Genomes and Genes


Fabio O Pedrosa


Affiliation: Universidade Federal do Paran
Country: Brazil


  1. Emori M, Tomazini L, Souza E, Pedrosa F, Chubatsu L, Oliveira M. The deuridylylation activity of Herbaspirillum seropedicae GlnD protein is regulated by the glutamine:2-oxoglutarate ratio. Biochim Biophys Acta Proteins Proteom. 2018;1866:1216-1223 pubmed publisher
    ..The results presented here suggest that GlnD can sense the glutamine:2-oxoglutarate ratio and confirm that the ACT domains of GlnD are the protein sensors of environment clues of nitrogen availability. ..
  2. Martini V, Glogauer A, Müller Santos M, Iulek J, de Souza E, Mitchell D, et al. First co-expression of a lipase and its specific foldase obtained by metagenomics. Microb Cell Fact. 2014;13:171 pubmed publisher
    ..This paper is the first to report the successful co-expression of a lipase and its associated foldase from a metagenomic library. The high activity and stability of Lip-LifG9 suggest that it has a good potential for use in biocatalysis. ..
  3. Inaba J, Thornton J, Huergo L, Monteiro R, Klassen G, Pedrosa F, et al. Mutational analysis of GlnB residues critical for NifA activation in Azospirillum brasilense. Microbiol Res. 2015;171:65-72 pubmed publisher
    ..The substitution V100A led to a lower affinity for ATP binding. Together the results suggest that NifA activation requires uridylylated GlnB bound to ATP. ..
  4. Batista M, Wassem R, Pedrosa F, de Souza E, Dixon R, Monteiro R. Enhanced oxygen consumption in Herbaspirillum seropedicae fnr mutants leads to increased NifA mediated transcriptional activation. BMC Microbiol. 2015;15:95 pubmed publisher
  5. Lammel D, Barth G, Ovaskainen O, Cruz L, Zanatta J, Ryo M, et al. Direct and indirect effects of a pH gradient bring insights into the mechanisms driving prokaryotic community structures. Microbiome. 2018;6:106 pubmed publisher
    ..Moreover, the indirect effects are highly relevant for some OTUs and consequently for the community structure; therefore, it is a mechanism that should be further investigated in microbial ecology. ..
  6. Sperb E, Tadra Sfeir M, Sperotto R, Fernandes G, Pedrosa F, de Souza E, et al. Iron deficiency resistance mechanisms enlightened by gene expression analysis in Paenibacillus riograndensis SBR5. Res Microbiol. 2016;167:501-9 pubmed publisher
    ..However, once iron becomes highly limiting and is no longer able to sustain exponential growth, bacteria begin to express genes related to several processes, like sporulation and DNA protection, as a way of resisting this stress. ..
  7. Pedrosa F, Monteiro R, Wassem R, Cruz L, Ayub R, Colauto N, et al. Genome of Herbaspirillum seropedicae strain SmR1, a specialized diazotrophic endophyte of tropical grasses. PLoS Genet. 2011;7:e1002064 pubmed publisher
    ..These features may endow H. seropedicae with the ability to establish an endophytic life-style in a large number of plant species...
  8. Rubel E, Raittz R, Coimbra N, Gehlen M, Pedrosa F. ProClaT, a new bioinformatics tool for in silico protein reclassification: case study of DraB, a protein coded from the draTGB operon in Azospirillum brasilense. BMC Bioinformatics. 2016;17:455 pubmed publisher
    ..An analysis of co-occurrence of draB, draT, draG and of other nif genes was performed, suggesting the involvement of draB (nifO) in nitrogen fixation, however, without the definition of a specific function. ..
  9. Ramos E, Camargo A, Braun K, Slowik R, Cavalli I, Ribeiro E, et al. Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer. BMC Cancer. 2010;10:23 pubmed publisher
    ..Therefore, the methylation pattern of these genes could be used as a molecular marker for the prediction of breast cancer outcome. ..

More Information


  1. Seniski G, Camargo A, Ierardi D, Ramos E, Grochoski M, Ribeiro E, et al. ADAM33 gene silencing by promoter hypermethylation as a molecular marker in breast invasive lobular carcinoma. BMC Cancer. 2009;9:80 pubmed publisher
    ..This seems to correlate with tumour progression and metastasis in breast cancer. In this study, we explored the involvement of ADAM33, another ADAM family member, in breast cancer...