Henning Ulrich

Summary

Country: Brazil

Publications

  1. ncbi request reprint DNA and RNA aptamers: from tools for basic research towards therapeutic applications
    Henning Ulrich
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Comb Chem High Throughput Screen 9:619-32. 2006
  2. pmc Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation
    Talita Glaser
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Avenida Professor Lineu Prestes, 748, Sao Paulo, CEP 05508 900, Brazil
    Cell Commun Signal 11:12. 2013
  3. doi request reprint Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair
    Henning Ulrich
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes, 748, Sao Paulo 05508 900, SP, Brazil
    Stem Cell Rev 8:755-67. 2012
  4. pmc New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders
    Paromita Majumder
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, 05508 900, Sao Paulo, SP, Brazil
    Purinergic Signal 3:317-31. 2007
  5. ncbi request reprint RNA and DNA aptamers in cytomics analysis
    Henning Ulrich
    Department of Biochemistry, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 59:220-31. 2004
  6. ncbi request reprint Neurotransmitter receptor expression and activity during neuronal differentiation of embryonal carcinoma and stem cells: from basic research towards clinical applications
    H Ulrich
    Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Caixa Postal 26077, Sao Paulo 05513 970, Brazil
    Cell Prolif 39:281-300. 2006
  7. ncbi request reprint DNA and RNA aptamers as modulators of protein function
    Henning Ulrich
    Department of Biochemistry, Instituto de Quimica, Universidade de Sao Paulo, Caixa Postal 26077, Sao Paulo 05513 970, Brazil
    Med Chem 1:199-208. 2005
  8. ncbi request reprint The use of synthetic oligonucleotides as protein inhibitors and anticode drugs in cancer therapy: accomplishments and limitations
    Marcella Faria
    Department of Biochemistry, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, S P 05513 970, Caixa Postal 26077, Brazil
    Curr Cancer Drug Targets 2:355-68. 2002
  9. doi request reprint Disease-specific biomarker discovery by aptamers
    Henning Ulrich
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Cytometry A 75:727-33. 2009
  10. pmc Bothrops jararaca peptide with anti-hypertensive action normalizes endothelium dysfunction involved in physiopathology of preeclampsia
    Gabriel Benedetti
    Center for Applied Toxinology Centros de Pesquisa, Inovacio e Difusao, Instituto Butantan, Sao Paulo, Brazil
    PLoS ONE 6:e23680. 2011

Collaborators

Detail Information

Publications53

  1. ncbi request reprint DNA and RNA aptamers: from tools for basic research towards therapeutic applications
    Henning Ulrich
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Comb Chem High Throughput Screen 9:619-32. 2006
    ..Recently, the anti-VEGF aptamer pegaptanib received FDA approval for treatment of human ocular vascular disease...
  2. pmc Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation
    Talita Glaser
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Avenida Professor Lineu Prestes, 748, Sao Paulo, CEP 05508 900, Brazil
    Cell Commun Signal 11:12. 2013
    ..The scope of this review is to discuss the roles of purinergic receptor-induced calcium spike and wave activity and its codification in neurodevelopmental and neurodifferentiation processes...
  3. doi request reprint Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair
    Henning Ulrich
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes, 748, Sao Paulo 05508 900, SP, Brazil
    Stem Cell Rev 8:755-67. 2012
    ..Targeting the purinergic system to develop new strategies for neurodevelopmental disorders and neurodegenerative diseases will be also discussed...
  4. pmc New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders
    Paromita Majumder
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, 05508 900, Sao Paulo, SP, Brazil
    Purinergic Signal 3:317-31. 2007
    ..In this review, we shall discuss the participation of purinergic receptors in developmental processes and in brain physiology, including neuron-glia interactions and pathophysiology...
  5. ncbi request reprint RNA and DNA aptamers in cytomics analysis
    Henning Ulrich
    Department of Biochemistry, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 59:220-31. 2004
    ....
  6. ncbi request reprint Neurotransmitter receptor expression and activity during neuronal differentiation of embryonal carcinoma and stem cells: from basic research towards clinical applications
    H Ulrich
    Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Caixa Postal 26077, Sao Paulo 05513 970, Brazil
    Cell Prolif 39:281-300. 2006
    ..Future success in obtaining desired neuronal phenotypes from pluripotent cells in vitro may offer new therapeutic perspectives for curing genetic and acquired dysfunctions of the developing and adult nervous system...
  7. ncbi request reprint DNA and RNA aptamers as modulators of protein function
    Henning Ulrich
    Department of Biochemistry, Instituto de Quimica, Universidade de Sao Paulo, Caixa Postal 26077, Sao Paulo 05513 970, Brazil
    Med Chem 1:199-208. 2005
    ..Furthermore, some results were already obtained in animal models and clinical trials...
  8. ncbi request reprint The use of synthetic oligonucleotides as protein inhibitors and anticode drugs in cancer therapy: accomplishments and limitations
    Marcella Faria
    Department of Biochemistry, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, S P 05513 970, Caixa Postal 26077, Brazil
    Curr Cancer Drug Targets 2:355-68. 2002
    ..The use of oligonucleotide drugs (of either the antiprotein or the anticode type) as a viable approach to cancer therapy is limited by some common problems that will be discussed...
  9. doi request reprint Disease-specific biomarker discovery by aptamers
    Henning Ulrich
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Cytometry A 75:727-33. 2009
    ..In this review, we discuss an approach for the development of aptamers targeting parasite-derived surface proteins of Trypanosoma and Plasmodium...
  10. pmc Bothrops jararaca peptide with anti-hypertensive action normalizes endothelium dysfunction involved in physiopathology of preeclampsia
    Gabriel Benedetti
    Center for Applied Toxinology Centros de Pesquisa, Inovacio e Difusao, Instituto Butantan, Sao Paulo, Brazil
    PLoS ONE 6:e23680. 2011
    ..Such properties may initiate the development of novel therapeutics for treating preeclampsia...
  11. doi request reprint Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3ε and calmodulin
    Lilian C Russo
    Department of Cell Biology and Development, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil
    Proteomics 12:2641-55. 2012
    ..Therefore, it is exciting to suggest that natural intracellular peptides are novel modulators of protein interactions and have biological functions within cells...
  12. ncbi request reprint Immobilized P2X2 purinergic receptor stationary phase for chromatographic determination of pharmacological properties and drug screening
    Cleber A Trujillo
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo 05508 900, Brazil
    J Pharm Biomed Anal 44:701-10. 2007
    ....
  13. doi request reprint Novel perspectives of neural stem cell differentiation: from neurotransmitters to therapeutics
    Cleber A Trujillo
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 75:38-53. 2009
    ....
  14. ncbi request reprint Neuronal differentiation of P19 embryonal carcinoma cells modulates kinin B2 receptor gene expression and function
    Antonio Henrique B Martins
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    J Biol Chem 280:19576-86. 2005
    ....
  15. pmc Interactions between the NO-citrulline cycle and brain-derived neurotrophic factor in differentiation of neural stem cells
    Claudiana Lameu
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
    J Biol Chem 287:29690-701. 2012
    ..We conclude that the NO-citrulline cycle acts together with BDNF for maintaining the progress of neural differentiation...
  16. doi request reprint The central nervous system as target for antihypertensive actions of a proline-rich peptide from Bothrops jararaca venom
    Claudiana Lameu
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 77:220-30. 2010
    ..Bj-PRO-10c promoted glutamate and GABA release that may be responsible for its antihypertensive activity and its effect on HR...
  17. doi request reprint Enhancement of the citrulline-nitric oxide cycle in astroglioma cells by the proline-rich peptide-10c from Bothrops jararaca venom
    Eduardo Fontana de Oliveira
    Center for Applied Toxinology CAT CEPID, Instituto Butantan, SP, Brazil
    Brain Res 1363:11-9. 2010
    ..Since NO donors have been studied for the treatment of solid cancers, Bj-PRO-10c may serve as structural model for developing drugs to improve the effects of cancer therapy based on the peptide's ability to augment NO production...
  18. doi request reprint Brain nitric oxide production by a proline-rich decapeptide from Bothrops jararaca venom improves baroreflex sensitivity of spontaneously hypertensive rats
    Claudiana Lameu
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Hypertens Res 33:1283-8. 2010
    ..Bj-PRO-10c may reveal novel approaches for treating diseases with impaired baroreflex function...
  19. doi request reprint Kinin-B2 receptor expression and activity during differentiation of embryonic rat neurospheres
    Antonio H Martins
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 73:361-8. 2008
    ..Functional kinin-B2 receptors and BK secretion indicate an autocrine loop during neurosphere differentiation to neurons, astrocytes, and oligodendrocytes, reflecting events occurring during early brain development...
  20. doi request reprint Regulation of neurogenesis and gliogenesis of retinoic acid-induced P19 embryonal carcinoma cells by P2X2 and P2X7 receptors studied by RNA interference
    Katia K Yuahasi
    Departamento de Neurologia Clínica, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Int J Dev Neurosci 30:91-7. 2012
    ..The shRNAs down-regulating P2X2 or P2X7 receptor gene expression, developed during this work, present useful tools for studying mechanisms of neural differentiation in other stem cell models...
  21. ncbi request reprint Mechanism of acetylcholine-induced calcium signaling during neuronal differentiation of P19 embryonal carcinoma cells in vitro
    Rodrigo R Resende
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Cell Calcium 43:107-21. 2008
    ..The presence of functional nAChRs in embryonic cells suggests that these receptors are involved in triggering Ca(2+) waves during initial neuronal differentiation...
  22. pmc Kinin-B2 receptor activity determines the differentiation fate of neural stem cells
    Cleber A Trujillo
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil 05508 000
    J Biol Chem 287:44046-61. 2012
    ..Because pharmacological treatments did not affect cell viability and proliferation, we conclude that bradykinin-induced signaling provides a switch for neural fate determination and specification of neurotransmitter receptor expression...
  23. doi request reprint Neural differentiation of P19 carcinoma cells and primary neurospheres: cell morphology, proliferation, viability, and functionality
    Priscilla D Negraes
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    Curr Protoc Stem Cell Biol . 2012
    ..The methods described here may be useful for optimizing in vitro protocols for stem cell differentiation into defined neural populations, as well as for studying mechanisms that underlie neurogenesis and gliogenesis...
  24. doi request reprint The snake venom peptide Bj-PRO-7a is a M1 muscarinic acetylcholine receptor agonist
    Priscilla D Negraes
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 79:77-83. 2011
    ..Our findings provide a novel M1 muscarinic receptor agonist that could be used for basic research and even for pharmacological applications...
  25. doi request reprint Directed differentiation of neural progenitors into neurons is accompanied by altered expression of P2X purinergic receptors
    Telma T Schwindt
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes, Brazil
    J Mol Neurosci 44:141-6. 2011
    ....
  26. doi request reprint Alpha 7 nicotinic acetylcholine receptor expression and activity during neuronal differentiation of PC12 pheochromocytoma cells
    Arthur A Nery
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Mol Neurosci 41:329-39. 2010
    ..In summary, PC12 cells are an adequate model to study the role and pharmacological properties of this receptor during neuronal differentiation...
  27. doi request reprint A novel physiological property of snake bradykinin-potentiating peptides-reversion of MK-801 inhibition of nicotinic acetylcholine receptors
    Arthur A Nery
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CEP 05508 900, Sao Paulo, SP, Brazil
    Peptides 29:1708-15. 2008
    ....
  28. doi request reprint Human mesenchymal stem cells: from immunophenotyping by flow cytometry to clinical applications
    Arthur A Nery
    Departamento de Bioquimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 83:48-61. 2013
    ..Immediate or medium term improvements of clinical symptoms have been reported as results of many clinical studies...
  29. ncbi request reprint Alternative splicing of P2X6 receptors in developing mouse brain and during in vitro neuronal differentiation
    Rogério L da Silva
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Caixa Postal 26077, CEP 05513 970, Sao Paulo, Brazil
    Exp Physiol 92:139-45. 2007
    ..During postnatal development, however, the full-length form was predominant compared to the spliced form. Alternative splicing is suggested to regulate P2X(6) receptor function during neuronal differentiation...
  30. doi request reprint Functions of neurotrophins and growth factors in neurogenesis and brain repair
    Sophia L B Oliveira
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 83:76-89. 2013
    ..The better understanding of neural stem cells proliferation and differentiation is crucial for any therapeutic intervention aiming at neural stem cell transplantation and recruitment of endogenous repair mechanisms...
  31. ncbi request reprint Inhibition mechanism of the recombinant rat P2X(2) receptor in glial cells by suramin and TNP-ATP
    Cleber A Trujillo
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo 05508 900, Brazil
    Biochemistry 45:224-33. 2006
    ..Taken together, both data support a noncompetitive inhibition mechanism of the rat recombinant P2X(2) receptor by suramin, confirm the competitive inhibition by TNP-ATP, and allow the prediction of a model for P2X(2) receptor inhibition...
  32. pmc Perspectives of purinergic signaling in stem cell differentiation and tissue regeneration
    Talita Glaser
    Departamento de Bioquimica, Instituto de Quimica, Universidade Sao Paulo, Av Prof Lineu Prestes, 748 Bloco 8S Room 0858, CEP 05508 900, Sao Paulo, SP, Brazil
    Purinergic Signal 8:523-37. 2012
    ....
  33. pmc Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists
    Antonio H Martins
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e30755. 2012
    ....
  34. doi request reprint Flow cytometry as a tool for analyzing changes in Plasmodium falciparum cell cycle following treatment with indol compounds
    Desirée Cigaran Schuck
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytometry A 79:959-64. 2011
    ..YOYO-1 staining of infected erythrocyte and subsequent flow cytometry analysis provides a powerful tool in malaria research for screening of bioactive compounds...
  35. pmc Development of the anti-VEGF aptamer to a therapeutic agent for clinical ophthalmology
    Cleber A Trujillo
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin Ophthalmol 1:393-402. 2007
    ....
  36. doi request reprint Recognition of biomarkers and cell-specific molecular signatures: aptamers as capture agents
    Arthur A Nery
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    J Sep Sci 32:1523-30. 2009
    ....
  37. doi request reprint Tobacco nitrosamine N-nitrosonornicotine as inhibitor of neuronal nicotinic acetylcholine receptors
    Ariane Nunes-Alves
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, Sao Paulo, Sao Paulo 05508 900, Brazil
    J Mol Neurosci 49:52-61. 2013
    ..In summary, this work shows that NNN inhibits rat α3β4 nAChR in a noncompetitive way and interacts weakly with muscular nAChR...
  38. doi request reprint Neural differentiation of rat aorta pericyte cells
    Enrique Montiel-Eulefi
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Cytometry A 81:65-71. 2012
    ..The study of neural differentiation of pericytes contributes to the understanding of induction of neuroectodermal differentiation as well as providing a new possible stem-cell source for cell regeneration therapy in the brain...
  39. ncbi request reprint 5-Aminolevulinate and 4, 5-dioxovalerate ions decrease GABA(A) receptor density in neuronal cells, synaptosomes and rat brain
    Avishek Adhikari
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, 05508 900 Sao Paulo, SP, Brazil
    Brain Res 1093:95-104. 2006
    ..Our results strongly suggest that ALA- and DOVA-promoted damage to GABA(A) receptors may contribute to the neurological manifestations of AIP and plumbism...
  40. doi request reprint Neuronal differentiation involves a shift from glucose oxidation to fermentation
    Maynara Fornazari
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, 05508 900 Sao Paulo, SP, Brazil
    J Bioenerg Biomembr 43:531-9. 2011
    ..Overall, we provide evidence that neuronal differentiation involves a shift from oxidative to fermentative metabolism, and that oxidative phosphorylation is not essential for this process...
  41. doi request reprint Aptamers: from bench side research towards patented molecules with therapeutic applications
    Paromita Majumder
    Universidade de Sao Paulo, Instituto de Quimica, Departamento de Bioquimica, Sao Paulo, SP, CEP 05508 900, Brazil
    Expert Opin Ther Pat 19:1603-13. 2009
    ..Aptamer sequences from the final pool of in vitro selection are screened for pharmacological activity and possible medical applications...
  42. doi request reprint Identification of aptamers as specific binders and modulators of cell-surface receptor activity
    Henning Ulrich
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Methods Mol Biol 986:17-39. 2013
    ....
  43. pmc Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a Peptide homologous to the nicotine binding domain of the alpha 7 subtype
    Arthur A Nery
    Department of Biochemistry, Chemistry Institute, Sao Paulo University, Sao Paulo, SP, Brazil
    PLoS ONE 8:e67194. 2013
    ....
  44. ncbi request reprint Amino acid metabolic routes in Trypanosoma cruzi: possible therapeutic targets against Chagas' disease
    Ariel Mariano Silber
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Caixa Postal 26077, Sao Paulo 05513 970, Brazil
    Curr Drug Targets Infect Disord 5:53-64. 2005
    ..Arginine kinase seems to be an essential component of energy management during stress conditions. Taken together, these data indicate that amino acid metabolism may provide multiple as yet unexplored targets for therapeutic drugs...
  45. doi request reprint Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine
    Flavia Dona
    Departamento Neurologia Neurocirurgia, Universidade Federal de Sao Paulo, UNIFESP, Sao Paulo, Brazil
    Epilepsy Res 83:157-67. 2009
    ..However, the reduction of hippocampal P2X(4) receptor immunostaining in the chronic phase could reflect neuronal loss or decreased GABAergic signaling...
  46. pmc Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation
    Lilian C Russo
    Department of Cell Biology and Development, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    FEBS J 276:4358-71. 2009
    ..15 secretion. Together, these data suggest that the interaction between EP24.15 and calmodulin is regulated within cells and is important for the stimulated secretion of EP24.15 from HEK293 cells...
  47. pmc α -RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom
    Maria Cristina Vianna Braga
    CAT CEPID, Instituto Butantan, Avenida Vital Brasil 1500, 05503 900 Sao Paulo, SP, Brazil Ministério da Ciência, Tecnologia e Inovacao, Esplanada dos Ministérios, Bloco E, 70067 900 Brasília, DF, Brazil
    Int J Pept 2013:543028. 2013
    ..The peptide blocked slow rise-time neuronal receptors, probably α 3 β 4 and/or α 3 β 4 α 5 subtype. According to the nomenclature, the new peptide was designated as α -RgIB...
  48. ncbi request reprint Sugar boost: when ribose modifications improve oligonucleotide performance
    Marcella Faria
    Instituto Butantan, Laboratório Especial de Toxinologia Aplicada CAT CEPID, Sao Paulo, Brazil
    Curr Opin Mol Ther 10:168-75. 2008
    ....
  49. ncbi request reprint In vitro selection of RNA aptamers that bind to cell adhesion receptors of Trypanosoma cruzi and inhibit cell invasion
    Henning Ulrich
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Caixa Postal 26077, Sao Paulo 05513 970, Brazil
    J Biol Chem 277:20756-62. 2002
    ..RNA pools following seven and eight selection rounds as well as individual aptamers sharing consensus motifs were active in inhibiting invasion of LLC-MK(2) monkey kidney cells by T. cruzi in vitro...
  50. doi request reprint RNA and DNA aptamers in cytomics analysis
    Henning Ulrich
    Universidade de Sao Paulo, Sao Paulo, Brazil
    Curr Protoc Cytom . 2005
    ..DNA aptamers do not need modifications for most applications. The protocols in this unit can be used for the development of fluorescent-tagged RNA or DNA aptamers for any cell surface protein in cytomics analysis...
  51. ncbi request reprint Reversing the action of noncompetitive inhibitors (MK-801 and cocaine) on a protein (nicotinic acetylcholine receptor)-mediated reaction
    George P Hess
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, New York 14853 2703, USA
    Biochemistry 42:6106-14. 2003
    ..The resulting whole-cell current pertaining to the nondesensitized nAChR was determined. Inhibitors and compounds that alleviate inhibition were tested by their effect on the whole-cell current...
  52. ncbi request reprint Peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by amyloid beta
    Margaret H Magdesian
    Instituto de Bioquimica Medica, Programa de Bioquimica e Biofisica Celular, Universidade Federal do Rio de Janeiro, 21944 590 Rio de Janeiro, Brazil
    J Biol Chem 280:31085-90. 2005
    ..Furthermore, the results suggest that the IQ peptide may be a lead for the development of novel drugs to block the inhibition of nAChRs in AD...
  53. pmc Water soluble RNA based antagonist of AMPA receptors
    Mei Du
    6431 Fannin, Center for Membrane Biology, Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, TX 77030, USA
    Neuropharmacology 53:242-51. 2007
    ....