K Brohi

Summary

Publications

  1. ncbi request reprint Endovascular management of acute blunt traumatic thoracic aortic injury: a single center experience
    Clare L Bent
    Department of Radiology, Barts and The London NHS Trust, London, United Kingdom
    J Vasc Surg 46:920-7. 2007
  2. doi request reprint Diagnosis and management of coagulopathy after major trauma
    K Brohi
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK
    Br J Surg 96:963-4. 2009
  3. pmc Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion
    Mitchell J Cohen
    The Department of Surgery, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    Crit Care 13:R174. 2009
  4. pmc Wegener's granulomatosis presenting as an abdominal aortic aneurysm: a case report
    Rajaraman Durai
    Department of Vascular Surgery, The Royal London Hospital, Whitechapel Road, Whitechapel, London, E1 1BB, UK
    Cases J 2:9346. 2009
  5. ncbi request reprint Evaluation of unstable cervical spine injury: a 6-year experience
    K Brohi
    Oxford Radcliffe Hospital, Oxfordshire, England
    J Trauma 49:76-80. 2000
  6. ncbi request reprint Acute traumatic coagulopathy
    Karim Brohi
    Trauma and Critical Care Unit, Royal London Hospital, United Kingdom
    J Trauma 54:1127-30. 2003
  7. ncbi request reprint Helical computed tomographic scanning for the evaluation of the cervical spine in the unconscious, intubated trauma patient
    Karim Brohi
    Department of Trauma Surgery, Royal London Hospital, London, United Kingdom
    J Trauma 58:897-901. 2005
  8. pmc Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
    Karim Brohi
    Department of Surgery, University of California at San Francisco, San Francisco, CA, USA
    Ann Surg 245:812-8. 2007
  9. ncbi request reprint Acute coagulopathy of trauma: mechanism, identification and effect
    Karim Brohi
    Department of Surgery, The Royal London Hospital, London, UK
    Curr Opin Crit Care 13:680-5. 2007
  10. doi request reprint The incidence and magnitude of fibrinolytic activation in trauma patients
    I Raza
    Centre for Trauma Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of, London, UK
    J Thromb Haemost 11:307-14. 2013

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Endovascular management of acute blunt traumatic thoracic aortic injury: a single center experience
    Clare L Bent
    Department of Radiology, Barts and The London NHS Trust, London, United Kingdom
    J Vasc Surg 46:920-7. 2007
    ..Endovascular stent-graft placement offers a safe, effective, and timely treatment option. The aim of this study was to assess our single center experience of endovascular repair following acute blunt traumatic aortic injury...
  2. doi request reprint Diagnosis and management of coagulopathy after major trauma
    K Brohi
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK
    Br J Surg 96:963-4. 2009
    ..In it Karim Brohi, Professor of Trauma Sciences at Queen Mary University of London, deals with the important topic of the defects in blood coagulation that are often encountered after serious injury...
  3. pmc Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion
    Mitchell J Cohen
    The Department of Surgery, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    Crit Care 13:R174. 2009
    ..However, whether HMGB1 is released early after trauma hemorrhage in humans and is associated with the development of an inflammatory response and coagulopathy is not known and therefore constitutes the aim of the present study...
  4. pmc Wegener's granulomatosis presenting as an abdominal aortic aneurysm: a case report
    Rajaraman Durai
    Department of Vascular Surgery, The Royal London Hospital, Whitechapel Road, Whitechapel, London, E1 1BB, UK
    Cases J 2:9346. 2009
    ..Aortic aneurysm is not common in young patient. When a young patient presents with abdominal aortic aneurysm, there may be an underlying cause...
  5. ncbi request reprint Evaluation of unstable cervical spine injury: a 6-year experience
    K Brohi
    Oxford Radcliffe Hospital, Oxfordshire, England
    J Trauma 49:76-80. 2000
    ..The diagnosis of the unstable cervical spine, and its subsequent management can be difficult and a missed cervical spine injury can obviously have devastating consequences...
  6. ncbi request reprint Acute traumatic coagulopathy
    Karim Brohi
    Trauma and Critical Care Unit, Royal London Hospital, United Kingdom
    J Trauma 54:1127-30. 2003
    ..Traumatic coagulopathy is thought to be caused primarily by fluid administration and hypothermia...
  7. ncbi request reprint Helical computed tomographic scanning for the evaluation of the cervical spine in the unconscious, intubated trauma patient
    Karim Brohi
    Department of Trauma Surgery, Royal London Hospital, London, United Kingdom
    J Trauma 58:897-901. 2005
    ..The potential of a missed unstable disc or ligamentous injury results in many patients remaining immobilized in critical care units for prolonged periods...
  8. pmc Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
    Karim Brohi
    Department of Surgery, University of California at San Francisco, San Francisco, CA, USA
    Ann Surg 245:812-8. 2007
    ..We hypothesized that early coagulopathy is due to tissue hypoperfusion, and investigated derangements in coagulation associated with this...
  9. ncbi request reprint Acute coagulopathy of trauma: mechanism, identification and effect
    Karim Brohi
    Department of Surgery, The Royal London Hospital, London, UK
    Curr Opin Crit Care 13:680-5. 2007
    ..Developing early in the postinjury phase, it is associated with increased transfusion requirements and poor outcomes. This review examines the possible initiators, mechanism and clinical importance of acute coagulopathy...
  10. doi request reprint The incidence and magnitude of fibrinolytic activation in trauma patients
    I Raza
    Centre for Trauma Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of, London, UK
    J Thromb Haemost 11:307-14. 2013
    ..5 million deaths annually from hemorrhage and coagulopathy. Overt hyperfibrinolysis is rare in trauma, and is associated with massive fatal injuries. Paradoxically, clinical trials suggest a much broader indication for antifibrinolytics...
  11. doi request reprint Can residents be effective trauma team leaders in a major trauma centre?
    E M Cole
    Trauma Outcomes Core, Centre for Neuroscience and Trauma Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Injury 44:18-22. 2013
    ..We aimed to identify the effect of seniority of leader on time-based performance measures and clinical outcomes...
  12. doi request reprint Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes
    C Rourke
    Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    J Thromb Haemost 10:1342-51. 2012
    ..Low fibrinogen levels are known to occur in trauma. However, the extent of fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and association with patient outcomes remain unclear...
  13. doi request reprint Epidemiology and outcome of vascular trauma at a British Major Trauma Centre
    Z B Perkins
    Trauma Clinical and Academic Unit, The Royal London Hospital, London, UK
    Eur J Vasc Endovasc Surg 44:203-9. 2012
    ..In the United Kingdom, the epidemiology, management strategies and outcomes from vascular trauma are unknown. The aim of this study was to describe the vascular trauma experience of a British Trauma Centre...
  14. doi request reprint Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations
    D Frith
    Trauma Clinical Academic Unit, The Royal London Hospital, Bart s and The London School of Medicine and Dentistry, Queen Mary University London, UK
    J Thromb Haemost 8:1919-25. 2010
    ..Acute traumatic coagulopathy (ATC) is an impairment of hemostasis that occurs early after injury and is associated with a 4-fold higher mortality, increased transfusion requirements and organ failure...
  15. doi request reprint Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway
    Mitchell Jay Cohen
    Departments of Surgery, San Francisco General Hospital, University of California, San Francisco, USA
    J Trauma 63:1254-61; discussion 1261-2. 2007
    ..The objective of the present study was to determine the importance of hypoperfusion and protein C activation in causing early coagulopathy in TBI patients...
  16. doi request reprint Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis
    Karim Brohi
    Department of Surgery, The Royal London Hospital, London, United Kingdom
    J Trauma 64:1211-7; discussion 1217. 2008
    ..The coagulopathy has recently been associated with systemic activation of the protein C pathway. This study was designed to characterize the thrombotic, coagulant and fibrinolytic derangements of trauma-induced shock...
  17. doi request reprint Clinical and biomarker profile of trauma-induced secondary cardiac injury
    H D De'Ath
    Trauma Sciences, Blizard Institute, Queen Mary University of London, London, UK
    Br J Surg 99:789-97. 2012
    ..The aim of this study was to establish the existence of trauma-induced secondary cardiac injury, and investigate its impact on outcomes in injured patients...
  18. doi request reprint The acute coagulopathy of trauma shock: clinical relevance
    Daniel Frith
    Trauma Clinical Academic Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Surgeon 8:159-63. 2010
    ..Delineation of this entity, with directed management protocols should lead to a reduction in avoidable deaths from haemorrhage after trauma...
  19. pmc Increase in activated protein C mediates acute traumatic coagulopathy in mice
    Brian B Chesebro
    The Department of Surgery, University of California, San Francisco, California, USA
    Shock 32:659-65. 2009
    ..In addition, the cytoprotective effect of protein C activation seems to be necessary for survival of the initial shock injury...
  20. doi request reprint Trauma alarmins as activators of damage-induced inflammation
    J Manson
    Trauma Sciences, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Br J Surg 99:12-20. 2012
    ..This review summarizes current preclinical and clinical evidence for trauma alarmins and their role in innate immune activation...
  21. pmc Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans
    Mitchell J Cohen
    Department of Surgery, Ward 3A, San Francisco General Hospital, 1001 Potrero Avenue, Room 3C 38, San Francisco, CA 94110, USA
    J Trauma 68:1273-8. 2010
    ....
  22. pmc Pre-hospital and in-hospital thoracostomy: indications and complications
    Christopher J Aylwin
    Trauma Service, Department of Surgery, Royal London Hospital, London, UK
    Ann R Coll Surg Engl 90:54-7. 2008
    ..We conducted a prospective cohort observational study of emergency pleural drainage procedures to validate the indications for pre-hospital thoracostomy and to identify complications from both pre- and in-hospital thoracostomies...
  23. doi request reprint Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia
    Mitchell J Cohen
    Department of Surgery, University of California, San Francisco, California, USA
    J Trauma 67:1176-81. 2009
    ..Furthermore, trauma patients with tissue injury and shock are at higher risk for the development of VAP...
  24. ncbi request reprint Reduction in critical mortality in urban mass casualty incidents: analysis of triage, surge, and resource use after the London bombings on July 7, 2005
    Christopher J Aylwin
    Department of Trauma Surgery, Royal London Hospital, London E1 1BB, UK
    Lancet 368:2219-25. 2006
    ..The aim of this study was to analyse the prehospital and in-hospital response to the incident and identify system processes that optimise resource use and reduce critical mortality...
  25. doi request reprint Coagulopathy in trauma patients: importance of thrombocyte function?
    Ross A Davenport
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry London, UK
    Curr Opin Anaesthesiol 22:261-6. 2009
    ..This review examines our current knowledge of platelet function in haemostasis, possible mechanisms for aberrant activity in trauma and the role of platelet transfusions in exsanguinating haemorrhage...
  26. doi request reprint A major trauma centre is a specialty hospital not a hospital of specialties
    R A Davenport
    Trauma Clinical Academic Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Royal London Hospital, London, UK
    Br J Surg 97:109-17. 2010
    ..Institution of a specialist multidisciplinary trauma service and performance improvement programme was hypothesized to have resulted in improved outcomes for severely injured patients...
  27. pmc Circulating mitochondrial DAMPs cause inflammatory responses to injury
    Qin Zhang
    Department of Surgery, Division of Trauma, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 464:104-7. 2010
    ..These signal through innate immune pathways identical to those activated in sepsis to create a sepsis-like state. The release of such mitochondrial 'enemies within' by cellular injury is a key link between trauma, inflammation and SIRS...
  28. doi request reprint The coagulopathy of trauma: a review of mechanisms
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    J Trauma 65:748-54. 2008
    ..Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined...
  29. ncbi request reprint Role of the alternative pathway in the early complement activation following major trauma
    Michael T Ganter
    Departments of Anesthesia, San Francisco General Hospital, University of California San Francisco, California 94110, USA
    Shock 28:29-34. 2007
    ..Besides complement activation by the classical and/or lectin pathways, there is an independent association between thrombin generation and complement activation...
  30. ncbi request reprint Pancreatic and duodenal injuries: keep it simple
    Matthew J F X Rickard
    Department of Colorectal Surgery, Concord Hospital, Sydney, New South Wales, Australia
    ANZ J Surg 75:581-6. 2005
    ..The management of pancreatic and duodenal trauma has moved away from complex reconstructive procedures to simpler methods in keeping with the trend towards organ-specific, damage control surgery...
  31. doi request reprint Traumatic coagulopathy: where are the good experimental models?
    Michael J Parr
    Intensive Care Unit, Liverpool Hospital, University of New South Wales, Sydney, Australia
    J Trauma 65:766-71. 2008
    ..This systematic review assessed the primary question "What are relevant experimental models with which to study early traumatic coagulopathy?" and secondary questions on mechanisms...
  32. doi request reprint Advanced trauma life support, 8th edition, the evidence for change
    John B Kortbeek
    Foothills Medical Centre, Calgary, Alberta T2N 2T9, Canada
    J Trauma 64:1638-50. 2008
    ..New materials related to principles of disaster management have been added. ATLS is a common language teaching one safe way of initial trauma assessment and management...
  33. doi request reprint Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?
    Michael T Ganter
    Department of Anesthesia, San Francisco General Hospital, University of California San Francisco, California, USA
    Ann Surg 247:320-6. 2008
    ..To measure plasma levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and vascular endothelial growth factor (VEGF) early after trauma and to determine their clinical significance...