Luisa Lina Villa

Summary

Country: Brazil

Publications

  1. ncbi request reprint Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, SP, Brazil
    Vaccine 24:5571-83. 2006
  2. ncbi request reprint Genetic susceptibility to infection with human papillomavirus and development of cervical cancer in women in Brazil
    Patricia Savio de Araujo Souza
    Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 4 degrees andar, 01509 010 Sao Paulo, SP, Brazil
    Mutat Res 544:375-83. 2003
  3. ncbi request reprint Re: Human papillomavirus type 16 and 18 variants: race-related distribution and persistence
    Laura Sichero
    J Natl Cancer Inst 99:653-4; author reply 654-5. 2007
  4. pmc Interaction between polymorphisms of the human leukocyte antigen and HPV-16 variants on the risk of invasive cervical cancer
    Patricia S de Araujo Souza
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    BMC Cancer 8:246. 2008
  5. pmc Awareness and knowledge of HPV, cervical cancer, and vaccines in young women after first delivery in São Paulo, Brazil--a cross-sectional study
    Cristina H Rama
    Hospital Maternidade Leonor Mendes de Barros, Sao Paulo, Brazil
    BMC Womens Health 10:35. 2010
  6. pmc Prevalence of human papillomavirus in archival samples obtained from patients with cervical pre-malignant and malignant lesions from Northeast Brazil
    José V Fernandes
    Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Av, Sen, Salgado Filho, S N, Lagoa Nova, CEP 59072 970, Natal, RN, Brazil
    BMC Res Notes 3:96. 2010
  7. pmc Validation of dot blot hybridization and denaturing high performance liquid chromatography as reliable methods for TP53 codon 72 genotyping in molecular epidemiologic studies
    Tatiana Rabachini
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    BMC Genet 11:44. 2010
  8. ncbi request reprint Vaccines against papillomavirus infections and disease
    Luisa Lina Villa
    Ludwig Institute for Cancer Research, R Prof Antônio Prudente, 109, 4o andar, 01509 010 Sao Paulo, SP, Brazil
    Salud Publica Mex 45:S443-8. 2003
  9. ncbi request reprint Prophylactic HPV vaccines: reducing the burden of HPV-related diseases
    Luisa Lina Villa
    Ludwig Institute for Cancer Research, Sao Paulo branch Rua Prof Antonio Prudente, 109, 4o andar, 01509 010 Sao Paulo, SP, Brazil
    Vaccine 24:S23-8. 2006
  10. ncbi request reprint Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Lancet Oncol 6:271-8. 2005

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, SP, Brazil
    Vaccine 24:5571-83. 2006
    ..Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported...
  2. ncbi request reprint Genetic susceptibility to infection with human papillomavirus and development of cervical cancer in women in Brazil
    Patricia Savio de Araujo Souza
    Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 4 degrees andar, 01509 010 Sao Paulo, SP, Brazil
    Mutat Res 544:375-83. 2003
    ..However, supportive and opposing data have been reported in different populations. Therefore, international collaborative studies need to be conducted to define the consistency of the associations described...
  3. ncbi request reprint Re: Human papillomavirus type 16 and 18 variants: race-related distribution and persistence
    Laura Sichero
    J Natl Cancer Inst 99:653-4; author reply 654-5. 2007
  4. pmc Interaction between polymorphisms of the human leukocyte antigen and HPV-16 variants on the risk of invasive cervical cancer
    Patricia S de Araujo Souza
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    BMC Cancer 8:246. 2008
    ..HLA class II polymorphisms are also associated with genetic susceptibility to ICC. Our aim is to verify if these associations are influenced by HPV-16 variability...
  5. pmc Awareness and knowledge of HPV, cervical cancer, and vaccines in young women after first delivery in São Paulo, Brazil--a cross-sectional study
    Cristina H Rama
    Hospital Maternidade Leonor Mendes de Barros, Sao Paulo, Brazil
    BMC Womens Health 10:35. 2010
    ....
  6. pmc Prevalence of human papillomavirus in archival samples obtained from patients with cervical pre-malignant and malignant lesions from Northeast Brazil
    José V Fernandes
    Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Av, Sen, Salgado Filho, S N, Lagoa Nova, CEP 59072 970, Natal, RN, Brazil
    BMC Res Notes 3:96. 2010
    ..The samples were submitted to histopathological revision examination and analysed by polymerase chain reaction (PCR) for the presence of HPV DNA, followed by HPV typing by dot blot hybridisation...
  7. pmc Validation of dot blot hybridization and denaturing high performance liquid chromatography as reliable methods for TP53 codon 72 genotyping in molecular epidemiologic studies
    Tatiana Rabachini
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    BMC Genet 11:44. 2010
    ..The most widely accepted method of detecting genotyping error is to confirm genotypes by sequencing and/or via a separate method...
  8. ncbi request reprint Vaccines against papillomavirus infections and disease
    Luisa Lina Villa
    Ludwig Institute for Cancer Research, R Prof Antônio Prudente, 109, 4o andar, 01509 010 Sao Paulo, SP, Brazil
    Salud Publica Mex 45:S443-8. 2003
    ..The scientific basis for the development of papillomavirus vaccines and present status of clinical trials will be addressed in this chapter. This paper is available too at: http://www.insp.mx/salud/index.html...
  9. ncbi request reprint Prophylactic HPV vaccines: reducing the burden of HPV-related diseases
    Luisa Lina Villa
    Ludwig Institute for Cancer Research, Sao Paulo branch Rua Prof Antonio Prudente, 109, 4o andar, 01509 010 Sao Paulo, SP, Brazil
    Vaccine 24:S23-8. 2006
    ....
  10. ncbi request reprint Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Lancet Oncol 6:271-8. 2005
    ....
  11. doi request reprint Overview of the clinical development and results of a quadrivalent HPV (types 6, 11, 16, 18) vaccine
    Luisa Lina Villa
    Ludwig Institute for Cancer Research Hospital Alemão Oswaldo Cruz, Sao Paulo, SP, Brazil
    Int J Infect Dis 11:S17-25. 2007
    ..g., HPV 16 and 18) and HPV 6 and 11, which contribute to development of low-grade cervical lesions and cause most anogenital warts, represents a logical primary prevention strategy...
  12. ncbi request reprint Past, present, and future of HPV research: highlights from the 19th International Papillomavirus Conference-HPV2001
    Luisa Lina Villa
    Virology Department, Ludwig Institute for Cancer Research, R Professor Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, Brazil
    Virus Res 89:163-73. 2002
    ..Highlights derive from the analysis of more than 500 papers presented at the Conference...
  13. pmc High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up
    L L Villa
    Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 01509 010 Sao Paulo, SP, Brazil
    Br J Cancer 95:1459-66. 2006
    ..This duration supports vaccination of adolescents and young adults, which is expected to greatly reduce the burden of cervical and genital cancers, precancerous dysplasia, and genital warts...
  14. pmc Deregulated expression of superoxide dismutase-2 correlates with different stages of cervical neoplasia
    Lara Termini
    Ludwig Institute for Cancer Research Hospital Alemão Oswaldo Cruz, Sao Paulo SP, Brazil
    Dis Markers 30:275-81. 2011
    ..Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer...
  15. ncbi request reprint High grade cervical lesions are caused preferentially by non-European variants of HPVs 16 and 18
    Laura Sichero
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Int J Cancer 120:1763-8. 2007
    ..Our study confirms the association between non-European variants and risk of cervical neoplasia, and highlights the importance of their geographic distribution for cervical cancer risk assessment...
  16. pmc HPV16 oncoproteins induce MMPs/RECK-TIMP-2 imbalance in primary keratinocytes: possible implications in cervical carcinogenesis
    Laura Beatriz da Silva Cardeal
    Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e33585. 2012
    ..Our results indicate that HPV oncoproteins promote MMPs/RECK-TIMP-2 imbalance which may be involved in HPV-associated lesions outcome...
  17. ncbi request reprint The prevalence of human papillomavirus in the oropharynx in healthy individuals in a Brazilian population
    Patrícia Rossi do Sacramento
    Departament of Biology, UNESP, Sao Paulo State University, IBILCE, Sao Jose do Rio Preto, Sao Paulo, Brazil
    J Med Virol 78:614-8. 2006
    ....
  18. pmc Overexpression of ANXA1 in penile carcinomas positive for high-risk HPVs
    Marilia Freitas Calmon
    Sao Paulo State University, Sao Jose do Rio Preto, Sao Paulo, Brazil
    PLoS ONE 8:e53260. 2013
    ..Overexpression of ANXA1 might be mediated by HPV E6 in penile squamous cell carcinoma of patients with high-risk HPVs, suggesting that this gene plays an important role in penile cancer...
  19. doi request reprint Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking
    Luciana Y Tomita
    Department of Nutrition, School of Public Health, University of Sao Paulo USP, Sao Paulo, SP, Brazil
    Br J Nutr 105:928-37. 2011
    ..Similar results were observed for total fruit, serum total carotene (including β-, α- and γ-carotene) and tocopherols. These findings suggest that the effect of nutritional factors on CIN3 is modified by smoking...
  20. doi request reprint Human papillomavirus type 16 variants in cervical cancer from an admixtured population in Brazil
    Katiana Junes-Gill
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    J Med Virol 80:1639-45. 2008
    ..These results corroborate previous data showing a high frequency of Asian-American variants in cervical neoplasia among women with multiethnic origin...
  21. pmc Production of human papillomavirus type 16 L1 virus-like particles by recombinant Lactobacillus casei cells
    Karina Araujo Aires
    Centro de Biotecnologia, Instituto Butantan, Sao Paulo, Brazil
    Appl Environ Microbiol 72:745-52. 2006
    ..The production of L1 VLPs by Lactobacillus opens the possibility for development of new live mucosal prophylactic vaccines...
  22. doi request reprint Value of HPV-DNA test in women with cytological diagnosis of atypical glandular cells (AGC)
    Luiz Carlos Zeferino
    Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Rua Alexander Fleming, 101, 13 024 110 Campinas, Sao Paulo, Brazil
    Eur J Obstet Gynecol Reprod Biol 159:160-4. 2011
    ..This study analyzed whether HPV (human papillomavirus) testing contributes towards defining histological abnormalities in women with atypical glandular cells (AGC) diagnosed at cervical cytology...
  23. doi request reprint Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women
    Luciana Yuki Tomita
    Department of Nutrition, School of Public Health, University of Sao Paulo USP, Sao Paulo, SP, Brazil
    Int J Cancer 126:703-14. 2010
    ..These results support the evidence that a healthy and balanced diet leading to provide high serum levels of antioxidants may reduce cervical neoplasia risk in low-income women...
  24. doi request reprint Nucleotide and phylogenetic analysis of human papillomavirus types 6 and 11 isolated from recurrent respiratory papillomatosis in Brazil
    Renata Prandini Adum de Matos
    UNESP Sao Paulo State University, IBILCE, Institute of Bioscience, Language and Literature and Exact Science, Department of Biology, Rua Cristóvão Colombo 2265, Bairro Jardim Nazareth, CEP 15054 010, Sao Jose do Rio Preto, Sao Paulo, Brazil
    Infect Genet Evol 16:282-9. 2013
    ..In both phylogenetic trees, the sequences from Brazil did not group together. We could not establish a geographical association between HPV-6 or HPV-11 variants, unlike HPV-16 and HPV-18...
  25. doi request reprint Seroprevalence of human papillomavirus 6, 11, 16, and 18 in young primiparous women in Sao Paulo, Brazil
    Cristina Helena Rama
    Department of Family Planning, Hospital Maternidade Leonor Mendes de Barros, Av Celso Garcia 2477, Sao Paulo, Brazil
    Int J Gynecol Cancer 20:1405-10. 2010
    ..The aim of this study was to determine the prevalence of serum antibodies to HPV types 6, 11, 16, and 18 and associated factors among young women after birth of the first child...
  26. ncbi request reprint Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia
    Lara Termini
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Int J Cancer 127:485-90. 2010
    ..Moreover, 92.5% of adenocarcinomas also exhibited intense hK7 staining. Differences in the expression of hK7 could potentially be used as a biomarker for the characterization of different stages of cervical disease...
  27. doi request reprint High-risk human papillomavirus in oral squamous cell carcinoma of young patients
    Estela Kaminagakura
    Department of Head and Neck Surgery and Otorhinolaryngology, A C Camargo Hospital, Sao Paulo, Brazil
    Int J Cancer 130:1726-32. 2012
    ..Association between HPV and p16 was verified, and it was statistically significant (p = 0.002). The higher prevalence of high-risk HPV types, especially HPV16, may be a contributing factor to oral carcinogenesis in younger individuals...
  28. ncbi request reprint HPV vaccination: the beginning of the end of cervical cancer? - A Review
    Ana Paula Lepique
    Instituto Ludwig de Pesquisa sobre o Câncer, Sao Paulo, SP, Brasil, 01323 903
    Mem Inst Oswaldo Cruz 104:1-10. 2009
    ..This review brings up to date information on the two commercially available prophylactic HPV vaccines against HPV, as well as presenting the ongoing research on HPV peptide, protein and dendritic cell based therapeutic vaccines...
  29. doi request reprint HPV prophylactic vaccination: The first years and what to expect from now
    Luisa Lina Villa
    Virology Group, Ludwig Institute for Cancer Research, Hospital Alemao Oswaldo Cruz, Rua João Julião 245, Sao Paulo, SP, Brazil
    Cancer Lett 305:106-12. 2011
    ..The ultimate goal is to implement worldwide cervical cancer control programs to include HPV vaccination and screening with cytology and HPV DNA testing, particularly in less-developed countries where it is most needed...
  30. doi request reprint Expression of human papillomavirus type 16 E7 oncoprotein alters keratinocytes expression profile in response to tumor necrosis factor-alpha
    Enrique Boccardo
    Virology Group, Ludwig Institute for Cancer Research, São Paulo 01323 903, Brazil
    Carcinogenesis 31:521-31. 2010
    ..Further evaluation of the role of such genes in TNF resistance and HPV-associated disease development is warranted...
  31. ncbi request reprint Identification of novel cellular transcription factors that regulate early promoters of human papillomavirus types 18 and 16
    Laura Sichero
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, SP, Brazil
    J Infect Dis 206:867-74. 2012
    ..The long control region (LCR) of human papillomavirus (HPV) regulates early gene transcription by interaction with several viral and cellular transcription factors (TFs)...
  32. ncbi request reprint Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas
    Sylvia Sanches Cortezzi
    Instituto de Biociencias, Letras e Ciencias Exatas, IBILCE UNESP, Rua Cristovao Colombo, 2265, CEP 15054 000, Sao Jose do Rio Preto, SP, Brazil
    Cancer Genet Cytogenet 150:44-9. 2004
    ..The arginine allele appears to protect against head and neck cancers. Also, the data showed that HPV infection results in no increased risk of developing head and neck tumors...
  33. ncbi request reprint HPV16 tumor associated macrophages suppress antitumor T cell responses
    Ana Paula Lepique
    Laboratory of Virology Ludwig Institute for Cancer Research, Sao Paulo Branch, Rua João Julião, 245, Sao Paulo, SP, Brazil
    Clin Cancer Res 15:4391-400. 2009
    ..The objective of this work is to characterize the role of tumor-associated macrophages (TAM) on the immune cellular response against the tumor...
  34. ncbi request reprint Different P105 promoter activities among natural variants of human papillomavirus type 18
    Laura Sichero
    Instituto de Quimica, Universidade de Sao Paulo, Cidade Universitaria, and Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    J Infect Dis 191:739-42. 2005
    ..All variants tested were more active than the P97 HPV-16 prototype promoter. Differences in the LCR that impact P105 promoter activity could be responsible for the observed variability in oncogenic potential...
  35. ncbi request reprint p53 as a new prognostic factor for lymph node metastasis in penile carcinoma: analysis of 82 patients treated with amputation and bilateral lymphadenectomy
    Ademar Lopes
    Division of Urology and Department of Pelvic Surgery, Ludwig Institute for Cancer Research, São Paulo Branch and Cancer Hospital A C Camargo, Fundacao Antonio Prudente, Sao Paulo, Brasil
    J Urol 168:81-6. 2002
    ..We studied 82 patients with penile carcinoma staged according to the 1978 TNM system who underwent amputation and bilateral lymphadenectomy to evaluate the prognostic value of immunohistochemical p53 staining in the primary tumor...
  36. ncbi request reprint Vaccines against rotavirus and human papillomavirus (HPV)
    Alexandre C Linhares
    Instituto Evandro Chagas, Belem, PA, Brazil
    J Pediatr (Rio J) 82:S25-34. 2006
    ..To briefly review strategies aimed at the development of rotavirus and HPV vaccines, with emphasis on the current status of studies assessing the safety, reactogenicity, immunogenicity and efficacy of recently developed vaccines...
  37. ncbi request reprint Human papillomavirus type 16 molecular variants in Guarani Indian women from Misiones, Argentina
    Sergio Andrés Tonon
    Laboratorio de Biologia Molecular Aplicada, Universidad Nacional de Misiones, Felix de Azara 1552, Posadas, Misiones, 3300 Argentina
    Int J Infect Dis 11:76-81. 2007
    ..Some intratypic molecular variants of HPV16 have been associated with greater oncogenic risk, but their implication in the etiology of cervical cancer is still uncertain...
  38. ncbi request reprint [Genital human papillomavirus infection identification by molecular biology among asymptomatic women]
    Bernadete Nonnenmacher
    Universidade Luterana do Brasil, Canoas, RS, Brasil
    Rev Saude Publica 36:95-100. 2002
    ..To evaluate whether epidemiological factors may be associated to genital human papillomavirus (HPV) infection...
  39. ncbi request reprint Human papillomavirus type-16 variants in Quechua aboriginals from Argentina
    Maria Alejandra Picconi
    Servicio Virus Oncogénicos, Instituto Nacional de Enfermedades Infecciosas ANLIS Dr Carlos G Malbran, Buenos Aires, Argentina
    J Med Virol 69:546-52. 2003
    ..The predominance of HPV-16 variants in pathologic samples when compared to normal controls could have implications for the natural history of cervical lesions...
  40. ncbi request reprint Monitoring HPV vaccination
    Margaret Stanley
    Department of Pathology, Cambridge, UK
    Vaccine 26:A24-7. 2008
    ....
  41. ncbi request reprint Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases
    Gary Clifford
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
    Vaccine 24:S3/26-34. 2006
    ..After HPV-16/18, the six most common HPV types are the same in all world regions, namely 31, 33, 35, 45, 52 and 58; these account for an additional 20% of cervical cancers worldwide...