R C Tostes
Bomfim G, Echem C, Martins C, Costa T, Sartoretto S, dos Santos R, et al
. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci. 2015;122:1-7 pubmed publisher
..Together, these results suggest that TLR4 is a key player in hypertension and vascular inflammatory process by a NFÎºB signaling pathway. ..
Silva M, Cau S, Lopes R, Manzato C, Neves K, Bruder Nascimento T, et al
. Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of typeÂ 2 diabetes mellitus. Clin Sci (Lond). 2015;129:533-45 pubmed publisher
..Spironolactone treatment prevented all these changes, indicating that MR importantly contributes to diabetes-associated vascular dysfunction by inducing oxidative stress and by increasing the activity of redox-sensitive proteins. ..
Pereira C, Ferreira N, Mestriner F, Antunes Rodrigues J, Evora P, Resstel L, et al
. Chronic fluoxetine treatment increases NO bioavailability and calcium-sensitive potassium channels activation in rat mesenteric resistance arteries. Eur J Pharmacol. 2015;765:375-83 pubmed publisher
..These effects may contribute to the cardiovascular effects associated with chronic fluoxetine treatment. ..
Tostes R, Carneiro F, Carvalho M, Reckelhoff J. Reactive oxygen species: players in the cardiovascular effects of testosterone. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1-14 pubmed publisher
..The controversial effects of testosterone on ROS generation and oxidant status, both prooxidant and antioxidant, in the cardiovascular system and in cells and tissues of other systems are reviewed. ..
Gohar E, Giachini F, Pollock D, Tostes R. Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases. Life Sci. 2016;159:20-29 pubmed publisher
..Knowledge of the mechanisms underlying sex differences in arterial hypertension can impact therapeutic strategies. Sex-targeted and/or sex-tailored approaches may improve treatment of cardiovascular and renal diseases. ..
Pereira C, Rodrigues F, Ruginsk S, Zanotto C, Rodrigues J, Duarte D, et al
. Chronic treatment with fluoxetine modulates vascular adrenergic responses by inhibition of pre- and post-synaptic mechanisms. Eur J Pharmacol. 2017;800:70-80 pubmed publisher
..In conclusion, chronic treatment with fluoxetine decreases sympathetic-mediated vascular responses by mechanisms that involve inhibition of NA release/reuptake and decreased Ca2+ stores. ..
Souza Silva L, Alves Lopes R, Silva Miguez J, Dela Justina V, Neves K, Mestriner F, et al
. Glycosylation with O-Linked ?-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion / reactive oxygen species. Can J Physiol Pharmacol. 2017;: pubmed publisher
..In conclusion, O-GlcNAc levels reduce endothelium-dependent relaxation by overproduction of •O2- via activation of NADPH oxidase. This may represent an additional mechanism by which augmented O-GlcNAc levels impair vascular function. ..
Wynne B, Labazi H, Carneiro Z, Tostes R, Webb R. Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta. Eur J Pharmacol. 2017;814:294-301 pubmed publisher
..We propose that HNO may be vasoprotective and that HNO donors studied as a therapeutic option where other organic nitrates are contraindicative. ..