José Maurício Sforcin

Summary

Country: Brazil

Publications

  1. doi request reprint Lemongrass effects on IL-1beta and IL-6 production by macrophages
    J M Sforcin
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    Nat Prod Res 23:1151-9. 2009
  2. doi request reprint Propolis: is there a potential for the development of new drugs?
    José Maurício Sforcin
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, SP, Brazil
    J Ethnopharmacol 133:253-60. 2011
  3. ncbi request reprint Effect of a leukotriene inhibitor (MK886) on nitric oxide and hydrogen peroxide production by macrophages of acutely and chronically stressed mice
    José Maurício Sforcin
    Departamento de Microbiologia e Imunologia, Instituto de Biociencias, UNESP, Botucatu, SP 18618 000, Brazil
    J Pharm Pharmacol 59:1249-54. 2007
  4. ncbi request reprint Propolis and the immune system: a review
    J M Sforcin
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, SP, Brazil
    J Ethnopharmacol 113:1-14. 2007
  5. doi request reprint Th1/Th2 cytokines' expression and production by propolis-treated mice
    Claudio Lera Orsatti
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    J Ethnopharmacol 129:314-8. 2010
  6. doi request reprint Th1/Th2 cytokine production by clove-treated mice
    Tatiana Fernanda Bachiega
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    Nat Prod Res 23:1552-8. 2009
  7. doi request reprint Propolis effects on pro-inflammatory cytokine production and Toll-like receptor 2 and 4 expression in stressed mice
    Ana Carolina Pagliarone
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, SP, Brazil
    Int Immunopharmacol 9:1352-6. 2009
  8. ncbi request reprint Modifying effect of propolis on dimethylhydrazine-induced DNA damage but not colonic aberrant crypt foci in rats
    Rodrigo O Alves de Lima
    Departamento de Patologia, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil
    Environ Mol Mutagen 45:8-16. 2005
  9. doi request reprint Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages
    Tatiana Fernanda Bachiega
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, Brazil
    J Pharm Pharmacol 64:610-6. 2012
  10. doi request reprint Propolis immunomodulatory activity on TLR-2 and TLR-4 expression by chronically stressed mice
    Claudio Lera Orsatti
    Department of Microbiology and Immunology, Biosciences Institute, Sao Paulo State University, Botucatu, Sao Paulo, Brazil
    Nat Prod Res 26:446-53. 2012

Collaborators

  • Vassya Bankova
  • Semíramis Guimarães
  • F Mani
  • Tatiana Fernanda Bachiega
  • Claudio Lera Orsatti
  • Michelle Cristiane Búfalo
  • Ana Carolina Pagliarone
  • Fabiane Missima
  • M C Búfalo
  • Bruno José Conti
  • Naiara Costa Cinegaglia
  • Marla Karine Amarante
  • Erica Boarato David
  • Jairo Kenupp Bastos
  • Vera Lucia Mores Rall
  • C L Orsatti
  • Ana Paula Bazo
  • J K Bastos
  • T G Rodrigues
  • S F Freitas
  • R O Orsi
  • Rodrigo O Alves de Lima
  • F C Lopes
  • J M Murad
  • Maria Celeste Lopes
  • Joana Liberal
  • Maria Teresa Cruz
  • Isabel Ferreira
  • Maria José Abigail Mendes Araújo
  • Paulo Ricardo Oliveira Bersano
  • Vera Francisco
  • Gustavo Costa
  • Márjorie de Assis Golim
  • Maria Teresa Batista
  • Leandra Lopes Fiori
  • Silvana Torossian Coradi
  • Clarisse Maria Boni de Oliveira
  • Ivete Conchon-Costa
  • Julie Massayo Maeda Oda
  • Thaís Batista de Carvalho
  • Maria Angelica Ehara Watanabe
  • João Paulo Barreto de Sousa
  • F Missima
  • T F Bachiega
  • Natália Cristina Godinho
  • Daniel Casaes de Sousa
  • Carlos Henrique Camargo
  • J P Araujo
  • Luciane Almeida Galindo
  • A C Pagliarone
  • Taíssa Cook Siqueira Soares
  • João Pessoa Araújo
  • Maria Fernanda Ramos de Deus
  • J P B de Sousa
  • A Fernandes
  • J P B Sousa
  • João Paulo Barreto Sousa
  • A S Figueiredo
  • João Pessoa Araújo Júnior
  • J M G Candeias
  • L Shinohara
  • F Frilli
  • S R C Funari
  • C Giovani
  • R Barbattini
  • Roueda A Said
  • Bruno R Darros
  • Daisy M F Salvadori
  • A M V C Soares
  • Lúcia Regina Ribeiro
  • João Lauro Viana de Camargo
  • S A Calvi
  • Daisy Maria Favero Salvadori
  • Maria Aparecida Marchesan Rodrigues

Detail Information

Publications29

  1. doi request reprint Lemongrass effects on IL-1beta and IL-6 production by macrophages
    J M Sforcin
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    Nat Prod Res 23:1151-9. 2009
    ..Taken together, these data suggest an anti-inflammatory action of this natural product...
  2. doi request reprint Propolis: is there a potential for the development of new drugs?
    José Maurício Sforcin
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, SP, Brazil
    J Ethnopharmacol 133:253-60. 2011
    ..Researchers have been interested in the investigation of isolated compounds responsible for propolis action; however, there is lack of clinical research on the effects of propolis...
  3. ncbi request reprint Effect of a leukotriene inhibitor (MK886) on nitric oxide and hydrogen peroxide production by macrophages of acutely and chronically stressed mice
    José Maurício Sforcin
    Departamento de Microbiologia e Imunologia, Instituto de Biociencias, UNESP, Botucatu, SP 18618 000, Brazil
    J Pharm Pharmacol 59:1249-54. 2007
    ..Our data suggest an important role of leukotrienes in NO synthesis, which is important in controlling replication of several infectious agents, mainly in stressed and immunosuppressed animals...
  4. ncbi request reprint Propolis and the immune system: a review
    J M Sforcin
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, SP, Brazil
    J Ethnopharmacol 113:1-14. 2007
    ..This review opens a new perspective on the investigation of propolis biological properties, mainly with respect to the immune system...
  5. doi request reprint Th1/Th2 cytokines' expression and production by propolis-treated mice
    Claudio Lera Orsatti
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    J Ethnopharmacol 129:314-8. 2010
    ..The goal of this work was to evaluate the effect of propolis administration over a short-term to mice on Th1 (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-10) cytokines' expression and production...
  6. doi request reprint Th1/Th2 cytokine production by clove-treated mice
    Tatiana Fernanda Bachiega
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    Nat Prod Res 23:1552-8. 2009
    ..Further studies dealing with cytokine expression and production will provide a better understanding of clove's immunomodulatory and anti-inflammatory actions, using different extract concentrations and different intake periods...
  7. doi request reprint Propolis effects on pro-inflammatory cytokine production and Toll-like receptor 2 and 4 expression in stressed mice
    Ana Carolina Pagliarone
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, SP, Brazil
    Int Immunopharmacol 9:1352-6. 2009
    ....
  8. ncbi request reprint Modifying effect of propolis on dimethylhydrazine-induced DNA damage but not colonic aberrant crypt foci in rats
    Rodrigo O Alves de Lima
    Departamento de Patologia, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil
    Environ Mol Mutagen 45:8-16. 2005
    ..Further investigations are recommended in order to establish the conditions under which propolis produces either protective or deleterious effects...
  9. doi request reprint Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages
    Tatiana Fernanda Bachiega
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, Brazil
    J Pharm Pharmacol 64:610-6. 2012
    ..Herein we have analysed the immunomodulatory/anti-inflammatory effect of clove and eugenol on cytokine production (interleukin (IL)-1β, IL-6 and IL-10) in vitro...
  10. doi request reprint Propolis immunomodulatory activity on TLR-2 and TLR-4 expression by chronically stressed mice
    Claudio Lera Orsatti
    Department of Microbiology and Immunology, Biosciences Institute, Sao Paulo State University, Botucatu, Sao Paulo, Brazil
    Nat Prod Res 26:446-53. 2012
    ....
  11. doi request reprint Polymerase chain reaction detection of enterotoxins genes in coagulase-negative staphylococci isolated from Brazilian Minas cheese
    Vera Lucia Mores Rall
    Department of Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University UNESP, Botucatu, Sao Paulo, Brazil
    Foodborne Pathog Dis 7:1121-3. 2010
    ..It is essential to understand the real role of CNS in food, and based on the presence of enterotoxin genes, CNS should not be ignored in epidemiological investigations of foodborne outbreaks...
  12. doi request reprint Propolis immunomodulatory action in vivo on Toll-like receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice
    C L Orsatti
    Department of Microbiology and Immunology, Bioscience Institute, UNESP, 18618 000 SP, Brazil
    Phytother Res 24:1141-6. 2010
    ..One may conclude that propolis activated the initial steps of the immune response by upregulating TLRs expression and the production of pro-inflammatory cytokines in mice, modulating the mechanisms of the innate immunity...
  13. ncbi request reprint Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables
    F Mani
    Department of Chemistry and Biochemistry, Biosciences Institute, UNESP, 18600 000 Botucatu, SP, Brazil
    J Ethnopharmacol 105:95-8. 2006
    ..On the basis of our findings, since propolis does not induce any significant change in seric parameters, it is claimed that long-term administration of propolis might not have any cardiac injury...
  14. doi request reprint In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages
    T G Rodrigues
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    Nat Prod Res 23:319-26. 2009
    ..Eugenol was found to be the major component of the clove extract and essential oil, and probably is the causative agent of cytokine inhibition. Taken together, these data suggest an anti-inflammatory action of this spice...
  15. doi request reprint Propolis effect on Th1/Th2 cytokines production by acutely stressed mice
    Ana Carolina Pagliarone
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, SP, Brazil
    J Ethnopharmacol 125:230-3. 2009
    ..The purpose of this study was to investigate propolis effect on Th1/Th2 cytokines production by spleen cells of acutely stressed mice. Serum corticosterone concentration was determined as a stress indicator...
  16. doi request reprint Lemongrass and citral effect on cytokines production by murine macrophages
    Tatiana Fernanda Bachiega
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP 18618 970, Brazil
    J Ethnopharmacol 137:909-13. 2011
    ..Thus, the goal of this work was to analyze the effect of LG and citral on cytokines production (IL-1β, IL-6 and IL-10) in vitro, as well as before or after LPS incubation...
  17. ncbi request reprint Protective action of propolis on the rat colon carcinogenesis
    Ana Paula Bazo
    Departamento de Patologia, Faculdade de Medicina, UNESP, Botucatu, Sao Paulo, Brazil
    Teratog Carcinog Mutagen 22:183-94. 2002
    ..These data suggest that propolis has a protective influence on the process of colon carcinogenesis, suppressing the development of preneoplastic lesions, and probably exerts no protection against the initiation of carcinogenesis...
  18. pmc Cinnamic Acid is partially involved in propolis immunomodulatory action on human monocytes
    Bruno José Conti
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 970 Botucatu, SP, Brazil
    Evid Based Complement Alternat Med 2013:109864. 2013
    ..Ci seemed to be partially involved in propolis activities...
  19. doi request reprint The effect of propolis on CCL5 and IFN-γ expression by peripheral blood mononuclear cells from leishmaniasis patients
    Marla Karine Amarante
    Department of Pathological Sciences, UEL, Londrina, PR, Brazil
    J Pharm Pharmacol 64:154-60. 2012
    ....
  20. ncbi request reprint Effects of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccidioides brasiliensis
    J M Murad
    Department of Microbiology and Immunology, Biosciences Institute, IB UNESP, 18618 000 Botucatu, SP, Brazil
    J Ethnopharmacol 79:331-4. 2002
    ..brasiliensis. Data suggest an increase in the fungicidal activity of macrophages by propolis stimulation, independently from its geographic origin...
  21. ncbi request reprint Effect of three vegetal sources of propolis on macrophages activation
    F C Lopes
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    Phytomedicine 10:343. 2003
  22. ncbi request reprint Effect of propolis, some isolated compounds and its source plant on antibody production
    J M Sforcin
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, S P, Brazil
    J Ethnopharmacol 98:301-5. 2005
    ..Propolis action is a consequence of plant-derived products with synergic effects, while isolated compounds or extracts from its plant sources had no effect in this assay...
  23. doi request reprint Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages
    Michelle Cristiane Búfalo
    Departamento de Microbiologia e Imunologia, Instituto de Biociencias, UNESP, 18618 970 Botucatu, SP, Brasil Faculdade de Farmácia, Universidade de Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000 548 Coimbra, Portugal
    J Ethnopharmacol 149:84-92. 2013
    ..Caffeic acid was investigated as a possible compound responsible for propolis action...
  24. pmc Anticancer effects of geopropolis produced by stingless bees on canine osteosarcoma cells in vitro
    Naiara Costa Cinegaglia
    Surgery and Orthopedics Department, Medical School, Sao Paulo State University UNESP, 18618 970 Botucatu, SP, Brazil
    Evid Based Complement Alternat Med 2013:737386. 2013
    ..Carboplatin had no effect on OSA cells. Geopropolis exerted a cytotoxic effect on canine osteosarcoma, and its introduction as a possible therapeutic agent in vivo could be investigated, providing a new contribution to OSA treatment...
  25. doi request reprint Characterisation of protease activity in extracellular products secreted by Giardia duodenalis trophozoites treated with propolis
    Erica Boarato David
    Department of Parasitology, Biosciences Institute, Universidade Estadual Paulista, Botucatu, SP, Brazil
    Nat Prod Res 26:370-4. 2012
    ..Although propolis had no effect on the proteolytic activity, further studies could identify the active constituents responsible for propolis antigiardial activity and their mechanisms of action...
  26. pmc Green brazilian propolis action on macrophages and lymphoid organs of chronically stressed mice
    Fabiane Missima
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, 18618 000 Botucatu, S P, Brazil
    Evid Based Complement Alternat Med 5:71-5. 2008
    ..Propolis treatment counteracted the alterations found in the spleen of stressed mice. New research is being carried out in order to elucidate propolis immunomodulatory action during stress...
  27. doi request reprint Anti-poliovirus activity of Baccharis dracunculifolia and propolis by cell viability determination and real-time PCR
    M C Búfalo
    Department of Microbiology and Immunology, Biosciences Institute, UNESP, Botucatu, SP, Brazil
    J Appl Microbiol 107:1669-80. 2009
    ....
  28. ncbi request reprint Radionuclides in honeybee propolis (Apis mellifera L.)
    R O Orsi
    Department of Production and Animal Exploration, School of Veterinary Medicine and Animal Husbandry, University of Sao Paulo State Unesp, Botucatu, Sao Paulo State, Brazil
    Bull Environ Contam Toxicol 76:637-40. 2006
  29. ncbi request reprint In vitro effects of propolis on Giardia duodenalis trophozoites
    S F Freitas
    Department of Parasitology, Biosciences Institute, IB UNESP, Botucatu, SP, Brazil
    Phytomedicine 13:170-5. 2006
    ..Our results hold the perspective for the utilization of propolis as an antigiardial agent...