Sergio Verjovski-Almeida

Summary

Country: Brazil

Publications

  1. pmc The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation
    Felipe C Beckedorff
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brasil
    PLoS Genet 9:e1003705. 2013
  2. pmc Expression analysis and in silico characterization of intronic long noncoding RNAs in renal cell carcinoma: emerging functional associations
    Angela A Fachel
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Mol Cancer 12:140. 2013
  3. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
  4. pmc Evaluation of reference-based two-color methods for measurement of gene expression ratios using spotted cDNA microarrays
    Bernardo R Peixoto
    Departamento de Matematica, Universidade dos Acores, 9501 801 Ponta Delgada, Acores, Portugal
    BMC Genomics 7:35. 2006
  5. ncbi request reprint Schistosome transcriptome: insights and perspectives for functional genomics
    Sergio Verjovski-Almeida
    Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Trends Parasitol 20:304-8. 2004
  6. ncbi request reprint Current developments on Schistosoma proteomics
    Sergio Verjovski-Almeida
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Acta Trop 108:183-5. 2008
  7. ncbi request reprint Use of a 44k oligoarray to explore the transcriptome of Schistosoma mansoni adult worms
    Sergio Verjovski-Almeida
    Laboratory of Gene Expression in Eukaryotes, Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes, 748, 05508 000 Sao Paulo, SP, Brazil
    Exp Parasitol 117:236-45. 2007
  8. ncbi request reprint Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni
    Sergio Verjovski-Almeida
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Nat Genet 35:148-57. 2003
  9. ncbi request reprint Zerg: a very fast BLAST parser library
    Apua C M Paquola
    Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo 05508 900, Sao Paulo, SP, Brazil
    Bioinformatics 19:1035-6. 2003
  10. ncbi request reprint Gene structure and splicing in schistosomes
    Sergio Verjovski-Almeida
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    J Proteomics 74:1515-8. 2011

Detail Information

Publications62

  1. pmc The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation
    Felipe C Beckedorff
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brasil
    PLoS Genet 9:e1003705. 2013
    ..In a broader perspective, our findings suggest that other non-characterized unspliced intronic lncRNAs transcribed in the human genome might contribute to a location-specific epigenetic modulation of genes. ..
  2. pmc Expression analysis and in silico characterization of intronic long noncoding RNAs in renal cell carcinoma: emerging functional associations
    Angela A Fachel
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Mol Cancer 12:140. 2013
    ..The molecular pathogenesis of renal cell carcinoma (RCC) is still poorly understood, and in particular, limited studies are available for intronic lncRNAs expressed in RCC...
  3. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  4. pmc Evaluation of reference-based two-color methods for measurement of gene expression ratios using spotted cDNA microarrays
    Bernardo R Peixoto
    Departamento de Matematica, Universidade dos Acores, 9501 801 Ponta Delgada, Acores, Portugal
    BMC Genomics 7:35. 2006
    ..Here we evaluated the precision and accuracy of reconstructed ratios from three indirect methods relative to ratios obtained from direct hybridizations, herein considered as the gold-standard...
  5. ncbi request reprint Schistosome transcriptome: insights and perspectives for functional genomics
    Sergio Verjovski-Almeida
    Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Trends Parasitol 20:304-8. 2004
  6. ncbi request reprint Current developments on Schistosoma proteomics
    Sergio Verjovski-Almeida
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Acta Trop 108:183-5. 2008
    ..Here we review the development of schistosome proteomic research around the world and provide an appreciation on the future opportunities in Brazil...
  7. ncbi request reprint Use of a 44k oligoarray to explore the transcriptome of Schistosoma mansoni adult worms
    Sergio Verjovski-Almeida
    Laboratory of Gene Expression in Eukaryotes, Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes, 748, 05508 000 Sao Paulo, SP, Brazil
    Exp Parasitol 117:236-45. 2007
    ..Moreover, detection of bi-directional transcription for 7% of the active "no match" genes in adults leads us to hypothesize a widespread production of antisense RNA in S. mansoni, with possible regulatory roles...
  8. ncbi request reprint Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni
    Sergio Verjovski-Almeida
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Nat Genet 35:148-57. 2003
    ....
  9. ncbi request reprint Zerg: a very fast BLAST parser library
    Apua C M Paquola
    Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo 05508 900, Sao Paulo, SP, Brazil
    Bioinformatics 19:1035-6. 2003
    ..It is optimized for speed, being especially useful for large-scale genomic analysis. Benchmark tests show that Zerg is over two orders of magnitude faster than some widely used BLAST parsers...
  10. ncbi request reprint Gene structure and splicing in schistosomes
    Sergio Verjovski-Almeida
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    J Proteomics 74:1515-8. 2011
    ..Complete description of the functions of these variable proteins will greatly contribute to our understanding of host-parasite interactions...
  11. ncbi request reprint RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 316:618-27. 2004
    ..These results highlight a previously uncharacterized subfamily of Ras-related genes that may have a tumor suppressor role in prostate cancer...
  12. ncbi request reprint As antisense RNA gets intronic
    Eduardo M Reis
    Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil
    OMICS 9:2-12. 2005
    ....
  13. doi request reprint Curupira-1 and Curupira-2, two novel Mutator-like DNA transposons from the genomes of human parasites Schistosoma mansoni and Schistosoma japonicum
    Daniele S Jacinto
    Departamento de Fisica e Informatica, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, 13566 590 Sao Carlos, SP, Brazil
    Parasitology 138:1124-33. 2011
    ..Description of these novel schistosome transposons provides new insights in the evolution of transposable elements in schistosomes...
  14. doi request reprint Bursts of transposition from non-long terminal repeat retrotransposon families of the RTE clade in Schistosoma mansoni
    Thiago M Venancio
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Int J Parasitol 40:743-9. 2010
    ..We hypothesise that these bursts could be a consequence of the evolutionary pressure resulting from migration of Schistosoma from Asia to Africa and their establishment in this new environment, helping both speciation and adaptation...
  15. doi request reprint Identification of protein-coding and intronic noncoding RNAs down-regulated in clear cell renal carcinoma
    Glauber Costa Brito
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, SP, Brazil
    Mol Carcinog 47:757-67. 2008
    ..Our results indicate a novel set of tumor suppressor gene candidates, including noncoding intronic RNAs, which may play a significant role in malignant transformations of normal renal cells...
  16. pmc Androgen responsive intronic non-coding RNAs
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
    BMC Biol 5:4. 2007
    ....
  17. ncbi request reprint Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brasil
    Genomics 92:18-25. 2008
    ..Altogether, these results support an evolutionarily conserved role of intronic ncRNAs in human and mouse, which are likely to be involved in the fine tuning of gene expression regulation in different mammalian tissues...
  18. pmc Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription
    Helder I Nakaya
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Genome Biol 8:R43. 2007
    ..However, the complement of human genes in which introns are transcribed, and the number of intronic transcriptional units and their tissue expression patterns are not known...
  19. pmc Identification of the Schistosoma mansoni TNF-alpha receptor gene and the effect of human TNF-alpha on the parasite gene expression profile
    Katia C Oliveira
    Laboratory of Gene Expression in Eukaryotes, Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS Negl Trop Dis 3:e556. 2009
    ....
  20. ncbi request reprint Gender biased differential alternative splicing patterns of the transcriptional cofactor CA150 gene in Schistosoma mansoni
    Ricardo DeMarco
    Laboratory of Gene Expression in Eukaryotes, Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    Mol Biochem Parasitol 150:123-31. 2006
    ..Due to the role of CA150 in RNA transcription and processing, we hypothesize that these differential expression events may be important in the generation and maintenance of the different phenotypes between male and female...
  21. pmc Saci-1, -2, and -3 and Perere, four novel retrotransposons with high transcriptional activities from the human parasite Schistosoma mansoni
    Ricardo DeMarco
    Laboratorio de Bioinformatica Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
    J Virol 78:2967-78. 2004
    ..mansoni target gene transcripts. The data presented here suggest a role for these elements in the dynamics of this complex human parasite genome...
  22. ncbi request reprint ESTWeb: bioinformatics services for EST sequencing projects
    Apua C M Paquola
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900, Sao Paulo, SP, Brazil
    Bioinformatics 19:1587-8. 2003
    ..The software facilitates real-time monitoring and evaluation of EST sequence acquisition progress along an EST sequencing project...
  23. doi request reprint Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates
    Leonardo P Farias
    Centro de Biotecnologia, Instituto Butantan, Av Vital Brasil 1500, 05503 900 Sao Paulo, Sao Paulo, Brazil
    Parasitol Res 108:123-35. 2011
    ....
  24. pmc SmTRC1, a novel Schistosoma mansoni DNA transposon, discloses new families of animal and fungi transposons belonging to the CACTA superfamily
    Ricardo DeMarco
    Laboratory of Gene Expression in Eukaryotes Departamento de Bioquímica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    BMC Evol Biol 6:89. 2006
    ..Despite the extensive description of retroelements in S. mansoni, just a single DNA-only transposon belonging to the Merlin family has so far been reported in this organism...
  25. pmc A quantitative view of the transcriptome of Schistosoma mansoni adult-worms using SAGE
    Elida P B Ojopi
    Laboratório de Neurociências LIM27, Instituto de Psiquiatria, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    BMC Genomics 8:186. 2007
    ..By using SAGE (Serial Analysis of Gene Expression) we describe here the first large-scale quantitative analysis of the Schistosoma mansoni transcriptome, one of the most epidemiologically relevant species of this genus...
  26. doi request reprint Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors
    Helder I Nakaya
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Pau lo, SP, Brazil
    Biochem Biophys Res Commun 364:918-23. 2007
    ..These results demonstrate that different isoforms of TLE genes are commonly transcribed in human tissues and suggest that TLE3 could be involved in prostate cancer development...
  27. ncbi request reprint Large-scale transcriptome analyses reveal new genetic marker candidates of head, neck, and thyroid cancer
    Eduardo M Reis
    Departamento de Bioquimica, Faculdade de Medicina, Universidade de Sao Paulo, Brazil
    Cancer Res 65:1693-9. 2005
    ..Similar analysis is warranted for a number of other tumors for which large EST data sets are available...
  28. doi request reprint ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells
    Mariana Lazarini
    Hematology and Hemotherapy Center, University of Campinas Hemocentro Unicamp, Instituto Nacional de Ciência e Tecnologia do Sangue, INCTS, Campinas, Sao Paulo, Brazil
    Biochim Biophys Acta 1832:365-74. 2013
    ..Here we studied the role of ARHGAP21 in two prostate adenocarcinoma cell lines, LNCaP and PC3, which respectively represent initial and advanced stages of prostate carcinogenesis...
  29. ncbi request reprint Non-coding RNAs in schistosomes: an unexplored world
    Katia C Oliveira
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, SP, Brasil
    An Acad Bras Cienc 83:673-94. 2011
    ..Exploring this world is a challenge for the scientists under a new molecular perspective of host-parasite interactions and parasite development...
  30. pmc Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer
    Ana C Tahira
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900, Sao Paulo, SP, Brasil
    Mol Cancer 10:141. 2011
    ..In the present work we investigated the relative abundance of a collection of lncRNAs in patients' pancreatic tissue samples aiming at identifying gene expression profiles correlated to pancreatic cancer and metastasis...
  31. ncbi request reprint Characterization of Schistosoma mansoni ATPDase2 gene, a novel apyrase family member
    Julio Levano-Garcia
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 352:384-9. 2007
    ..Taken together these data suggest a non-redundant role for SmATPDase2 in the parasite-host interplay...
  32. ncbi request reprint Exploring the Schistosoma mansoni adult male transcriptome using RNA-seq
    Giulliana Tessarin Almeida
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Exp Parasitol 132:22-31. 2012
    ..Interestingly, we identified 11 novel Micro-exon genes (MEGs). These data reveal new features of the S. mansoni transcriptional landscape and significantly advance our understanding of the parasite transcriptome...
  33. pmc Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood
    Mariane Secco
    Human Genome Research Center, Department of Genetic and Evolutive Biology, University of Sao Paulo, 106 Cidade Universitária, 05508 090 São Paulo, SP, Brazil
    Stem Cell Rev 5:387-401. 2009
    ..In addition, these findings reinforce our previous suggestion on the importance of banking the whole umbilical cord unit for research or future therapeutic use...
  34. ncbi request reprint Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer
    Eduardo M Reis
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brasil
    Oncogene 23:6684-92. 2004
    ..024) between the low/high degrees of tumor differentiation and antisense intronic RASSF1 transcript levels. The need to use intron arrays to reveal the transcriptome profile of antisense intronic RNA in cancer has clearly emerged...
  35. ncbi request reprint Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma
    Jucimara Colombo
    UNESP Universidade Estadual Paulista, Instituto de Biociencias, Letras e Ciências Exatas IBILCE, Departamento de Biologia, Sao Paulo, Brazil
    Oncol Rep 21:649-63. 2009
    ..0001). The set of genes identified here contribute to a better understanding of the molecular basis of larynx cancer, and provide candidate markers for improving diagnosis, prognosis and treatment of this carcinoma...
  36. pmc Analysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions
    Thiago M Venancio
    Laboratory of Bioinformatics Departamento de Bioquímica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    BMC Genomics 8:407. 2007
    ....
  37. ncbi request reprint Identification of 18 new transcribed retrotransposons in Schistosoma mansoni
    Ricardo DeMarco
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    Biochem Biophys Res Commun 333:230-40. 2005
    ..These results allow for a comprehensive description of the transcribed retrotransposon diversity of this complex human parasite...
  38. ncbi request reprint Mapping transposon insertion sites by touchdown PCR and hybrid degenerate primers
    Julio Levano-Garcia
    Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Biotechniques 38:225-9. 2005
    ..citri mutants. Restriction mapping and Southern blot analysis confirmed the insertion sites for eight randomly chosen mutants. This method is a very useful tool for large-scale characterization of mutants in functional genomics studies...
  39. doi request reprint Long intronic noncoding RNA transcription: expression noise or expression choice?
    Rodrigo Louro
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Genomics 93:291-8. 2009
    ..Deciphering nature's choice of different types of messages conveyed by ncRNAs will shed light on the RNA-based layer of regulatory processes in eukaryotic cells...
  40. ncbi request reprint Gene expression arrays in cancer research: methods and applications
    Ricardo R Brentani
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Crit Rev Oncol Hematol 54:95-105. 2005
    ..Hence, we shall also highlight some of the already available and promising applications of array technology on the day-to-day practice of oncology...
  41. pmc Identification of protein-coding and non-coding RNA expression profiles in CD34+ and in stromal cells in refractory anemia with ringed sideroblasts
    Mariana O Baratti
    Department of Internal Medicine, School of Medical Science, Hematology and Hemotherapy Center, University of Campinas, 13083 970 Campinas, SP, Brazil
    BMC Med Genomics 3:30. 2010
    ..Characterization of ncRNAs in progenitor cells and stromal cells of MDS patients could be strategic for understanding gene expression regulation in this disease...
  42. pmc Effect of human TGF-β on the gene expression profile of Schistosoma mansoni adult worms
    Katia C Oliveira
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Mol Biochem Parasitol 183:132-9. 2012
    ..These datasets offer potential targets to be explored in order to understand the molecular mechanisms behind the possible role of hTGF-β effects on parasite biology...
  43. doi request reprint Schistosomes--proteomics studies for potential novel vaccines and drug targets
    Ricardo DeMarco
    Departamento de Fisica e Informatica, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, 13560 970 Sao Carlos, SP, Brazil
    Drug Discov Today 14:472-8. 2009
    ..Successful preliminary trials of two vaccine candidates that have been detected at the parasite surface by proteomics give grounds for believing that such an approach may provide a fresh start for the field...
  44. ncbi request reprint Molecular characterization and immunolocalization of Schistosoma mansoni ATP-diphosphohydrolase
    Ricardo DeMarco
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 307:831-8. 2003
    ..The presence of an ATPDase ortholog on the surface of S. mansoni suggests that the enzyme might play a role in the escape from host defenses that would involve platelet activation...
  45. ncbi request reprint Schistosoma mansoni histones: from transcription to chromatin regulation; an in silico analysis
    Letícia Anderson
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 000 Sao Paulo, SP, Brazil
    Mol Biochem Parasitol 183:105-14. 2012
    ....
  46. doi request reprint Effects of curcumin on the parasite Schistosoma mansoni: a transcriptomic approach
    Enyara R Morais
    Faculdade de Medicina de Ribeirao Preto, Departamento de Bioquimica e Imunologia, Universidade de Sao Paulo, Av Bandeirantes, 3900, Monte Alegre, 14040 900 Ribeirão Preto, SP, Brazil
    Mol Biochem Parasitol 187:91-7. 2013
    ..Here we suggest that transcriptional repression observed in Notch and TGF-β pathways could explain the effects on oviposition and egg development described in the literature...
  47. pmc Immunization with tegument nucleotidases associated with a subcurative praziquantel treatment reduces worm burden following Schistosoma mansoni challenge
    Henrique K Rofatto
    Pós Graduação Interunidades em Biotecnologia, Instituto Butantan, Sao Paulo, Brazil Centro de Biotecnologia, Instituto Butantan, Sao Paulo, Brazil
    Peerj 1:e58. 2013
    ..The immunogenicity and relative exposure of SmAP to the host immune system are discussed, as key factors involved in the apparently synergistic effect of SmAP immunization and subcurative PZQ treatment...
  48. pmc Apert p.Ser252Trp mutation in FGFR2 alters osteogenic potential and gene expression of cranial periosteal cells
    Roberto D Fanganiello
    Departamento de Genética e Biologia Evolutiva, Instituto de Biociencias, Universidade de Sao Paulo, Brazil
    Mol Med 13:422-42. 2007
    ....
  49. ncbi request reprint Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis
    Carlos DeOcesano-Pereira
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brasil
    Nucleic Acids Res 42:8343-55. 2014
    ..We revealed an endogenous lncRNA that induces apoptosis, suggesting that INXS is a possible target to be explored in cancer therapies. ..
  50. ncbi request reprint Human malaria parasites display a receptor for activated C kinase ortholog
    Luciana Madeira
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508 900, Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 306:995-1001. 2003
    ....
  51. doi request reprint Loss of caspase 7 expression is associated with poor prognosis in renal cell carcinoma clear cell subtype
    Santiago A Vilella-Arias
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Urology 82:974.e1-7. 2013
    ..To investigate the expression of CASP7 protein in renal cell carcinoma clear cell subtype (ccRCC) and its value to predict cancer-specific survival (CSS)...
  52. pmc The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags
    Helena Brentani
    Laboratório de Genética Molecular do Câncer, Departmento de Radiologia, Universidade de Sao Paulo, Travessa da Rua Dr Ovídeo Pires de Campos S N, 4deg, Brazil
    Proc Natl Acad Sci U S A 100:13418-23. 2003
    ....
  53. ncbi request reprint Schistosomiasis--a century searching for chemotherapeutic drugs
    Gabriela Ribeiro-dos-Santos
    Centro de Biotecnologia, Instituto Butantan, 05503 900, Sao Paulo, SP, Brazil
    Parasitol Res 99:505-21. 2006
    ....
  54. pmc Transcriptional regulation differs in affected facioscapulohumeral muscular dystrophy patients compared to asymptomatic related carriers
    Patricia Arashiro
    Human Genome Research Center, Department of Genetics and Evolutive Biology, Institute of Biosciences, University of Sao Paulo, 05508 090, Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 106:6220-5. 2009
    ....
  55. ncbi request reprint Use of degenerate primers and touchdown PCR for construction of cDNA libraries
    Juliana L R Fietto
    Universidade de Sao Paulo, Brasil
    Biotechniques 32:1404-8, 1410-1. 2002
    ..20-40 sequences/ mini-library). The optimized high-throughput approach described here is likely to help in the discovery of expressed genes in any complex organism...
  56. pmc DNA microarray-based genome comparison of a pathogenic and a nonpathogenic strain of Xylella fastidiosa delineates genes important for bacterial virulence
    Tie Koide
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, SP, Brazil
    J Bacteriol 186:5442-9. 2004
    ..These results provide the first detailed comparison between a nonpathogenic strain and a pathogenic strain of X. fastidiosa, constituting an important step towards understanding the molecular basis of the disease...
  57. pmc Perspectives of Long Non-Coding RNAs in Cancer Diagnostics
    Eduardo M Reis
    Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo São Paulo, Brasil
    Front Genet 3:32. 2012
    ..Annotation and functional characterization of the lncRNA complement of the cancer transcriptome will conceivably provide new venues for early diagnosis and treatment of the disease...
  58. ncbi request reprint Cloning the genes and DNA binding properties of High Mobility Group B1 (HMGB1) proteins from the human blood flukes Schistosoma mansoni and Schistosoma japonicum
    Francisco Meirelles Bastos de Oliveira
    Instituto de Bioquimica Medica, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Ilha do Fundao, Brazil
    Gene 377:33-45. 2006
    ....
  59. pmc Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene
    Ahmed Osman
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    PLoS Pathog 2:e54. 2006
    ..The results also provide additional evidence for a role for the TGF-beta signaling pathway in male-induced female reproductive development...
  60. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...
  61. ncbi request reprint The tegument surface membranes of the human blood parasite Schistosoma mansoni: a proteomic analysis after differential extraction
    Simon Braschi
    Department of Biology, University of York, York, UK
    Proteomics 6:1471-82. 2006
    ..The proteins identified were categorised by their function and putative location on the basis of their homology with annotated proteins in other organisms...