Thereza Quirico-Santos

Summary

Affiliation: Universidade Federal Fluminense
Country: Brazil

Publications

  1. pmc Characteristic pattern of skeletal muscle remodelling in different mouse strains
    Jussara Lagrota-Candido
    Department of Immunobiology, Institute of Biology, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil
    Int J Exp Pathol 91:522-9. 2010
  2. ncbi request reprint Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation
    Clovis O Da Fonseca
    Laboratory of Cellular Pathology, Institute of Biology, Fluminense Federal University, Niteroi, RJ, 24020 141, Brazil
    Anticancer Res 33:5625-31. 2013
  3. ncbi request reprint Increased metalloprotease activity in the epileptogenic lesion--Lobectomy reduces metalloprotease activity and urokinase-type uPAR circulating levels
    Thereza Quirico-Santos
    Department of Cellular and Molecular Biology, Fluminense Federal University, Niteroi, Rio de Janeiro 24020 141, Brazil Electronic address
    Brain Res 1538:172-81. 2013
  4. doi request reprint Resection of the epileptogenic lesion abolishes seizures and reduces inflammatory cytokines of patients with temporal lobe epilepsy
    Thereza Quirico-Santos
    Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Rio de Janeiro Federal University, Rio de Janeiro, Brazil
    J Neuroimmunol 254:125-30. 2013
  5. ncbi request reprint Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis
    Thereza Quirico-Santos
    Applied Genomics Research Group, School of Pharmacy, Queens University Belfast, Belfast, UK
    Arq Neuropsiquiatr 65:15-9. 2007
  6. ncbi request reprint Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
    Thereza Quirico-Santos
    Laboratory of Cellular Pathology, Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Niteroi, RJ, Brasil
    Arq Neuropsiquiatr 68:799-803. 2010
  7. ncbi request reprint Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review
    Clovis O Da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, 24030 210 Niterói, RJ, Brazil
    Surg Neurol 66:611-5. 2006
  8. ncbi request reprint Gender dimorphism influences extracellular matrix expression and regeneration of muscular tissue in mdx dystrophic mice
    Maria Cristina Salimena
    Department of Immunobiology, Institute of Biology, Fluminense Federal University, Rio de Janeiro, Brazil
    Histochem Cell Biol 122:435-44. 2004
  9. doi request reprint Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Niterói 24030 210, RJ, Brazil
    Surg Neurol 70:259-66; discussion 266-7. 2008
  10. ncbi request reprint Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, UFF, Niteroi, Rio de Janeiro, Brazil
    Surg Neurol 65:S1:2-1:8; discussion S1:8-1:9. 2006

Collaborators

  • Wilson C Santos
  • Joseli Lannes-Vieira
  • Wilson Savino
  • Steven S Clark
  • Koen Vandenbroeck
  • Jussara Lagrota-Candido
  • Clovis Orlando da Fonseca
  • Selma Maria de Azevedo Sias
  • Claudia M Mano
  • Andrea Henriques-Pons
  • Edson Marchiori
  • Clovis O Da Fonseca
  • Clovis Orlando da Fonseca
  • Paulo Emilio Correa Leite
  • Débora Futuro
  • Cerli Rocha Gattass
  • Rafael Ferreira da Silva
  • Douglas Florindo Pinheiro
  • Marcela D'Alincourt Salazar
  • Maria Cristina Salimena
  • Eustaquio Luiz Paiva-Oliveira
  • Francisco das Chagas Abreu da Silveira
  • Diogo G Garcia
  • Marcela Simão
  • José Alberto Landeiro
  • Cristiane Bani
  • Ricardo de Pascual
  • Carmen Nanclares
  • Luis Gandia
  • Inés Colmena
  • Juliana de Saldanha da Gama Fischer
  • Júlio César T Silva
  • Osório C Meirelles
  • Raphael M Teixeira
  • Izabel Christina Nunes de Palmer Paixão
  • Lian P Carvalho
  • Maria de Fátima Pinho
  • Lídia Maria da Fonte de Amorim
  • Paulo Emilio C Leite
  • Eustaquio L Paiva-Oliveira
  • Rafael F da Silva
  • Jose Carlos Cogo
  • Ricardo S Pereira
  • Paulo Emílio Correa Leite
  • Bruno de Almeida Lopes
  • Regina O Caetano
  • Igor R Lins
  • Katia G Lima-Araújo
  • Lidia M F Amorim
  • Mauro V de Castro Faria
  • Pablo Trindade
  • Ricardo E Santelli
  • Patricia Burth
  • Manuel Gustavo L Ribeiro
  • Aline S Freire
  • Kessiane Belshoff de Almeida
  • Adriano Arnobio
  • Julio Thome Silva
  • Igor Rodrigo Lins
  • Juliana Fischer
  • Rafael Linden
  • Gilberto Schwartsmann
  • Janaina Nagel
  • Regina Caetano
  • Marcos Masini
  • Maria da Gloria da Costa Carvalho

Detail Information

Publications24

  1. pmc Characteristic pattern of skeletal muscle remodelling in different mouse strains
    Jussara Lagrota-Candido
    Department of Immunobiology, Institute of Biology, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil
    Int J Exp Pathol 91:522-9. 2010
    ..These data support that skeletal muscle remodelling is greatly influenced by the genetic backgrounds, shedding light on the molecular mechanisms influencing differential muscular remodelling and tissue regeneration among individuals...
  2. ncbi request reprint Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation
    Clovis O Da Fonseca
    Laboratory of Cellular Pathology, Institute of Biology, Fluminense Federal University, Niteroi, RJ, 24020 141, Brazil
    Anticancer Res 33:5625-31. 2013
    ..This retrospective study aimed to evaluate the long-term response and toxicity of recurrent malignant glioma patients to inhalation chemotherapy with perillyl alcohol (POH)...
  3. ncbi request reprint Increased metalloprotease activity in the epileptogenic lesion--Lobectomy reduces metalloprotease activity and urokinase-type uPAR circulating levels
    Thereza Quirico-Santos
    Department of Cellular and Molecular Biology, Fluminense Federal University, Niteroi, Rio de Janeiro 24020 141, Brazil Electronic address
    Brain Res 1538:172-81. 2013
    ....
  4. doi request reprint Resection of the epileptogenic lesion abolishes seizures and reduces inflammatory cytokines of patients with temporal lobe epilepsy
    Thereza Quirico-Santos
    Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Rio de Janeiro Federal University, Rio de Janeiro, Brazil
    J Neuroimmunol 254:125-30. 2013
    ..Maintenance of high TGF-β1 and IL-6 cytokines in both groups suggests a role in down-regulation of neuroinflammation and promotion of brain tissue remodeling for neuronal reorganization...
  5. ncbi request reprint Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis
    Thereza Quirico-Santos
    Applied Genomics Research Group, School of Pharmacy, Queens University Belfast, Belfast, UK
    Arq Neuropsiquiatr 65:15-9. 2007
    ..Additionally neither IL4 nor IL4R genes are susceptibility factors for Brazilian MS but may be able to modify ethnicity-dependent disease risk and penetrance of susceptibility factors...
  6. ncbi request reprint Brain sweet brain: importance of sugars for the cerebral microenvironment and tumor development
    Thereza Quirico-Santos
    Laboratory of Cellular Pathology, Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Niteroi, RJ, Brasil
    Arq Neuropsiquiatr 68:799-803. 2010
    ..In this review, we will discuss the latest insights into the roles of brain glycoproteins as modulators of cell adhesion, migration, neurite outgrowth and glial tumor invasion...
  7. ncbi request reprint Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review
    Clovis O Da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, 24030 210 Niterói, RJ, Brazil
    Surg Neurol 66:611-5. 2006
    ..To explore therapeutic strategies and evaluate the clinical results, we report a case of a patient with anaplastic oligodendroglioma managed with intranasal delivery of POH...
  8. ncbi request reprint Gender dimorphism influences extracellular matrix expression and regeneration of muscular tissue in mdx dystrophic mice
    Maria Cristina Salimena
    Department of Immunobiology, Institute of Biology, Fluminense Federal University, Rio de Janeiro, Brazil
    Histochem Cell Biol 122:435-44. 2004
    ..These results suggest a role for female hormones in the control of myonecrosis probably by promoting regeneration of muscular tissue and mitigating inflammation especially at ages under the critical influence of sex hormones...
  9. doi request reprint Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Niterói 24030 210, RJ, Brazil
    Surg Neurol 70:259-66; discussion 266-7. 2008
    ..The intranasal delivery allows drugs that do not cross the BBB to enter the CNS; moreover, it eliminates the need for systemic delivery, thereby reducing unwanted systemic side effects...
  10. ncbi request reprint Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, UFF, Niteroi, Rio de Janeiro, Brazil
    Surg Neurol 65:S1:2-1:8; discussion S1:8-1:9. 2006
    ..This article describes the effect of intranasal delivery of POH in a patient with relapsed GBM...
  11. doi request reprint Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol
    Clovis O Da Fonseca
    Service of Neurosurgery, Department of General and Specialized Surgery, Antonio Pedro University Hospital, Fluminense Federal University, Rua Marquês do Paraná 303, 4 andar, Niteroi, Rio de Janeiro, Brazil
    Invest New Drugs 27:557-64. 2009
    ....
  12. doi request reprint Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma
    Clovis O Da Fonseca
    Departamento de Cirurgia Geral e Especializada, Unidade de Pesquisa Clínica, Hospital Universitario Antonio Pedro, Niteroi, RJ 24030 210, Brazil
    J Cancer Res Clin Oncol 137:287-93. 2011
    ..The present study aimed to investigate the efficacy of intranasal administration of monoterpene POH upon survival rate of patients with recurrent glioblastoma (GBM) in comparison with historical control group of GBM patients...
  13. pmc Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-gamma production
    Jussara Lagrota-Candido
    Department of Immunobiology, Fluminense Federal University, Rio de Janeiro, Brazil
    Int J Exp Pathol 83:121-32. 2002
    ..As these alterations occurred mainly during the recovery period, we suggested that local activation of the immune system could be an influence which mitigates the myonecrosis of muscular tissue in the mdx dystrophic mouse...
  14. doi request reprint The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor
    Diogo G Garcia
    Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista, S N, Centro, Niteroi, RJ, 24020 141, Brazil
    Mol Cell Biochem 345:29-34. 2010
    ..We suggest that POH antitumor action could be linked to its Na/K-ATPase binding properties...
  15. pmc Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol
    Clovis Orlando da Fonseca
    Servico de Neurocirurgia, Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Niteroi, RJ, Brazil
    Arch Immunol Ther Exp (Warsz) 56:267-76. 2008
    ..Intranasal delivery allows drugs that do not cross the blood-brain barrier to enter the central nervous system. Moreover, it eliminates the need for systemic delivery, thereby reducing unwanted systemic side effects...
  16. doi request reprint Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy
    Francisco das Chagas Abreu da Silveira
    Department of Neurobiology, Institute of Biology, Fluminense Federal University, Niteroi, RJ, Brazil
    J Cancer Res Clin Oncol 138:1347-54. 2012
    ..This study aimed to establish a putative association of EGF+61A>G with risk of glioma development, production of angiogenic growth factor EGF, and the response to perillyl alcohol administered by intranasal route...
  17. ncbi request reprint Evolution of exogenous lipoid pneumonia in children: clinical aspects, radiological aspects and the role of bronchoalveolar lavage
    Selma Maria de Azevedo Sias
    Universidade Federal Fluminense, Niteroi, RJ, Brasil
    J Bras Pneumol 35:839-45. 2009
    ..To present aspects of the evolution of lipoid pneumonia in children, based on clinical, radiological and bronchoalveolar lavage fluid findings, emphasizing the importance of bronchoalveolar lavage for the diagnosis and treatment...
  18. doi request reprint Clinic and radiological improvement of lipoid pneumonia with multiple bronchoalveolar lavages
    Selma M A Sias
    Department of Pediatrics, Hospital Universitario Antonio Pedro, Fluminense Federal University, Rio de Janeiro, Brazil
    Pediatr Pulmonol 44:309-15. 2009
    ..To assess the potential role of multiple bronchoalveolar lavages (BALs) in the treatment of children with lipoid pneumonia (LP)...
  19. ncbi request reprint Selective activation of α7 nicotinic acetylcholine receptor (nAChRα7) inhibits muscular degeneration in mdx dystrophic mice
    Paulo Emilio Correa Leite
    Department of Cellular and Molecular Biology, Fluminense Federal University, Rio de Janeiro, Brazil Electronic address
    Brain Res 1573:27-36. 2014
    ..The nAChRα7 activation may be considered as a potential target for pharmacological strategies to reduce inflammation and activate mechanisms of muscular regeneration. ..
  20. doi request reprint Intranasal administration of perillyl alcohol activates peripheral and bronchus-associated immune system in vivo
    Marcela D'Alincourt Salazar
    Laboratory of Cellular Pathology, Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Niteroi, Rio de Janeiro, 24020 141, Brazil
    Arch Immunol Ther Exp (Warsz) 62:59-66. 2014
    ....
  21. doi request reprint Anti-inflammatory activity of Eugenia punicifolia extract on muscular lesion of mdx dystrophic mice
    Paulo Emilio Correa Leite
    Departamento de Biologia Celular e Molecular, Universidade Federal Fluminense, Niteroi, Rio de Janeiro 24020 141, Brazil
    J Cell Biochem 111:1652-60. 2010
    ..In vivo treatment of mdx dystrophic mice with Ep-CM caused significant reduction of muscular inflammation and improved skeletal muscle regeneration without inducing fibrosis...
  22. doi request reprint Persistent activation of omentum influences the pattern of muscular lesion in the mdx diaphragm
    Douglas Florindo Pinheiro
    Department of Immunobiology, Fluminense Federal University, Niteroi, RJ 24 020 141, Brazil
    Cell Tissue Res 350:77-88. 2012
    ....
  23. doi request reprint TLR4 signaling protects from excessive muscular damage induced by Bothrops jararacussu snake venom
    Eustaquio Luiz Paiva-Oliveira
    Department of Immunobiology, Institute of Biology, Fluminense Federal University, Niteroi, Rio de Janeiro 24020 141, Brazil
    Toxicon 60:1396-403. 2012
    ..Since such effect was not observed in the mouse strain with functional receptor it is concluded that TLR4 signaling exerts a protective role preventing from excessive muscular damage induced by B. jararacussu venom...
  24. doi request reprint Pattern of metalloprotease activity and myofiber regeneration in skeletal muscles of mdx mice
    Cristiane Bani
    Department of Cellular and Molecular Biology, Institute of Biology Federal Fluminense University, Niteroi, RJ 24210 150, Brazil
    Muscle Nerve 37:583-92. 2008
    ....