Genomes and Genes


Juergen Brieger



  1. Strozynski J, Heim J, Bunbanjerdsuk S, Wiesmann N, Zografidou L, Becker S, et al. Proteomic identification of the heterogeneous nuclear ribonucleoprotein K as irradiation responsive protein related to migration. J Proteomics. 2015;113:154-61 pubmed publisher
    ..We showed completely impaired migration of irradiated hnRNPK-knock-out HNSCC cells, suggesting this molecule as a potential drug target in combined treatment schedules. ..
  2. Heim J, Felder E, Tahir M, Kaltbeitzel A, Heinrich U, Brochhausen C, et al. Genotoxic effects of zinc oxide nanoparticles. Nanoscale. 2015;7:8931-8 pubmed publisher
    ..Subsequently increased ROS-levels cause DNA damage. However, we found evidence for the assumption that DNA-DSBs could be caused by Zn(2+) without the involvement of ROS. ..
  3. Metzger C, Koutsimpelas D, Brieger J. Transcriptional regulation of the VEGF gene in dependence of individual genomic variations. Cytokine. 2015;76:519-526 pubmed publisher
    ..The comprehension of the association of specific SNPs and TFB could be an essential part in our understanding of individual differences of VEGF regulation and course of diseases. ..
  4. Brieger J, Mann S, Pongsapich W, Koutsimpelas D, Fruth K, Mann W. Pharmacological genome demethylation increases radiosensitivity of head and neck squamous carcinoma cells. Int J Mol Med. 2012;29:505-9 pubmed publisher
    ..Our data show that the combined application of 5-Aza and irradiation is effective in vitro. A demethylating concept prior to irradiation should be further evaluated for its potential to reduce irradiation resistance. ..