Maria Julia Marques

Summary

Affiliation: Universidade Estadual de Campinas
Country: Brazil

Publications

  1. ncbi request reprint Axonal sprouting in mdx mice and its relevance to cell and gene mediated therapies for Duchenne muscular dystrophy
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, Campinas, 13084 971 São Paulo, Brazil
    Neurosci Lett 343:67-9. 2003
  2. doi request reprint Estimation of the number and size of motor units in intrinsic laryngeal muscles using morphometric methods
    Humberto Santo Neto
    Department of Anatomy, Institute of Biology, State University of Campinas UNICAMP, Campinas, Brazil
    Clin Anat 21:301-6. 2008
  3. ncbi request reprint Disodium cromoglycate protects dystrophin-deficient muscle fibers from leakiness
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    Muscle Nerve 37:61-7. 2008
  4. ncbi request reprint Nerve terminal contributes to acetylcholine receptor organization at the dystrophic neuromuscular junction of mdx mice
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas, Sao Paulo, Brazil
    Anat Rec (Hoboken) 290:181-7. 2007
  5. ncbi request reprint Alterations in the permeability of dystrophic fibers during neuromuscular junction development
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    Acta Biol Hung 58:1-9. 2007
  6. ncbi request reprint Acetylcholine receptors and nerve terminal distribution at the neuromuscular junction of long-term regenerated muscle fibers
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas UNICAMP, Campinas, Sao Paulo, 13084 971, Brazil
    J Neurocytol 34:387-96. 2005
  7. ncbi request reprint Nerve-terminal and Schwann-cell response after nerve injury in the absence of nitric oxide
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas UNICAMP, Campinas, SP 13083 970, Brazil
    Muscle Nerve 34:225-31. 2006
  8. ncbi request reprint Microvessel damage by B. jararacussu snake venom: pathogenesis and influence on muscle regeneration
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, 13083 970 Campinas, SP, Brazil
    Toxicon 46:814-9. 2005
  9. ncbi request reprint Trigeminal neuralgia is caused by maxillary and mandibular nerve entrapment: greater incidence of right-sided facial symptoms is due to the foramen rotundum and foramen ovale being narrower on the right side of the cranium
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, Campinas 13084 971, SP, Brazil
    Med Hypotheses 65:1179-82. 2005
  10. ncbi request reprint Muscle regeneration in dystrophic mdx mice is enhanced by isosorbide dinitrate
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, Campinas 13084 971, Sao Paulo, Brazil
    Neurosci Lett 382:342-5. 2005

Collaborators

  • Renato Passini
  • José Angelo Camilli
  • Humberto Santo Neto
  • Renato Ferretti
  • Ana Paula Tiemi Taniguti
  • Cintia Yuri Matsumura
  • Adriana Pertille
  • Elaine Minatel
  • Viviane Urbini Vomero
  • Adriana Fogagnolo Mauricio
  • Juliano Alves Pereira
  • Drielen De Oliveira Moreira
  • Rafael de Senzi Moraes Pinto
  • Samara Camaçari de Carvalho
  • Erika Tonon
  • Rafael Ventura Machado
  • Marcus Alexandre Mendes Luz
  • Anderson Neri Guido
  • Luciano de Souza Queiroz
  • Leticia Montanholi Apolinário
  • Luis Henrique Rapucci Moraes
  • Luis Alberto Ferreira Ramos
  • Miguel Arcanjo Areas
  • Selma Maria Michelin Matheus
  • Jean Hideki Shiratori
  • Cintia Matsumura
  • Lea Rodrigues-Simioni
  • Gerson Eduardo Rocha Campos
  • Candida Luiza Tonizza de Carvalho
  • Tereza C P Albuquerque
  • Mário José Jorge Sabha
  • Marco Cesar Somazz
  • José Meciano Filho
  • Rosana Marcher Teodori
  • Airton José Martins

Detail Information

Publications40

  1. ncbi request reprint Axonal sprouting in mdx mice and its relevance to cell and gene mediated therapies for Duchenne muscular dystrophy
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, Campinas, 13084 971 São Paulo, Brazil
    Neurosci Lett 343:67-9. 2003
    ....
  2. doi request reprint Estimation of the number and size of motor units in intrinsic laryngeal muscles using morphometric methods
    Humberto Santo Neto
    Department of Anatomy, Institute of Biology, State University of Campinas UNICAMP, Campinas, Brazil
    Clin Anat 21:301-6. 2008
    ..It is suggested that synaptic rearrangements may occur at the level of the neuromuscular junction in the human larynx that may explain the age-related changes in motor units reported by clinical methods...
  3. ncbi request reprint Disodium cromoglycate protects dystrophin-deficient muscle fibers from leakiness
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    Muscle Nerve 37:61-7. 2008
    ..This study supports the protective effects of cromolyn in dystrophic muscles and further indicates its action against muscle fiber leakiness in muscles that are differently affected by the lack of dystrophin...
  4. ncbi request reprint Nerve terminal contributes to acetylcholine receptor organization at the dystrophic neuromuscular junction of mdx mice
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas, Sao Paulo, Brazil
    Anat Rec (Hoboken) 290:181-7. 2007
    ..These findings show that nerve-dependent mechanisms are also involved in the changes in receptor distribution in young dystrophic muscles. In older dystrophic muscles, other factors may play a role in receptor distribution...
  5. ncbi request reprint Alterations in the permeability of dystrophic fibers during neuromuscular junction development
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    Acta Biol Hung 58:1-9. 2007
    ..These results suggest that there is no sarcolemmal damage detected by EBD during development of dystrophic neuromuscular junctions and other factors may contribute to the earlier synapse elimination seen in dystrophic muscle...
  6. ncbi request reprint Acetylcholine receptors and nerve terminal distribution at the neuromuscular junction of long-term regenerated muscle fibers
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas UNICAMP, Campinas, Sao Paulo, 13084 971, Brazil
    J Neurocytol 34:387-96. 2005
    ....
  7. ncbi request reprint Nerve-terminal and Schwann-cell response after nerve injury in the absence of nitric oxide
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas UNICAMP, Campinas, SP 13083 970, Brazil
    Muscle Nerve 34:225-31. 2006
    ..They also suggest that presynaptic molecular signaling may be impaired in dystrophic muscles, and this could influence the innervation and survival of newly formed myofibers generated by cell-mediated therapies...
  8. ncbi request reprint Microvessel damage by B. jararacussu snake venom: pathogenesis and influence on muscle regeneration
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, 13083 970 Campinas, SP, Brazil
    Toxicon 46:814-9. 2005
    ..The revascularization of muscle damaged by venom, but not by BthTX-I, occurred later and was very poor. These results indicate a central role for vascular lesions in muscle regeneration after damage by B. jararacussu venom...
  9. ncbi request reprint Trigeminal neuralgia is caused by maxillary and mandibular nerve entrapment: greater incidence of right-sided facial symptoms is due to the foramen rotundum and foramen ovale being narrower on the right side of the cranium
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, Campinas 13084 971, SP, Brazil
    Med Hypotheses 65:1179-82. 2005
    ....
  10. ncbi request reprint Muscle regeneration in dystrophic mdx mice is enhanced by isosorbide dinitrate
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, CP 6109, Campinas 13084 971, Sao Paulo, Brazil
    Neurosci Lett 382:342-5. 2005
    ..These results suggested that NO derived from ISD stimulated and/or recruited satellite cells. Pharmacological treatment with ISD could be clinically useful for improving muscle regeneration in Duchenne muscular dystrophy...
  11. doi request reprint Stretch-activated calcium channel protein TRPC1 is correlated with the different degrees of the dystrophic phenotype in mdx mice
    Cintia Yuri Matsumura
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil
    Am J Physiol Cell Physiol 301:C1344-50. 2011
    ..Early treatment designed to regulate the activity of these channels may ameliorate the progression of dystrophy in the most affected muscle, the diaphragm...
  12. ncbi request reprint Insights into the loss of muscle mass following B. jararacussu venom in mice
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, CEP 13083 970 Campinas, SP, Brazil
    Toxicon 44:847-50. 2004
    ..These results show that the loss of muscle mass was most likely related to a decrease in the ability of the muscle to regenerate rather than to nerve lesions...
  13. ncbi request reprint Distribution of calcitonin gene-related peptide at the neuromuscular junction of mdx mice
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas, Campinas, Sao Paulo, Brazil
    Anat Rec A Discov Mol Cell Evol Biol 279:798-803. 2004
    ..Since CGRP-positive and -negative fibers showed similar changes in AChR distribution, it is suggested that CGRP is probably not directly involved in the altered pattern of AChR seen in dystrophin-deficient muscle fibers of mdx mice...
  14. ncbi request reprint Acetylcholine receptor organization at the dystrophic extraocular muscle neuromuscular junction
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo 13083 970, Brazil
    Anat Rec (Hoboken) 290:846-54. 2007
    ..These results suggest that the lack of dystrophin per se does not influence the distribution of acetylcholine receptors at the neuromuscular junction of spared extraocular muscles...
  15. pmc Calcium-binding proteins in skeletal muscles of the mdx mice: potential role in the pathogenesis of Duchenne muscular dystrophy
    Adriana Pertille
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Int J Exp Pathol 91:63-71. 2010
    ..Understanding the signaling mechanisms involving Ca(2+)-calmodulin activation and calsequestrin expression may be a valuable way to develop new therapeutic approaches to the dystrophinopaties...
  16. ncbi request reprint Intrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of Duchenne muscular dystrophy
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    Muscle Nerve 35:349-53. 2007
    ..Thus, we have shown that the intrinsic laryngeal muscles are spared from the lack of dystrophin and may serve as a useful model to study the mechanisms of muscle sparing in dystrophinopathy...
  17. doi request reprint Suramin attenuates dystrophin-deficient cardiomyopathy in the mdx mouse model of duchenne muscular dystrophy
    Drielen De Oliveira Moreira
    Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, 13083 970, Brazil
    Muscle Nerve 48:911-9. 2013
    ..The purpose of this study was to determine the effects of suramin, an antifibrotic agent, on cardiac function and remodeling in mdx mice...
  18. ncbi request reprint Primary nerve repair by muscle autografts prepared with local anesthetic
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    Microsurgery 24:188-93. 2004
    ....
  19. doi request reprint Expression of utrophin at dystrophin-deficient neuromuscular synapses of mdx mice: a study of protected and affected muscles
    Renato Ferretti
    Department of Anatomy, Cell Biology, Physiology and Biophysics, Institute of Biology, State University of Campinas UNICAMP, Campinas, Sao Paulo 13083 970, Brazil
    Anat Rec (Hoboken) 294:283-6. 2011
    ....
  20. doi request reprint Diltiazem and verapamil protect dystrophin-deficient muscle fibers of MDX mice from degeneration: a potential role in calcium buffering and sarcolemmal stability
    Cintia Yuri Matsumura
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, 13083 970, Brazil
    Muscle Nerve 39:167-76. 2009
    ..Possible interactions of these drugs with the sarcoplasmic reticulum and sarcolemma may also contribute to the improvement of the dystrophic phenotype...
  21. doi request reprint N-acetylcysteine treatment reduces TNF-α levels and myonecrosis in diaphragm muscle of mdx mice
    Rafael de Senzi Moraes Pinto
    Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo 13083 970, Brazil
    Clin Nutr 32:472-5. 2013
    ..In this study we investigated whether the antioxidant N-acetylcysteine (NAC) decreases TNF-α levels and protects the diaphragm muscle of mdx mice against necrosis...
  22. doi request reprint Age-related changes in dystrophin-glycoprotein complex and in utrophin are not correlated with intrinsic laryngeal muscles protection in mdx mice
    Renato Ferretti
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    Muscle Nerve 44:978-80. 2011
    ....
  23. doi request reprint Suramin affects metalloproteinase-9 activity and increases β-dystroglycan levels in the diaphragm of the dystrophin-deficient mdx mouse
    Ana Paula Tiemi Taniguti
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    Muscle Nerve 46:810-3. 2012
    ..In this study, we were interested to see whether suramin could affect metalloproteinases (MMP) and improve the functional activity of the mdx diaphragm muscle...
  24. doi request reprint Ascorbic acid protects the diaphragm muscle against myonecrosis in mdx mice
    Erika Tonon
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    Nutrition 28:686-90. 2012
    ..We examined the effects of ascorbic acid (AA), an antioxidant and free radical scavenger, on the dystrophic diaphragm muscle...
  25. ncbi request reprint Acetylcholine receptor distribution and synapse elimination at the developing neuromuscular junction of mdx mice
    Elaine Minatel
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo 13083 970, Brazil
    Muscle Nerve 28:561-9. 2003
    ..7% controls, n = 200 per group). These results show that dystrophic fibers achieve single innervation earlier, perhaps because dystrophin or a normal cytoskeletal complex is implicated in this phenomenon...
  26. doi request reprint Treatment with an anti-inflammatory drug is detrimental for muscle regeneration at Bothrops jararacussu envenoming: an experimental study
    Viviane Urbini Vomero
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Toxicon 54:361-3. 2009
    ..We conclude that DFZ treatment may aggravate the loss of muscle mass after B. jararacussu envenoming...
  27. ncbi request reprint Cryopreserved muscle basal lamina grafts retain their grafting potential for nerve repair
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, 13083 970, Campinas, SP, Brazil
    Cryobiology 50:112-5. 2005
    ..In conclusion, muscle basal lamina autografts retain their potential usefulness for nerve repair after cryopreservation, providing a basis for the development of a bioprostheses from muscle basal lamina...
  28. ncbi request reprint L-arginine enhances muscle regeneration after experimental envenomation by B. jararacussu: a future for nitric oxide-based therapy?
    Humberto Santo Neto
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, CEP 13083 970 Campinas, SP, Brazil
    Toxicon 48:353-7. 2006
    ..jararacussu...
  29. doi request reprint Sarcoplasmic-endoplasmic-reticulum Ca2+-ATPase and calsequestrin are overexpressed in spared intrinsic laryngeal muscles of dystrophin-deficient mdx mice
    Renato Ferretti
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo 13083 970, Brazil
    Muscle Nerve 39:609-15. 2009
    ..The results further support the concept that abnormal Ca(2+)-handling is involved in dystrophinopathies. Muscle Nerve, 2009...
  30. doi request reprint Prevention of muscle fibrosis and myonecrosis in mdx mice by suramin, a TGF-β1 blocker
    Ana Paula Tiemi Taniguti
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SãoPaulo 13083 970, Brazil
    Muscle Nerve 43:82-7. 2011
    ..These findings support a role for TGF-β1 in fibrinogenesis and myonecrosis during the later stages of disease in mdx mice. Suramin might be a useful therapeutic alternative for the treatment of dystrophinopathies...
  31. ncbi request reprint Acute local nerve lesions induced by Bothrops jararacussu snake venom
    Luciano de Souza Queiroz
    Departamento de Anatomia Patologica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13083 970, Campinas, SP, Brazil
    Toxicon 40:1483-6. 2002
    ..The axonal damage reported here may be of relevance to explain, at least in part, the muscular atrophy and poor recovery in muscle function seen in human and experimental envenomations...
  32. doi request reprint Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice
    Adriana Fogagnolo Mauricio
    Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    Clin Nutr 32:636-42. 2013
    ..In this study, we evaluated the effects of commercially available fish oil containing EPA and docosahexaenoic acid (DHA) on mdx...
  33. doi request reprint EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype
    Samara Camaçari de Carvalho
    Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo 13083 970, Brazil
    J Neuroimmunol 264:41-7. 2013
    ..Immunofluorescence, immunoblotting and ELISA assays showed that EPA increased interleucin-10, reduced interferon-γ and was more effective than DFZ in promoting a shift from M1 to M2...
  34. doi request reprint Doxycycline ameliorates the dystrophic phenotype of skeletal and cardiac muscles in mdx mice
    Juliano Alves Pereira
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo, 13083 970, Brazil
    Muscle Nerve 46:400-6. 2012
    ..We examined whether doxycycline, an antibiotic member of the tetracycline family, improves the histopathology and muscle function in mdx mice, the experimental model of DMD...
  35. ncbi request reprint Number and size of motor units in thenar muscles
    Humberto Santo Neto
    Department of Anatomy, Institute of Biology, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Clin Anat 17:308-11. 2004
    ..The number of MUs in our histological study was in agreement with the number reported in previous studies using multiple point stimulation, the method currently used in the clinical investigation of neuromuscular disorders...
  36. ncbi request reprint Acetylcholine receptors and nerve terminal distribution at the neuromuscular junction of non-obese diabetic mice
    Maria Julia Marques
    Department of Anatomy, Institute of Biology, State University of Campinas, Campinas, Sao Paulo, CEP 13083 970 Brazil
    Anat Rec 267:112-9. 2002
    ..These results suggest that metabolic alterations in the diabetic muscle fiber can affect the distribution and expression of molecules, such as AChRs, in the postsynaptic membrane of the neuromuscular junction...
  37. doi request reprint Eicosapentaenoic acid decreases TNF-α and protects dystrophic muscles of mdx mice from degeneration
    Rafael Ventura Machado
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo 13083 970, Brazil
    J Neuroimmunol 232:145-50. 2011
    ..These results suggest that EPA plays a protective role in dystrophic muscle degeneration, possibly by reducing TNF-α, and support further investigations of EPA as a potential therapy for dystrophinopathies...
  38. doi request reprint Fiber type composition of the sternomastoid and diaphragm muscles of dystrophin-deficient mdx mice
    Anderson Neri Guido
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    Anat Rec (Hoboken) 293:1722-8. 2010
    ..In contrast to the pure fast fibers of the more affected DIA, the hybrid phenotype of the STN may permit dynamic adaptations during progression of the disease...
  39. doi request reprint Surgical anatomy of the Guyon canal in children
    Marcus Alexandre Mendes Luz
    Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Sao Paulo, Brazil
    J Neurosurg Pediatr 7:286-9. 2011
    ..It is also of interest for surgical treatment of carpal canal syndromes. Whereas the Guyon canal is largely described in adults, no studies exist in children. In the present study, the authors examined the Guyon canal in children...
  40. doi request reprint Long-term therapy with deflazacort decreases myocardial fibrosis in mdx mice
    Maria Julia Marques
    Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, 13083 970, Campinas, SP, Brazil
    Muscle Nerve 40:466-8. 2009
    ..DFZ significantly decreased MF. We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart...