Jose E Tanus-Santos

Summary

Country: Brazil

Publications

  1. ncbi request reprint nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction
    Riccardo Lacchini
    Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Pharmacogenomics 15:775-84. 2014
  2. ncbi request reprint Inducible nitric oxide synthase as a possible target in hypertension
    Gustavo H Oliveira-Paula
    Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Curr Drug Targets 15:164-74. 2014
  3. pmc The relationship between training status, blood pressure and uric acid in adults and elderly
    Atila Alexandre Trapé
    Faculty of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    BMC Cardiovasc Disord 13:44. 2013
  4. ncbi request reprint Inhibition of matrix metalloproteinases (MMPs) as a potential strategy to ameliorate hypertension-induced cardiovascular alterations
    Michele M Castro
    Department of Pharmacology, Cardiovascular Research Centre, 4 62 Heritage Medical Research Centre, Univ of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Curr Drug Targets 14:335-43. 2013
  5. ncbi request reprint Matrix metalloproteinases as drug targets in acute pulmonary embolism
    Evandro M Neto-Neves
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Curr Drug Targets 14:344-52. 2013
  6. pmc Matrix metalloproteinases as drug targets in preeclampsia
    Ana C T Palei
    aDepartment of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216, USA
    Curr Drug Targets 14:325-34. 2013
  7. ncbi request reprint Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy
    Marcelo R Luizon
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Hypertens Res 35:917-21. 2012
  8. doi request reprint Ethanol consumption increases the expression of endothelial nitric oxide synthase, inducible nitric oxide synthase and metalloproteinases in the rat kidney
    Luis F Tirapelli
    Faculty of Medicine of Ribeirao Preto, Department of Clinical, Toxicological, and Food Science Analysis, University of Sao Paulo, SP, Brazil
    J Pharm Pharmacol 64:68-76. 2012
  9. doi request reprint Effects of matrix metalloproteinase (MMP)-2 polymorphisms on responsiveness to antihypertensive therapy of women with hypertensive disorders of pregnancy
    Ana C T Palei
    Department of Pharmacology, Faculty of Medicinal Sciences, State University of Campinas, Campinas, SP, Brazil
    Basic Clin Pharmacol Toxicol 111:262-7. 2012
  10. doi request reprint Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-β in renovascular hypertension-induced cardiac hypertrophy
    Elen Rizzi
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Exp Mol Pathol 94:1-9. 2013

Collaborators

  • Riccardo Lacchini
  • Carlos R Tirapelli
  • Evelin C Carnio
  • Geraldo Duarte
  • Thiago M Cunha
  • Carlos J S Passos
  • Fernando Barbosa
  • Roberto Schreiber
  • Richard Schulz
  • Andrea M Marcaccini
  • Zeruesenay Desta
  • Paulo R B Evora
  • Melanie Lemire
  • Diana Mühl
  • Caroline Demacq
  • Arthur B Novaes
  • Heitor Moreno
  • Donna Mergler
  • Rubens Fazan
  • Myriam Fillion
  • Raquel F Gerlach
  • Elen Rizzi
  • Evandro M Neto-Neves
  • Carla S Ceron
  • Alisson Martins-Oliveira
  • Marcelo F Montenegro
  • Vanessa A Belo
  • Flavia M Gonçalves
  • Ana C T Palei
  • Vanessa Fontana
  • Bernardo P Marson
  • Michele M Castro
  • Ozelia Sousa-Santos
  • Lucas C Pinheiro
  • Danielle A Guimaraes
  • Marcelo R Luizon
  • Tatiane C Izidoro-Toledo
  • Jefferson H Amaral
  • Jaqueline J Muniz
  • Fabiola Dach
  • Jose G Speciali
  • Valeria C Sandrim
  • Valeria A Gomes
  • Jonas T Sertorio
  • Karina C Ferraz
  • Anna L B Jacob-Ferreira
  • Gustavo H Oliveira-Paula
  • Cesar A Meschiari
  • Lorena M Amaral
  • Marcos A Rossi
  • Ricardo C Cavalli
  • Pamela S Silva
  • Luis F Tirapelli
  • Marcelo E Batalhao
  • Regina H Queiroz
  • Diogo M O Marçal
  • Carlos A Dias-Junior
  • Ingrid F Metzger
  • Raquel C Antonio
  • Debora C Souza-Costa
  • Cibele M Prado
  • Graziele C Ferreira
  • Juliana T Rocha
  • Ulisses V Hipólito
  • Juliana A Uzuelli
  • Atila Alexandre Trapé
  • Bruno R Silva
  • Eduardo B Coelho
  • Tamas Kiss
  • Josiane A Miranda
  • Rafael L Portella
  • Stefany B A Cau
  • Thiago Quinaglia
  • Carla M M Lanna
  • Antonio J Costa-Filho
  • Vanessa Belo
  • Thiago de O S Mansur
  • Renata Dellalibera-Joviliano
  • Carlos A Dias
  • Tatiane Izidoro-Toledo
  • Bartira P da Costa
  • Jackeline S R Machado
  • Carlos E Poli de Figueiredo
  • Vania B Rezende
  • Samantha Dickel
  • Alisson M Oliveira
  • Daniela P Tirapelli
  • Carolina S Vieira
  • Celso Biagi
  • Gustavo M Soares

Detail Information

Publications74

  1. ncbi request reprint nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction
    Riccardo Lacchini
    Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Pharmacogenomics 15:775-84. 2014
    ..Sildenafil potentiates the nitric oxide (NO) signaling pathway. Since neuronal NOS is very important in the penis, we assessed whether NOS1 polymorphisms are associated with altered responsiveness to sildenafil in erectile dysfunction (ED)...
  2. ncbi request reprint Inducible nitric oxide synthase as a possible target in hypertension
    Gustavo H Oliveira-Paula
    Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Curr Drug Targets 15:164-74. 2014
    ..Together, these studies highlight the possibility that iNOS is a potential pharmacological target in hypertension. ..
  3. pmc The relationship between training status, blood pressure and uric acid in adults and elderly
    Atila Alexandre Trapé
    Faculty of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    BMC Cardiovasc Disord 13:44. 2013
    ..The purpose of this study was to investigate the relationship between BP and UA and whether this relationship may be mediated by the functional fitness index...
  4. ncbi request reprint Inhibition of matrix metalloproteinases (MMPs) as a potential strategy to ameliorate hypertension-induced cardiovascular alterations
    Michele M Castro
    Department of Pharmacology, Cardiovascular Research Centre, 4 62 Heritage Medical Research Centre, Univ of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Curr Drug Targets 14:335-43. 2013
    ..Particularly, the effects of doxycycline used as a non selective MMP inhibitor in experimental and clinical studies will be discussed...
  5. ncbi request reprint Matrix metalloproteinases as drug targets in acute pulmonary embolism
    Evandro M Neto-Neves
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Curr Drug Targets 14:344-52. 2013
    ..We review current evidence indicating that MMPs are targets in this critical condition. MMP inhibition apparently exerts antihypertensive effects and protects against cardiomyocyte injury caused by acute pulmonary embolism...
  6. pmc Matrix metalloproteinases as drug targets in preeclampsia
    Ana C T Palei
    aDepartment of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216, USA
    Curr Drug Targets 14:325-34. 2013
    ....
  7. ncbi request reprint Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy
    Marcelo R Luizon
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Hypertens Res 35:917-21. 2012
    ..05). These results are obscured when single polymorphisms in these genes are considered and suggest that specific genotype combinations of MMP-9 and VEGF contribute to PE susceptibility...
  8. doi request reprint Ethanol consumption increases the expression of endothelial nitric oxide synthase, inducible nitric oxide synthase and metalloproteinases in the rat kidney
    Luis F Tirapelli
    Faculty of Medicine of Ribeirao Preto, Department of Clinical, Toxicological, and Food Science Analysis, University of Sao Paulo, SP, Brazil
    J Pharm Pharmacol 64:68-76. 2012
    ..The effects of longterm ethanol consumption on the levels of nitric oxide (NO) and the expression of endothelial NO synthase (eNOS), inducible NO synthase (iNOS) and metalloproteinase-2 (MMP-2) were studied in rat kidney...
  9. doi request reprint Effects of matrix metalloproteinase (MMP)-2 polymorphisms on responsiveness to antihypertensive therapy of women with hypertensive disorders of pregnancy
    Ana C T Palei
    Department of Pharmacology, Faculty of Medicinal Sciences, State University of Campinas, Campinas, SP, Brazil
    Basic Clin Pharmacol Toxicol 111:262-7. 2012
    ..In parallel, MMP-2 polymorphisms apparently do not affect the responsiveness to antihypertensive therapy of women with these hypertensive disorders of pregnancy...
  10. doi request reprint Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-β in renovascular hypertension-induced cardiac hypertrophy
    Elen Rizzi
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Exp Mol Pathol 94:1-9. 2013
    ..Higher TIMP-4 levels were found in hypertensive rats only after 75 days after surgery. Our findings show that increased MMP-2 activity is associated with concomitant development of LV hypertrophy and increased TGF-β and ROS levels...
  11. doi request reprint Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats
    Lucas C Pinheiro
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13081 970 Campinas, SP, Brazil
    Free Radic Biol Med 53:701-9. 2012
    ..The increase in gastric pH induced by treatment with omeprazole blunts part of the beneficial cardiovascular effects of dietary nitrate and nitrite...
  12. doi request reprint Endothelial nitric oxide synthase haplotypes associated with aura in patients with migraine
    Flavia M Gonçalves
    Department of Pharmacology, State University of Campinas, Campinas, Brazil
    DNA Cell Biol 30:363-9. 2011
    ..61-586.4 and odds ratio = 17.26, 95% CI = 1.94-153.4, respectively; both p < 0.0015625). These findings suggest that these two eNOS haplotypes affect the susceptibility to the presence of aura in patients with migraine...
  13. doi request reprint Antioxidant treatment protects against matrix metalloproteinase activation and cardiomyocyte injury during acute pulmonary thromboembolism
    Ozelia Sousa-Santos
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, Ribeirão Preto 14049 900, Sao Paulo, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 385:685-96. 2012
    ..RV oxidative stress after APT increases the RV MMP activities, leading to the degradation of sarcomeric proteins, including cTI. Antioxidant treatment may prevent MMP activation and protect against cardiomyocyte injury after APT...
  14. doi request reprint Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension
    Carla S Ceron
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, 14049 900, Brazil
    Matrix Biol 31:261-70. 2012
    ..Using antioxidants or MMPs inhibitors in the early phase of hypertension may prevent the vascular alterations of hypertension...
  15. doi request reprint Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension
    Marcelo F Montenegro
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 385:509-17. 2012
    ..05), whereas catalase was not affected. These data suggest that even a single daily oral dose of sodium nitrite is able to lower SBP and exert antioxidant effects in renovascular hypertension...
  16. doi request reprint Interaction among nitric oxide (NO)-related genes in migraine susceptibility
    Flavia M Gonçalves
    Department of Pharmacology, State University of Campinas, Campinas, SP, Brazil
    Mol Cell Biochem 370:183-9. 2012
    ..05), suggesting that this combination affect the susceptibility to migraine. Further studies are needed to determine the molecular mechanisms explaining this interaction...
  17. doi request reprint Doxycycline dose-dependently inhibits MMP-2-mediated vascular changes in 2K1C hypertension
    Danielle A Guimaraes
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Basic Clin Pharmacol Toxicol 108:318-25. 2011
    ..Our results support the idea that the effects of doxycycline on MMP-2 and vascular structure are pressure independent...
  18. doi request reprint Ethanol consumption alters the expression and reactivity of adrenomedullin in the rat mesenteric arterial bed
    Juliana T Rocha
    College of Nursing of Ribeirão Preto, University of Sao Paulo, Brazil
    Alcohol Alcohol 47:9-17. 2012
    ..We investigated the effects of chronic ethanol consumption on arterial blood pressure, vascular reactivity to AM and the expression of AM system components in the rat mesenteric arterial bed (MAB)...
  19. ncbi request reprint Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism
    Evandro M Neto-Neves
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    J Cell Mol Med 17:1588-97. 2013
    ..05), doxycycline partially prevented this alteration (P < 0.05). We found evidence to support that doxycycline prevents RV dysfunction and improves the cardiac responses to dobutamine during APT. ..
  20. doi request reprint Sildenafil improves the beneficial hemodynamic effects exerted by atorvastatin during acute pulmonary thromboembolism
    Evandro M Neto-Neves
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Eur J Pharmacol 670:554-60. 2011
    ..These findings may reflect antioxidant effects and inhibited neutrophils/MMPs activation...
  21. doi request reprint Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine
    Alisson Martins-Oliveira
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    J Neuroimmunol 252:89-94. 2012
    ..Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 "C L Q" haplotype was associated with higher plasma MMP-9 concentrations in migraine patients...
  22. doi request reprint Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension
    Marcelo F Montenegro
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, SP, Brazil
    Free Radic Biol Med 51:144-52. 2011
    ..Taken together, our results show for the first time that nitrite has antihypertensive effects in 2K1C hypertensive rats, which may be due to its antioxidant properties resulting from vascular NADPH oxidase activity inhibition...
  23. ncbi request reprint Acute cardiac and hemodynamic effects of sildenafil on resistant hypertension
    Thiago Quinaglia
    Laboratory of Cardiovascular Pharmacology, Faculty of Medical Sciences and Clinic Hospital, University of Campinas UNICAMP, FCM 10 Building, 1st Floor, Campinas, SP, Brazil, 13083 970
    Eur J Clin Pharmacol 69:2027-36. 2013
    ..Also, an exploratory analysis was performed to assess the influence of the T-786C endothelial NO synthase polymorphism on those responses...
  24. doi request reprint Comprehensive evaluation of the effects of enalapril on matrix metalloproteinases levels in hypertension
    Vanessa Fontana
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Cardiovasc Drugs Ther 26:511-9. 2012
    ..Moreover, we assessed the effects of enalaprilat on MMP-9 and TIMP-1 secretion by human endothelial cells (HUVECs)...
  25. doi request reprint Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura
    Flavia M Gonçalves
    Department of Pharmacology, State University of Campinas, Campinas, SP, Brazil
    Gene 512:35-40. 2013
    ....
  26. doi request reprint Mercury exposure increases circulating net matrix metalloproteinase (MMP)-2 and MMP-9 activities
    Anna L B Jacob-Ferreira
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Basic Clin Pharmacol Toxicol 105:281-8. 2009
    ..These findings provide a new insight into the possible biological mechanisms of Hg toxicity, particularly in cardiovascular diseases...
  27. doi request reprint Inducible nitric oxide synthase haplotype associated with migraine and aura
    Thiago de O S Mansur
    Department of Pharmacology, State University of Campinas, Campinas, SP, Brazil
    Mol Cell Biochem 364:303-8. 2012
    ..These finding may have therapeutic implications when examining the effects of selective iNOS inhibitors...
  28. ncbi request reprint The antioxidant tempol decreases acute pulmonary thromboembolism-induced hemolysis and nitric oxide consumption
    Ozelia Sousa-Santos
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo
    Thromb Res 132:578-83. 2013
    ..We hypothesized that the antioxidant tempol could attenuate APT-induced hemolysis, and therefore attenuate APT-induced increases in plasma NO consumption...
  29. doi request reprint Endogenous nitric oxide formation correlates negatively with circulating matrix metalloproteinase (MMP)-2 and MMP-9 levels in black subjects
    Ingrid F Metzger
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, SP, Ribeirao Preto, Brazil
    Mol Cell Biochem 360:393-9. 2012
    ..Our findings suggest a mechanistic link between deficient NO formation and increased MMPs levels, which may promote cardiovascular diseases...
  30. doi request reprint Metalloproteinase inhibition protects against cardiomyocyte injury during experimental acute pulmonary thromboembolism
    Evandro M Neto-Neves
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Crit Care Med 39:349-56. 2011
    ..We examined whether pretreatment with doxycycline (a nonspecific matrix metalloproteinase inhibitor) protects against cardiomyocyte injury associated with acute pulmonary thromboembolism...
  31. doi request reprint Matrix metalloproteinase (MMP)-2 genetic variants modify the circulating MMP-2 levels in end-stage kidney disease
    Bernardo P Marson
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Brazil
    Am J Nephrol 35:209-15. 2012
    ..We have examined whether MMP-2 gene polymorphisms and haplotypes modify MMP-2 and TIMP-2 levels in ESKD patients as well as the effects of hemodialysis on the concentrations of these biomarkers...
  32. doi request reprint Vascular endothelial growth factor haplotypes associated with childhood obesity
    Vanessa A Belo
    Department of Pharmacology, State University of Campinas, Campinas, Sao Paulo, Brazil
    DNA Cell Biol 30:709-14. 2011
    ..008; odds ratio = 10.148 (95% confidence interval: 1.098-93.788). Our findings suggest that VEGF haplotypes affect susceptibility to obesity in children and adolescents...
  33. doi request reprint Oral contraceptive containing chlormadinone acetate and ethinylestradiol reduces plasma concentrations of matrix metalloproteinase-2 in women with polycystic ovary syndrome
    Valeria A Gomes
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil
    Basic Clin Pharmacol Toxicol 111:211-6. 2012
    ..As the latter have imbalances in circulating matrix MMPs, treatment of these women with an OC may be beneficial...
  34. ncbi request reprint T allele of -344 C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension
    Riccardo Lacchini
    Cardiovascular Pharmacology Laboratory, Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Hypertens Res 32:159-62. 2009
    ..005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups...
  35. doi request reprint Chronic ethanol consumption reduces adrenomedullin-induced relaxation in the isolated rat aorta
    Ulisses V Hipólito
    Department of Psychiatric Nursing and Human Sciences, Laboratory of Pharmacology, College of Nursing of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Alcohol 45:805-14. 2011
    ..This response could be one of the mechanisms by which ethanol predisposes individuals to vascular dysfunction and hypertension...
  36. doi request reprint Comparative study on antioxidant effects and vascular matrix metalloproteinase-2 downregulation by dihydropyridines in renovascular hypertension
    Diogo M O Marçal
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 383:35-44. 2011
    ..These findings suggest lack of superiority of one particular dihydropyridine, at least with respect to antioxidant effects, MMPs downregulation, and inhibition of vascular remodeling in hypertension...
  37. doi request reprint Low nitric oxide bioavailability is associated with better responses to sildenafil in patients with erectile dysfunction
    Jaqueline J Muniz
    Department of Pharmacology, State University of Campinas, Campinas, Sao Paulo, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 386:805-11. 2013
    ..05). No other significant associations were found. Our findings show evidence that low NO bioavailability is associated with better responses to sildenafil in patients with ED (with or without DM)...
  38. doi request reprint Recombinant human matrix metalloproteinase-2 impairs cardiovascular β-adrenergic responses
    Karina C Ferraz
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Basic Clin Pharmacol Toxicol 112:103-9. 2013
    ..Our findings show that rhMMP-2 exerts no major haemodynamic effects in lambs. However, rhMMP-2 impairs the responses elicited by activation of β-adrenoreceptors...
  39. doi request reprint Consistent alterations of circulating matrix metalloproteinases levels in untreated hypertensives and in spontaneously hypertensive rats: a relevant pharmacological target
    Vanessa Fontana
    Department of Pharmacology, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Basic Clin Pharmacol Toxicol 109:130-7. 2011
    ..While MMPs may be a relevant pharmacological target, antihypertensive drugs that down-regulate MMPs may offer advantages in the management of this disease...
  40. doi request reprint Losartan exerts no protective effects against acute pulmonary embolism-induced hemodynamic changes
    Carlos A Dias
    Department of Pharmacology, Campus Centro Oeste Dona Lindu, Federal University of Sao Joao Del Rei, Rua Sebastiao Goncalves Coelho 400, 35501 296 Divinópolis, MG, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 385:211-7. 2012
    ..The lack of significant effects of losartan on the pulmonary vascular resistance suggests that losartan does not protect against the hemodynamic changes found during APE...
  41. doi request reprint Imbalanced matrix metalloproteinases in cardiovascular complications of end-stage kidney disease: a potential pharmacological target
    Bernardo P Marson
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Sao Paulo, Brazil
    Basic Clin Pharmacol Toxicol 110:409-15. 2012
    ..While current research shows that MMPs play a role in the pathogenesis of the cardiovascular alterations found in ESKD patients, clinical studies are required to validate the idea of using MMPIs in ESKD...
  42. doi request reprint Vascular endothelial growth factor genetic polymorphisms and haplotypes in women with migraine
    Flavia M Gonçalves
    Department of Pharmacology, State University of Campinas, Sao Paulo, Brazil
    DNA Cell Biol 29:357-62. 2010
    ..05). These findings suggest that VEGF haplotypes affect susceptibility to migraine...
  43. doi request reprint Effect of genetic polymorphisms of vascular endothelial growth factor on left ventricular hypertrophy in patients with systemic hypertension
    Riccardo Lacchini
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Am J Cardiol 113:491-6. 2014
    ..010). Our results suggest that VEGF polymorphisms affect cardiac remodeling. Genotypes for VEGFA polymorphisms can be useful to help to identify hypertensive patients at greater intrinsic risk for heart failure...
  44. doi request reprint Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension
    Carla S Ceron
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Free Radic Biol Med 65:47-56. 2013
    ..These results show for the first time that nebivolol, but not metoprolol, attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMP-2 and MMP-9, which promote vascular remodeling in hypertension...
  45. doi request reprint Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy
    Vania B Rezende
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Monte Alegre, Ribeirao Preto, SP, CEP 14049 900, Brazil
    Mol Biol Rep 39:10903-6. 2012
    ..05). Our results showing no significant association between VDR polymorphisms or haplotypes with PE or GH suggest that genetic variations in VDR do not predispose to hypertensive disorders of pregnancy...
  46. doi request reprint Imbalanced circulating matrix metalloproteinases in polycystic ovary syndrome
    Valeria A Gomes
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, SP 13081 970, Brazil
    Mol Cell Biochem 353:251-7. 2011
    ..35, P = 0.04) and the MMP-9/TIMP-1 ratio (estimate = 0.01, P = 0.04). We found evidence indicating that the balance between MMPs and TIMPs in women with PCOS is altered, probably due to androgen excess found in these women...
  47. doi request reprint Endothelial nitric oxide genotypes and haplotypes are not associated with end-stage renal disease
    Bernardo P Marson
    Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    DNA Cell Biol 30:55-9. 2011
    ..05). The lack of significant associations between eNOS polymorphisms and ESRD suggests that eNOS polymorphisms may not be relevant to the genetic component of CKD that leads to ESRD...
  48. doi request reprint Functional matrix metalloproteinase (MMP)-9 genetic variants modify the effects of hemodialysis on circulating MMP-9 levels
    Bernardo P Marson
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Clin Chim Acta 414:46-51. 2012
    ..Genetic polymorphisms in MMP-9 gene affect MMP-9 levels. We examined how MMP-9 polymorphisms and haplotypes affect the changes in plasma MMP-9 and TIMP-1 levels found in patients with ESKD undergoing hemodialysis...
  49. doi request reprint A common matrix metalloproteinase (MMP)-2 polymorphism affects plasma MMP-2 levels in subjects environmentally exposed to mercury
    Anna L B Jacob-Ferreira
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Sci Total Environ 409:4242-6. 2011
    ..These findings suggest a significant interaction between the C(-1306)T polymorphism and Hg exposure, possibly increasing the risk of developing diseases in subjects with the C allele...
  50. doi request reprint Interethnic differences in the distribution of clinically relevant vascular endothelial growth factor genetic polymorphisms
    Jaqueline J Muniz
    Department of Pharmacology, State University of Campinas, Campinas, Brazil
    DNA Cell Biol 28:567-72. 2009
    ..05). These results show marked interethnic differences in the distribution of genetic variants of VEGF that may explain, at least in part, interethnic disparities in the susceptibility to cardiovascular diseases...
  51. doi request reprint Circulating matrix metalloproteinases and their inhibitors in hypertension
    Vanessa Fontana
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 413:656-62. 2012
    ..Circulating MMPs may predict increased risk of developing cardiovascular complications associated with hypertension. As such, patients could benefit from early pharmacologic intervention including use of MMP inhibitors...
  52. doi request reprint Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling
    Alisson Martins-Oliveira
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, SP, Brazil
    Int J Cardiol 167:1199-205. 2013
    ..We also hypothesized that aliskiren could enhance the effects of losartan...
  53. doi request reprint Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy
    Ana C T Palei
    Department of Pharmacology, Faculty of Medicinal Sciences, State University of Campinas, Campinas, SP, Brazil
    Exp Mol Pathol 92:217-21. 2012
    ..1306C>T and g.-735C>T polymorphisms may benefit from the use of MMPs inhibitors such as doxycycline. However, this possibility remains to be determined...
  54. doi request reprint Imbalanced matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 activities in patients with thromboangiitis obliterans
    Renata Dellalibera-Joviliano
    University Center UNIFAFIBE, Bebedouro, SP, Brazil
    Vasc Med 17:73-8. 2012
    ..These data suggest that smoke compounds could activate MMP-9 production or inhibit TIMP-1 activity...
  55. ncbi request reprint Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia
    Lorena M Amaral
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Cell Mol Med 17:1300-7. 2013
    ..This issue deserves further confirmation. ..
  56. doi request reprint Doxycycline prevents acute pulmonary embolism-induced mortality and right ventricular deformation in rats
    Stefany B A Cau
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Cardiovasc Drugs Ther 27:259-67. 2013
    ..We tested this hypothesis in rats...
  57. doi request reprint Effect of metabolic syndrome risk factors and MMP-2 genetic variations on circulating MMP-2 levels in childhood obesity
    Vanessa A Belo
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, Ribeirao Preto, SP, 14049 900, Brazil
    Mol Biol Rep 40:2697-704. 2013
    ....
  58. doi request reprint Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR
    Raquel C Antonio
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, Ribeirao Preto, SP, Brazil
    Mol Cell Biochem 386:99-105. 2014
    ....
  59. doi request reprint Salivary MMPs, TIMPs, and MPO levels in periodontal disease patients and controls
    Cesar A Meschiari
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 421:140-6. 2013
    ..We investigate the changes in salivary MMP-8, MMP-9, TIMP-1, TIMP-2, and MPO concentrations during PD treatment and compare results with plasma levels...
  60. doi request reprint Chronic ethanol consumption induces histopathological changes and increases nitric oxide generation in the rat liver
    Luis F Tirapelli
    Faculty of Medicine of Ribeirao Preto, University of Sao Paulo USP, Brazil
    Tissue Cell 43:384-91. 2011
    ..Therefore, increases in NO generation may be an early indicator of ethanol-induced liver damage...
  61. doi request reprint Circulating cell-free DNA levels in plasma increase with severity in experimental acute pulmonary thromboembolism
    Juliana A Uzuelli
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 409:112-6. 2009
    ..In vitro DNA release from blood clots was also studied...
  62. doi request reprint Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis
    Marcelo F Montenegro
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Cardiovasc Pharmacol 58:647-53. 2011
    ..These results show that Tam and its metabolites cause acute vasorelaxation by inducing vasodilator prostanoids synthesis...
  63. ncbi request reprint Hydrogen peroxide modulates phenylephrine-induced contractile response in renal hypertensive rat aorta
    Bruno R Silva
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, SP, Brazil
    Eur J Pharmacol 721:193-200. 2013
    ..Superoxide plays an important role on the PE-induced contraction in 2K rat denuded aorta, whereas in 2K-1C rat aorta, it is H2O2 that plays an important role in this effect...
  64. doi request reprint TEMPOL enhances the antihypertensive effects of sodium nitrite by mechanisms facilitating nitrite-derived gastric nitric oxide formation
    Jefferson H Amaral
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Free Radic Biol Med 65:446-55. 2013
    ..This may relate to enhanced nitrite uptake or reduced nitrate formation from NO or nitrite. ..
  65. doi request reprint Elevated plasma hemoglobin levels increase nitric oxide consumption in experimental and clinical acute pulmonary thromboembolism
    Jonas T Sertorio
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil
    Crit Care Med 41:e118-24. 2013
    ..These parameters were also measured in patients with acute pulmonary thromboembolism at baseline conditions and after thrombolysis, and in healthy controls...
  66. doi request reprint eNOS polymorphism associated with metabolic syndrome in children and adolescents
    Josiane A Miranda
    Department of Pharmacology, State University of Campinas, Campinas, SP 13081 970, Brazil
    Mol Cell Biochem 372:155-60. 2013
    ..Further studies examining interactions of eNOS haplotypes with environmental factors and other genetic markers are warranted...
  67. doi request reprint Nitric oxide attenuates matrix metalloproteinase-9 production by endothelial cells independent of cGMP- or NFκB-mediated mechanisms
    Cesar A Meschiari
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Mol Cell Biochem 378:127-35. 2013
    ..Our results may offer an important pharmacological strategy to approach cardiovascular diseases...
  68. doi request reprint Inducible nitric oxide synthase haplotype associated with hypertension and responsiveness to antihypertensive drug therapy
    Gustavo H Oliveira-Paula
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Gene 515:391-5. 2013
    ..2087G>A polymorphism in the iNOS gene affects the susceptibility to hypertension. Moreover, while the S-C-A haplotype is associated with hypertension, it is also associated with responsiveness to antihypertensive therapy...
  69. doi request reprint Tempol inhibits TGF-β and MMPs upregulation and prevents cardiac hypertensive changes
    Elen Rizzi
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, Brazil
    Int J Cardiol 165:165-73. 2013
    ..We tested the hypothesis that tempol (an antioxidant) could prevent these alterations in two-kidney, one-clip (2K1C) hypertension...
  70. doi request reprint Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy
    Andrea M Marcaccini
    Department of Bucco Maxillo Facial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 409:117-22. 2009
    ..The present study was designed to assess the circulating matrix metalloproteinases (MMPs) from chronic periodontal disease patients and, subsequently, after periodontal therapy...
  71. doi request reprint Matrix metalloproteinase inhibition improves cardiac dysfunction and remodeling in 2-kidney, 1-clip hypertension
    Elen Rizzi
    Department of Pharmacology, Faculty of Medicine of Ribeirao, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Card Fail 16:599-608. 2010
    ..To test this hypothesis, we used 2K1C rats after 2 weeks of surgery treated or not with a nonspecific inhibitor of MMPs (doxycycline)...
  72. ncbi request reprint A pharmacogenetics-based approach to reduce cardiovascular mortality with the prophylactic use of statins
    Riccardo Lacchini
    Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil
    Basic Clin Pharmacol Toxicol 106:357-61. 2010
    ..It is necessary although to validate this hypothesis with clinical trials which will require a long follow-up to assess relevant clinical events and not only surrogate biomarkers...
  73. doi request reprint Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL)
    Caroline Demacq
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 411:1335-40. 2010
    ....
  74. doi request reprint Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension
    Marcelo F Montenegro
    Department of Pharmacology, University of Sao Paulo, Av Bandeirantes, Sao Paulo, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 382:293-301. 2010
    ..05). These results suggest that the antihypertensive effects of quercetin were associated with increased NO formation and improved endothelial function, which probably result from its antioxidant effects...