Carlos R Tirapelli

Summary

Country: Brazil

Publications

  1. Gonzaga N, Awata W, Tanus Santos J, Padovan J, Tirapelli C. Mechanisms underlying vascular hypocontractility induced by ethanol withdrawal: Role of cyclooxygenase 2-derived prostacyclin. Eur J Pharmacol. 2019;847:103-112 pubmed publisher
    ..Our studies show that the vascular hypocontractility induced by ethanol withdrawal is independent of the endothelium and it is mediated by PGI2 derived from COX-2. ..
  2. Guidi Pinto C, Colombo Marchi K, Amarante Arizza A, Silveira Leite A, Tirapelli C, Michelin Matheus S. Cholecalciferol in ethanol-preferring rats muscle fibers increases the number and area of type II fibers. Acta Histochem. 2018;120:789-796 pubmed publisher
    ..The EDL muscle glycolytic patterns in the high-drinker UChB rats may be associated with the differential effects of cholecalciferol on metabolism and protein synthesis in skeletal muscle. ..
  3. Gonzaga N, Awata W, do Vale G, Marchi K, Muniz J, Tanus Santos J, et al. Perivascular adipose tissue protects against the vascular dysfunction induced by acute ethanol intake: Role of hydrogen peroxide. Vascul Pharmacol. 2018;111:44-53 pubmed publisher
    ..Our study provides novel evidence that the periaortic PVAT protects against the vascular dysfunction induced by acute ethanol intake through a mechanism that involves increased generation of H2O2. ..
  4. do Vale G, Simplicio J, Gonzaga N, Yokota R, Ribeiro A, Casarini D, et al. Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol. Atherosclerosis. 2018;274:67-76 pubmed publisher
    ..Additionally, we showed that the sympathetic nervous system (SNS) and the renin-angiotensin system (RAS) are important endogenous mediators of the cardiovascular effects of ethanol. ..
  5. Gonzaga N, do Vale G, Parente J, Yokota R, De Martinis B, Casarini D, et al. Ethanol withdrawal increases blood pressure and vascular oxidative stress: a role for angiotensin type 1 receptors. J Am Soc Hypertens. 2018;12:561-573 pubmed publisher
    ..These findings highlight the importance of angiotensin II in ethanol withdrawal-induced increase in blood pressure and vascular oxidative damage. ..
  6. Passaglia P, Ceron C, Mecawi A, Antunes Rodrigues J, Coelho E, Tirapelli C. Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress. Vascul Pharmacol. 2015;74:49-59 pubmed publisher
    ..Our study provides novel evidence that chronic ethanol intake increases blood pressure, induces vascular oxidative stress and decreases nitric oxide (NO) bioavailability through AT1-dependent mechanisms. ..
  7. Muniz J, Leite L, De Martinis B, Carneiro F, Tirapelli C. Chronic ethanol consumption induces erectile dysfunction: Role of oxidative stress. Life Sci. 2015;141:44-53 pubmed publisher
  8. Hipólito U, Callera G, Simplicio J, De Martinis B, Touyz R, Tirapelli C. Vitamin C prevents the endothelial dysfunction induced by acute ethanol intake. Life Sci. 2015;141:99-107 pubmed publisher
    ..Our study provides novel evidence that vitamin C prevents the endothelial dysfunction induced by acute ethanol intake by a mechanism that involves reduced ROS generation and increased NO availability in endothelial cells. ..
  9. Tirapelli L, Batalhao M, Jacob Ferreira A, Tirapelli D, Carnio E, Tanus Santos J, et al. Chronic ethanol consumption induces histopathological changes and increases nitric oxide generation in the rat liver. Tissue Cell. 2011;43:384-91 pubmed publisher
    ..Therefore, increases in NO generation may be an early indicator of ethanol-induced liver damage. ..

More Information

Publications21

  1. Gonzaga N, Mecawi A, Antunes Rodrigues J, De Martinis B, Padovan C, Tirapelli C. Ethanol withdrawal increases oxidative stress and reduces nitric oxide bioavailability in the vasculature of rats. Alcohol. 2015;49:47-56 pubmed publisher
    ..These responses could predispose individuals to the development of cardiovascular diseases. ..
  2. Tirapelli C, dos Anjos Neto Filho M, Bonaventura D, Melo M, Ambrosio S, de Oliveira A, et al. Pimaradienoic acid inhibits vascular contraction and induces hypotension in normotensive rats. J Pharm Pharmacol. 2008;60:453-9 pubmed publisher
  3. Simplicio J, Resstel L, Tirapelli D, D Orléans Juste P, Tirapelli C. Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment. Vascul Pharmacol. 2015;73:124-37 pubmed publisher
    ..Finally, our findings raise the possibility that fluoxetine treatment increases the risk for vascular injury, a response that could predisposes to cardiovascular diseases. ..
  4. Leite L, Gonzaga N, Simplicio J, do Vale G, Carballido J, Alves Filho J, et al. Pharmacological characterization of the mechanisms underlying the vascular effects of succinate. Eur J Pharmacol. 2016;789:334-343 pubmed publisher
    ..The vascular relaxation induced by succinate is partially mediated by endothelial GPR91 receptors via the NO-cGMP pathway, a vasodilator cyclooxygenase (COX) product(s) and the opening of K(+) channels. ..
  5. Simplicio J, do Vale G, Gonzaga N, Leite L, Hipólito U, Pereira C, et al. Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries. J Physiol Biochem. 2017;73:5-16 pubmed publisher
    ..Moreover, ethanol consumption affects the expression and phosphorylation of proteins that regulate vascular function and NAD(P)H oxidase-derived ROS play a role in such responses. ..
  6. do Vale G, Gonzaga N, Simplicio J, Tirapelli C. Nebivolol prevents ethanol-induced reactive oxygen species generation and lipoperoxidation in the rat kidney by regulating NADPH oxidase activation and expression. Eur J Pharmacol. 2017;799:33-40 pubmed publisher
    ..Additionally, we demonstrated that nebivolol reduces NADPH oxidase-derived reactive oxygen species by decreasing the expression of PKC? and Rac1, which are important activators of NADPH oxidase. ..
  7. Ceron C, do Vale G, Simplicio J, Ricci S, De Martinis B, de Freitas A, et al. Chronic ethanol consumption increases vascular oxidative stress and the mortality induced by sub-lethal sepsis: Potential role of iNOS. Eur J Pharmacol. 2018;825:39-47 pubmed publisher
    ..Although ethanol led to vascular alterations, it did not aggravate the vascular injury induced by SL-CLP. Finally, iNOS mediated the increase in oxidative stress and pro-inflammatory cytokines induced by SL-CLP in the vasculature. ..
  8. Marchi K, Ceron C, Muniz J, De Martinis B, Tanus Santos J, Tirapelli C. NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature. Alcohol Alcohol. 2016;51:522-34 pubmed publisher
    ..Moreover, increased vascular Nox1 expression is related to the generation of reactive oxygen species (ROS) by ethanol. Finally, ROS induced by ethanol increase the expression of the regulatory vascular proteins. ..
  9. Leite L, do Vale G, Simplicio J, De Martinis B, Carneiro F, Tirapelli C. Ethanol-induced erectile dysfunction and increased expression of pro-inflammatory proteins in the rat cavernosal smooth muscle are mediated by NADPH oxidase-derived reactive oxygen species. Eur J Pharmacol. 2017;804:82-93 pubmed publisher
    ..The major new finding of this study is that NADPH oxidase-derived reactive oxygen species play a role on chronic ethanol consumption-induced ED and endothelial dysfunction in the rat CSM. ..
  10. Simplicio J, Gonzaga N, Nakashima M, De Martinis B, Cunha T, Tirapelli L, et al. Tumor necrosis factor-? receptor 1 contributes to ethanol-induced vascular reactive oxygen species generation and hypertension. J Am Soc Hypertens. 2017;11:684-696.e3 pubmed publisher
    ..Additionally, TNFR1 plays a role in ethanol-induced increase in proinflammatory cytokines and neutrophils migration. However, PVAT does not counteract or aggravate the effects induced by ethanol. ..
  11. Muniz J, Leite L, Lacchini R, Tanus Santos J, Tirapelli C. Dysregulated mitogen-activated protein kinase and matrix metalloproteinase in ethanol-induced cavernosal dysfunction. Can J Physiol Pharmacol. 2017;: pubmed publisher
    ..Additionally, we found that SAPK/JNK plays a role in ethanol-induced increase on ET-1 contraction in the isolated rat CSM. ..
  12. request reprint
    Ceron C, Marchi K, Muniz J, Tirapelli C. Vascular oxidative stress: a key factor in the development of hypertension associated with ethanol consumption. Curr Hypertens Rev. 2014;10:213-22 pubmed
    ..The present article reviews the role of ROS in vascular (patho)biology of ethanol. ..