Eduardo Monguilhott Dalmarco
Affiliation: Universidade Federal de Santa Catarina
Dos Santos Nascimento M, Mattar Munhoz A, de Campos Facchin B, Fratoni E, Rossa T, Mandolesi Sá M, et al
. New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole. Biomed Pharmacother. 2019;111:1399-1407 pubmed publisher
..Taken together, the results shows that fluorophenyl imidazole is a promising prototype for the development of a novel anti-inflammatory drug in which p38 MAPK and NF-κB plays a pivotal role. ..
Nascimento M, Munhoz A, Theindl L, Mohr E, Saleh N, Parisotto E, et al
. A Novel Tetrasubstituted Imidazole as a Prototype for the Development of Anti-inflammatory Drugs. Inflammation. 2018;41:1334-1348 pubmed publisher
..Graphical Abstract ᅟ. ..
Dos Santos Nascimento M, Arruda Silva F, Luz A, Venzke D, Queiroz G, Mendes B, et al
. 7-prenyloxi-6-methoxycoumarin from Polygala sabulosa A.W. Bennett Regulates p38 MAPK and NF-kB Pathways Inhibiting the Inflammation Induced by Carrageenan in the Mouse Model of Pleurisy. Inflamm Allergy Drug Targets. 2015;14:37-46 pubmed
..The presented results show that P. sabulosa has significant anti-inflammatory activity, as does its main compound, PC. Moreover, the results suggest that PC exerts its effects mainly by inhibited the NF-ÎºB and p38 MAPK pathways. ..
Luz A, da Silva C, Nascimento M, de Campos Facchin B, Baratto B, Fröde T, et al
. The anti-inflammatory effect of Ilex paraguariensis A. St. Hil (Mate) in a murine model of pleurisy. Int Immunopharmacol. 2016;36:165-172 pubmed publisher
..paraguariensis exerts its anti-inflammatory action by attenuating the Th1/Th17 polarization in this model. This fact suggests that the use of this plant as a beverage can protect against Th1/Th17 inflammatory diseases. ..
Duarte L, Chaves V, Nascimento M, Calvete E, Li M, Ciraolo E, et al
. Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits. Food Chem. 2018;247:56-65 pubmed publisher
..The results reinforce that strawberry fruits are functional foods that can act as an adjuvant in the treatment of inflammatory conditions. ..