Elisabeth F Schwartz

Summary

Country: Brazil

Publications

  1. ncbi request reprint Occurrence of tetrodotoxin and its analogues in the Brazilian frog Brachycephalus ephippium (Anura: Brachycephalidae)
    Osmindo R Pires
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia, DF 70910 900, Brazil
    Toxicon 40:761-6. 2002
  2. doi request reprint Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum
    Elisabeth F Schwartz
    Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia DF 70910 900, Brazil
    Toxicon 51:1499-508. 2008
  3. doi request reprint OcyKTx2, a new K⁺-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum
    Elisabeth F Schwartz
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910 900 DF, Brazil
    Peptides 46:40-6. 2013
  4. ncbi request reprint Occurrence of hemolytic activity in the skin secretion of the caecilian siphonops paulensis
    E N Schwartz
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, DF, Brazil
    Nat Toxins 6:179-82. 1998
  5. pmc Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)
    Elisabeth F Schwartz
    Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Avenida Universidad, Cuernavaca, Mexico
    BMC Genomics 8:119. 2007
  6. ncbi request reprint Skin secretion of Siphonops paulensis (Gymnophiona, Amphibia) forms voltage-dependent ionic channels in lipid membranes
    E F Schwartz
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia, DF, Brasil
    Braz J Med Biol Res 36:1279-82. 2003
  7. doi request reprint Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum
    Edelyn C N Silva
    Departamento de Ciencias Fisiologicas, Universidade de Brasilia, Brasilia, DF 70910 900, Brazil
    Toxicon 54:252-61. 2009
  8. ncbi request reprint HgeTx1, the first K+-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad
    Elisabeth F Schwartz
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, DF 70910 900, Brazil
    Toxicon 48:1046-53. 2006
  9. ncbi request reprint Further report of the occurrence of tetrodotoxin and new analogues in the Anuran family Brachycephalidae
    Osmindo R Pires
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia, DF, 70910 900, Brazil
    Toxicon 45:73-9. 2005
  10. pmc Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors
    Elisabeth F Schwartz
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil
    Br J Pharmacol 157:392-403. 2009

Collaborators

  • L D Possani
  • Froylan Gomez-Lagunas
  • Gina D'suze
  • Gyorgy Panyi
  • José Roberto S A Leite
  • Paulo A Melo
  • Caroline B F Mourão
  • Fagner Neves Oliveira
  • Carlos Bloch
  • Osmindo R Pires
  • Carlos A Schwartz
  • Caroline Barbosa F Mourão
  • Jimmy A Guerrero-Vargas
  • Edelyn C N Silva
  • Daniel N Sifuentes
  • Luciano P Silva
  • Elia Diego-Garcia
  • Flávio S Dourado
  • Antonio Sebben
  • Rodrigo A V Morales
  • Rita Restano-Cassulini
  • Adriano M C Pimenta
  • Harry Morales Duque
  • Daniel M Santos
  • Jacqueline C Gonçalves
  • Jéssica K A Macedo
  • Fabiana Pirani Carneiro
  • Andréa C E Carvalho
  • Eder A Barbosa
  • Maria de Fátima M Almeida Santos
  • FRANK MARI
  • Jimmy Alexander Guerrero-Vargas
  • Claudia J Arenas
  • Priscilla Galante
  • Márcia R Mortari
  • Mari D Heghinian
  • Marcia Renata Mortari
  • Verónica Quintero-Hernández
  • Thalita S Camargos
  • Ildinete Silva-Pereira
  • Andrea Q Maranhão
  • Marcelo A Tomaz
  • Hilmar D Ricardo
  • Emerson Z Arruda
  • Camila Z El-Kik
  • Marcelo A Strauch
  • Sabrina Calil-Elias
  • Blanca I Garcia
  • Jorge A T Melo
  • Cesar V F Batista
  • Ricardo C Rodríguez de la Vega
  • Sergio A Román González
  • Simone W R Largura

Detail Information

Publications19

  1. ncbi request reprint Occurrence of tetrodotoxin and its analogues in the Brazilian frog Brachycephalus ephippium (Anura: Brachycephalidae)
    Osmindo R Pires
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia, DF 70910 900, Brazil
    Toxicon 40:761-6. 2002
    ..TTX and 11-nortetrodotoxin-6(S)-ol had their presence confirmed by mass spectrometry (MALDI-TOF). The results confirm Brachycephalidae as a fourth family of anurans containing TTX...
  2. doi request reprint Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum
    Elisabeth F Schwartz
    Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia DF 70910 900, Brazil
    Toxicon 51:1499-508. 2008
    ..Comparative analysis of venom from male and female O. cayaporum was performed by HPLC and MALDI-TOF-MS showing no qualitative variations, but rather quantitative differences among both samples...
  3. doi request reprint OcyKTx2, a new K⁺-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum
    Elisabeth F Schwartz
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910 900 DF, Brazil
    Peptides 46:40-6. 2013
    ..Sequence comparison, chain length and number of disulfide bridges analysis classify OcyKTx2 into subfamily 6 of the α-KTx scorpion toxins (systematic name, α-KTx6.17)...
  4. ncbi request reprint Occurrence of hemolytic activity in the skin secretion of the caecilian siphonops paulensis
    E N Schwartz
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, DF, Brazil
    Nat Toxins 6:179-82. 1998
    ..Both trypsin- and chymotrypsin-treated SpSS were ineffective in inducing RBC lysis. The treatment of SpSS with sheep RBC ghosts reduced its activity. There is no phospholipase activity in the SpSS...
  5. pmc Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)
    Elisabeth F Schwartz
    Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Avenida Universidad, Cuernavaca, Mexico
    BMC Genomics 8:119. 2007
    ..To gain insights into the scorpion venom gland biology, we have decided to perform a transcriptomic analysis by constructing a cDNA library and conducting a random sequencing screening of the transcripts...
  6. ncbi request reprint Skin secretion of Siphonops paulensis (Gymnophiona, Amphibia) forms voltage-dependent ionic channels in lipid membranes
    E F Schwartz
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia, DF, Brasil
    Braz J Med Biol Res 36:1279-82. 2003
    ..These channels were not sensitive to 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid or tetraethylammonium ion, but the experimental protocol used does not permit us to specify their characteristics...
  7. doi request reprint Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum
    Edelyn C N Silva
    Departamento de Ciencias Fisiologicas, Universidade de Brasilia, Brasilia, DF 70910 900, Brazil
    Toxicon 54:252-61. 2009
    ....
  8. ncbi request reprint HgeTx1, the first K+-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad
    Elisabeth F Schwartz
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, DF 70910 900, Brazil
    Toxicon 48:1046-53. 2006
    ..Sequence comparison, chain length and number of disulfide bridges analysis classify HgeTx1 into subfamily 6 of the alpha-KTx scorpion toxins (systematic name: alpha-KTx 6.14)...
  9. ncbi request reprint Further report of the occurrence of tetrodotoxin and new analogues in the Anuran family Brachycephalidae
    Osmindo R Pires
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia, DF, 70910 900, Brazil
    Toxicon 45:73-9. 2005
    ..Two new components were also identified by mass spectrometry (348 and 330Da). These unknown compounds have daughter ions similar to TTX, suggesting new putative TTX analogues...
  10. pmc Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors
    Elisabeth F Schwartz
    Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil
    Br J Pharmacol 157:392-403. 2009
    ..Here we describe hadrucalcin, a novel member of this family...
  11. ncbi request reprint Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of "orphan" components
    Elia Diego-Garcia
    Department of Molecular Medicine and Bioprocesses, Institute of Biotechnology, National Autonomous University of Mexico, Avenida Universidad, 2001, Cuernavaca 62210, Mexico
    Peptides 28:31-7. 2007
    ..The biological function for most of these peptides is not well known; that is why they are here considered "orphan" peptides...
  12. doi request reprint Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family
    Caroline B F Mourão
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Universidade de Brasilia, Brasilia, DF 70910 900, Brazil
    Biochemistry 52:2440-52. 2013
    ..2, hNav1.4, hNav1.5, and hNav1.6 channels. Because of its unique sequence and cysteine assignment to the HWTX-II family, Ap1a is a significant contribution to the structure-function study of this family of toxins...
  13. pmc Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins
    Jimmy A Guerrero-Vargas
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Universidade de Brasilia, Brasilia, Distrito Federal, Brazil
    PLoS ONE 7:e30478. 2012
    ..pachyurus and T. obscurus venom glands and to analyze their phylogenetic relationship with other known NaScTxs from Tityus species...
  14. doi request reprint Another record of significant regional variation in toxicity of Tityus serrulatus venom in Brazil: a step towards understanding the possible role of sodium channel modulators
    Fagner Neves Oliveira
    Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Brasilia, DF 70910 900, Brazil
    Toxicon 73:33-46. 2013
    ....
  15. ncbi request reprint Antimicrobial peptide from the skin secretion of the frog Leptodactylus syphax
    Flávio S Dourado
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Instituto de Ciencias Biologicas, Universidade de Brasilia, Campus Universitario Darcy Ribeiro, Brasilia, DF 70910 900, Brazil
    Toxicon 50:572-80. 2007
    ....
  16. pmc Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals
    Caroline B F Mourão
    Laboratory of Toxinology, Department of Physiological Sciences, University of Brasilia, Brasilia, DF 70910 900, Brazil
    Mar Drugs 11:2069-112. 2013
    ..The key-residues for the K+ channel blocking activity was also compared...
  17. doi request reprint Venomic and pharmacological activity of Acanthoscurria paulensis (Theraphosidae) spider venom
    Caroline Barbosa F Mourão
    Laboratorio de Toxinologia, Departamento de Ciencias Fisiologicas, Universidade de Brasilia, Instituto de Ciencias Biologicas, Brasília 70910 900, DF, Brazil
    Toxicon 61:129-38. 2013
    ..These results suggest that despite low toxicity, A. paulensis venom can induce severe physiological disturbances in mice...
  18. ncbi request reprint Arthropod venoms: a vast arsenal of insecticidal neuropeptides
    Elisabeth F Schwartz
    Departamento de Ciencias Fisiologicas, Laboratorio de Toxinologia, Universidade de Brasilia, Brasilia, DF 70910 900, Brazil
    Biopolymers 98:385-405. 2012
    ....
  19. ncbi request reprint Ability of suramin to antagonize the cardiotoxic and some enzymatic activities of Bothrops jararacussu venom
    Daniel N Sifuentes
    Laboratorio de Toxinologia, Departamento de Ciências Fisiológicas IB, UnB, Brazil
    Toxicon 51:28-36. 2008
    ..The PLA(2) and proteolytic activities of B. jararacussu crude venom were also inhibited in a concentration-dependent way by suramin, showing that this polyanion antivenom activity has therapeutic potential to be used as an antivenom...