Yana Bromberg

Summary

Publications

  1. pmc SNAP: predict effect of non-synonymous polymorphisms on function
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Nucleic Acids Res 35:3823-35. 2007
  2. pmc SNAP predicts effect of mutations on protein function
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Bioinformatics 24:2397-8. 2008
  3. ncbi request reprint New in protein structure and function annotation: hotspots, single nucleotide polymorphisms and the 'Deep Web'
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Curr Opin Drug Discov Devel 12:408-19. 2009
  4. pmc In silico mutagenesis: a case study of the melanocortin 4 receptor
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA
    FASEB J 23:3059-69. 2009
  5. pmc Correlating protein function and stability through the analysis of single amino acid substitutions
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    BMC Bioinformatics 10:S8. 2009
  6. pmc Comprehensive in silico mutagenesis highlights functionally important residues in proteins
    Yana Bromberg
    Department of Biochemistry Molecular Biophysics, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Bioinformatics 24:i207-12. 2008

Detail Information

Publications6

  1. pmc SNAP: predict effect of non-synonymous polymorphisms on function
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Nucleic Acids Res 35:3823-35. 2007
    ..This measure will allow users to focus on the most accurate predictions and/or the most severe effects. Available at http://www.rostlab.org/services/SNAP...
  2. pmc SNAP predicts effect of mutations on protein function
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Bioinformatics 24:2397-8. 2008
    ..Each prediction is associated with a reliability index that correlates with accuracy and thereby enables experimentalists to zoom into the most promising predictions...
  3. ncbi request reprint New in protein structure and function annotation: hotspots, single nucleotide polymorphisms and the 'Deep Web'
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Curr Opin Drug Discov Devel 12:408-19. 2009
    ..The availability of this direct connection, and the resulting access to a wealth of data, may impact drug discovery and development more than any existing method that contributes to protein annotation...
  4. pmc In silico mutagenesis: a case study of the melanocortin 4 receptor
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA
    FASEB J 23:3059-69. 2009
    ..other GPCRs, such as hMC1R...
  5. pmc Correlating protein function and stability through the analysis of single amino acid substitutions
    Yana Bromberg
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    BMC Bioinformatics 10:S8. 2009
    ..However, experimental 3D structures are available for only 1% of all known proteins; the magnitude of stability change caused by a given mutation is more widely available...
  6. pmc Comprehensive in silico mutagenesis highlights functionally important residues in proteins
    Yana Bromberg
    Department of Biochemistry Molecular Biophysics, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Bioinformatics 24:i207-12. 2008
    ..In vitro mutagenesis is cumbersome and costly: probing all residues in a protein is typically as impossible as substituting by all non-native amino acids. In contrast, such exhaustive mutagenesis is feasible in silico...