Factors affecting survival and tumor recurrence in patients transplanted for hepatocellular carcinoma and coexistent hepatitis C virusJ Briceno
Liver Transplantation Unit, Hospital Reina Sofia, Cordoba, Spain
Transplant Proc 40:2990-3. 2008
..7; P = .001) and vascular invasion (OR = 1.6; P = .002) were independent predictors of recurrence. In conclusion, advanced pTNM and the presence of vascular invasion are strong predictors of poor survival and tumor recurrence...
Late hepatic artery pseudoaneurysm: a rare complication after resection of hilar cholangiocarcinomaJavier Briceno
Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Hospital Reina Sofia, Avenida Menendez Pidal s n, Cordoba 14004, Spain
World J Gastroenterol 14:5920-3. 2008
....
Contribution of marginal donors to liver transplantation for hepatitis C virus infectionJ Briceno
Liver Transplantation Unit, Hospital Reina Sofia, Cordoba, Spain
Transplant Proc 39:2297-9. 2007
..Among HCV recipients, marginal liver donors worked similar to those from "good" donors, except for those with fatty livers >30%, especially when combined with a prolonged cold ischemia time...
- Early graft dysfunction after liver transplantation
J Briceno
Liver Transplantation Unit, University Hospital Reina Sofia, Cordoba, Spain
Transplant Proc 42:631-3. 2010
..Donor-, procurement-, operative- and recipient-related factors influence the development of graft dysfunction. We have presented herein a review of the impact of these factors on graft dysfunction...
- Assignment of steatotic livers by the Mayo model for end-stage liver disease
Javier Briceno
Unit of Liver Transplantation, Department of Surgery, Hospital Reina Sofia, Cordoba, Spain
Transpl Int 18:577-83. 2005
..Exactly 30-60% steatotic grafts work poorly in high-risk recipients (MELD > or = 20), and very poorly with > or = 60% steatosis. Prognosis of candidates is optimally influenced when divergence of recipient-donor risks is presented...
- Prediction of graft dysfunction based on extended criteria donors in the model for end-stage liver disease score era
Javier Briceno
Unit of Hepatobiliary Surgery and Liver Transplantation, Hospital Universitario Reina Sofia, Cordoba, Spain
Transplantation 90:530-9. 2010
....
- Extended criteria donors in liver transplant candidates with hepatorenal syndrome
Javier Briceno
Unit of Liver Transplantation and Hepatobiliary Surgery, University Hospital Reina Sofia, Cordoba, Spain
Clin Transplant 25:E257-63. 2011
..In conclusion, the use of ECD in recipients with cirrhosis and HRS is a good option. However, grafts from moderate-to-severe steatosis and those from aged donors must be carefully allocated in candidates with HRS...
- Model for end-stage liver disease can predict very early outcome after liver transplantation
J Briceno
Liver Transplantation Unit, Hospital Reina Sofia, Cordoba, Spain
Transplant Proc 40:2952-4. 2008
..3%, a negative predictive value of 33.1%, and an accuracy of 79.2%. In conclusion, this study corroborated the suggestion that the MELD score may serve as a reliable tool to assess very early death after OLT...
- Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas
Francisco C Muñoz-Casares
Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
J Pineal Res 40:195-203. 2006
..Preventive or therapeutic administration of melatonin protected against the induction of oxidative stress and tissue injury, and restored cell function in experimental pancreatic IR in rats...
- Impact of donor graft steatosis on overall outcome and viral recurrence after liver transplantation for hepatitis C virus cirrhosis
Javier Briceno
Unit of Hepatobiliary Surgery and Liver Transplantation, Reina Sofia University Hospital, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas CIBEREHD, Cordoba, Spain
Liver Transpl 15:37-48. 2009
..HCV recurrence is more frequent and earlier in recipients of moderately and severely steatotic livers. Fibrosis evolution is higher when graft steatosis is >30%. OLT with >30% steatotic donor livers should be precluded in HCV recipients...
- Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids
Raul Gonzalez
Liver Research Unit, Hospital Universitario Reina Sofia, IMIBIC Instituto Maimónides para la Investigación Biomédica de Córdoba, Av Menendez Pidal s n, 14004 Cordoba, Spain
J Hepatobiliary Pancreat Sci 18:740-50. 2011
..This study evaluated the effect of rifampicin on the expression of different detoxification systems and bile acid transporters during in-vivo and in-vitro experimental models of cholestasis...
- Nitric oxide mimics transcriptional and post-translational regulation during α-tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes
Raul Gonzalez
Instituto Maimónides para la Investigación Biomédica de Córdoba, Reina Sofia University Hospital, Cordoba, Spain
J Hepatol 55:133-44. 2011
..Whether α-Tocopherol regulates oxidative and nitrosative stress, bile acid transporter expression and their NO-dependent post-translational modifications, and cell death were assessed in vitro and in vivo...
- Impact of age on liver regeneration response to injury after partial hepatectomy in a rat model
Juan Manuel Sánchez-Hidalgo
Unit of Hepatobiliary Surgery and Liver Transplantation, University Hospital Reina Sofia, Cordoba, Spain
J Surg Res 175:e1-9. 2012
..Liver resection is a feasible treatment for multiple liver diseases. There is no evidence about the impact of age on liver regeneration...
- Alteration of S-nitrosothiol homeostasis and targets for protein S-nitrosation in human hepatocytes
Laura M Lopez-Sanchez
Liver Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
Proteomics 8:4709-20. 2008
....
- Influence of marginal donors on liver preservation injury
Javier Briceno
Unit of Liver Transplantation, Department of Surgery, Hospital Reina Sofia, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
Transplantation 74:522-6. 2002
..The purpose of this study was to assess the accumulated effects of marginal donor quality factors on liver preservation injury (LPI)...
- A prospective study of the efficacy of clinical application of a new carrier-bound fibrin sealant after liver resection
Javier Briceno
Unit of Hepatobiliary Surgery and Liver Transplantation, Department of General Surgery, University Hospital Reina Sofia, Cordoba, Spain
Arch Surg 145:482-8. 2010
..To examine the effectiveness of fibrin sealants as supportive treatment to improve hemostasis and decrease the incidence of bile leakage and intra-abdominal collections...
- Proteomic analysis for developing new biomarkers of hepatocellular carcinoma
Maria Pleguezuelo
Maria Pleguezuelo, Ruben Ciria, Liver Research Unit and Academic Department of Surgery, Reina Sofia University Hospital, Avda Menendez Pidal s n, Cordoba 14004, Spain
World J Hepatol 2:127-35. 2010
..To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis...
- Radical surgery-peritonectomy and intraoperative intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis in recurrent or primary ovarian cancer
Sebastián Rufián
Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
J Surg Oncol 94:316-24. 2006
....
- N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes
Raul Gonzalez
Liver Research Unit, Reina Sofia University Hospital, Cordoba, Spain
Chem Biol Interact 181:95-106. 2009
....
- Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis
Francisco J Padillo
Unit of Hepatobiliary Surgery, Department of General Surgery, Reina Sofia University Hospital, Avda Menendez Pidal s n 14 004, Cordoba, Spain
Free Radic Res 38:697-704. 2004
..004) with a significant improvement in all oxidative stress markers. In conclusion, our results showed that MEL recovered the antioxidant status and reduced apoptosis and necrosis induced by experimental cholestasis...
- Predictors of early graft survival after pediatric liver transplantation
Ruben Ciria
Institute of Liver Studies, King s Health Partners, King s College Hospital, London, United Kingdom Unit of Hepatobiliary Surgery and Liver Transplantation, IMIBIC Reina Sofia University Hospital, Cordoba, Spain
Liver Transpl 18:1324-32. 2012
..A more aggressive attitude to considering early retransplantation in this group may further improve survival after LT...
- Effect of internal biliary drainage on plasma levels of endotoxin, cytokines, and C-reactive protein in patients with obstructive jaundice
Francisco J Padillo
Department of Surgery 5a B, Hospital Reina Sofia, Avda Menendez Pidal s n, 14 004, Cordoba, Spain
World J Surg 26:1328-32. 2002
..After biliary drainage a transitory improvement of these alterations was observed, although values remained high 1 week postdrainage. These findings were associated with positive bile cultures...
