Edgar Carvalho

Summary

Affiliation: Universidade Federal da Bahia
Country: Brazil

Publications

  1. pmc Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis
    Maria de Lourdes Bastos
    Serviço de Imunologia do Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    BMC Infect Dis 12:199. 2012
  2. pmc Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
    Angela Giudice
    Servico de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    BMC Infect Dis 12:75. 2012
  3. pmc CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study
    Lea Castellucci
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    BMC Med Genet 11:10. 2010
  4. pmc Resistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation with antimony therapy and TNF-alpha production
    Anselmo S Souza
    Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil
    BMC Infect Dis 10:209. 2010
  5. pmc Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study
    Johan Van Weyenbergh
    LIMI, Gonçalo Moniz Research Center Oswaldo Cruz Foundation FIOCRUZ, Rua Waldemar Falcao 121, 40295 001 Salvador BA, Brazil
    BMC Infect Dis 4:50. 2004
  6. pmc Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis to nitric oxide correlates with disease severity in Tegumentary Leishmaniasis
    Angela Giudice
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Instituto de Investigação em Imunologia iii, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    BMC Infect Dis 7:7. 2007
  7. pmc Differential effects of antigens from L. braziliensis isolates from disseminated and cutaneous leishmaniasis on in vitro cytokine production
    Paulo T G Leopoldo
    Departamento de Fisiologia, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil
    BMC Infect Dis 6:75. 2006
  8. pmc Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers
    Silvane Braga Santos
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brasil
    BMC Infect Dis 4:7. 2004
  9. ncbi request reprint Worms and allergy
    E M Carvalho
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    Parasite Immunol 28:525-34. 2006
  10. ncbi request reprint Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis
    E M Carvalho
    Federal University of Bahia, Hospital Universitario Prof Edgard Santos, Servico de Imunologia, Salvador BA, Brazil
    Parasite Immunol 26:487-97. 2004

Collaborators

Detail Information

Publications66

  1. pmc Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis
    Maria de Lourdes Bastos
    Serviço de Imunologia do Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    BMC Infect Dis 12:199. 2012
    ..The aim of this study was to evaluate how HTLV-1 may influence the clinical, bacteriologic and immunologic presentation of tuberculosis...
  2. pmc Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection
    Angela Giudice
    Servico de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    BMC Infect Dis 12:75. 2012
    ....
  3. pmc CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study
    Lea Castellucci
    Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK
    BMC Med Genet 11:10. 2010
    ....
  4. pmc Resistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation with antimony therapy and TNF-alpha production
    Anselmo S Souza
    Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil
    BMC Infect Dis 10:209. 2010
    ..The aim of this study is to investigate if there is an association between the resistance of L. (V.) braziliensis to NO and nonresponsiveness to antimony therapy and cytokine production...
  5. pmc Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study
    Johan Van Weyenbergh
    LIMI, Gonçalo Moniz Research Center Oswaldo Cruz Foundation FIOCRUZ, Rua Waldemar Falcao 121, 40295 001 Salvador BA, Brazil
    BMC Infect Dis 4:50. 2004
    ..We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite...
  6. pmc Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis to nitric oxide correlates with disease severity in Tegumentary Leishmaniasis
    Angela Giudice
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Instituto de Investigação em Imunologia iii, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    BMC Infect Dis 7:7. 2007
    ..Nitric oxide (NO*) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO* resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases...
  7. pmc Differential effects of antigens from L. braziliensis isolates from disseminated and cutaneous leishmaniasis on in vitro cytokine production
    Paulo T G Leopoldo
    Departamento de Fisiologia, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil
    BMC Infect Dis 6:75. 2006
    ..Disseminated leishmaniasis is an emerging infectious disease, mostly due to L. braziliensis, which has clinical and histopathological features distinct from cutaneous leishmaniasis...
  8. pmc Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers
    Silvane Braga Santos
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brasil
    BMC Infect Dis 4:7. 2004
    ..In this study the immunological responses in HAM/TSP patients and in HTLV-I asymptomatic carriers were compared using several immunological assays to identify immunological markers associated with progression from infection to disease...
  9. ncbi request reprint Worms and allergy
    E M Carvalho
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    Parasite Immunol 28:525-34. 2006
    ..Moreover, although several helminth species have been shown to modulate immune responses, most in vitro and in vivo studies have focused on the importance of Schistosoma mansoni in down-modulating allergic reactions...
  10. ncbi request reprint Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis
    E M Carvalho
    Federal University of Bahia, Hospital Universitario Prof Edgard Santos, Servico de Imunologia, Salvador BA, Brazil
    Parasite Immunol 26:487-97. 2004
    ....
  11. ncbi request reprint Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis
    Aurelia F Porto
    Serviço de Imunologia do Hospital Unversitário Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    J Infect Dis 191:612-8. 2005
    ..05). These data show that helminthic infection decreases activation of type 1 cells, which may influence the clinical outcome of HTLV-1 infection...
  12. pmc Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection
    Amelia Ribeiro de Jesus
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Infect Immun 72:3391-7. 2004
    ..The data suggest a role for type 2 cytokines in hepatic fibrosis in human schistosomiasis mansoni...
  13. ncbi request reprint Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection
    Silvane Braga Santos
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Rua Joao das Botas, S N, 40110 160 Salvador, BA, Brazil
    Mem Inst Oswaldo Cruz 99:121-6. 2004
    ..Moreover, helminths may protect HTLV-I infected patients to produce large quantities of pro-inflammatory cytokines such as IFN-gamma...
  14. ncbi request reprint Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1
    Silvane B Santos
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Salvador, Brazil
    Neuroimmunomodulation 13:145-51. 2006
    ..In this study, the ability of regulatory cytokines and cytokine antagonists to inhibit spontaneous IFN-gamma production was investigated...
  15. pmc Up-regulation of Th1-type responses in mucosal leishmaniasis patients
    Olivia Bacellar
    Serviço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil
    Infect Immun 70:6734-40. 2002
    ..These abnormalities may be the basis for the pathological findings observed in this disease...
  16. ncbi request reprint Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni
    Amelia Ribeiro de Jesus
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil
    J Infect Dis 185:98-105. 2002
    ..Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis...
  17. ncbi request reprint Cytokine profile associated with human chronic schistosomiasis mansoni
    Andrea Magalhaes
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas s no, 40110 160 Salvador, BA, Brazil
    Mem Inst Oswaldo Cruz 99:21-6. 2004
    ..The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni...
  18. ncbi request reprint Immunomodulation of the allergic inflammatory response: new developments
    Maria I Araujo
    Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    Inflamm Allergy Drug Targets 9:73-82. 2010
    ..Studies using parasite antigens to induce the modulation of allergic inflammatory response are being conducted by several groups of researchers and represent new perspectives for the treatment of allergic diseases...
  19. doi request reprint Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma
    Ricardo R Oliveira
    Immunology Service, Federal University of Bahia, Brazil
    Microbes Infect 11:223-9. 2009
    ..mansoni-infected asthmatics...
  20. ncbi request reprint Familial aggregation of mucosal leishmaniasis in northeast Brazil
    Lea Castellucci
    Serviço de Imunologia Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Salvador Bahia, Brazil
    Am J Trop Med Hyg 73:69-73. 2005
    ..6%) of DTH-positive individuals than control families (9.4%). These data demonstrate familial clustering of CL, ML, and positive DTH skin tests in an area endemic for L. braziliensis infection...
  21. doi request reprint Pentoxifylline down modulate in vitro T cell responses and attenuate pathology in Leishmania and HTLV-I infections
    Amelia Ribeiro de Jesus
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    Int Immunopharmacol 8:1344-53. 2008
    ..Moreover, we review the results of clinical studies from the last 10 years using pentoxifylline to treat HTLV-1 associated myelopathy and cutaneous and mucosal leishmaniasis...
  22. pmc Geographic clustering of leishmaniasis in northeastern Brazil
    Albert Schriefer
    Universidade Federal da Bahia, Salvador, Brazil
    Emerg Infect Dis 15:871-6. 2009
    ..These findings indicate that leishmaniasis outcomes are distributed differently within transmission foci and show that DL is rapidly spreading in northeastern Brazil...
  23. pmc Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
    Tatiana R de Moura
    Centro de Pesquisas Goncalo Moniz, Fundação Oswaldo Cruz FIOCRUZ, Salvador, Brazil
    PLoS Negl Trop Dis 1:e84. 2007
    ..braziliensis infection employing an intradermal experimental model...
  24. ncbi request reprint Microbiological and immunological features of oral candidiasis
    Marcos André M de Oliveira
    Serviço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Rua João das Botas S N, 40110 160 Salvador, Bahia, Brazil
    Microbiol Immunol 51:713-9. 2007
    ..albicans in saliva, and that a systemic immune response characterized by the production of TNF-alpha and IFN-gamma is observed in patients with oral candidiasis...
  25. ncbi request reprint Association of cytokines, neurological disability, and disease duration in HAM/TSP patients
    André Luiz Muniz
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Arq Neuropsiquiatr 64:217-21. 2006
    ..To identify clinical and immunological markers associated with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)...
  26. ncbi request reprint Urinary symptoms associated with human T-cell lymphotropic virus type I infection: evidence of urinary manifestations in large group of HTLV-I carriers
    Neviton M Castro
    Serviço de Imunologia do Hospital Unversitário Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Urology 69:813-8. 2007
    ....
  27. ncbi request reprint Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma
    Maria Ilma A S Araujo
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Salvador, Bahia, Brazil
    J Infect Dis 190:1797-803. 2004
    ..pteronyssinus Ag 1-specific production of IL-10 in vitro. S. mansoni-infected patients with asthma produce lower levels of Th2 cytokines than do helminth-free patients with asthma, and this modulation is likely done by IL-10...
  28. ncbi request reprint Association between mite allergen (Der p 1, Der f 1, Blo t 5) levels and microscopic identification of mites or skin prick test results in asthmatic subjects
    Manoel Medeiros
    Servico de Imunologia, Hospital Universitario Professor Edgar Santos, Federal University of Bahia, Salvador, Brazil
    Int Arch Allergy Immunol 129:237-41. 2002
    ..The present study analyzed the association between levels of HDM allergen and results of mite identification or skin prick test (SPT) in two different areas of Bahia, Brazil...
  29. ncbi request reprint Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases
    Maria Ilma Araujo
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Instituto de Investigação em Imunologia, Universidade Federal da Bahia, Rua João das Botas S N, 5o andar, 40110 160 Salvador, BA, Brazil
    Mem Inst Oswaldo Cruz 99:27-32. 2004
    ..In conclusion, helminthic infections, through induction of regulatory mechanisms, such as IL-10 production, are able to modulate the inflammatory immune response involved in the pathology of auto-immune and allergic disease...
  30. ncbi request reprint Characterization of the immune response to Leishmania infantum recombinant antigens
    Lucas Pedreira de Carvalho
    Serviço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, 5 degrees andar, Rua João das Botas S N, Canela 40110 160, Salvador, Bahia, Brazil
    Microbes Infect 5:7-12. 2003
    ..chagasi infection. Thus, KMP11 is recognized by cells and sera of patients with different clinical forms of leishmaniasis, and KMP11, through IL-10 production, proved to be a potent antigen in modulating type 1 immune response...
  31. ncbi request reprint Schistosoma mansoni infection is associated with a reduced course of asthma
    Manoel Medeiros
    Serviço de Imunologia do Hospital Universitario Prof Edgar Santos, Salvador, Bahia Instituto de Saude Coletiva, Salvador, Bahia, Brazil
    J Allergy Clin Immunol 111:947-51. 2003
    ..Helminthic infections decrease skin reactivity to indoor allergens, but data on whether they influence asthma severity are lacking...
  32. ncbi request reprint [Evaluation of cellular immune response in patients with recurrent candidiasis]
    Lucas P Carvalho
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brasil
    Rev Soc Bras Med Trop 36:571-6. 2003
    ..Candidiasis patients have an impairment in the lymphoproliferative response specific to C. albicans antigen and on IFN-gamma production and the lymphoproliferative response can be partially restored, in vitro, by IL-10 neutralization...
  33. pmc Characterization of the T-cell receptor Vbeta repertoire in the human immune response against Leishmania parasites
    Jorge Clarencio
    Centro de Pesquisas Goncalo Moniz, FIOCRUZ, Rua Waldemar Falcão, 121, Salvador, Bahia 40296 710, Brazil
    Infect Immun 74:4757-65. 2006
    ..Collectively, these results both indicate that infection with live parasites or exposure to parasite antigen can modulate the TCR Vbeta repertoire and suggest that TCR Vbeta12 may be implicated in the response to Leishmania...
  34. ncbi request reprint IL6 -174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil
    Lea Castellucci
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    J Infect Dis 194:519-27. 2006
    ..Interleukin (IL)-6 down-regulates T helper (Th) cell type 1 differentiation and drives Th2 cell differentiation. The IL6 -174 G/C polymorphism is associated with proinflammatory diseases and IL-6 regulation...
  35. ncbi request reprint Spontaneous neutrophil activation in HTLV-1 infected patients
    Jaqueline B Guerreiro
    Universitary Hospital Prof Edgard Santos, Federal University of Bahia, Salvador, BA, Brazil
    Braz J Infect Dis 9:510-4. 2005
    ..In vivo activation of neutrophils observed in HTLV-1 infected subjects is likely to be the same process that causes spontaneous IFN-gamma production, or it may partially result from direct IFN-gamma stimulation...
  36. pmc The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil
    Rajendranath Ramasawmy
    Universidade Federal da Bahia, Salvador, Brazil
    Infect Genet Evol 10:607-13. 2010
    ..679; P=0.007). Higher levels of MCP-1 occurred in plasma (P=0.03) and macrophages (P<0.0001) from GG compared to AA individuals. These results suggest that high MCP-1 increases risk of ML...
  37. pmc Interleukin 17 production among patients with American cutaneous leishmaniasis
    Olivia Bacellar
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador Bahia, Brazil
    J Infect Dis 200:75-8. 2009
    ..86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis...
  38. ncbi request reprint Downregulation of IFN-gamma production in patients with recurrent vaginal candidiasis
    Lucas P Carvalho
    Serviço de Imunologia do Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    J Allergy Clin Immunol 109:102-5. 2002
    ..Although impairment of the T-cell response is associated with persistent or recurrent candidiasis, data on immunologic responses in patients with RVC are controversial...
  39. ncbi request reprint Evidence of in situ cytotoxicity in American cutaneous leishmaniasis
    Paulo Machado
    Servico de Imunologia, Hospital Universit rio Prof Edgard Santos, Universidade Federal da Bahia, Rua Joâo das Botas 5 andar Canela, 40 110 160 s n, Salvador Bahia, Brasil
    Eur J Dermatol 12:449-51. 2002
    ..These data suggest that cytotoxic activity occurs in situ in American cutaneous leishmaniasis and that both NK cells and activated CD8+ T cells are involved in this reaction...
  40. ncbi request reprint Successful treatment of refractory cutaneous leishmaniasis with GM-CSF and antimonials
    Roque P Almeida
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Am J Trop Med Hyg 73:79-81. 2005
    ..There were no side effects. This study shows that combined topically applied GM-CSF and antimony can be effective and well tolerated in the treatment of relapsed CL...
  41. ncbi request reprint Urodynamic features of the voiding dysfunction in HTLV-1 infected individuals
    Neviton M Castro
    Section of Immunology, University Hospital, Bahia Federal University, Salvador, Bahia, Brazil
    Int Braz J Urol 33:238-44; discussion 244-5. 2007
    ..To describe urodynamic abnormalities in HTLV-1 infected individuals presenting urinary symptoms and verify if these findings and quality of life (QOL) evaluation correlate with overall neurological impairment...
  42. ncbi request reprint Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection
    Ivonise Follador
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador Bahia, Brazil
    Clin Infect Dis 34:E54-8. 2002
    ..These data indicate that, unlike patients with CL, individuals who do not develop disease when infected with L. braziliensis may have the ability to modulate their immune response...
  43. ncbi request reprint Evaluation of IFN-gamma and TNF-alpha as immunological markers of clinical outcome in cutaneous leishmaniasis
    Argemiro D'Oliveira
    Servico de Imunologia, Hospital Universitário Prof Edgar Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Rev Soc Bras Med Trop 35:7-10. 2002
    ..In both groups of patients, TNF-alpha levels were similar before therapy and fell significantly after treatment, irrespective of cure or maintenance of active lesion...
  44. ncbi request reprint Failure of early treatment of cutaneous leishmaniasis in preventing the development of an ulcer
    Paulo Machado
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Clin Infect Dis 34:E69-73. 2002
    ..This unfavorable outcome underlines the relevance of local exacerbated inflammatory and immune response in the pathogenesis of the disease...
  45. doi request reprint Flower cells in patients with infective dermatitis associated with HTLV-1
    Maria de Fátima Paim de Oliveira
    Department of Dermatology, Professor Edgar Santos Teaching Hospital, Federal University of Bahia, Salvador, Bahia, Brazil
    J Clin Virol 48:288-90. 2010
    ..Infective dermatitis associated with HTLV-1 (IDH) is a severe childhood form of eczema that may progress to adult T-cell leukemia/lymphoma (ATL)...
  46. pmc Recent developments leading toward a paradigm switch in the diagnostic and therapeutic approach to human leishmaniasis
    Albert Schriefer
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Federal Unviersity of Bahia, Salvador, Bahia, Brazil
    Curr Opin Infect Dis 21:483-8. 2008
    ..To identify recent papers showing how human and parasite genetics influence leishmaniasis, and how understanding of the immunopathology may be utilized in immunotherapy for these diseases...
  47. ncbi request reprint Atypical clinical presentation of strongyloidiasis in a patient co-infected with human T cell lymphotrophic virus type I
    Maria Aurélia F Porto
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, e Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Am J Trop Med Hyg 72:124-5. 2005
    ..Strongyloides stercoralis was found in the analysis of the sperm and specific therapy for strongyloidiasis was associated with disappearance of the symptoms...
  48. pmc The cause of urinary symptoms among Human T Lymphotropic Virus Type I (HLTV-I) infected patients: a cross sectional study
    Paulo N Rocha
    Immunology Service, University Hospital Professor Edgard Santos, Federal University of Bahia, Rua Joao das Botas, S N, 40110 160 Salvador, BA, Brazil
    BMC Infect Dis 7:15. 2007
    ..The purpose of this study was to investigate the role of urinary tract infection (UTI) as the cause of urinary symptoms in HTLV-I infected patients...
  49. ncbi request reprint Antimony plus recombinant human granulocyte-macrophage colony-stimulating factor applied topically in low doses enhances healing of cutaneous Leishmaniasis ulcers: a randomized, double-blind, placebo-controlled study
    Jussamara B Santos
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    J Infect Dis 190:1793-6. 2004
    ..Two of the patients in the placebo group required retreatment with antimony. In conclusion, topically applied GM-CSF is effective in the management of CL...
  50. ncbi request reprint Urinary and sexual manifestations of patients infected by HTLV-I
    Paulo Oliveira
    Immunology Service, Hospital Universitario, Federal University of Bahia, Salvador, BA, Brazil
    Clinics (Sao Paulo) 62:191-6. 2007
    ..Despite the lack of an effective treatment for myelopathy, the use of anticholinergic drugs and phosphodiesterase type 5 (PDE5) inhibitors may improve urinary complaints and erectile dysfunction in these patients...
  51. ncbi request reprint Successful treatment of refractory recurrent vaginal candidiasis with cetirizine plus fluconazole
    Nilma A Neves
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Rua João das Botas S N, Canela 40110 160, Salvador, Bahia, Brazil
    J Low Genit Tract Dis 9:167-70. 2005
    ..To determine the prevalence of allergy in patients with recurrent vaginal candidiasis (RVC) and the efficacy of fluconazole in combination with an antihistamine drug in RVC patients who do not respond to fluconazole alone...
  52. pmc Prevalence of erectile dysfunction in HTLV-1-infected patients and its association with overactive bladder
    Paulo Oliveira
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais INCT DT, Universidade Federal da Bahia, Salvador Bahia, Brazil
    Urology 75:1100-3. 2010
    ..To determine the prevalence of erectile dysfunction (ED) in human T-cell lymphotropic virus type I (HTLV-I)-infected patients, and its association with overactive bladder (OB)...
  53. ncbi request reprint Oral pentoxifylline combined with pentavalent antimony: a randomized trial for mucosal leishmaniasis
    Paulo R L Machado
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador Bahia, Brazil
    Clin Infect Dis 44:788-93. 2007
    ..We previously showed that an inhibitor of tumor necrosis factor-alpha (pentoxifylline) combined with Sb(v) cured 90% patients refractory to monotherapy with Sb(v)...
  54. ncbi request reprint Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients
    Ronaldo P Costa
    Laboratory of Cell Cell Interactions, Department of Morphology, C P 486 Av Antônio Carlos, Universidade Federal de Minas Gerais, Biological Sciences Institute, 6627 Pampulha, Belo Horizonte, CEP30161 970, MG, Brazil
    Immunol Lett 90:155-9. 2003
    ....
  55. pmc Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis
    Daniela R Faria
    Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Infect Immun 73:7853-9. 2005
    ....
  56. ncbi request reprint Low frequency of positive skin tests in asthmatic patients infected with Schistosoma mansoni exposed to high levels of mite allergens
    Manoel Medeiros
    Serviço de Imunologia do Hospital Universitario Prof Edgar Santos, Salvador, Bahia, Brasil
    Pediatr Allergy Immunol 15:142-7. 2004
    ..2%) and group III (57.1%; p < 0.001). This result suggests that S. mansoni infection could modulate the immediate hypersensitivity skin response to mite allergens in highly exposed subjects...
  57. ncbi request reprint Majority of interferon-gamma-producing CD4+ cells in patients infected with human T cell lymphotrophic virus do not express tax protein
    Edward Mitre
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 188:428-32. 2003
    ..In the patients with HTLV-1 with detectable Tax, the majority of CD4(+) cells making IFN-gamma did not express Tax...
  58. ncbi request reprint Influence of helminth infections on the clinical course of and immune response to Leishmania braziliensis cutaneous leishmaniasis
    Luiz Henrique Guimaraes
    School of Medicine, Oregon Health and Sciences University, Portland, OR, USA
    J Infect Dis 195:142-8. 2007
    ..Helminth infections influence the clinical outcome of and immune response to certain immune-mediated diseases...
  59. pmc Clinical manifestations associated with HTLV type I infection: a cross-sectional study
    Marina F Caskey
    Division of International Medicine and Infectious Diseases, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    AIDS Res Hum Retroviruses 23:365-71. 2007
    ..9), periodontitis (OR = 10.0, 95% CI: 2.3-42.8), and dry oral mucosa (OR = 7.5, 95% CI: 1.7-32.8). HTLV-I infection is associated with a variety of clinical manifestations, which may occur in patients who have not developed myelopathy...
  60. ncbi request reprint Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil
    Meredith L Turetz
    Division of International Medicine and Infectious Diseases, Weill Medical College, Cornell University, New York, New York, USA
    J Infect Dis 186:1829-34. 2002
    ..05) and tumor necrosis factor-alpha (P<.05) production, compared with patients with LCL. DL is an emerging clinical distinct form of leishmaniasis associated with agricultural activities and host immunological response...
  61. ncbi request reprint Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis
    Lis R V Antonelli
    Department of Biochemistry Immunology, Institute of Biological Sciences Federal University of Minas Gerais UFMG ICB, Av Antonio Carlos, 6627 Belo Horizonte, MG 31640 970, Brazil
    Immunol Lett 101:226-30. 2005
    ..These studies demonstrate that immunological markers are correlated with clinical indicators of human leishmaniasis and serve to better understand the evolution of this important parasitic disease...
  62. pmc Immunoglobulin E antileishmanial antibody response in cutaneous leishmaniasis
    Maria L B Sousa-Atta
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmácia da Universidade Federal da Bahia, 40110 160 Salvador, Bahia, Brazil
    Clin Diagn Lab Immunol 9:101-4. 2002
    ..The presence of antileishmanial IgE antibodies in cutaneous leishmaniasis may be a result of immunoregulatory events with clinical implications...
  63. ncbi request reprint Immune responses to an inactive vaccine against American cutaneous leishmaniasis together with granulocyte-macrophage colony-stimulating factor
    Ivonise Follador
    Serviço de Imunologia do Hospital, Universitário Prof Edgard Santos, Salvador 50 andar, Rua João das Botas S N, Canela, 40110 160 Salvador, Bahia, Brazil
    Vaccine 20:1365-8. 2002
    ..Leishvacin is capable of sensitizing lymphocytes from individuals not previously exposed to leishmania antigen. Use of rhGM-CSF enhanced the immune response, indicating that it may improve immunological response to the vaccine...
  64. ncbi request reprint The unheralded and essential contribution of the field worker in tropical medicine: a committed technician making a difference in Corte de Pedra, Brazil
    Daniel J Morgan
    Am J Trop Med Hyg 76:607. 2007
  65. ncbi request reprint Mucosal leishmaniasis: epidemiological and clinical aspects
    Marcus Miranda Lessa
    Immunology and Otorhimolaryngology Units of the HUPES at the Federal University of Bahia
    Braz J Otorhinolaryngol 73:843-7. 2007
    ..In addition to parasite-related factors, the host immune response may be involved in the pathogenicity of lesions in mucosal leishmaniasis...
  66. ncbi request reprint Cutaneous leishmaniasis during pregnancy: exuberant lesions and potential fetal complications
    Daniel J Morgan
    Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Infect Dis 45:478-82. 2007
    ..High rates of preterm births (10.5%) and stillbirths (10.5%) were reported. Cutaneous leishmaniasis during pregnancy produces distinct lesions and may have adverse fetal effects...

Research Grants4

  1. Immunological response, Viral Factors and Helminth Infections in Disease Expressi
    Edgar M Carvalho; Fiscal Year: 2010
    ..This study will allow us Identify neurological manifestations in an early phase of the disease, when potential interventions may prevent neurological damage and improve recovery of neurological function. ..
  2. Immunological Response and Disease Expression in HTLV-1
    Edgar Carvalho; Fiscal Year: 2006
    ..abstract_text> ..
  3. Immunological response, Viral Factors and Helminth Infections in Disease Expressi
    Edgar Carvalho; Fiscal Year: 2009
    ..This study will allow us Identify neurological manifestations in an early phase of the disease, when potential interventions may prevent neurological damage and improve recovery of neurological function. ..