Research Topics
Species | F CendesSummaryAffiliation: Universidade Estadual de Campinas Country: Brazil Publications
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Publications
Familial temporal lobe epilepsy with auditory featuresFernando Cendes
Department of Neurology, State University of Campinas- UNICAMP, Campinas, SP, Brazil
Epilepsia 46:59-60. 2005
Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRIFabrício R S Pereira
Neuroimaging Laboratory, Department of Neurology, University of Campinas UNICAMP, Cidade Universitaria, Campinas, SP, Brazil
BMC Neurosci 11:66. 2010..In this study, we investigated the functional connectivity patterns of 9 control subjects, 9 patients with right MTLE and 9 patients with left MTLE...
Febrile seizures and mesial temporal sclerosisFernando Cendes
Department of Neurology, FCM, UNICAMP, Campinas, Sao Paulo, Brazil
Curr Opin Neurol 17:161-4. 2004..Another possibility is that the child has a prolonged febrile seizure because the hippocampus was previously damaged by a prenatal or perinatal insult or by genetic predisposition...
MRS and fMRI in partial epilepsiesFernando Cendes
Department of Neurology, University of Campinas, Campinas, SP, Brazil
Arq Neuropsiquiatr 61:78-82. 2003
Partial epilepsies: overviewFernando Cendes
Departamento de Neurologia, FCM, UNICAMP, Campinas, SP, Brazil
Arq Neuropsiquiatr 61:1-7. 2003
Progressive hippocampal and extrahippocampal atrophy in drug resistant epilepsyFernando Cendes
Department of Neurology, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
Curr Opin Neurol 18:173-7. 2005..This article reviews recent experimental and clinical evidence for seizure-related progressive brain damage and discusses possible mechanisms of ongoing brain atrophy in epilepsy...
Neuroimaging predictors of AED resistance in new-onset epilepsiesFernando Cendes
Department of Neurology, University of Campinas, UNICAMP, Campinas, SP, Brazil
Epilepsia 52:7-9. 2011..Combined MRI measures may have potential clinical value for predicting AED response in near future...
Vaccinations and febrile seizuresFernando Cendes
Department of Neurology, University of Campinas, Campinas, Sao Paulo, Brazil
Epilepsia 52:23-5. 2011....
Striatal and extrastriatal atrophy in Huntington's disease and its relationship with length of the CAG repeatH H Ruocco
Departamento de Neurologia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, SP, Brasil
Braz J Med Biol Res 39:1129-36. 2006..Extrastriatal atrophy occurs later in HD and may be related to disease duration...
Longitudinal analysis of regional grey matter loss in Huntington disease: effects of the length of the expanded CAG repeatH H Ruocco
Department of Neurology, State University of Campinas, Faculdade de Ciencias Medicas, Sao Paulo, Brazil
J Neurol Neurosurg Psychiatry 79:130-5. 2008..Moreover, the relationship between cortical and subcortical grey matter atrophy and the severity of motor symptoms of HD is controversial...
Bilateral posterior parietal polymicrogyria: a mild form of congenital bilateral perisylvian syndrome?M A Montenegro
Department of Neurology, University of Campinas, Campinas, SP, Brazil
Epilepsia 42:845-9. 2001..The objective of this study was to present the different imaging and clinical findings of 17 patients with CBPS, their genetic background, and the occurrence of prenatal injury during their pregnancies...
Patterns of hippocampal abnormalities in malformations of cortical developmentM A Montenegro
Department of Neurology, University of Campinas/FCM-UNICAMP, Campinas, SP, Brazil
J Neurol Neurosurg Psychiatry 77:367-71. 2006..Abnormal enlargement of the hippocampus was associated with only diffuse MCD due to abnormal neuronal migration (lissencephaly-agyria-pachygyria and SLH)...
The importance of accurate anatomic assessment for the volumetric analysis of the amygdalaL Bonilha
, Departamento de Neurologia, Faculdade de Medicina, UNICAMP, Campinas, SP, Brasil
Braz J Med Biol Res 38:409-18. 2005..Three-dimensional analysis is preferred because it is based on more extensive anatomical assessment and the results are similar to those obtained in post-mortem studies...
Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsyA C Coan
Department of Neurology, University of Campinas UNICAMP, SP, Brazil, ClnAPCe Program, MRC UNICAMP, SP, Brazil
Neurology 73:834-42. 2009..The objective of this study was to evaluate whether progressive hippocampal and extrahippocampal atrophy occur in patients with MTLE and whether this atrophy is related to seizures...
Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawalT A M Cardoso
Department of Neurology, FCM, State University of Campinas-UNICAMP, Brazil
Neurology 67:134-6. 2006..Seizure recurrence after AED withdrawal was more frequent among patients with hippocampal atrophy and abnormal hippocampal T2 signal...
Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsyE Kobayashi
Department of Neurology, , University of Campinas-UNICAMP, Campinas, SP, Brazil
Neurology 56:166-72. 2001..In addition, these findings indicate the presence of a strong genetic component determining the development of mesial temporal sclerosis in these families...
Antiepileptic drug response in temporal lobe epilepsy: a clinical and MRI morphometry studyE Bilevicius
Neuroimaging Laboratory, UNICAMP University of Campinas, Campinas, SP, Brazil
Neurology 75:1695-701. 2010..To investigate the relationship between brain MRI and clinical characteristics and patterns of antiepileptic drug (AED) response in patients with mesial temporal lobe epilepsy (MTLE)...
Relationship between environmental factors and gray matter atrophy in refractory MTLEC L Yasuda
Department of Neurology, University of Campinas, Cidade Universitaria, Campinas, SP, Brazil 13083 970
Neurology 74:1062-8. 2010..To investigate clinical, neuropsychological, and MRI abnormalities (gray matter atrophy [GMA] and white matter atrophy [WMA]) in surgical mesial temporal lobe epilepsy (MTLE) patients with and without familial antecedent for epilepsy...
Congenital bilateral perisylvian syndrome: familial occurrence, clinical and psycholinguistic aspects correlated with MRII L Brandão-Almeida
Department of Medical Genetics, State University of Campinas UNICAMP, Campinas, SP, Brazil
Neuropediatrics 39:139-45. 2008..Congenital bilateral perisylvian syndrome (CBPS) is frequently caused by polymicrogyria (PMG). The aim of this study was to correlate the clinical and psycholinguistic aspects with neuroradiological data of patients with CBPS...
Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophyA Alessio
Department of Neurology, FCM, UNICAMP, Campinas, Brazil
Epilepsy Behav 5:22-7. 2004....
Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsyA C Coan
Departamento de Neurologia, , Universidade de Campinas, SP, Brasil
Braz J Med Biol Res 37:827-32. 2004..These results indicate that subtle abnormalities leading to an abnormal hippocampal signal in FMTLE are not necessarily related to seizures and may be determined by genetic factors...
MR imaging texture analysis of the corpus callosum and thalamus in amnestic mild cognitive impairment and mild Alzheimer diseaseM S de Oliveira
Department of Cosmic Rays and Chronology, Institute of Physics Gleb Wataghin, University of Campinas, Sao Paulo, Brazil
AJNR Am J Neuroradiol 32:60-6. 2011..Our objective was to attempt to find differences among patients with aMCI and mild AD and normal-aging subjects, by using TA applied to the MR images of the CC and the thalami of these groups of subjects...
Proton MRS may predict AED response in patients with TLEBruno A G Campos
Department of Neurology, FCM, University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
Epilepsia 51:783-8. 2010....
Hippocampal atrophy in systemic lupus erythematosusS Appenzeller
Department of Rheumatology, University of Campinas, , Brazil
Ann Rheum Dis 65:1585-9. 2006..A significant progression of hippocampal atrophy related to total corticosteroid dose and number of CNS events was observed. Further studies are necessary to confirm these findings...
Medial temporal lobe atrophy in patients with refractory temporal lobe epilepsyL Bonilha
Neuroimaging Laboratory, Department of Neurology, State University of Campinas, Brazil
J Neurol Neurosurg Psychiatry 74:1627-30. 2003..CONCLUSION: Patients with refractory MTLE have damage in the temporal lobe that extends beyond the hippocampus, and affects the regions with close anatomical and functional connections to the hippocampus...
Texture analysis of hippocampal sclerosisLeonardo Bonilha
Department of Neurology, Medical School, State University of Campinas, , Campinas, SP, CEP 13083-970, Brazil
Epilepsia 44:1546-50. 2003....
Manual and semi-automatic quantification of in vivo ¹H-MRS data for the classification of human primary brain tumorsS Cuellar-Baena
Departamento de Raios Cósmicos e Cronologia, Instituto de Fisica Gleb Wataghin, Faculdade de Ciencias Medicas, Universidade de Campinas, SP, Brasil
Braz J Med Biol Res 44:345-53. 2011..Both methods classified all control subjects correctly. The study demonstrated that ¹H-MRS accurately differentiated normal from tumoral brain tissue and confirmed the superiority of the semi-automatic quantification method...
MRI reveals structural abnormalities in patients with idiopathic generalized epilepsyL E Betting
Department of Neurology, State University of Campinas, UNICAMP, Brazil
Neurology 67:848-52. 2006..CONCLUSIONS: Twenty-four percent of patients with idiopathic generalized epilepsies had MRI abnormalities. However, the majority of these abnormalities were nonspecific...
Late onset temporal lobe epilepsy with MRI evidence of mesial temporal sclerosis following acute neurocysticercosis: case reportE Kobayashi
Departamento de Neurologia, , Universidade Estadual de Campinas, Campinas, SP, Brazil
Arq Neuropsiquiatr 59:255-8. 2001..This suggests that acute neurocysticercosis associated with repeated seizures may cause MTS and late onset TLE...
Hippocampal atrophy and T2-weighted signal changes in familial mesial temporal lobe epilepsyE Kobayashi
Department of Neurology, , UNICAMP-Campinas, Brazil
Neurology 60:405-9. 2003..These observations suggest that one or more genes resulting in familial mesial temporal lobe epilepsy predisposes both to the clinical features of mesial temporal lobe epilepsy and to the development of hippocampal sclerosis...
Differences in grey and white matter atrophy in amnestic mild cognitive impairment and mild Alzheimer's diseaseM L F Balthazar
Department of Neurology, Medical School, University of Campinas, SP, Brazil
Eur J Neurol 16:468-74. 2009..Despite these findings, the validity of aMCI concept as prodromal AD has been questioned...
Neurometabolic changes in normal white matter may predict appearance of hyperintense lesions in systemic lupus erythematosusS Appenzeller
Department of Rheumatology, University of Campinas, Sao Paulo, Brazil
Lupus 16:963-71. 2007..001). We observed a correlation between Cho/Cr ratios and number of WM lesions (r = 0.69; P = 0.001). Increased Cho/Cr in normal appearing WM may be indicative of future appearance of hyperintense T2-weighted MRI lesions in SLE patients...
Efficacy of clobazam as add-on therapy in patients with refractory partial epilepsyM A Montenegro
Department of Neurology, University of Campinas/UNICAMP, Brazil
Epilepsia 42:539-42. 2001..CLB should be considered an economic alternative in the treatment of patients with refractory epilepsy...
Evidence of reversible axonal dysfunction in systemic lupus erythematosus: a proton MRS studySimone Appenzeller
Department of Rheumatology, University of Campinas, , Brazil
Brain 128:2933-40. 2005..2). This study shows evidence of axonal dysfunction in patients with active SLE, independently of CNS manifestations that may be reversible, at least in part, during periods of inactivity of disease...
Cerebellar ataxia in systemic lupus erythematosusS Appenzeller
Department of Medicine, Rheumatology Unit, Faculty of Medical Sciences, PO Box 6111 University of Campinas UNICAMP, Zip Code 13083 970, Campinas, SP, Brazil
Lupus 17:1122-6. 2008..A review of the literature was performed by documenting cases of cerebellar ataxia in SLE and the importance of neuroimaging in the evaluation of these patients...
EEG spike source localization before and after surgery for temporal lobe epilepsy: a BOLD EEG-fMRI and independent component analysis studyM S Sercheli
Instituto de Fisica Gleb Wataghin, Universidade Estadual de Campinas, Campinas, SP, Brasil
Braz J Med Biol Res 42:582-7. 2009..On the other hand, the combined EEG-fMRI technique made it possible to highlight the epileptogenic foci quite efficiently...
Texture analysis of medical imagesG Castellano
Neuroimage Laboratory, Faculty of Medical Sciences, State University of Campinas, Brazil
Clin Radiol 59:1061-9. 2004..In this article we clarify the principles of texture analysis and give examples of its applications, reviewing studies of the technique...
Developmental language disorder associated with polymicrogyriaM M Guerreiro
Department of Neurology, University of Campinas UNICAMP, SP, Brazil
Neurology 59:245-50. 2002..Subtle disorders of neuronal migration occur in the brains of some dyslexic patients who presented developmental language disorder (DLD) during early childhood...
NeurolupusSimone Appenzeller
Rheumatology Unit, Departments of Internal Medicine and Neurology, State University of Campinas, Campinas, Brazil
Arch Neurol 63:458-60. 2006
[Treatment of epilepsy: consensus of the Brazilian specialists]Luiz Eduardo Betting
Departamento de Neurologia, , Universidade Estadual de Campinas, Campinas SP, Brasil
Arq Neuropsiquiatr 61:1045-70. 2003..As compared to the North-American guidelines our study better reflects the resources available in our country...
Brain tumor-like lesion in Behçet diseaseSimone Appenzeller
Department of Rheumatology, State University of Campinas, Campinas, Brazil
Rheumatol Int 26:577-80. 2006..After 8 weeks she had improved and a new MRI showed disappearance of the tumor-like lesion. The differential diagnosis, especially with central nervous system tumor is emphasized...
Thalamic dysfunction in juvenile myoclonic epilepsy: a proton MRS studySusana B Mory
Department of Neurology, University of Campinas-UNICAMP, Campinas, SP, Brazil
Epilepsia 44:1402-5. 2003..CONCLUSIONS: This study shows evidence of neuronal dysfunction in the thalami of patients with JME, which may have relevance for the mechanisms of seizure generation in this form of generalized epilepsy...
Demonstration project on epilepsy in Brazil: outcome assessmentLi M Li
Department of Neurology, Faculty of Medicine, UNICAMP, Campinas, SP, Brazil
Arq Neuropsiquiatr 65:58-62. 2007..To assess the outcome of patients with epilepsy treated at primary care health units under the framework of the demonstration project on epilepsy in Brazil, part of the WHO/ILAE/IBE Global Campaign Against Epilepsy...
Interrelationship of genetics and prenatal injury in the genesis of malformations of cortical developmentMaria Augusta Montenegro
Department of Neurology, University of Campinas, PO Box 6111, 13083 970 Campinas, Sao Paulo, Brazil
Arch Neurol 59:1147-53. 2002..There are several lines of evidence supporting the theory of a complex mechanism that involves genetic and environmental factors...
Midline facial defects with hypertelorism and low-grade astrocytoma: a previously undescribed associationSilvyo David Araújo Giffoni
Departamento de Genética Médica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, CEP 13084 971 Campinas, Sao Paulo, Brazil
Cleft Palate Craniofac J 43:748-51. 2006..It also suggests that individuals with MFDH might require a prospective follow-up with central nervous system magnetic resonance imaging...
Acute psychosis in systemic lupus erythematosusSimone Appenzeller
Rheumatology Unit, State University of Campinas, Sao Paulo, Brazil
Rheumatol Int 28:237-43. 2008..Psychosis resolved after tapering prednisone down in all patients. Acute psychosis related to SLE was observed in 11.3% of our cohort. Recurrence of primary psychosis was associated with other CNS manifestations related to SLE...
[Morphological characteristics from the insula's lobe in patients with medial temporal lobe epilepsy]Feres Chaddad Neto
, , Brazil
Arq Neuropsiquiatr 64:639-44. 2006..There is no variation statistical between the insula's volume and insula's measurement for the two clusters. This paper didn't show the insula's morphological variation when these two groups were compared...
Demonstration Project on Epilepsy in Brazil: situation assessmentLi M Li
Department of Neurology, Faculty of Medicine, UNICAMP, Campinas, SP, Brazil
Arq Neuropsiquiatr 65:5-13. 2007....
Cerebral and corpus callosum atrophy in systemic lupus erythematosusSimone Appenzeller
University of Campinas, Sao Paulo, Brazil
Arthritis Rheum 52:2783-9. 2005..The total corticosteroid dose and the presence of antiphospholipid antibodies were not associated with more pronounced atrophy...
[Perisylvian syndrome: report of one Brazilian family with focus on the genetic mode of inheritance and clinical spectrum.]Eliane P Herrera
Departamento de Neurologia, , Universidade Estadual de Campinas, Brazil
Arq Neuropsiquiatr 63:459-63. 2005..Most reported families provide evidence suggestive of X-linked transmission. However, the most likely mode of inheritance in our family is autosomal dominant, since a male to male transmission was documented...
Clobazam as add-on therapy for temporal lobe epilepsy and hippocampal sclerosisMaria Augusta Montenegro
Department of Neurology, University of Campinas, , SP, Brazil
Can J Neurol Sci 32:93-6. 2005..CONCLUSION: Our data suggest that clobazam should be considered as add-on therapy in the treatment of patients with temporal lobe epilepsy associated with MRI signs of HS...
Voxel-based morphometry of the thalamus in patients with refractory medial temporal lobe epilepsyLeonardo Bonilha
Laboratory of Neuroimaging, Department of Neurology, Faculty of Medicine, State University of Campinas, 13083-970 Campinas, SP, Brazil
Neuroimage 25:1016-21. 2005..This finding suggests that thalamic atrophy reflects this region's anatomical and functional association with the limbic system rather than a general vulnerability to damage...
Effects of method and MRI slice thickness on entorhinal cortex volumetryLeonardo Bonilha
Laboratory of Neuroimaging, State University of Campinas, Campinas, SP, Brazil
Neuroreport 14:1291-5. 2003..The form of volumetric analysis of the entorhinal cortex should be evaluated in advance to prevent false estimates in longitudinal studies...
Distribution of regional gray matter abnormalities in a pediatric population with temporal lobe epilepsy and correlation with neuropsychological performanceCatarina A Guimarães
Department of Neurology, State University of Campinas, Campinas, Brazil
Epilepsy Behav 11:558-66. 2007....
Mesial temporal lobe epilepsy: clinical and neuropathologic findings of familial and sporadic formsLuciana Patrízia A Andrade-Valença
Department of Neurology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
Epilepsia 49:1046-54. 2008..To evaluate the clinical and hippocampal histological features of patients with mesial temporal lobe epilepsy (MTLE) in both familial (FMTLE) and sporadic (SMTLE) forms...
Evidence of thalamic dysfunction in Huntington disease by proton magnetic resonance spectroscopyHeloisa H Ruocco
Department of Neurology, University of Campinas, Campinas, Sao Paulo, Brazil
Mov Disord 22:2052-6. 2007..This is in agreement with previous studies that indicated the involvement of mitochondrial dysfunction in the neurodegenerative process of HD...
Structural abnormalities are similar in familial and nonfamilial mesial temporal lobe epilepsyFabio Thadeu Ferreira
Campinas State University, Campinas, , Brazil
Can J Neurol Sci 31:368-72. 2004..Despite the genetic basis, hippocampal atrophy in FMTLE is not associated with other abnormalities outside the mesial temporal regions...
Classification of brain tumor extracts by high resolution ¹H MRS using partial least squares discriminant analysisA V Faria
Departamento de Radiologia, Universidade Estadual de Campinas, Campinas, SP, Brazil
Braz J Med Biol Res 44:149-64. 2011....
Neuroimaging findings in scleroderma en coup de sabreS Appenzeller
Department of Internal Medicine, Rheumatology Unit, University of Campinas, SP, Brazil
Neurology 62:1585-9. 2004..Epilepsy, when present, is related to these brain lesions. Imaging findings and histopathology indicated that the process, most likely focal inflammatory, may be progressive...
Neuroimaging in pineal tumorsF Reis
Department of Radiology, State University of Campinas - UNICAMP, Campinas, SP, Brazil
J Neuroimaging 16:52-8. 2006..CONCLUSIONS: Pineal region tumors have no pathognomonic imaging pattern. MRI and CT are complementary in diagnosis and are important to determine localization, extension, and meningeal spread...
Magnetic resonance spectroscopy in the evaluation of central nervous system manifestations of systemic lupus erythematosusSimone Appenzeller
State University of Campinas, Campinas, Brazil
Arthritis Rheum 55:807-11. 2006
Brain SPECT in mesial temporal lobe epilepsy: comparison between visual analysis and SPMBarbara Juarez Amorim
Division of Nuclear Medicine, Department of Radiology, School of Medical Sciences, Campinas State University, Campinas, SP, Brazil
Arq Neuropsiquiatr 68:153-60. 2010..To compare the accuracy of SPM and visual analysis of brain SPECT in patients with mesial temporal lobe epilepsy (MTLE)...
MRI shows dorsal lesions and spinal cord atrophy in chronic sensory neuronopathiesMarcondes C Franca
Department of Neurology, Campinas State University Unicamp, Campinas, Brazil
J Neuroimaging 18:168-72. 2008..We tried to estimate the frequency and extent of spinal cord MRI abnormalities in a group of patients with SN and correlate these with clinical and neurophysiological features...
Voxel-based morphometry and epilepsyClarissa Lin Yasuda
University of Campinas, SP, Brazil
Expert Rev Neurother 10:975-84. 2010..In generalized epilepsies, gray matter abnormalities were identified mainly in the thalamus and frontal cortex, reinforcing the role of the thalamocortical network in the mechanisms of generalized seizures...
Voxel-based morphometry in patients with idiopathic generalized epilepsiesLuiz Eduardo Betting
Department of Neurology, Brazil
Neuroimage 32:498-502. 2006..Our results support subtle GMC abnormalities in patients with JME and AE when compared to controls. These findings suggest the existence of different patterns of cortical abnormalities in IGE subsyndromes...
The role of neuroimaging in the investigation of patients with single seizures, febrile seizures, or refractory partial seizuresLeonardo Bonilha
Neuroimaging Laboratory, Department of Neurology, Campinas State University, Campinas, Brazil
Med Sci Monit 10:RA40-6. 2004..This makes it possible to accurately define the location and the nature of the epileptogenic lesions related to seizures...
A combined voxel-based morphometry and 1H-MRS study in patients with Friedreich's ataxiaMarcondes C Franca
Department of Neurology, University of Campinas, Campinas, Sao Paulo, Brazil
J Neurol 256:1114-20. 2009..006), but not Cho/Cr (P = 0.08). Our results provide evidence of axonal damage in the cerebellum, brainstem and subcortical WM in FA. This suggests that neuronal dysfunction is more widespread than previously thought in FA...
Intrapartum complications associated with malformations of cortical developmentMaria Augusta Montenegro
Department of Neurology, University of Campinas, FCM/UNICAMP, Brazil
J Child Neurol 20:675-8. 2005..5%) patients, as opposed to only 2 in the control group (p < 0.001). Patients with cortical malformations frequently present intrapartum complications, which could lead to the misdiagnosis of hypoxic-ischemic encephalopathy...
Focal transient lesions of the corpus callosum in systemic lupus erythematosusSimone Appenzeller
Rheumatology Unit, Department of Internal Medicine, State University of Campinas (UNICAMP, Campinas, SP, Brazil
Clin Rheumatol 25:568-71. 2006..The complete and rapid reversibility in all cases with disease control is emphasized and any invasive diagnostic or therapeutic approach is discouraged...
Hippocampal texture analysis in patients with familial mesial temporal lobe epilepsyGisele Resende Coelho Caselato
, Campinas, SP, Brazil
Arq Neuropsiquiatr 61:83-7. 2003
Early development destructive brain lesions and their relationship to epilepsy and hippocampal damageRicardo A Teixeira
Department of Neurology, University of Campinas (UNICAMP, Campinas, SP, CEP 13083-970, Brazil
Brain Dev 25:560-70. 2003..This association seems to be related to a common and synchronic pathogenic mechanism. The recognition of the pattern and degree of HA among these patients with intractable seizures may influence the surgical rationale...
Quantification of hippocampal signal intensity in patients with mesial temporal lobe epilepsyAna Carolina Coan
Department of Neurology, Campinas State University (UNICAMP, Campinas, SP, Brazil
J Neuroimaging 13:228-33. 2003..The assessment of the entire extension of the hippocampal formation may provide important additional data, compared to T2 relaxometry maps limited to one segment of the hippocampus...
T2-weighted and T2 relaxometry images in patients with medial temporal lobe epilepsyAna Carolina Coan
Neuroimaging Laboratory, Department of Neurology, State University of Campinas, 13083-970 Campinas, SP, Brazil
J Neuroimaging 16:260-5. 2006..This is a possible indicator that T2 relaxometry is more sensitive in detecting T2 abnormalities within the body and tail of the hippocampus in patients with MTLE...
Neuroimaging characteristics of pseudosubcortical laminar heterotopiaMaria Augusta Montenegro
Department of Neurology, University of Campinas, P.O. Box 6111, Campinas, SP 13083-970, Brazil
J Neuroimaging 12:52-4. 2002..Conversely, pseudo-SLH is a normal variant present only at the posterior aspect of the brain, and with dark signal on both T1- and T2-weighted/FLAIR images...
[Idiopathic generalized epilepsies misdiagnosed as partial epilepsies]Susana B Mory
Departamento de Neurologia, , Universidade Estadual de Campinas, Campinas, SP, Brasil
Arq Neuropsiquiatr 60:788-96. 2002..An appropriate questioning to identify myoclonic and absence seizures and a proper interpretation in the context of whole clinical constellation are essential for a correct seizure classification and diagnosis of IGE in adults...
Outcome of surgical treatment in familial mesial temporal lobe epilepsyEliane Kobayashi
Department of Neurology, University of Campinas, UNICAMP, Campinas, SP, Brazil
Epilepsia 44:1080-4. 2003..CONCLUSIONS: Refractory FMTLE patients have good surgical outcome when unilateral or clearly asymmetric HA is identified. Preoperative investigation should be the same as that in patients with sporadic refractory MTLE...
Brain single-photon emission computed tomography and magnetic resonance imaging in Machado-Joseph diseaseE C Etchebehere
Department of Radiology, Campinas State University, UNICAMP, Caixa Postal 6142, 13081 970 Campinas, Brazil
Arch Neurol 58:1257-63. 2001....
THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsyCláudia Vianna Maurer-Morelli
Department of Medical Genetics, Universidade Estadual de Campinas UNICAMP, Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas CEP 13084 971, SP, Brazil
Epilepsy Res 71:233-6. 2006..Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE...
Association of family history of epilepsy with earlier age at seizure onset in patients with focal cortical dysplasiaMaria Augusta Montenegro
Department of Neurology, University of Campinas, Campinas, SP, Brazil
Mayo Clin Proc 77:1291-4. 2002....
Acute psychotic disorders induced by topiramate: report of two casesFlorindo Stella
, Universidade Estadual Paulista, Rio Claro, SP, Brasil
Arq Neuropsiquiatr 60:285-7. 2002..Clinicians should be aware of the possibility of development of acute psychotic symptoms in patients undergoing TPM treatment...
Magnetic resonance imaging abnormalities in familial temporal lobe epilepsy with auditory aurasEliane Kobayashi
Department of Neurology, Campinas State University, Campinas, Brazil
Arch Neurol 60:1546-51. 2003..In contrast with mesial FTLE, none of the affected individuals had MRI evidence of hippocampal sclerosis...
Axonal dysfunction in the deep white matter in Machado-Joseph diseaseAnelyssa D'Abreu
Neuroimaging Laboratory, Universidade Estadual de Campinas UNICAMP, Campinas Sao Paulo, Brazil
J Neuroimaging 19:9-12. 2009..0; P= .004), as well as Cho/Cr levels (U test = 53.0; P= .014). We conclude that the metabolic abnormalities observed in the deep white matter in MJD suggest extensive neuronal and axonal dysfunction in these patients...
Interictal EEG in temporal lobe epilepsy in childhoodRenata C Franzon
Department of Neurology, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
J Clin Neurophysiol 24:11-5. 2007..05). These results suggest a close interaction between temporal and other cerebral regions in children with epilepsy and provide further evidence of the existence of neural networks...
Magnetic resonance imaging evidence of hippocampal sclerosis in asymptomatic, first-degree relatives of patients with familial mesial temporal lobe epilepsyEliane Kobayashi
Department of Neurology, University of Campinas, , Brazil
Arch Neurol 59:1891-4. 2002..The determination of seizure severity in patients with FMTLE probably depends on the interaction of different factors, both genetic and environmental...
Focal transient lesion in the splenium of the corpus callosum in three non-epileptic patientsAntonio Jose da Rocha
Section of Radiology, Centro de Medicina Diagnóstica Fleury, Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil
Neuroradiology 48:731-5. 2006..We analyzed the imaging features of transient focal lesions in the splenium of the corpus callosum (SCC) in non-epileptic patients receiving antiepileptic drugs (AEDs)...
Interictal electroencephalographic findings in children and adults with temporal lobe tumorsRenata C Franzon
Departamento de Neurologia, Universidade Estadual de Campinas, 13083-970 Campinas SP, Brazil
Arq Neuropsiquiatr 64:359-62. 2006..CONCLUSION: Our data show that children and adults with TLE due to expansive lesions present with similar EEG findings...
Voxel based morphometry study of partial epilepsiesLeonardo Bonilha
Department of Neurology, Campinas State University, SP, Brazil
Arq Neuropsiquiatr 61:93-7. 2003
Voxel-based morphometry reveals gray matter network atrophy in refractory medial temporal lobe epilepsyLeonardo Bonilha
Laboratory of Neuroimaging, State University of Campinas, Campinas, Brazil
Arch Neurol 61:1379-84. 2004..CONCLUSIONS: Patients with MTLE exhibit a reduction in GMC in regions outside the temporal lobe, specifically in areas that are connected to the hippocampus and parahippocampal region, suggesting an anatomical route for atrophy...
The clinical spectrum of malformations of cortical developmentMaria Augusta Montenegro
Department of Neurology, State University of Campinas, SP, Brazil
Arq Neuropsiquiatr 65:196-201. 2007..Malformations of cortical development (MCD) usually manifest in childhood with epilepsy, developmental delay and focal neurological abnormalities...
Mutation screening in a cohort of patients with lissencephaly and subcortical band heterotopiaF R Torres
Department of Medical Genetics, University of Campinas UNICAMP, Brazil
Neurology 62:799-802. 2004..The authors believe that the site of the mutation, present in a functionally critical region of the protein, could explain the unusual severe phenotype found in this patient...
Focal status epilepticus as the first manifestation of paracoccidioidomycosisM C França
Department of Neurology, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
Eur J Neurol 12:73-4. 2005..We emphasize the need for a comprehensive work-up and increased awareness for central nervous system involvement in PCM, particularly in endemic areas...
Sleep symptoms and their clinical correlates in Machado-Joseph diseaseA D'Abreu
University of Campinas, Brazil
Acta Neurol Scand 119:277-80. 2009..To evaluate the presence of sleep symptoms in Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)...
Gray matter atrophy associated with duration of temporal lobe epilepsyLeonardo Bonilha
Department of Neuropsychiatry, University of South Carolina, SC 29425, USA
Neuroimage 32:1070-9. 2006..The mechanism of progressive neuronal damage in MTLE may be related to active seizure activity within a limbic network, and early seizure control may prevent further brain atrophy in patients with refractory MTLE...
Voxel-based morphometry reveals excess gray matter concentration in patients with focal cortical dysplasiaLeonardo Bonilha
Department of Neuropsychiatry, University of South Carolina, Columbia, South Carolina, USA
Epilepsia 47:908-15. 2006....
Does resection of the medial temporal lobe improve the outcome of temporal lobe epilepsy surgery?Leonardo Bonilha
Department of Neuropsychiatry, University of South Carolina, Columbia, South Carolina, USA
Epilepsia 48:571-8. 2007..The question of whether the resection of medial temporal lobe structures in addition to the hippocampus would influence the surgical outcome in patients with MTLE was examined...
