Research Topics

Genomes and Genes

Species

Gerly Anne Brito

Summary

Publications

  1. Costa C, López Ureña D, de Oliveira Assis T, Ribeiro R, Silva R, Rupnik M, et al. A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption. Anaerobe. 2016;40:76-84 pubmed publisher
    ..difficile Clade 2 strains. Finally, this work contributes to the description of differences in virulence among various C. difficile strains. ..
  2. Freitas R, do Val D, Fernandes M, Gomes F, de Lacerda J, SantiGadelha T, et al. Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-? and il-1? suppression. Int Immunopharmacol. 2016;38:313-23 pubmed publisher
    ..AEL effects, however, were not observed in the presence of ZnPP-IX. These findings suggest that AEL efficacy depends on TNF-?/IL-1? inhibition and HO-1 pathway integrity. ..
  3. Dos Santos A, do Val D, da Silveira F, Gomes F, Freitas H, de Assis E, et al. Antinociceptive, anti-inflammatory and toxicological evaluation of semi-synthetic molecules obtained from a benzyl-isothiocyanate isolated from Moringa oleifera Lam. in a temporomandibular joint inflammatory hypernociception model in rats. Biomed Pharmacother. 2018;98:609-618 pubmed publisher
    ..The analogues MC-D7, MC-D9, and MC-H were safe at the tested doses and efficient in reducing the formalin-induced TMJ hypernociception in rats. Our next steps include determining their mechanisms of anti-nociceptive action. ..
  4. Leitão R, Brito G, Oriá R, Braga Neto M, Bellaguarda E, Silva J, et al. Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents. BMC Gastroenterol. 2011;11:90 pubmed publisher
    ..MTX did not cause significant inflammation in the iNOS-/- mice. These results suggest an important role of NO, via activation of iNOS, in the pathogenesis of intestinal mucositis. ..
  5. Nogueira L, Costa D, Gomes A, Martins C, Silva A, Coelho Aguiar J, et al. The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis. J Neuroinflammation. 2017;14:79 pubmed publisher
    ..Our data suggests the participation of mast cells on the CPT-11-induced intestinal mucositis, macrophages activation, enteric reactive gliosis, and neuron loss. ..
  6. Alves S, Abreu S, Lemos J, Gomes F, Alves S, do Val D, et al. Anti-inflammatory and anti-nociceptive effects of strontium ranelate on the zymosan-induced temporomandibular joint inflammatory hypernociception in rats depend on TNF-? inhibition. Pharmacol Rep. 2017;69:764-772 pubmed publisher
    ..Strontium ranelate may achieve its antinociceptive effects through the reduction of TNF-? levels in the trigeminal ganglion, but not suppressing IL-1? expression nor inducing the HO-1 pathway. ..
  7. Bomfin L, Braga C, Oliveira T, Martins C, Foschetti D, Santos A, et al. 5-Fluorouracil induces inflammation and oxidative stress in the major salivary glands affecting salivary flow and saliva composition. Biochem Pharmacol. 2017;145:34-45 pubmed publisher
    ....
  8. Costa C, Mano de Carvalho C, González R, Gifoni M, Ribeiro R, Quesada Gómez C, et al. Molecular epidemiology of Clostridium difficile infection in a Brazilian cancer hospital. Anaerobe. 2017;48:232-236 pubmed publisher
    ..These data emphasize the importance to a better understanding of the epidemiological situation of this infection in Brazilian hospitals...

Locale

Detail Information

Publications8

  1. Costa C, López Ureña D, de Oliveira Assis T, Ribeiro R, Silva R, Rupnik M, et al. A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption. Anaerobe. 2016;40:76-84 pubmed publisher
    ..difficile Clade 2 strains. Finally, this work contributes to the description of differences in virulence among various C. difficile strains. ..
  2. Freitas R, do Val D, Fernandes M, Gomes F, de Lacerda J, SantiGadelha T, et al. Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-? and il-1? suppression. Int Immunopharmacol. 2016;38:313-23 pubmed publisher
    ..AEL effects, however, were not observed in the presence of ZnPP-IX. These findings suggest that AEL efficacy depends on TNF-?/IL-1? inhibition and HO-1 pathway integrity. ..
  3. Dos Santos A, do Val D, da Silveira F, Gomes F, Freitas H, de Assis E, et al. Antinociceptive, anti-inflammatory and toxicological evaluation of semi-synthetic molecules obtained from a benzyl-isothiocyanate isolated from Moringa oleifera Lam. in a temporomandibular joint inflammatory hypernociception model in rats. Biomed Pharmacother. 2018;98:609-618 pubmed publisher
    ..The analogues MC-D7, MC-D9, and MC-H were safe at the tested doses and efficient in reducing the formalin-induced TMJ hypernociception in rats. Our next steps include determining their mechanisms of anti-nociceptive action. ..
  4. Leitão R, Brito G, Oriá R, Braga Neto M, Bellaguarda E, Silva J, et al. Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents. BMC Gastroenterol. 2011;11:90 pubmed publisher
    ..MTX did not cause significant inflammation in the iNOS-/- mice. These results suggest an important role of NO, via activation of iNOS, in the pathogenesis of intestinal mucositis. ..
  5. Nogueira L, Costa D, Gomes A, Martins C, Silva A, Coelho Aguiar J, et al. The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis. J Neuroinflammation. 2017;14:79 pubmed publisher
    ..Our data suggests the participation of mast cells on the CPT-11-induced intestinal mucositis, macrophages activation, enteric reactive gliosis, and neuron loss. ..
  6. Alves S, Abreu S, Lemos J, Gomes F, Alves S, do Val D, et al. Anti-inflammatory and anti-nociceptive effects of strontium ranelate on the zymosan-induced temporomandibular joint inflammatory hypernociception in rats depend on TNF-? inhibition. Pharmacol Rep. 2017;69:764-772 pubmed publisher
    ..Strontium ranelate may achieve its antinociceptive effects through the reduction of TNF-? levels in the trigeminal ganglion, but not suppressing IL-1? expression nor inducing the HO-1 pathway. ..
  7. Bomfin L, Braga C, Oliveira T, Martins C, Foschetti D, Santos A, et al. 5-Fluorouracil induces inflammation and oxidative stress in the major salivary glands affecting salivary flow and saliva composition. Biochem Pharmacol. 2017;145:34-45 pubmed publisher
    ....
  8. Costa C, Mano de Carvalho C, González R, Gifoni M, Ribeiro R, Quesada Gómez C, et al. Molecular epidemiology of Clostridium difficile infection in a Brazilian cancer hospital. Anaerobe. 2017;48:232-236 pubmed publisher
    ..These data emphasize the importance to a better understanding of the epidemiological situation of this infection in Brazilian hospitals...