S Breton

Summary

Publications

  1. ncbi request reprint Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract
    S Breton
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Physiol Renal Physiol 278:F717-25. 2000
  2. ncbi request reprint Role of V-ATPase-rich cells in acidification of the male reproductive tract
    D Brown
    Renal Unit, Massachusetts General Hospital, Boston, USA
    J Exp Biol 200:257-62. 1997
  3. ncbi request reprint H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways
    D Brown
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02129, USA
    J Exp Biol 203:137-45. 2000
  4. ncbi request reprint Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis
    S Breton
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital East, Charlestown 02129, USA
    Histochem Cell Biol 111:97-105. 1999
  5. ncbi request reprint Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition
    C Bagnis
    Program in Membrane Biology, Massachusetts General Hospital, Boston, Massachusetts 02120, USA
    Am J Physiol Renal Physiol 280:F437-48. 2001
  6. ncbi request reprint Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice
    S Breton
    Renal Unit, Massachusetts General Hospital, Boston, USA
    Am J Physiol 269:F761-74. 1995
  7. ncbi request reprint Mitochondria-rich, proton-secreting epithelial cells
    D Brown
    Renal Unit, Massachusetts General Hospital, Boston 02129, USA
    J Exp Biol 199:2345-58. 1996
  8. pmc Segmental expression of the bradykinin type 2 receptor in rat efferent ducts and epididymis and its role in the regulation of aquaporin 9
    C Belleannee
    Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Reprod 80:134-43. 2009
  9. ncbi request reprint Acidification of the male reproductive tract by a proton pumping (H+)-ATPase
    S Breton
    Renal Unit, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Nat Med 2:470-2. 1996
  10. ncbi request reprint Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis
    C Pietrement
    Program in Membrane Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Biol Reprod 74:185-94. 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract
    S Breton
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Physiol Renal Physiol 278:F717-25. 2000
    ..These results suggest that H(+)-ATPase is actively endocytosed and exocytosed in proton-secreting cells of the epididymis and vas deferens and that net proton secretion requires the participation of the v-SNARE cellubrevin...
  2. ncbi request reprint Role of V-ATPase-rich cells in acidification of the male reproductive tract
    D Brown
    Renal Unit, Massachusetts General Hospital, Boston, USA
    J Exp Biol 200:257-62. 1997
    ....
  3. ncbi request reprint H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways
    D Brown
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02129, USA
    J Exp Biol 203:137-45. 2000
    ..We propose that the 'polarity reversal' of the H(+)V-ATPase in B-intercalated cells is mediated by a physiologically regulated transcytotic pathway that may be similar to that existing in some other cell types...
  4. ncbi request reprint Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis
    S Breton
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital East, Charlestown 02129, USA
    Histochem Cell Biol 111:97-105. 1999
    ..These results demonstrate that differentiated subpopulations of proton-secreting epithelial cells appear early during epididymal development, and that the induction of H+ ATPase in these cells occurs prior to sexual maturation...
  5. ncbi request reprint Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition
    C Bagnis
    Program in Membrane Biology, Massachusetts General Hospital, Boston, Massachusetts 02120, USA
    Am J Physiol Renal Physiol 280:F437-48. 2001
    ....
  6. ncbi request reprint Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice
    S Breton
    Renal Unit, Massachusetts General Hospital, Boston, USA
    Am J Physiol 269:F761-74. 1995
    ..Elucidation of the mechanism(s) responsible for this phenotype will be of importance in understanding the origin and development of intercalated cells in the kidney...
  7. ncbi request reprint Mitochondria-rich, proton-secreting epithelial cells
    D Brown
    Renal Unit, Massachusetts General Hospital, Boston 02129, USA
    J Exp Biol 199:2345-58. 1996
    ..This review emphasizes important structural and functional features of proton-secreting cells, describes the tissue distribution of these cells and discusses the known functions of these cells in their respective epithelia...
  8. pmc Segmental expression of the bradykinin type 2 receptor in rat efferent ducts and epididymis and its role in the regulation of aquaporin 9
    C Belleannee
    Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Reprod 80:134-43. 2009
    ..This effect was inhibited by BAPTA-AM, demonstrating the participation of calcium in this process. This study, therefore, identifies BK as an important regulator of AQP9...
  9. ncbi request reprint Acidification of the male reproductive tract by a proton pumping (H+)-ATPase
    S Breton
    Renal Unit, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Nat Med 2:470-2. 1996
    ..This acidification mechanism is a potential target for novel strategies aimed at modulating the acidification capacity of parts of the male reproductive tract and, therefore, in regulating male fertility...
  10. ncbi request reprint Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis
    C Pietrement
    Program in Membrane Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Biol Reprod 74:185-94. 2006
    ..In principal cells, the ATP6V0D1 isoform may have a physiological function that is distinct from its role in proton transport via the V-ATPase complex...
  11. ncbi request reprint Immunolocalization of AE2 anion exchanger in rat and mouse epididymis
    L J Jensen
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Biol Reprod 61:973-80. 1999
    ..Basolateral AE2 may participate in bicarbonate reabsorption and luminal acidification, and/or may be involved in intracellular pH homeostasis of epithelial cells of the male reproductive tract...
  12. ncbi request reprint Sorting proteins to their target membranes
    D Brown
    Renal Unit, Massachusetts General Hospital, USA
    Kidney Int 57:816-24. 2000
    ..In some cases, the mutated protein is retained and degraded intracellularly, while in others it may not be delivered to the cell surface after the appropriate physiological stimulation...
  13. ncbi request reprint Na+/H+-exchange activity and immunolocalization of NHE3 in rat epididymis
    C Bagnis
    Program in Membrane Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Am J Physiol Renal Physiol 280:F426-36. 2001
    ..These data indicate that HOE694- and EIPA-sensitive Na+/H+ exchange may participate, together with the H+-ATPase, in luminal acidification in the male excurrent duct...