Hermogenes D Oliveira
Affiliation: Universidade Federal do Cear
Campos D, Costa A, Lima A, Silva F, Lobo M, Monteiro Moreira A, et al
. First isolation and antinociceptive activity of a lipid transfer protein from noni (Morinda citrifolia) seeds. Int J Biol Macromol. 2016;86:71-9 pubmed publisher
..Naloxone (2 mg/kg, i.p.) antagonised the antinociceptive effect of McLTP1 suggesting that the opioid mechanisms mediate the analgesic properties of this protein. ..
Souza A, Costa A, Campos D, Batista A, Sales G, Nogueira N, et al
. Lipid transfer protein isolated from noni seeds displays antibacterial activity in vitro and improves survival in lethal sepsis induced by CLP in mice. Biochimie. 2018;149:9-17 pubmed publisher
..In conclusion, McLTP1 could be exploited for its antimicrobial properties, and can be considered a potential therapeutic candidate for the management of clinical sepsis. ..
Campos D, Costa A, Luz P, Soares P, Alencar N, Oliveira H. Morinda citrifolia lipid transfer protein 1 exhibits anti-inflammatory activity by modulation of pro- and anti-inflammatory cytokines. Int J Biol Macromol. 2017;103:1121-1129 pubmed publisher
..This study suggested that the observed anti-inflammatory effects of McLTP1 can be related to modulation of pro- and anti-inflammatory cytokine levels. ..