Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reducedTurid Hellevik
Department of Oncology, University Hospital of Northern Norway, 9038 Tromsø, Norway
Radiat Oncol 7:59. 2012
....
- Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas
Sveinung W Sorbye
Dept of Clinical Pathology, University Hospital of North Norway, 9038 Tromso, Norway
BMC Clin Pathol 12:5. 2012
..abstract:..
- Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients
Thomas K Kilvaer
Institute of Medical Biology, University of Tromso, PB 9037, Tromso, Norway
J Transl Med 9:104. 2011
..This study investigates the prognostic impact of FGF2 and FGFR-1 and explores the impact of their co-expression with PDGF-B and VEGFR-3 in widely resected tumors from non-GIST STS patients...
The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancerRoy M Bremnes
Department of Oncology, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
J Thorac Oncol 6:209-17. 2011
..Furthermore, it presents recent literature on relevant tumor stroma- and CAF-related research in non-small cell lung cancer...
- The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer
Roy M Bremnes
Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
J Thorac Oncol 6:824-33. 2011
..This review reports on the tumor stroma and in particular tumor-suppressing and -promoting roles of the immune system. Furthermore, it presents recent literature on relevant immune cell-related research in NSCLC...
- High-dose chemotherapy with autologous stem cell support in patients with metastatic non-seminomatous testicular cancer - a report from the Swedish Norwegian Testicular Cancer Group (SWENOTECA)
Hege S Haugnes
Department of Oncology, University Hospital of North Norway, Tromsø, Norway
Acta Oncol 51:168-76. 2012
..The aim of this study was to present survival and toxicity data for patients treated with high-dose chemotherapy (HDCT) within the SWENOTECA IV cancer care program...
- Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
Tom Donnem
Department of Oncology, University Hospital of North Norway, Tromso, Norway
Cancer 117:3193-200. 2011
..miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression with VEGF-A in nonsmall cell lung cancer (NSCLC) patients...
- Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study
Hege S Haugnes
Department of Oncology, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
J Clin Oncol 28:4649-57. 2010
..To evaluate the prevalence of cardiovascular risk factors and long-term incidence of cardiovascular disease (CVD) in survivors of testicular cancer (TC)...
- Chemotherapy and quality of life in NSCLC PS 2 patients
Nina Helbekkmo
Institute of Clinical Medicine, University of Tromsø and Dept of Oncology, University Hospital of Northern Norway, Tromsø, Norway
Acta Oncol 48:1019-25. 2009
..Data on how platinum-based combination chemotherapy affects Health Related Quality of Life (HRQOL) of patients with PS 2 are scarce and the treatment of this important group of patients is controversial...
- MicroRNA signatures in tumor tissue related to angiogenesis in non-small cell lung cancer
Tom Donnem
Department of Oncology, University Hospital of North Norway, Tromsφ, Norway
PLoS ONE 7:e29671. 2012
..MicroRNAs (miRs) are small non-coding, endogenous, single stranded RNAs that regulate gene expression. In this study we aimed to identify significantly altered miRs related to angiogenesis in NSCLC...
- The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas
Andrej Valkov
Dept of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
J Transl Med 9:200. 2011
....
Correlation and coexpression of HIFs and NOTCH markers in NSCLCSigve Andersen
Institute of Clinical Medicine, University of Tromso, Norway
Anticancer Res 31:1603-6. 2011
..NOTCH and hypoxia pathways are both known to be highly involved in cancer. Because of the close interplay between both of these pathways, we investigated correlation and co-expression of molecules in these pathways...
- Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
Tom Donnem
Institute of Clinical Medicine, University of Tromso, Norway
J Thorac Oncol 3:963-70. 2008
..This study investigates the prognostic impact of these molecular markers in tumor cells and tumor stroma of resected non-small cell lung cancer (NSCLC) tumors...
- VEGF-A and VEGFR-3 correlate with nodal status in operable non-small cell lung cancer: inverse correlation between expression in tumor and stromal cells
Tom Donnem
Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
Lung Cancer 63:277-83. 2009
..We aimed to explore the correlations between nodal metastasis and the expression of VEGFs and VEGFRs in tumor cells and in tumor-related stroma...
- Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
Tom Donnem
Institute of Clinical Medicine, University of Tromso, Norway
J Thorac Oncol 4:578-85. 2009
..This study investigates the prognostic impact of FGF2 and FGFR-1 in tumor cells and tumor stroma of resected non-small cell lung carcinomas (NSCLC) and explores the importance of their coexpression with VEGFR-3 or PDGF-B...
- Management of seminomatous testicular cancer: a binational prospective population-based study from the Swedish norwegian testicular cancer study group
Torgrim Tandstad
Department of Oncology, St Olavs University Hospital, Post Box 3250 Sluppen, 7006 Trondheim, Norway
J Clin Oncol 29:719-25. 2011
..The aim was to standardize care for all patients with seminoma to further improve the good results expected for this disease...
- Angiogenic markers show high prognostic impact on survival in marginally operable non-small cell lung cancer patients treated with adjuvant radiotherapy
Sigve Andersen
Institute of Clinical Medicine, University of Tromso, Tromso, Norway
J Thorac Oncol 4:463-71. 2009
..Both expression and its prognostic impact may be associated with patient selection. Data addressing the prognostic relevance of angiogenic marker expression in NSCLC patients treated with postoperative radiotherapy (PORT) is warranted...
- Paternity and testicular function among testicular cancer survivors treated with two to four cycles of cisplatin-based chemotherapy
Marianne Brydøy
Department of Oncology, Haukeland University Hospital, Bergen, Norway
Eur Urol 58:134-40. 2010
..Preserved fertility is an important issue for testicular cancer (TC) survivors...
- Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: correlation with a favorable clinical outcome
Helge Stenvold
Institute of Clinical Medicine, University of Tromso, Norway
Lung Cancer 75:235-41. 2012
..As both malignant cells and cells of the surrounding stroma contribute to tumor growth, we have explored the impact of MMP-2, -7 and -9 expression in both the tumor and stromal compartment of non-small-cell lung cancers (NSCLC)...
- Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival
Sigve Andersen
Institute of Clinical Medicine, University of Tromso, Tromso, Norway
PLoS ONE 6:e23847. 2011
..HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen sensors in NSCLC...
- Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer
Tom Donnem
Institute of Clinical Medicine, University of Tromso, University Hospital of Northern Norway, Tromso, Norway
Clin Cancer Res 13:6649-57. 2007
..This study elucidates the prognostic significance of these molecular markers in tumor cells as well as in the tumor stroma of resected non-small cell lung cancer tumors...
- Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
Sigve Andersen
Institute of Clinical Medicine, University of Tromso, Tromso, Norway
PLoS ONE 6:e19773. 2011
..This study evaluates the prognostic impact of all known human angiopoietins (Ang-1, Ang-2 and Ang-4) and their receptor Tie-2, as well as their relation to the prognostic expression of VEGF-A...
- Long-term and late effects of germ cell testicular cancer treatment and implications for follow-up
Hege S Haugnes
Oncology Department, University Hospital of North Norway, Tromsø, Norway
J Clin Oncol 30:3752-63. 2012
..Moreover, we postulate recommendations for general medical evaluations that should begin after treatment is completed and continue during follow-up...
- Prognostic impact of MiR-155 in non-small cell lung cancer evaluated by in situ hybridization
Tom Donnem
Department of Oncology, University Hospital of North Norway, Tromso, Norway
J Transl Med 9:6. 2011
..MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. We aimed to investigate the prognostic impact of the multifunctional miR-155 in non-small cell lung cancer (NSCLC) patients...
- Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival
Tom Donnem
Institute of Clinical Medicine, University of Tromso, Tromso, Norway
Cancer 116:5676-85. 2010
..The authors aimed to study the prognostic role of the angiogenesis-related Notch ligands and receptors and investigate the prognostic impact of the coexpression of vascular endothelial growth factor-A (VEGF-A) and Notch signaling...
- Diverging prognostic impacts of hypoxic markers according to NSCLC histology
Sigve Andersen
Institute of Clinical Medicine, University of Tromso, Norway
Lung Cancer 72:294-302. 2011
....
- Combination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer
Tom Donnem
Institute of Clinical Medicine, University of Tromso, Tromso, Norway
Cancer 116:4318-25. 2010
..The authors of this report investigated the prognostic role of angiogenic markers in coexpression with immune system markers in patients with nonsmall cell lung cancer (NSCLC)...
- The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas
Andrej Valkov
Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
PLoS ONE 6:e17507. 2011
..We aimed to investigate the prognostic impact of TGF-β1, NF-κB p105, PKC-ζ, Par-6α, E-cadherin and vimentin in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STSs)...
- Observational study of prevalence of long-term Raynaud-like phenomena and neurological side effects in testicular cancer survivors
Marianne Brydøy
Department of Oncology, Haukeland University Hospital, N 5021 Bergen, Norway
J Natl Cancer Inst 101:1682-95. 2009
..We assessed the long-term occurrence of these side effects among testicular cancer survivors according to the treatment they received...
- Prognostic impacts of hypoxic markers in soft tissue sarcoma
Eivind Smeland
Institute of Clinical Medicine, University of Tromso, 9037 Tromso, Norway
Sarcoma 2012:541650. 2012
..7, CI 95% 1.1-2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS...
- Treatment outcome in performance status 2 advanced NSCLC patients administered platinum-based combination chemotherapy
Nina Helbekkmo
Institute of Clinical Medicine, University of Tromsø and Department of Oncology, University Hospital of Northern Norway, Norway
Lung Cancer 62:253-60. 2008
..Using data from a national multicenter study comparing two third-generation carboplatin-based regimens in ANSCLC patients, we evaluated the outcome of PS 2 patients...
- Bridging the distance: a prospective tele-oncology study in Northern Norway
Tom Donnem
Department of Oncology, University Hospital of North Norway, Tromso, Norway
Support Care Cancer 20:2097-103. 2012
..In this study, we aimed to evaluate the feasibility of these VCs...
- Risk-adapted treatment in clinical stage I nonseminomatous germ cell testicular cancer: the SWENOTECA management program
Torgrim Tandstad
Department of Oncology, St Olavs University Hospital, Olav Kyrres gt 17, 7006 Trondheim, Norway
J Clin Oncol 27:2122-8. 2009
..The aim was to reduce the risk of relapse and thereby reducing the need of later salvage chemotherapy while maintaining a high cure rate...
- Prognostic impact of angiogenic markers in non-small-cell lung cancer is related to tumor size
Tom Donnem
Department of Oncology, University Hospital of North Norway, Tromso
Clin Lung Cancer 12:106-15. 2011
....
- Assessment of late urinary, bowel and sexual function after dose escalation from 70 to 76 Gy using image-guided radiotherapy in curative treatment of prostate cancer
Hege S Haugnes
Department of Oncology, University Hospital of North Norway, Tromsø, Norway
Scand J Urol Nephrol 46:124-32. 2012
....
- Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood
Roy M Bremnes
Department of Oncology, University Hospital of Northern Norway, Tromsø
Lung Cancer 51:143-58. 2006
....
- Palliative thoracic radiotherapy in locally advanced non-small cell lung cancer: can quality-of-life assessments help in selection of patients for short- or long-course radiotherapy?
Stein Sundstrøm
Department of Oncology, St Olavs Hospital, University Hospital of Trondheim, Norway
J Thorac Oncol 1:816-24. 2006
....
- Circulating tumour-derived DNA and RNA markers in blood: a tool for early detection, diagnostics, and follow-up?
Roy M Bremnes
Department of Oncology, University Hospital of Northern Norway, University of Tromsø, N 9038 Tromsø, Norway
Lung Cancer 49:1-12. 2005
..A non-invasive blood test effective in detecting preneoplastic changes or early lung cancer in high risk individuals has been perceived as a holy grail by cancer researchers...
- Pulmonary function in long-term survivors of testicular cancer
Hege S Haugnes
Department of Oncology, Institute of Clinical Medicine, University of Tromsø, Tromsø N 9037, Norway
J Clin Oncol 27:2779-86. 2009
..Long-term toxicity after cancer treatment has gained increasing clinical attention. We evaluated pulmonary function in long-term survivors of testicular cancer (TC)...
- Paternity following treatment for testicular cancer
Marianne Brydøy
Department of Oncology, Haukeland University Hospital, Bergen, Norway
J Natl Cancer Inst 97:1580-8. 2005
..Studies of fertility in men treated for testicular cancer have mainly addressed serum follicle-stimulating hormone levels and sperm parameters. We assessed post-treatment paternity among long-term survivors of testicular cancer...
- Second-line chemotherapy in recurrent small cell lung cancer. Results from a crossover schedule after primary treatment with cisplatin and etoposide (EP-regimen) or cyclophosphamide, epirubicin, and vincristin (CEV-regimen)
Stein Sundstrøm
Department of Oncology, St Olavs Hospital, University Hospital of Trondheim, N 7006 Trondheim, Norway
Lung Cancer 48:251-61. 2005
..Further, to compare the crossover group with patients not receiving chemotherapy...
- The value of prognostic factors in small cell lung cancer: results from a randomised multicenter study with minimum 5 year follow-up
Roy M Bremnes
Department Oncology, University Hospital of Tromsø, N 9038, Tromsø, Norway
Lung Cancer 39:303-13. 2003
..However, the prognostic value of these factors depends highly on whether all or subsets of SCLC patients are studied...
