Thomas A Brown

Summary

Publications

  1. pmc Kinetic analysis of estrogen receptor/ligand interactions
    Rebecca L Rich
    Center for Biomolecular Interaction Analysis, University of Utah, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 99:8562-7. 2002
  2. ncbi request reprint Acute appendicitis in the setting of Clostridium difficile colitis: case report and review of the literature
    Thomas A Brown
    Department of Medicine, Summa Health System, Akron, Ohio 44221, USA
    Clin Gastroenterol Hepatol 5:969-71. 2007
  3. ncbi request reprint Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands
    Richard Chesworth
    Cardiovascular and Metabolic Diseases, Medicinal Chemistry, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Bioorg Med Chem Lett 15:5562-6. 2005
  4. ncbi request reprint Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists
    Richard Chesworth
    Pfizer Global Research and Development, CVMD Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Bioorg Med Chem Lett 14:2729-33. 2004
  5. ncbi request reprint Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules
    José A C Lemos
    Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Road, Gainesville, FL 32610 0424, USA
    FEMS Microbiol Lett 253:251-7. 2005

Collaborators

  • Richard Chesworth
  • H Z Ke
  • José A C Lemos
  • Rebecca L Rich
  • Robert A Burne
  • Jacqueline Abranches
  • Samuel P Simons
  • Preston Hensley
  • Kieran F Geoghegan
  • Lise R Hoth
  • Peter K LeMotte
  • David G Myszka

Detail Information

Publications5

  1. pmc Kinetic analysis of estrogen receptor/ligand interactions
    Rebecca L Rich
    Center for Biomolecular Interaction Analysis, University of Utah, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 99:8562-7. 2002
    ....
  2. ncbi request reprint Acute appendicitis in the setting of Clostridium difficile colitis: case report and review of the literature
    Thomas A Brown
    Department of Medicine, Summa Health System, Akron, Ohio 44221, USA
    Clin Gastroenterol Hepatol 5:969-71. 2007
    ..In each scenario, the involvement of the appendix might be overlooked...
  3. ncbi request reprint Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands
    Richard Chesworth
    Cardiovascular and Metabolic Diseases, Medicinal Chemistry, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Bioorg Med Chem Lett 15:5562-6. 2005
    ..A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity's (up to >100x) for ER-beta over ER-alpha are reported...
  4. ncbi request reprint Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists
    Richard Chesworth
    Pfizer Global Research and Development, CVMD Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Bioorg Med Chem Lett 14:2729-33. 2004
    ..Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER alpha and ER beta selective analogs...
  5. ncbi request reprint Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules
    José A C Lemos
    Department of Oral Biology, University of Florida College of Dentistry, 1600 SW Archer Road, Gainesville, FL 32610 0424, USA
    FEMS Microbiol Lett 253:251-7. 2005
    ..This is the first report that demonstrates a physiological role for TA modules in Gram-positive bacteria...