I Brook

Summary

Publications

  1. ncbi Two cases of diskitis attributable to anaerobic bacteria in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatrics 107:E26. 2001
  2. ncbi Microbiology and management of post-surgical wounds infection in children
    Itzhak Brook
    Pediatr Rehabil 5:171-6. 2002
  3. ncbi Joint and bone infections due to anaerobic bacteria in children
    Itzhak Brook
    Pediatr Rehabil 5:11-9. 2002
  4. ncbi Recovery of anaerobic bacteria from a glossal abscess in an adolescent
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 18:358-9. 2002
  5. ncbi Sinusitis -- overcoming bacterial resistance
    I Brook
    Georgetown University, 4431 Albemarle Street, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 58:27-36. 2001
  6. ncbi Recovery of anaerobic bacteria from 3 patients with infection at a pierced body site
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Clin Infect Dis 33:e12-3. 2001
  7. ncbi Recovery of anaerobic bacteria from four children with postthoracotomy sternal wound infection
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatrics 108:E17. 2001
  8. ncbi Bacteriology and beta-lactamase activity in acute exacerbation of chronic bronchitis
    I Brook
    Naval Medical Center, Bethesda, Maryland, USA
    Int J Infect Dis 5:74-7. 2001
  9. ncbi Effect of amoxycillin with or without clavulanate on adenoid bacterial flora
    I Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    J Antimicrob Chemother 48:269-73. 2001
  10. ncbi Cutaneous and subcutaneous infections in newborns due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Perinat Med 30:197-208. 2002

Detail Information

Publications105 found, 100 shown here

  1. ncbi Two cases of diskitis attributable to anaerobic bacteria in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatrics 107:E26. 2001
    ..Future prospective studies are warranted to elucidate the role of anaerobic bacteria in diskitis in children...
  2. ncbi Microbiology and management of post-surgical wounds infection in children
    Itzhak Brook
    Pediatr Rehabil 5:171-6. 2002
    ..were most frequently recovered in wounds proximal to the oral area. Management of PSW should include administration of antimicrobials effective against the polymicrobial bacterial flora adjacent to the anatomic site of the wound...
  3. ncbi Joint and bone infections due to anaerobic bacteria in children
    Itzhak Brook
    Pediatr Rehabil 5:11-9. 2002
    ..Treatment of arthritis and osteomyelitis involving anaerobic bacteria includes symptomatic therapy, immobilization in some cases, adequate drainage of purulent material and antibiotic therapy effective to these organisms...
  4. ncbi Recovery of anaerobic bacteria from a glossal abscess in an adolescent
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 18:358-9. 2002
    ..The patient recovered following incision and drainage and 14 days of antimicrobial therapy with clindamycin. This report illustrates the recovery of anaerobic bacteria from glossal abscess in an adolescent...
  5. ncbi Sinusitis -- overcoming bacterial resistance
    I Brook
    Georgetown University, 4431 Albemarle Street, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 58:27-36. 2001
    ..Accurate diagnosis and careful consideration when choosing therapy for sinusitis will optimise the chances of achieving an early cure...
  6. ncbi Recovery of anaerobic bacteria from 3 patients with infection at a pierced body site
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Clin Infect Dis 33:e12-3. 2001
    ..The infection resolved in all patients after removal of the ornaments and use of antimicrobial drug treatment...
  7. ncbi Recovery of anaerobic bacteria from four children with postthoracotomy sternal wound infection
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatrics 108:E17. 2001
    ..These findings highlight the potential importance of anaerobic bacteria in postthoracotomy sternal wound infection...
  8. ncbi Bacteriology and beta-lactamase activity in acute exacerbation of chronic bronchitis
    I Brook
    Naval Medical Center, Bethesda, Maryland, USA
    Int J Infect Dis 5:74-7. 2001
    ..To assess the bacteriology of beta-lactamase (BL) enzyme activity in sputum of 40 patients with acute exacerbation of chronic bronchitis (AECB)...
  9. ncbi Effect of amoxycillin with or without clavulanate on adenoid bacterial flora
    I Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    J Antimicrob Chemother 48:269-73. 2001
    ..025) or no antibiotic (P < 0.001). These data illustrate the ability of AMX and AMC to reduce the bacterial load as well as potential pathogens and BLPB from the adenoids of children with ROM...
  10. ncbi Cutaneous and subcutaneous infections in newborns due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Perinat Med 30:197-208. 2002
    ..Managements of these infections include surgical debridement and drainage when appropriate as well as topical and systemic use of antimicrobial agents effective against both aerobic and anaerobic bacteria...
  11. ncbi The role of anaerobic bacteria in sinusitis
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 12:5-12. 2006
    ..These organisms were also recovered in acute sinusitis that was associated with dental infections. The predominant isolates were pigmented Prevotella and Porphyromonas, Fusobacterium and Peptostreptococcus spp...
  12. ncbi Aerobic and anaerobic bacteriology of concurrent chronic otitis media with effusion and chronic sinusitis in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 126:174-6. 2000
    ..To correlate the aerobic and anaerobic microbiologic findings of concurrent chronic otitis media with effusion and chronic maxillary sinusitis...
  13. ncbi The microbiology of mucopyocele
    I Brook
    Department of Pediatrics and Infectious Disease, Navy Hospital, Bethesda, Maryland, USA
    Laryngoscope 111:1771-3. 2001
    ..To evaluate the aerobic and anaerobic microbiology of mucopyocele...
  14. doi Anaerobic infections in children
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Adv Exp Med Biol 697:117-52. 2011
    ..Because anaerobic bacteria generally are recovered mixed with aerobic organisms, the choice of appropriate antimicrobial agents should provide for adequate coverage of both types of pathogen...
  15. ncbi Pathogenicity of capsulate and non-capsulate members of Bacteroides fragilis and B. melaninogenicus groups in mixed infection with Escherichia coli and Streptococcus pyogenes
    I Brook
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 5145
    J Med Microbiol 27:191-8. 1988
    ..fragilis group and E. coli and between the B. melaninogenicus group and S. pyogenes, and reiterate the need to direct antimicrobial therapy at the eradication of the aerobic and anaerobic components of mixed infections...
  16. ncbi Interference by aerobic and anaerobic bacteria in children with recurrent group A beta-hemolytic streptococcal tonsillitis
    I Brook
    Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 125:552-4. 1999
    ..To compare the frequency of recovery of aerobic and anaerobic bacteria with interfering capability of group A beta-hemolytic streptococci (GABHS) in the tonsils of children with and without a history of recurrent GABHS pharyngotonsillitis...
  17. ncbi Aerobic and anaerobic microbiology of necrotizing fasciitis in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, USA
    Pediatr Dermatol 13:281-4. 1996
    ..These findings illustrate the polymicrobial aerobic-anaerobic flora of NF in children...
  18. ncbi In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolides and quinolones
    I Brook
    Radiation Medicine Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Int J Antimicrob Agents 18:559-62. 2001
    ..All isolates selected for resistance to one quinolone were also resistant to the other two quinolones, but not to doxycycline. The doxycycline-resistant isolate was not resistant to any quinolone...
  19. ncbi Prophylaxis with amoxicillin or sulfisoxazole for otitis media: effect on the recovery of penicillin-resistant bacteria from children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, D C, USA
    Clin Infect Dis 22:143-5. 1996
    ..pneumoniae. These data illustrate that amoxicillin prophylaxis induces an increase in the number of penicillin-resistant bacteria in the oropharynx...
  20. ncbi Microbiology of infected poison ivy dermatitis
    I Brook
    Departments of Paediatrics, Dermatology and Laboratory Medicine, Naval Hospital, Bethesda, MD, USA
    Br J Dermatol 142:943-6. 2000
    ..The polymicrobial aetiology of secondarily infected poison ivy lesions, and the association of bacterial flora with the anatomical site of the lesions, are demonstrated...
  21. ncbi The role of beta-lactamase producing bacteria and bacterial interference in streptococcal tonsillitis
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street, Washington, DC 20016, USA
    Int J Antimicrob Agents 17:439-42. 2001
    ..The use of antimicrobials that can overcome and modulate these two phenomena and achieve better cure of the infection is described...
  22. ncbi In vitro susceptibility and in vivo efficacy of antimicrobials in the treatment of Bacteroides fragilis-Escherichia coli infection in mice
    I Brook
    Naval Medical Research Institute, Bethesda, Maryland
    J Infect Dis 160:651-6. 1989
    ..Cefamandole was effective against only E. coli and was not effective against any member of the B. fragilis group. These in vivo data confirm the in vitro activity of these antimicrobials...
  23. ncbi Susceptibility of irradiated mice to Bacillus anthracis sterne by the intratracheal route of infection
    I Brook
    Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5603, USA
    J Med Microbiol 50:702-11. 2001
    ..anthracis was observed above 4 Gy. The lethal toxin of B. anthracis may enhance the emergence of polymicrobial infection with B. anthracis and enteric micro-organisms...
  24. ncbi Microbiology of intracranial abscesses and their associated sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:1017-9. 2005
    ..To evaluate the organisms recovered from infected sinuses and associated intracranial abscesses (IAs)...
  25. ncbi The effects of amoxicillin therapy on skin flora in infants
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Dermatol 17:360-3. 2000
    ..albicans. This study demonstrates the effects of amoxicillin on the ecology of skin microbial flora in infants-a decrease in the number of bacterial isolates and an increase in recovery of C. albicans...
  26. ncbi Quantitative bacterial cultures and beta-lactamase activity in chronic suppurative otitis media
    I Brook
    Naval Medical Research Institute, Bethesda, Maryland
    Ann Otol Rhinol Laryngol 98:293-7. 1989
    ..The detection of beta-lactamase activity in the ear aspirates provides evidence of the role of BLPB in the failure of penicillin therapy to eradicate chronic ear infection...
  27. ncbi Acute bacterial suppurative parotitis: microbiology and management
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    J Craniofac Surg 14:37-40. 2003
    ..The choice of antimicrobial depends on the etiologic agent. Maintenance of good oral hygiene, adequate hydration, and early and proper therapy of bacterial infection of the oropharynx may reduce the occurrence of suppurative parotitis...
  28. ncbi Bacteriology of adenoids and tonsils in children with recurrent adenotonsillitis
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 110:844-8. 2001
    ..This study demonstrates a polymicrobial aerobic-anaerobic flora in both adenoids and tonsils, and discrepancies in recovery of pathogens such as GABHS. The adenoids may serve as a potential source of tonsillitis caused by GABHS...
  29. ncbi Microbiology of serous otitis media in children: correlation with age and length of effusion
    I Brook
    School of Medicine, George Washington University, Washington, DC, USA
    Ann Otol Rhinol Laryngol 110:87-90. 2001
    ..These data illustrate the effects of the length of effusion and age on the recovery of aerobic and anaerobic bacteria in serous otitis media...
  30. pmc Aerobic and anaerobic microbiology of surgical-site infection following spinal fusion
    I Brook
    Department of Infectious Diseases, Naval Hospital, Bethesda, Maryland, USA
    J Clin Microbiol 37:841-3. 1999
    ..An increase in recovery of E. coli and B. fragilis was noted in patients with bowel or bladder incontinence. This study highlights the polymicrobial nature of SSI and the importance of anaerobic bacteria in SSI following spinal fusion...
  31. ncbi Microbiology and management of human and animal bite wound infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street, NW, Washington, DC, USA
    Prim Care 30:25-39, v. 2003
    ..Wound management includes the administration of proper local care and the use of proper antimicrobial agents when needed...
  32. ncbi Chronic sinusitis in children and adults: role of bacteria and antimicrobial management
    Itzhak Brook
    Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Curr Allergy Asthma Rep 5:482-90. 2005
    ..The choice of antimicrobial agent in chronic sinusitis should provide coverage for the usual pathogens in acute sinusitis as well as beta-lactamase-producing aerobic and anaerobic organisms...
  33. ncbi Discrepancies in the recovery of bacteria from multiple sinuses in acute and chronic sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Med Microbiol 53:879-85. 2004
    ..These findings illustrate that there are differences in the distribution of organisms in single patients who suffer from infections in multiple sinuses and emphasize the importance of obtaining cultures from all infected sinuses...
  34. ncbi Beta-lactamase-producing bacteria in mixed infections
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    Clin Microbiol Infect 10:777-84. 2004
    ..The in-vitro and in-vivo clinical evidence supporting the role of BLPB in the increasing failure of penicillin to resolve such infections, and the implications of this phenomenon for the management of infections, are discussed...
  35. doi The impact of smoking on oral and nasopharyngeal bacterial flora
    I Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Dent Res 90:704-10. 2011
    ..Analysis of the data presented illustrates the adverse effects of direct and indirect exposure to smoking on colonization with potential pathogens...
  36. ncbi Open-Label, parallel-group, multicenter, randomized study of cefprozil versus erythromycin in children with group A streptococcal pharyngitis/tonsillitis
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    Clin Ther 23:1889-900. 2001
    ..Cefprozil and erythromycin are acceptable alternatives to penicillin in the treatment of pharyngitis/tonsillitis due to group A beta-hemolytic streptococcus (GABHS)...
  37. ncbi Microbiology of acute and chronic maxillary sinusitis associated with an odontogenic origin
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Laryngoscope 115:823-5. 2005
    ..To study the microbiology of sinusitis associated with odontogenic origin...
  38. doi Treatment modalities for bacterial rhinosinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Expert Opin Pharmacother 11:755-69. 2010
    ..Accurate diagnosis of rhinosinusitis depends upon clinical assessment. Isolation of the causative agents must be considered in cases failing initial treatment...
  39. ncbi Bacteriology of chronic sinusitis and acute exacerbation of chronic sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    Arch Otolaryngol Head Neck Surg 132:1099-101. 2006
    ..To establish the microbiological characteristics of acute exacerbation of chronic sinusitis (AECS)...
  40. doi Microbiology and management of joint and bone infections due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University, School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, USA
    J Orthop Sci 13:160-9. 2008
    ..To describes the microbiology, diagnosis, and management of septic arthritis and osteomyelitis due to anaerobic bacteria...
  41. ncbi Bacterial infection and antibiotic treatment in chronic rhinosinusitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Clin Allergy Immunol 20:147-62. 2007
    ..In cases where empiric antibiotics have failed, the need for bacterial cultures is even more critical to assure proper treatment and to minimize antibiotic side effects...
  42. ncbi Bacteriology of acute and chronic frontal sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 128:583-5. 2002
    ..The predominant anaerobes included Prevotella species (8), Peptostreptococcus species (6), and Fusobacterium species (4). These findings illustrate the microbiologic features of acute and chronic frontal sinusitis...
  43. ncbi Failure of penicillin to eradicate group A beta-hemolytic streptococci tonsillitis: causes and management
    I Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    J Otolaryngol 30:324-9. 2001
    ..This review will describe the scientific and clinical data that demonstrate and explain the phenomena of beta-lactamase production and bacterial interference...
  44. ncbi Dynamics of nasopharyngitis in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Otolaryngol Head Neck Surg 122:696-700. 2000
    ....
  45. ncbi Aerobic and anaerobic microbiology in intra-abdominal infections associated with diverticulitis
    I Brook
    Department of Infectious Diseases, Naval Hospital, Bethesda, MD, USA
    J Med Microbiol 49:827-30. 2000
    ..The most frequently isolated anaerobes were Bacteroides spp. (B. fragilis group), Peptostreptococcus, Clostridium and Fusobacterium spp...
  46. doi Infections of the upper respiratory tract, head, and neck. The role of anaerobic bacteria
    I Brook
    Georgetown University School of Medicine, Washington, DC 20016, USA
    Postgrad Med 108:37-48. 2000
    ..Adequate antimicrobial coverage of both anaerobic and aerobic bacteria is essential because culture usually reveals a mixed infection. Failure to select the appropriate antibiotics may lead to clinical failure...
  47. ncbi The role of anaerobic bacteria in mediastinitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC 20016, USA
    Drugs 66:315-20. 2006
    ..Selection of antibacterials for the treatment of mediastinitis is determined by bacteriological studies...
  48. doi The role of anaerobic bacteria in chronic suppurative otitis media in children: implications for medical therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Anaerobe 14:297-300. 2008
    ..The medical therapy of CSOM should be directed at the eradication of the pathogenic aerobic and anaerobic organisms...
  49. ncbi Acute and chronic bacterial sinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Infect Dis Clin North Am 21:427-48, vii. 2007
    ..This article discusses the microbiology and pathogenesis of acute and chronic bacterial sinusitis. The role anaerobic bacterial in chronic and recurrent sinusitis is emphasized, and appropriate antimicrobial regimens are discussed...
  50. ncbi Cephalosporins in overcoming beta-lactamase-producing bacteria and preservation of the interfering bacteria in the treatment of otitis, sinusitis and tonsillitis
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:939-50. 2007
    ..The use of some of the cephalosporins that are able to overcome the effect of BLPB and preserve the beneficial interfering bacteria can overcome and modulate these phenomena and achieve better cure of URTIs...
  51. ncbi Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Laryngol Otol 119:251-8. 2005
    ..The antimicrobials that are the most effective in management of chronic sinusitis are amoxycillinclavulanate, clindamycin and the combination of metronidazole and a penicillin...
  52. ncbi Infected neonatal cephalohematomas caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    J Perinat Med 33:255-8. 2005
    ..To present the microbiological and clinical features of six children with infected cephalohematomas (IC) caused by anaerobic bacteria...
  53. ncbi Microbiology and management of soft tissue and muscle infections
    Itzhak Brook
    Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Surg 6:328-38. 2008
    ..The infections can progress rapidly and early recognition and proper medical and surgical management is the cornerstone of therapy...
  54. ncbi Current issues in the management of acute bacterial sinusitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Schools of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 71:1653-61. 2007
    ..To review and summarize recent challenges in the microbiology and treatment of acute bacterial sinusitis (ABS), one of the most common infectious diseases in the pediatric community...
  55. ncbi Microbiology and management of endodontic infections in children
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    J Clin Pediatr Dent 28:13-7. 2003
    ..These agents include amoxicillin-clavulanate, clindamycin or the combination of metronidazole plus amoxicillin or a macrolide...
  56. ncbi Microbiology of polymicrobial abscesses and implications for therapy
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    J Antimicrob Chemother 50:805-10. 2002
    ..Appropriate management of these mixed aerobic and anaerobic infections may also require the administration of antimicrobials that are effective against both the aerobic and anaerobic components of the infections...
  57. ncbi Microbiology and management of intra-abdominal infections in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC, United States of America
    Pediatr Int 45:123-9. 2003
    ..and Clostridium spp. The treatment of abdominal infection includes surgical correction and drainage, and administration of antimicrobials that are effective against both aerobic and anaerobic micro-organisms...
  58. ncbi Acute and chronic frontal sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Curr Opin Pulm Med 9:171-4. 2003
    ..Surgery is indicated to treat patients with acute and chronic sinusitis and their complications. Several surgical procedures were recently evaluated, and these are briefly reviewed...
  59. ncbi Microbiology and antimicrobial management of sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Otolaryngol Clin North Am 37:253-66, v-vi. 2004
    ..This article summarizes the current information regarding the microbiology of all forms of sinusitis and approaches to antimicrobial therapy...
  60. ncbi Anaerobic bacteria in upper respiratory tract and other head and neck infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 111:430-40. 2002
    ..Because anaerobic bacteria generally are recovered mixed with aerobic organisms, the choice of appropriate antimicrobial agents should provide for adequate coverage of both types of pathogens...
  61. ncbi Anaerobic infections in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Microbes Infect 4:1271-80. 2002
    ..Because anaerobes are generally recovered mixed with aerobic organisms, the choice of antimicrobial agents should provide coverage of both types of pathogens...
  62. pmc Microbiology and management of myositis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    Int Orthop 28:257-60. 2004
    ..Intensive surgical and medical therapy that includes the administration of intravenous fluids and antimicrobial therapy is an essential element in management of muscle infection...
  63. ncbi Aerobic and anaerobic microbiology of suppurative sialadenitis
    Itzhak Brook
    Georgetown University School of Medicine, Washington DC, USA
    J Med Microbiol 51:526-9. 2002
    ..and Fusobacterium spp.) and Peptostreptococcus spp. The study highlights the polymicrobial nature and importance of anaerobic bacteria in acute suppurative sialadenitis...
  64. ncbi Suppurative parotitis caused by anaerobic bacteria in newborns
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Infect Dis J 21:81-2. 2002
    ..Peptostreptococcus intermedius and Prevotella melaninogenica were isolated from one child and Prevotella intermedia from the other patient. Complete recovery occurred after 4 weeks of antimicrobial therapy...
  65. ncbi Microbiology and management of infected solid tumours
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Eur J Cancer Care (Engl) 16:12-6. 2007
    ..This review describes the microbiology and management of infection in necrotic tumours...
  66. doi Role of methicillin-resistant Staphylococcus aureus in head and neck infections
    I Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington DC, USA
    J Laryngol Otol 123:1301-7. 2009
    ....
  67. ncbi Clindamycin and quinolone therapy for Bacillus anthracis Sterne infection in 60Co-gamma-photon-irradiated and sham-irradiated mice
    I Brook
    Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    J Antimicrob Chemother 56:1074-80. 2005
    ..anthracis Sterne spores. Clindamycin has in vitro activity against B. anthracis and inhibits the production of toxin from other species, although no direct evidence exists that production of B. anthracis toxin is inhibited...
  68. ncbi Microbiology of nonbullous impetigo
    I Brook
    Department of Pediatrics, Bethesda Naval Hospital, Maryland, USA
    Pediatr Dermatol 14:192-5. 1997
    ..were isolated from one infection of the buttocks area. Thirty-three organisms isolated from 32 patients (80%) produced the enzyme beta-lactamase. This study demonstrates the polymicrobial aerobic-anaerobic microbiology of NI lesions...
  69. ncbi Ocular infections due to anaerobic bacteria
    I Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Int Ophthalmol 24:269-77. 2001
    ..Propionibacterium spp., Prevotella spp., and Fusobacterium spp. This review describes the microbiology, diagnosis and management of ocular infections due to anaerobic bacteria in children...
  70. ncbi Management of group A beta-hemolytic streptococcal pharyngotonsillitis in children
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    J Fam Pract 55:S1-11; quiz S12. 2006
    ....
  71. ncbi Treatment of anaerobic infection
    Itzhak Brook
    Georgetown University School of Medicine, Department of Pediatrics, 4431 Albemarle St NW, Washington, DC 20016, USA
    Expert Rev Anti Infect Ther 5:991-1006. 2007
    ....
  72. ncbi Eradication of pathogens from the nasopharynx after therapy of acute maxillary sinusitis with low- or high-dose amoxicillin/clavulanic acid
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine and Alachua General and North Florida Regional Hospitals, Gainesville, FL, USA
    Int J Antimicrob Agents 26:416-9. 2005
    ..These data illustrate the superiority of 4.0 g/day amoxicillin/clavulanic acid compared with 1.5 g/day amoxicillin/clavulanic acid in the eradication of S. pneumoniae from the nasopharynx...
  73. doi Microbiology and antimicrobial treatment of orbital and intracranial complications of sinusitis in children and their management
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 73:1183-6. 2009
    ..Early recognition and appropriate surgical and medical therapy are essential to ensure recovery...
  74. ncbi Antibacterial therapy for acute group a streptococcal pharyngotonsillitis: short-course versus traditional 10-day oral regimens
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Paediatr Drugs 4:747-54. 2002
    ..In conclusion, short courses of amoxicillin, cephalosporins, and macrolides provide superior or equal efficacy to a 10-day course of penicillin therapy in the treatment of GABHS pharyngotonsillitis...
  75. ncbi The role of anaerobic bacteria in cutaneous and soft tissue abscesses and infected cysts
    Itzhak Brook
    Schools of Medicine, Georgetown University, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Anaerobe 13:171-7. 2007
    ..The infections can progress rapidly and early recognition and proper medical and surgical management is the cornerstone of therapy...
  76. ncbi Antibiotic resistance of oral anaerobic bacteria and their effect on the management of upper respiratory tract and head and neck infections
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC, USA
    Semin Respir Infect 17:195-203. 2002
    ..Because anaerobes generally are isolated mixed with aerobic organisms, therapy should provide for adequate coverage of both types of pathogens...
  77. doi Pericarditis caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Int J Antimicrob Agents 33:297-300. 2009
    ..Identification of pathogens and determination of their antimicrobial susceptibility and beta-lactamase production are essential for adequate selection of antibiotic therapy effective against these organisms...
  78. ncbi The role of bacteria in chronic rhinosinusitis
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, 4431 Albemarle Street Northwest, Washington, DC 20016, USA
    Otolaryngol Clin North Am 38:1171-92. 2005
    ..The bacterial pathogens in acute sinusitis are S. pneumoniae, H. influenzae, and M. catarrhalis, while anaerobic bacteria and S. aureus predominant in CRS...
  79. ncbi Microbiology of infected hemangiomas in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Pediatr Dermatol 21:113-6. 2004
    ..The polymicrobial etiology of secondarily infected hemangiomas and the association of bacterial flora with the anatomic site of the lesions is thereby demonstrated...
  80. ncbi Microbial dynamics of purulent nasopharyngitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle Street NW, Washington, DC 20016, USA
    Int J Pediatr Otorhinolaryngol 67:1047-53. 2003
    ..Controversy exists regarding the management of NPT as no conclusive evidence exists to date that the administration of antimicrobials will shorten the illness...
  81. ncbi Anaerobic pulmonary infections in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Pediatr Emerg Care 20:636-40. 2004
    ..and Bacteroides fragilis group. Management of these infections includes the administration of antimicrobials effective against the anaerobic as well as the aerobic pathogens...
  82. ncbi Management of human and animal bite wounds: an overview
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Adv Skin Wound Care 18:197-203. 2005
    ..Wound management includes proper local care and, when needed, antimicrobial therapy...
  83. pmc The role of beta-lactamase-producing-bacteria in mixed infections
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    BMC Infect Dis 9:202. 2009
    ....
  84. ncbi Bacteriology of chronic maxillary sinusitis associated with nasal polyposis
    Itzhak Brook
    Department of Pediatrics, Otolaryngology and Infectious Diseases, Navy Hospital, Bethesda, MD, USA
    J Med Microbiol 54:595-7. 2005
    ..being predominant. These findings illustrate for the first time the presence of polymicrobial aerobic-anaerobic flora in patients with chronic maxillary sinusitis who had nasal polyposis...
  85. pmc Bacteriology of acute and chronic ethmoid sinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, 4431 Albemarle St NW, Washington, DC 20016, USA
    J Clin Microbiol 43:3479-80. 2005
    ..Twenty-seven aerobes and 41 anaerobes were found in isolates from patients with chronic sinusitis. The predominant isolates were anaerobic gram-negative bacilli and Peptostreptococcus spp...
  86. ncbi Pericarditis due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Cardiology 97:55-8. 2002
    ..Treatment of pericarditis involving anaerobic bacteria includes the use of antibiotic therapy effective against these organisms...
  87. ncbi Urinary tract and genito-urinary suppurative infections due to anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    Int J Urol 11:133-41. 2004
    ..Percutaneous drainage, open surgical drainage or nephectomy might be indicated for abscesses...
  88. ncbi Recovery of potential pathogens and interfering bacteria in the nasopharynx of smokers and nonsmokers
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Chest 127:2072-5. 2005
    ....
  89. ncbi The role of bacterial interference in otitis, sinusitis and tonsillitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, USA
    Otolaryngol Head Neck Surg 133:139-46. 2005
    ....
  90. ncbi Microbiology and management of peritonsillar, retropharyngeal, and parapharyngeal abscesses
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    J Oral Maxillofac Surg 62:1545-50. 2004
    ..Death can occur from aspiration, airway obstruction, erosion into major blood vessels, or extension to the mediastinum...
  91. ncbi Long-term effects on the nasopharyngeal flora of children following antimicrobial therapy of acute otitis media with cefdinir or amoxycillin-clavulanate
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington DC 20016, USA
    J Med Microbiol 54:553-6. 2005
    ..In contrast, utilization of a broad-spectrum antimicrobial is associated with prolonged absence of inhibitory organisms and rapid recolonization with pathogens...
  92. doi Infective endocarditis caused by anaerobic bacteria
    Itzhak Brook
    Department of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Arch Cardiovasc Dis 101:665-76. 2008
    ..The mortality rate for patients with anaerobic IE ranges from 21 to 43%. Treatment of anaerobic IE includes the use of antimicrobial effective against these organisms. Surgical intervention may be indicated in some patients...
  93. ncbi Microbiology of recurrent acute rhinosinusitis
    Itzhak Brook
    Department of Pediatrics, Georgetown University, Washington, DC, USA
    Laryngoscope 114:129-31. 2004
    ..We undertook to evaluate the microbiology of recurrent acute rhinosinusitis...
  94. ncbi Recovery of potential pathogens and interfering bacteria in the nasopharynx of otitis media-prone children and their smoking and nonsmoking parents
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Arch Otolaryngol Head Neck Surg 131:509-12. 2005
    ....
  95. pmc Recovery of interfering bacteria in the nasopharynx following antimicrobial therapy of acute maxillary sinusitis with telithromycin or amoxicillin-clavulanate
    Itzhak Brook
    Georgetown University School of Medicine, Washington, DC 20016, USA
    Antimicrob Agents Chemother 49:4793-4. 2005
    ..However, the number of interfering Prevotella spp. declined more significantly after amoxicillin-clavulanate treatment...
  96. doi Current management of upper respiratory tract and head and neck infections
    Itzhak Brook
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC 20016, USA
    Eur Arch Otorhinolaryngol 266:315-23. 2009
    ..In conclusion, the proper management of these infections requires an accurate clinical and bacteriological diagnosis...
  97. ncbi Intra-abdominal, retroperitoneal, and visceral abscesses in children
    I Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016, USA
    Eur J Pediatr Surg 14:265-73. 2004
    ..Fusobacterium spp., and Clostridium spp. The treatment of intraabdominal abscesses includes drainage, surgical correction of pathology, and administration of antimicrobials effective against both aerobic and anaerobic microorganisms...
  98. ncbi Recovery of anaerobic bacteria from a case of dissecting cellulitis
    Itzhak Brook
    Int J Dermatol 45:168-9. 2006
  99. ncbi Management of anaerobic infection
    Itzhak Brook
    Expert Rev Anti Infect Ther 2:153-8. 2004
    ..The more suitable agents include penicillins, cephalosporins, carbapenems, chloramphenicol, clindamycin, metronidazole, macrolides, glycopeptides, tetracyclines and quinolones...
  100. pmc Antimicrobial therapy for bacillus anthracis-induced polymicrobial infection in (60)Co gamma-irradiated mice
    Thomas B Elliott
    Nuclear, Biological, and Chemical Interactions and Countermeasures Research Team, Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Antimicrob Agents Chemother 46:3463-71. 2002
    ..To limit mortality following nonlethal irradiation and challenge with B. anthracis spores, antimicrobial therapy needs to be initiated within a few hours after challenge and continued for up to 21 days...
  101. ncbi Microbiology of acute sinusitis of odontogenic origin presenting with periorbital cellulitis in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 116:386-8. 2007
    ..This study was undertaken to evaluate the aerobic and anaerobic microbiology of acute maxillary sinusitis of odontogenic origin presenting with periodontal infection in children...