility to show spontaneously occurring spike-wave discharges. ..
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    Farries T, Harris A, Auffret A, Aitken A. Removal of N-acetyl groups from blocked peptides with acylpeptide hydrolase. Stabilization of the enzyme and its application to protein sequencing. Eur J Biochem. 1991;196:679-85 pubmed
    ..No chromatographic separation are required. The N-terminal sequence can then be obtained by automated Edman degradation. This procedure has been successfully demonstrated on a large synthetic peptide. ..
  3. van Loevezijn A, Venhorst J, Iwema Bakker W, de Korte C, de Looff W, Verhoog S, et al. N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT?R) antagonists with unique structural features. J Med Chem. 2011;54:7030-54 pubmed publisher
    ..The optimized structure 42 is an extremely selective, hERG-free, high-affinity 5-HT(6)R antagonist showing good human in vitro metabolic stability. Rat pharmacokinetic data were sufficiently good to enable further in vivo profiling. ..
  4. De Bruin N, Lange J, Kruse C, Herremans A, Schoffelmeer A, van Drimmelen M, et al. SLV330, a cannabinoid CB(1) receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats. Behav Brain Res. 2011;217:408-15 pubmed publisher
    ..The combined action of reducing the reinforcing and motivational properties of nicotine and alcohol and the improvement of impulse control supports the idea that the cannabinoid system is a promising target for anti-relapse medication. ..
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    de Bruin N, Mahieu M, Patel T, Willems R, Lesage A, Megens A. Performance of F2 B6x129 hybrid mice in the Morris water maze, latent inhibition and prepulse inhibition paradigms: Comparison with C57Bl/6J and 129sv inbred mice. Behav Brain Res. 2006;172:122-34 pubmed
    ..Following the setup of these procedures in mice, we are now able to compare the effects of gene knockout/mutations used for target validation with results in the present study as a frame of reference. ..
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    Ellenbroek B, de Bruin N, van Den Kroonenburg P, van Luijtelaar E, Cools A. The effects of early maternal deprivation on auditory information processing in adult Wistar rats. Biol Psychiatry. 2004;55:701-7 pubmed
    ..At longer intervals (250-1000 milliseconds), no effect was seen. The implications for the model and the development of disturbances in information processes are discussed. ..
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    de Bruin N, Ellenbroek B, van Luijtelaar E, Cools A, Stevens K. Hippocampal and cortical sensory gating in rats: effects of quinpirole microinjections in nucleus accumbens core and shell. Neuroscience. 2001;105:169-80 pubmed
    ..This casts doubt on whether dopamine receptor activation affects the putative inhibitory process between the first and the second stimulus. ..
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    van Luijtelaar G, Fabene P, de Bruin N, Jongema C, Ellenbroek B, Veening J. Neural correlates of sensory gating in the rat: decreased Fos induction in the lateral septum. Brain Res Bull. 2001;54:145-51 pubmed
    ..The results might be relevant for theories on sensory gating deficits in schizophrenia. ..
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    de Bruin N, van Luijtelaar E, Jansen S, Cools A, Ellenbroek B. Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. Neurosci Res. 2000;38:165-73 pubmed
    ..Finally, further research is required to provide evidence in favor of the hypothesis that the relative dominance of the dopaminergic mesolimbic system is smaller in WAG/Rij than in APO-SUS. ..

Detail Information


  1. request reprint
    de Bruin N, van Luijtelaar E, Cools A, Ellenbroek B. Auditory information processing in rat genotypes with different dopaminergic properties. Psychopharmacology (Berl). 2001;156:352-9 pubmed
    ..On the basis of these results we have concluded that both auditory filtering processes are differently regulated by DA in the nigrostriatal and mesolimbic systems. ..
  2. request reprint
    de Bruin N, Ellenbroek B, van Schaijk W, Cools A, Coenen A, van Luijtelaar E. Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval. Biol Psychol. 2001;55:195-213 pubmed
    ..The ISI effects on gating are due to an increase of the amplitude to S2. The results have implications for the discussion about the rat homologue of the human P50. ..
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    De Bruin N, Fransen F, Duytschaever H, Grantham C, Megens A. Attentional performance of (C57BL/6Jx129Sv)F2 mice in the five-choice serial reaction time task. Physiol Behav. 2006;89:692-703 pubmed
    ..This offers the opportunity to test transgenic and knockout mice with similar background as the B6129F2 as animal models of psychiatric and neurological diseases. ..
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    de Bruin N, Pouzet B. Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: deficits induced by scopolamine and by prolonging the retention interval. Pharmacol Biochem Behav. 2006;85:253-60 pubmed
    ..In conclusion, galantamine was shown to possess memory-enhancing effects in two conditions that reduced object discrimination: scopolamine-induced deficits and when a longer retention interval was used. ..
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    de Bruin N, Ellenbroek B, Cools A, Coenen A, van Luijtelaar E. Differential effects of ketamine on gating of auditory evoked potentials and prepulse inhibition in rats. Psychopharmacology (Berl). 1999;142:9-17 pubmed
    ..Secondly, PPI and the C-T paradigm reflect distinct inhibitory sensory processes, since both paradigms are differentially influenced by ketamine. ..
  6. den Boon F, Body S, Hampson C, Bradshaw C, Szabadi E, de Bruin N. Effects of amisulpride and aripiprazole on progressive-ratio schedule performance: comparison with clozapine and haloperidol. J Psychopharmacol. 2012;26:1231-43 pubmed publisher
    ..Amisulpride produced a short-lived enhancement, followed by a long-lasting reduction, of reinforcer value. Both drugs impaired motor performance. ..
  7. De Bruin N, van Drimmelen M, Kops M, Van Elk J, Wetering M, Schwienbacher I. Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats. Behav Brain Res. 2013;244:15-28 pubmed publisher
    ..The lowest dose of GSK-742457 (0.63 mg/kg) fully reversed the PCP-induced deficits while the higher dose (5.0 mg/kg) had an intermediate effect. ..
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    De Bruin N, Kiliaan A, De Wilde M, Broersen L. Combined uridine and choline administration improves cognitive deficits in spontaneously hypertensive rats. Neurobiol Learn Mem. 2003;80:63-79 pubmed
    ..A combination of uridine and choline administration improved selective attention and spatial learning in SHR. ..
  9. De Bruin N, Kloeze B, McCreary A. The 5-HT? serotonin receptor antagonist SB-271046 attenuates the development and expression of nicotine-induced locomotor sensitisation in Wistar rats. Neuropharmacology. 2011;61:451-7 pubmed publisher
    ..Further studies are warranted to substantiate this conclusion and further understand the role of 5-HT(6) receptors in addiction. ..
  10. De Bruin N, Prickaerts J, van Loevezijn A, Venhorst J, de Groote L, Houba P, et al. Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats. Neurobiol Learn Mem. 2011;96:392-402 pubmed publisher
    ..This suggests that these compounds could have potential as monotherapy, but also as adjunctive therapy in patients with AD treated with common treatments such as donepezil. ..
  11. Lange J, Venhorst J, van Dongen M, Frankena J, Bassissi F, de Bruin N, et al. Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. Eur J Med Chem. 2011;46:4808-19 pubmed publisher
    ..The presented holistic approach is anticipated to facilitate the identification of compounds with best-in-class properties at an early research stage. ..
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    Przewłocka B, Lason W, Turchan J, de Bruin N, van Luijtelaar G, Przewłocki R, et al. Anatomical and functional aspects of mu opioid receptors in epileptic WAG/Rij rats. Epilepsy Res. 1998;29:167-73 pubmed
  13. De Bruin N, McCreary A, van Loevezijn A, de Vries T, Venhorst J, van Drimmelen M, et al. A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats. Behav Brain Res. 2013;236:157-65 pubmed publisher
    ..Specifically, we demonstrated for the first time effects on nicotine self-administration and on nicotine and ethanol reinstatement. Further, these effects are probably not mediated by effects on impulse control. ..
  14. De Bruin N, van Loevezijn A, Wicke K, de Haan M, Venhorst J, Lange J, et al. The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment. Neurobiol Learn Mem. 2016;133:100-117 pubmed publisher
    ..In conclusion, SLV was investigated in several rodent animal models and found to be effective at a least effective dose (LED) of 20mg/kg and 10mg/kg (p.o.) in the rat and the mouse, respectively. ..
  15. De Bruin N, Schmitz K, Schiffmann S, Tafferner N, Schmidt M, Jordan H, et al. Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behav Brain Res. 2016;300:160-74 pubmed publisher
    ..These data indicate that improvements in behavioral deficits can occur in absence of clinical scores, which indicate subtle drug effects and may have translational value for human MS. ..