Fernando Spiller

Summary

Country: Brazil

Publications

  1. doi Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation
    Fernando Spiller
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Pharm Pharmacol 60:473-8. 2008
  2. pmc Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
    Jose C Alves-Filho
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Brazil
    Proc Natl Acad Sci U S A 106:4018-23. 2009
  3. pmc α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice
    Fernando Spiller
    Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Diabetes 61:1584-91. 2012
  4. doi Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation
    Fernando Spiller
    Department of Pharmacology, University of Sao Paulo, Avenida Bandeirantes, Ribeirao Preto, Sao Paulo, Brazil
    Am J Respir Crit Care Med 182:360-8. 2010
  5. doi Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice
    Fernando Spiller
    Department of Pharmacology, University of Sao Paulo, Av Bandeirantes, Ribeirao Preto, SP, Brazil
    Am J Respir Crit Care Med 183:922-31. 2011
  6. doi Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model
    Daniela Carlos
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    J Immunol 191:1373-82. 2013
  7. doi Divergent role of heme oxygenase inhibition in the pathogenesis of sepsis
    Andressa Freitas
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Shock 35:550-9. 2011
  8. doi Neutrophil paralysis in sepsis
    Jose C Alves-Filho
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Shock 34:15-21. 2010
  9. doi Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis
    Paula Giselle Czaikoski
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Shock 39:389-96. 2013
  10. doi Sildenafil improves the beneficial hemodynamic effects exerted by atorvastatin during acute pulmonary thromboembolism
    Evandro M Neto-Neves
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Eur J Pharmacol 670:554-60. 2011

Collaborators

  • Jose C Alves-Filho
  • Fernando Q Cunha
  • Joao S Silva
  • M M Teixeira
  • Jose C Rosa
  • Jamil Assreuy
  • Emanuela Tolosano
  • Jose E Tanus-Santos
  • M A Rossi
  • Paula Giselle Czaikoski
  • Andressa Freitas
  • Andressa de Freitas
  • Daniela Carlos
  • Fabiane Sonego
  • Daniele Carvalho Nascimento
  • Evandro M Neto-Neves
  • Fabricio Rios-Santos
  • Fernanda B Morrone
  • Cristiane Tefé-Silva
  • Fabricio O Souto
  • Gisele Pena de Oliveira
  • Sérgio Henrique Ferreira
  • Patricia Rieken Macedo Rocco
  • Michel A de Carvalho
  • Bernhard Ryffel
  • Raquel Souza Santos
  • Cynthia Dos Santos Samary
  • Silvia C Trevelin
  • Walter Miguel Turato
  • Vanessa F Borges
  • Christina Barja-Fidalgo
  • Carlos A Dias-Junior
  • Cezar Rangel Pestana
  • Silvia Cellone Trevelin
  • Juliana A Uzuelli
  • Paula G Czaikoski
  • Carlos Curti
  • Daniela Dal-Secco
  • Marina Moreira Suavinha
  • Romaiana P Pereira
  • Celina Monteiro C Lotufo
  • Milena Botelho Pereira Soares
  • Ricardo Ribeiro dos Santos
  • Fabrício Oliveira Souto
  • Guido Lenz
  • Joseli Stella
  • Ana Maria O Battastini
  • Christianne G Salbego
  • Ana Paula Horn
  • João J F Sarkis

Detail Information

Publications13

  1. doi Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation
    Fernando Spiller
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Pharm Pharmacol 60:473-8. 2008
    ..baccatum juice and our data suggest that this effect may be induced by capsaicin. Moreover, the anti-inflammatory effect induced by red pepper may be by inhibition of pro-inflammatory cytokine production at the inflammatory site...
  2. pmc Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
    Jose C Alves-Filho
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Brazil
    Proc Natl Acad Sci U S A 106:4018-23. 2009
    ..Our findings identify an unexpected detrimental role of TLR2 in polymicrobial sepsis and suggest that inhibition of TLR2 signaling may improve survival from sepsis...
  3. pmc α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice
    Fernando Spiller
    Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Diabetes 61:1584-91. 2012
    ..Together, these data suggest that AGP may be involved in reduction of neutrophil migration and increased susceptibility to sepsis in diabetic mice...
  4. doi Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation
    Fernando Spiller
    Department of Pharmacology, University of Sao Paulo, Avenida Bandeirantes, Ribeirao Preto, Sao Paulo, Brazil
    Am J Respir Crit Care Med 182:360-8. 2010
    ..Recently, we demonstrated that the cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) pathway increased neutrophil recruitment to inflammatory focus during sterile inflammation...
  5. doi Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice
    Fernando Spiller
    Department of Pharmacology, University of Sao Paulo, Av Bandeirantes, Ribeirao Preto, SP, Brazil
    Am J Respir Crit Care Med 183:922-31. 2011
    ..The reduction of neutrophil migration to the bacterial focus is associated with poor outcome in sepsis...
  6. doi Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model
    Daniela Carlos
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    J Immunol 191:1373-82. 2013
    ..These results demonstrate that histamine released by MCs reduces diabetic host resistance to septic peritonitis in mice. ..
  7. doi Divergent role of heme oxygenase inhibition in the pathogenesis of sepsis
    Andressa Freitas
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Shock 35:550-9. 2011
    ..However, the combination of pretreatment plus posttreatment with ZnPP IX enhances sepsis severity because of an increase in circulating levels of heme, which is deleterious to the host tissues and also inhibits neutrophil migration...
  8. doi Neutrophil paralysis in sepsis
    Jose C Alves-Filho
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Shock 34:15-21. 2010
    ..In this review, we highlight the recent insights into the molecular mechanisms of neutrophil paralysis during sepsis...
  9. doi Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis
    Paula Giselle Czaikoski
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Shock 39:389-96. 2013
    ..These results show that heme oxygenase is involved in the pathophysiology of pneumonia-induced sepsis and suggest that HO inhibitors could be helpful for the management of this disease...
  10. doi Sildenafil improves the beneficial hemodynamic effects exerted by atorvastatin during acute pulmonary thromboembolism
    Evandro M Neto-Neves
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Eur J Pharmacol 670:554-60. 2011
    ..These findings may reflect antioxidant effects and inhibited neutrophils/MMPs activation...
  11. ncbi Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide
    Fabricio Rios-Santos
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Monte Alegre, 14049 900 Ribeirao Preto, SP, Brazil
    Am J Respir Crit Care Med 175:490-7. 2007
    ..Our laboratory has shown that inducible nitric oxide synthase (iNOS) induction and NO production contribute to the failure of neutrophils to migrate in the context of sepsis. Objectives and..
  12. doi The role of neutrophils in severe sepsis
    Jose C Alves-Filho
    Shock 30:3-9. 2008
    ..Additionally, the NO effect, at least in part, is mediated by peroxynitrite. In this review, we summarize what is known regarding the mechanisms of neutrophil migration impairment in severe sepsis...
  13. ncbi Increased resistance of glioma cell lines to extracellular ATP cytotoxicity
    Fernanda B Morrone
    Departamento de Bioquimica, Instituto de Ciências Básicas de Saúde, UFRGS, Rua Ramiro Barcelos 2600 anexo, 90 035 003, Porto Alegre, RS, Brazil
    J Neurooncol 71:135-40. 2005
    ..Our data indicate that ATP released in these situations can induce cell death of the normal tissue surrounding the tumor, potentially opening space to the fast growth and invasion of the tumor...