Renan P Souza

Summary

Country: Brazil

Publications

  1. ncbi request reprint Prolactin as a biomarker for treatment response and tardive dyskinesia in schizophrenia subjects: old thoughts revisited from a genetic perspective
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Psychopharmacol 26:21-7. 2011
  2. doi request reprint Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Eur Neuropsychopharmacol 20:688-94. 2010
  3. doi request reprint Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects
    Renan P Souza
    Neurogenetics Section, CAMH and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Hum Psychopharmacol 24:676-9. 2009
  4. doi request reprint Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Psychopharmacol 25:582-5. 2010
  5. doi request reprint Methylphenidate alters NCS-1 expression in rat brain
    Renan P Souza
    Grupo de Pesquisa em Neuropsiquiatria Clínica e Molecular, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Neurochem Int 53:12-6. 2008
  6. doi request reprint Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response
    Renan P Souza
    Grupo de Pesquisa em Neuropsiquiatria Clínica e Molecular, UFMG, Belo Horizonte, Brazil
    Psychopharmacology (Berl) 200:177-86. 2008
  7. doi request reprint Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response
    Renan P Souza
    Laboratorio de Neurociencia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    J Psychiatr Res 44:700-6. 2010
  8. doi request reprint Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia
    Renan P Souza
    Neurogenetics Section, Department of Neuroscience, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada
    Pharmacogenet Genomics 20:274-6. 2010
  9. doi request reprint The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain
    Gwyneth C M Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 39:96-101. 2012
  10. ncbi request reprint DARPP-32 expression in rat brain after electroconvulsive stimulation
    Daniela V F Rosa
    Grupo de Pesquisa em Neuropsiquiatria Clínica e Molecular, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Belo Horizonte 31270 901, Minas Gerais, Brazil
    Brain Res 1179:35-41. 2007

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Prolactin as a biomarker for treatment response and tardive dyskinesia in schizophrenia subjects: old thoughts revisited from a genetic perspective
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Psychopharmacol 26:21-7. 2011
    ..Our results suggest that more studies in this context are required to shed light in the molecular mechanisms underlying antipsychotic response and tardive dyskinesia occurrence...
  2. doi request reprint Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Eur Neuropsychopharmacol 20:688-94. 2010
    ..These findings should be read with caution particularly before independent replication...
  3. doi request reprint Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects
    Renan P Souza
    Neurogenetics Section, CAMH and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Hum Psychopharmacol 24:676-9. 2009
    ..Our results present that GPX1 (Pro200Leu) and MNSOD (Ala16Val) polymorphisms seem do not play a central role in the clozapine response, although studies in larger and independent samples are necessary to confirm our findings...
  4. doi request reprint Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Psychopharmacol 25:582-5. 2010
    ..We observed a trend toward association of clozapine response with the rs12467557 (permuted p = 0.051). These results should be read with caution before independent replication...
  5. doi request reprint Methylphenidate alters NCS-1 expression in rat brain
    Renan P Souza
    Grupo de Pesquisa em Neuropsiquiatria Clínica e Molecular, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    Neurochem Int 53:12-6. 2008
    ....
  6. doi request reprint Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response
    Renan P Souza
    Grupo de Pesquisa em Neuropsiquiatria Clínica e Molecular, UFMG, Belo Horizonte, Brazil
    Psychopharmacology (Berl) 200:177-86. 2008
    ..Since GSK3beta regulation is altered in schizophrenia, polymorphic variation in this gene may affect susceptibility to schizophrenia or treatment response...
  7. doi request reprint Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response
    Renan P Souza
    Laboratorio de Neurociencia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    J Psychiatr Res 44:700-6. 2010
    ..We also found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia...
  8. doi request reprint Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia
    Renan P Souza
    Neurogenetics Section, Department of Neuroscience, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario, Canada
    Pharmacogenet Genomics 20:274-6. 2010
    ..Further studies are necessary to confirm the reported associations...
  9. doi request reprint The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain
    Gwyneth C M Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 39:96-101. 2012
    ..Therefore, we hypothesized that genetic variation in this candidate gene helps in explaining the inter-individual variation observed in antipsychotic drug treatment with respect to response and induced weight gain...
  10. ncbi request reprint DARPP-32 expression in rat brain after electroconvulsive stimulation
    Daniela V F Rosa
    Grupo de Pesquisa em Neuropsiquiatria Clínica e Molecular, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Belo Horizonte 31270 901, Minas Gerais, Brazil
    Brain Res 1179:35-41. 2007
    ....
  11. doi request reprint Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 210:347-54. 2010
    ..Clinical trials have also investigated whether GDNF may ameliorate Parkinson's disease symptoms...
  12. doi request reprint Cerebral DARPP-32 expression after methylphenidate administration in young and adult rats
    Renan P Souza
    Laboratorio de Neurociencia, Departamento de Saude Mental, Faculdade de Medicina da Universidade Federal de Minas Gerais, Av Alfredo Balena, 190, Belo Horizonte, 30130 100 MG, Brazil
    Int J Dev Neurosci 27:1-7. 2009
    ....
  13. doi request reprint Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
    J Psychiatr Res 46:462-8. 2012
    ..5 kg ± 2.9, p = 0.014) under antipsychotic treatment. In conclusion, we observed significant associations between polymorphisms in AMPK subunit genes and weight gain induced by clozapine and olanzapine...
  14. doi request reprint Phosphodiesterase 4B genetic variants are not associated with antipsychotic-induced tardive dyskinesia
    Renan P Souza
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Int Clin Psychopharmacol 25:264-9. 2010
    ..None of these results survived correction for multiple testing. Overall, our results do not support a genetic association between tardive dyskinesia and PDE4B...
  15. doi request reprint Finite mixture regression model analysis on antipsychotics induced weight gain: investigation of the role of the serotonergic genes
    Behdin Nowrouzi
    Laurentian University, Sudbury, Ontario, Canada
    Eur Neuropsychopharmacol 23:224-8. 2013
    ..The mixture regression model appears to be a useful strategy to highlight different weight gain subgroups that are affected differently by clinical and genetic predictors...
  16. doi request reprint DARPP-32 expression in rat brain after an inhibitory avoidance task
    Daniela V F Rosa
    Laboratório de Neurociência e Departamento de Saúde Mental, Faculdade de Medicina da Universidade Federal de Minas Gerais, Av Alfredo Balena, 190 sl 325, Belo Horizonte, 30130 100, MG, Brazil
    Neurochem Res 33:2257-62. 2008
    ..These changes suggest that DARPP-32 might play a central role in the IA, as previously described as an integrator of the dopaminergic signal...
  17. doi request reprint Downregulation of the cAMP/PKA pathway in PC12 cells overexpressing NCS-1
    Bruno R Souza
    Departamento de Saude Mental, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Cell Mol Neurobiol 31:135-43. 2011
    ....
  18. doi request reprint Inhibitory avoidance task does not change NCS-1 level in rat brain
    Daniela V F Rosa
    Laboratório de Neurociência e Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Departamento de Saude Mental, Faculdade de Medicina da Universidade Federal de Minas Gerais, Av Alfredo Balena, 190 sl 114, Belo Horizonte 30130 100, MG, Brazil
    Brain Res Bull 82:289-92. 2010
    ..Furthermore, other experiments are needed to shed more light on the role of NCS-1 and other mechanisms linked to signaling pathways related to inhibitory avoidance task...
  19. doi request reprint Cocaine and amphetamine regulated transcript (CART) gene in the comorbidity of schizophrenia with alcohol use disorders and nicotine dependence
    Amaya Busto
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 34:834-6. 2010
    ..Additional association studies in independent samples can evaluate whether CART gene is playing a role in the schizophrenia comorbidity with alcohol use disorders and nicotine dependence...
  20. doi request reprint Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis
    Michelle N Sicard
    Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
    Pharmacogenomics 11:1561-71. 2010
    ..This study aims to test for possible associations between the gene coding for the 5-HT2C receptor and antipsychotic-induced weight gain...
  21. doi request reprint Are serotonin 3A and 3B receptor genes associated with suicidal behavior in schizophrenia subjects?
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neurosci Lett 489:137-41. 2011
    ..Moreover, gene-gene interaction and haplotype association may have consistent results for genes located in the same chromosome...
  22. doi request reprint Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: replication and exploration
    Rudi Hwang
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 37:62-75. 2012
    ....
  23. pmc Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1
    Bruno R Souza
    Laboratorio de Neurociencias, Departamento de Saude Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena 190, Belo Horizonte, MG, Brazil
    J Negat Results Biomed 9:4. 2010
    ....
  24. doi request reprint Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples
    Yuko Hirata
    Neurogenetics Section, CAMH, Toronto, ON, Canada
    Psychiatry Res 175:176-8. 2010
    ..The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample...
  25. doi request reprint Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Int J Neuropsychopharmacol 13:793-8. 2010
    ..Additional association studies in independent samples will be able evaluate whether OXT and OXTR genes are truly playing a role in the clozapine treatment outcome...
  26. doi request reprint Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour
    Crystal Pinto
    Neurobiology of Schizophrenia Section, Neuroscience Department, Centre for Addiction and Mental Health Toronto, Toronto, ON, Canada
    Eur Arch Psychiatry Clin Neurosci 261:533-8. 2011
    ..Small sample size and the fact that RNA was obtained from lymphoblastoid cell lines were some of the limitations of this study...
  27. doi request reprint Lack of association of NALCN genetic variants with schizophrenia
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Psychiatry Res 185:450-2. 2011
    ..We analyzed 21 polymorphisms in 464 schizophrenia subjects, 220 controls subjects and 119 small nuclear families. We observed nominal association with rs9518320 and rs9518331, suggesting that NALCN is not related to schizophrenia risk...
  28. doi request reprint Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects
    Daniela S S Lobo
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychol 85:33-7. 2010
    ..06). Both trends were associated with lower CPGI score. Our results provide further evidence for the role of dopamine D2-like receptor in addiction susceptibility...
  29. pmc A common polymorphism in the cannabinoid receptor 1 (CNR1) gene is associated with antipsychotic-induced weight gain in Schizophrenia
    Arun K Tiwari
    Department of Neuroscience, Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 35:1315-24. 2010
    ..However, these observations were made in a relatively small patient population; therefore these results need to be replicated in larger sample sets...
  30. doi request reprint Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies
    Yuko Hirata
    Neurogenetics Section, Center for Addiction and Mental Health, Toronto, ON, Canada
    Hum Psychopharmacol 27:345-51. 2012
    ..Within the glutamate system, the glutamate receptor ionotropic kainate-1 (GRIK1) gene is thought to be particularly involved in schizophrenia because of the reported reduction of GRIK1 in the dorsolateral prefrontal cortex of patients...
  31. doi request reprint Parent of origin effect and differential allelic expression of BDNF Val66Met in suicidal behaviour
    Vincenzo De Luca
    Department of Psychiatry, University of Toronto, Toronto, Canada
    World J Biol Psychiatry 12:42-7. 2011
    ....
  32. ncbi request reprint NCS-1 expression in rat brain after electroconvulsive stimulation
    Daniela V F Rosa
    Grupo de Pesquisa em Neuropsiquiatria Clínica e Molecular, ICB, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Belo Horizonte 31270 901, MG, Brazil
    Neurochem Res 32:81-5. 2007
    ....
  33. doi request reprint Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response
    Rudi Hwang
    Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, 5T1R8, Canada
    Pharmacogenomics 12:277-91. 2011
    ..To investigate the possible association and gene-gene interaction effects of polymorphisms in NMDA receptor subunit (GRIN1, GRIN2A and GRIN2B) and dopamine receptor (DRD1, DRD2 and DRD3) genes with clozapine response...
  34. pmc Dopaminergic intracellular signal integrating proteins: relevance to schizophrenia
    Bruno R Souza
    Departamento de Farmacologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte MG, Brazil
    Dialogues Clin Neurosci 8:95-100. 2006
    ..Here, we review some of the current evidence and new ideas that are being proposed as a result, as well as future perspectives that are now being recognized...
  35. doi request reprint Association of antipsychotic induced weight gain and body mass index with GNB3 gene: a meta-analysis
    Renan P Souza
    Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 32:1848-53. 2008
    ..Our meta-analysis indicates that firmly establishing the role of pharmacogenetics in clinical psychiatry requires much larger sample sizes that have been reported...
  36. doi request reprint Reduced prefrontal cortex DARPP-32 mRNA in completed suicide victims with schizophrenia
    Laura A Feldcamp
    Department of Pharmacology, University of Toronto, 250 College St, M5T1R8, Toronto, Canada
    Schizophr Res 103:192-200. 2008
    ..Work in a larger sample is needed to confirm these findings...
  37. doi request reprint Genetic interactions in the adrenergic system genes: analysis of antipsychotic-induced weight gain
    Vincenzo De Luca
    Neurogenetics Section, Centre for Addictions and Mental Health, Toronto, ON, Canada
    Hum Psychopharmacol 26:386-91. 2011
    ....
  38. doi request reprint The role of tyrosine hydroxylase gene variants in suicide attempt in schizophrenia
    Jiayi Hu
    Group for Suicide Studies, Centre for Addiction and Mental Health CAMH, Toronto, Canada
    Neurosci Lett 559:39-43. 2014
    ..Further larger scale studies are needed to confirm these findings and to understand the mechanisms underlying the role of TH gene variants in suicide attempt in schizophrenia. ..
  39. ncbi request reprint Is DARPP-32 a potential therapeutic target?
    Helton J Reis
    Universidade Federal de Minas Gerais, Departamento de Farmacologia, Av Antonio Carlos, 6627 Belo Horizonte MG, 31270 901, Brazil
    Expert Opin Ther Targets 11:1649-61. 2007
    ..This review considers some of these apparently compartmentalized functions of DARPP-32 and its potential as a therapeutic target...
  40. doi request reprint Pharmacogenetics of anxiolytic drugs
    Arun K Tiwari
    Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, R 30, Toronto ONM5T1R8, Canada
    J Neural Transm 116:667-77. 2009
    ..As research progresses, it is likely that further gene variants will be detected that in conjunction with clinical variables will lead to algorithms allowing for individualized anxiolytic drug treatment...