Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tractS Breton
Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Charlestown 02129, USA
Am J Physiol Renal Physiol 278:F717-25. 2000
..These results suggest that H(+)-ATPase is actively endocytosed and exocytosed in proton-secreting cells of the epididymis and vas deferens and that net proton secretion requires the participation of the v-SNARE cellubrevin...
- Role of V-ATPase-rich cells in acidification of the male reproductive tract
D Brown
Renal Unit, Massachusetts General Hospital, Boston, USA
J Exp Biol 200:257-62. 1997
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- H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways
D Brown
Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02129, USA
J Exp Biol 203:137-45. 2000
..We propose that the 'polarity reversal' of the H(+)V-ATPase in B-intercalated cells is mediated by a physiologically regulated transcytotic pathway that may be similar to that existing in some other cell types...
- Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis
S Breton
Renal Unit and Program in Membrane Biology, Massachusetts General Hospital East, Charlestown 02129, USA
Histochem Cell Biol 111:97-105. 1999
..These results demonstrate that differentiated subpopulations of proton-secreting epithelial cells appear early during epididymal development, and that the induction of H+ ATPase in these cells occurs prior to sexual maturation...
- Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition
C Bagnis
Program in Membrane Biology, Massachusetts General Hospital, Boston, Massachusetts 02120, USA
Am J Physiol Renal Physiol 280:F437-48. 2001
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- Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice
S Breton
Renal Unit, Massachusetts General Hospital, Boston, USA
Am J Physiol 269:F761-74. 1995
..Elucidation of the mechanism(s) responsible for this phenotype will be of importance in understanding the origin and development of intercalated cells in the kidney...
- Mitochondria-rich, proton-secreting epithelial cells
D Brown
Renal Unit, Massachusetts General Hospital, Boston 02129, USA
J Exp Biol 199:2345-58. 1996
..This review emphasizes important structural and functional features of proton-secreting cells, describes the tissue distribution of these cells and discusses the known functions of these cells in their respective epithelia...
Segmental expression of the bradykinin type 2 receptor in rat efferent ducts and epididymis and its role in the regulation of aquaporin 9C Belleannee
Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Reprod 80:134-43. 2009
..This effect was inhibited by BAPTA-AM, demonstrating the participation of calcium in this process. This study, therefore, identifies BK as an important regulator of AQP9...
- Acidification of the male reproductive tract by a proton pumping (H+)-ATPase
S Breton
Renal Unit, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
Nat Med 2:470-2. 1996
..This acidification mechanism is a potential target for novel strategies aimed at modulating the acidification capacity of parts of the male reproductive tract and, therefore, in regulating male fertility...
- Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis
C Pietrement
Program in Membrane Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Biol Reprod 74:185-94. 2006
..In principal cells, the ATP6V0D1 isoform may have a physiological function that is distinct from its role in proton transport via the V-ATPase complex...
- Immunolocalization of AE2 anion exchanger in rat and mouse epididymis
L J Jensen
Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Biol Reprod 61:973-80. 1999
..Basolateral AE2 may participate in bicarbonate reabsorption and luminal acidification, and/or may be involved in intracellular pH homeostasis of epithelial cells of the male reproductive tract...
- Sorting proteins to their target membranes
D Brown
Renal Unit, Massachusetts General Hospital, USA
Kidney Int 57:816-24. 2000
..In some cases, the mutated protein is retained and degraded intracellularly, while in others it may not be delivered to the cell surface after the appropriate physiological stimulation...
- Na+/H+-exchange activity and immunolocalization of NHE3 in rat epididymis
C Bagnis
Program in Membrane Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Am J Physiol Renal Physiol 280:F426-36. 2001
..These data indicate that HOE694- and EIPA-sensitive Na+/H+ exchange may participate, together with the H+-ATPase, in luminal acidification in the male excurrent duct...
