Raul D Santos

Summary

Country: Brazil

Publications

  1. ncbi request reprint Atorvastatin enhances the plasma clearance of chylomicron-like emulsions in subjects with atherogenic dyslipidemia: relevance to the in vivo metabolism of triglyceride-rich lipoproteins
    Andrei C Sposito
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Atherosclerosis 166:311-21. 2003
  2. ncbi request reprint Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency
    Raul D Santos
    Lipid Clinic and Lipid Metabolism Laboratory, Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    J Lipid Res 49:349-57. 2008
  3. doi request reprint A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: the Lipid Treatment Assessment Project 2
    Raul D Santos
    The Lipid Clinic Heart Institute InCor, University of São Paulo Hospital, Sao Paulo, Brazil
    Atherosclerosis 224:150-3. 2012
  4. ncbi request reprint Elevated uric acid, the metabolic syndrome and cardiovascular disease: cause, consequence, or just a not so innocent bystander?
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Endocrine 41:350-2. 2012
  5. pmc Algorithm for the treatment of type 2 diabetes: a position statement of Brazilian Diabetes Society
    Antonio C Lerario
    Medicine School of State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Diabetol Metab Syndr 2:35. 2010
  6. doi request reprint Clinical perspective: have the results of recent clinical trials of lipid-lowering therapies influenced the way we should practice? A Latin American perspective of current issues in clinical lipidology
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Av Dr Eneas C Aguiar 44 Bloco 2 Segundo Andar Sala 4 CEP 05403 900, Sao Paulo, Brazil
    J Clin Lipidol 5:124-32. 2011
  7. doi request reprint Association of changes in bone remodeling and coronary calcification in hemodialysis patients: a prospective study
    Daniela Veit Barreto
    Department of Internal Medicine, Division of Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Am J Kidney Dis 52:1139-50. 2008
  8. doi request reprint Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study
    Carolina L Z Vieira
    Heart Institute, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Periodontol 82:683-8. 2011
  9. ncbi request reprint Delayed intravascular catabolism of chylomicron-like emulsions is an independent predictor of coronary artery disease
    Andrei C Sposito
    Heart Institute InCor, University of Sao Paulo Medical School, Hospital, Av Dr Enéas Carvalho Aguiar 44, 1o andar, 5403 900 São Paulo, Brazil
    Atherosclerosis 176:397-403. 2004
  10. ncbi request reprint No correlation and low agreement of imaging and inflammatory atherosclerosis' markers in familial hypercholesterolemia
    Lilton R C Martinez
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 200:83-8. 2008

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Atorvastatin enhances the plasma clearance of chylomicron-like emulsions in subjects with atherogenic dyslipidemia: relevance to the in vivo metabolism of triglyceride-rich lipoproteins
    Andrei C Sposito
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Atherosclerosis 166:311-21. 2003
    ..Such effect might implicate in reduction of cardiovascular risk...
  2. ncbi request reprint Characterization of high density lipoprotein particles in familial apolipoprotein A-I deficiency
    Raul D Santos
    Lipid Clinic and Lipid Metabolism Laboratory, Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    J Lipid Res 49:349-57. 2008
    ....
  3. doi request reprint A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: the Lipid Treatment Assessment Project 2
    Raul D Santos
    The Lipid Clinic Heart Institute InCor, University of São Paulo Hospital, Sao Paulo, Brazil
    Atherosclerosis 224:150-3. 2012
    ..This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study...
  4. ncbi request reprint Elevated uric acid, the metabolic syndrome and cardiovascular disease: cause, consequence, or just a not so innocent bystander?
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Endocrine 41:350-2. 2012
    ..The topic of increased UA concentrations, its consequences or associations is getting more important nowadays due to the increments in the prevalence of obesity and the MS in both developed and developing countries...
  5. pmc Algorithm for the treatment of type 2 diabetes: a position statement of Brazilian Diabetes Society
    Antonio C Lerario
    Medicine School of State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Diabetol Metab Syndr 2:35. 2010
    ....
  6. doi request reprint Clinical perspective: have the results of recent clinical trials of lipid-lowering therapies influenced the way we should practice? A Latin American perspective of current issues in clinical lipidology
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Av Dr Eneas C Aguiar 44 Bloco 2 Segundo Andar Sala 4 CEP 05403 900, Sao Paulo, Brazil
    J Clin Lipidol 5:124-32. 2011
    ..The group also agreed that the evidence from recent clinical trials supports the potential role of new biomarkers for the screening and identification of patients at high cardiovascular risk in the absence of overt hyperlipidemia...
  7. doi request reprint Association of changes in bone remodeling and coronary calcification in hemodialysis patients: a prospective study
    Daniela Veit Barreto
    Department of Internal Medicine, Division of Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Am J Kidney Dis 52:1139-50. 2008
    ..The aim of this study is to prospectively evaluate the association between bone remodeling disorders and progression of coronary artery calcification (CAC) in hemodialysis patients...
  8. doi request reprint Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study
    Carolina L Z Vieira
    Heart Institute, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Periodontol 82:683-8. 2011
    ..All subjects were free of previous vascular disease manifestations...
  9. ncbi request reprint Delayed intravascular catabolism of chylomicron-like emulsions is an independent predictor of coronary artery disease
    Andrei C Sposito
    Heart Institute InCor, University of Sao Paulo Medical School, Hospital, Av Dr Enéas Carvalho Aguiar 44, 1o andar, 5403 900 São Paulo, Brazil
    Atherosclerosis 176:397-403. 2004
    ..In conclusion, we presently show that the rate of lipolysis and removal from the circulation of chylomicron-like emulsions constitutes an independent predictor of CAD and a marker of CAD severity...
  10. ncbi request reprint No correlation and low agreement of imaging and inflammatory atherosclerosis' markers in familial hypercholesterolemia
    Lilton R C Martinez
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 200:83-8. 2008
    ..1). In conclusion, clinical parameters poorly explained IMT, CAC and PWV variability in FH subjects. Furthermore, imaging markers and inflammatory biomarkers presented a poor agreement degree of their severity for CHD prediction...
  11. ncbi request reprint Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome in patients with stable angina undergoing secondary prevention treatment: a long-term follow-up study
    Andrei C Sposito
    Heart Institute InCor, Zerbini Foundation, Brasilia, Brazil
    J Am Coll Cardiol 43:2225-32. 2004
    ..We sought to verify whether the intravascular metabolism of chylomicron-like emulsion may predict the clinical evolution of patients with coronary artery disease (CAD) undergoing secondary prevention therapy of CAD...
  12. doi request reprint Thioredoxin interacting protein genetic variation is associated with diabetes and hypertension in the Brazilian general population
    Noely E Ferreira
    Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Atherosclerosis 221:131-6. 2012
    ..To investigate the relationship between TXNIP polymorphisms, diabetes and hypertension phenotypes in the Brazilian general population...
  13. ncbi request reprint Relation of uric acid levels to presence of coronary artery calcium detected by electron beam tomography in men free of symptomatic myocardial ischemia with versus without the metabolic syndrome
    Raul D Santos
    Lipid Clinic, The Heart Institute InCor University of Sao Paulo Medical School Hospital Sao Paulo, Sao Paulo, Brazil
    Am J Cardiol 99:42-5. 2007
    ..11) or higher levels of CAC (p = 0.16). In conclusion, our study suggests that, among asymptomatic moderate-risk men, high UA levels were independently associated with CAC in subjects with the MS...
  14. ncbi request reprint Metabolic syndrome is associated with coronary artery calcium in asymptomatic white Brazilian men considered low-risk by Framingham risk score
    Raul D Santos
    Lipid Clinic Heart Institute InCor, Univerisity of São Paulo Medical School Hospital, Sao Paulo, Brazil
    Prev Cardiol 10:141-6. 2007
    ..In conclusion, metabolic syndrome is associated with subclinical atherosclerosis in Brazilian participants considered at low risk according to FRS...
  15. doi request reprint Low- and high-density lipoprotein cholesterol goal attainment in dyslipidemic women: The Lipid Treatment Assessment Project (L-TAP) 2
    Raul D Santos
    Lipid Clinic, Heart Institute, University of São Paulo Hospital, Brazil
    Am Heart J 158:860-6. 2009
    ..This analysis evaluates whether low-density lipoprotein cholesterol (LDL-C) success rates according to current guidelines and high-density lipoprotein cholesterol (HDL-C) levels differ by gender in the L-TAP 2 population...
  16. doi request reprint Vertebral bone density by quantitative computed tomography mirrors bone structure histomorphometric parameters in hemodialysis patients
    Aluizio Barbosa Carvalho
    Nephrology Division, Federal University of Sao Paulo, Rua Borges Lagoa, 960, Sao Paulo, SP, 04038 002, Brazil
    J Bone Miner Metab 31:551-5. 2013
    ..06; 95 % CI 0.02-0.11; p = 0.006; R² = 0.49). VTBD measured by QCT mirrored bone volume and microarchitecture parameters obtained by histomorphometry in HD patients...
  17. pmc Is coronary artery calcification associated with vertebral bone density in nondialyzed chronic kidney disease patients?
    Agostinho Filgueira
    Department of Internal Medicine, Division of Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Clin J Am Soc Nephrol 6:1456-62. 2011
    ..The study presented here aimed to investigate whether reduced vertebral bone density (VBD) was associated with the presence of CAC in the earlier stages of CKD...
  18. ncbi request reprint Non-invasive detection of aortic and coronary atherosclerosis in homozygous familial hypercholesterolemia by 64 slice multi-detector row computed tomography angiography
    Raul D Santos
    Lipid Clinic, Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 197:910-5. 2008
    ..Our data suggest that CTCA could be a useful non-invasive method for detection of early aortic and coronary atherosclerosis specifically affecting the coronary ostia in HoFH subjects...
  19. doi request reprint Thoracic aorta calcification detected by electron beam tomography predicts all-cause mortality
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 209:131-5. 2010
    ..However, the predictive value of thoracic aorta calcification (TAC), which can be additionally identified without further scanning during assessment of CAC, is unknown...
  20. doi request reprint Transfer of lipids to high-density lipoprotein (HDL) is altered in patients with familial hypercholesterolemia
    Lilton R C Martinez
    Lipid Clinic, Heart Institute InCor of the Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Metabolism 62:1061-4. 2013
    ..Here, lipid transfers to HDL, an important step for HDL intravascular metabolism and for HDL role in reverse cholesterol transport (RCT) were investigated in FH patients...
  21. doi request reprint Atorvastatin treatment improves myocardial and peripheral blood flow in familial hypercholesterolemia subjects without evidence of coronary atherosclerosis
    Fabio C Lario
    Echocardiography Laboratory, Heart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Echocardiography 30:64-71. 2013
    ..This study investigated the effects of lipid-lowering therapy on coronary and peripheral artery circulation in patients with familial hypercholesterolemia (FH)...
  22. doi request reprint Evaluation of subclinical atherosclerosis by computed tomography coronary angiography and its association with risk factors in familial hypercholesterolemia
    Marcio H Miname
    Lipid Clinic Heart Institute InCor, University of Sao Paulo, Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 213:486-91. 2010
    ..Increasing age and cholesterol levels, male gender, and family history of early coronary heart disease (CHD) are associated with early onset of CHD in familial hypercholesterolemia (FH)...
  23. doi request reprint Uric acid: A marker of increased cardiovascular risk
    Ana C M Gagliardi
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 202:11-7. 2009
    ..Increased uric acid levels are independent markers of cardiovascular disease risk. Prospective studies are necessary to show that reduction of uric acid levels prevent cardiovascular events...
  24. ncbi request reprint Clinical presentation, laboratory values, and coronary heart disease risk in marked high-density lipoprotein-deficiency states
    Raul D Santos
    Lipid Clinic, Heart Institute InCor University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    J Clin Lipidol 2:237-47. 2008
    ..Marked HDL deficiency has different etiologies and is generally associated with early CHD risk...
  25. pmc Hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased systemic inflammation
    Chiadi E Ndumele
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 31:1927-32. 2011
    ..The goal of this study was to assess the independent and collective associations of hepatic steatosis, obesity, and the metabolic syndrome with elevated high-sensitivity C-reactive protein (hs-CRP) levels...
  26. ncbi request reprint Hypercholesterolemia blunts forearm vasorelaxation and enhances the pressor response during acute systemic hypoxia
    José Augusto S Barreto-Filho
    The Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Brazil
    Arterioscler Thromb Vasc Biol 23:1660-6. 2003
    ..As hypercholesterolemia is a major cause of endothelial dysfunction, it may interfere with these responses...
  27. doi request reprint The Finnish Diabetes Risk Score (FINDRISC) as a screening tool for hepatic steatosis
    Jose A M Carvalho
    Preventive Medicine Center Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Ann Med 43:487-94. 2011
    ..80 (95% CI 0.77-0.83); 0.80 in men (95% CI 0.77-0.83) and 0.83 (95% CI 0.73-0.93) in women. CONCLUSIONS. Our data suggest that the FINDRISC could be a useful primary screening tool for the presence of steatosis...
  28. ncbi request reprint Plasma kinetics of a cholesterol-rich emulsion in subjects with or without coronary artery disease
    Raul D Santos
    Lipid Metabolism Laboratory, The Heart Institute InCor, Medical School Hospital InCor HCFMUSP, University of Sao Paulo, Sao Paulo, Brazil
    J Lipid Res 44:464-9. 2003
    ..In conclusion, both removal from the plasma and esterification of the LDE-cholesterol were increased in CAD. These findings may contribute for unraveling pro-atherogenic mechanisms and the establishment of novel CAD markers...
  29. ncbi request reprint Clearance of a 3H-labeled chylomicron-like emulsion following the acute phase of myocardial infarction
    Ana Paula M Chacra
    Heart Institute InCor University of Sao Paulo Medical School, Sao Paulo, Brazil
    Int J Cardiol 93:181-7. 2004
    ..The metabolism of chylomicrons, the lipoproteins that carry the dietary lipids in the bloodstream has not yet been studied in acute myocardial infarction patients...
  30. ncbi request reprint Effects in post-menopausal women of transdermal estrogen associated with progestin upon the removal from the plasma of a microemulsion that resembles low-density lipoprotein (LDL)
    Nilson R Melo
    Department of Gynecology, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Maturitas 50:275-81. 2005
    ....
  31. ncbi request reprint Difference in atherosclerosis burden in different nations and continents assessed by coronary artery calcium
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 187:378-84. 2006
    ..In this study, significant differences in CACS were detected among three nations in different continents. The CACS differences paralleled the respective cardiovascular mortality rates...
  32. doi request reprint Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study
    Maria C Izar
    Cardiology Division, Department of Medicine, Rua Pedro de Toledo 276, Sao Paulo, SP, Brazil
    Atherosclerosis 204:165-70. 2009
    ....
  33. ncbi request reprint Favorable effects of ezetimibe alone or in association with simvastatin on the removal from plasma of chylomicrons in coronary heart disease subjects
    Otavio Celeste Mangili
    Heart Institute InCor University of Sao Paulo Medical Scholl Hospital, Sao Paulo, Brazil
    Atherosclerosis 233:319-25. 2014
    ..Effects of ezetimibe alone or in combination with simvastatin were compared with low and high dose of the latter, upon the kinetics of a chylomicron-like emulsion in coronary heart disease (CHD) patients...
  34. doi request reprint Association between postprandial triglycerides and coronary artery disease detected by coronary computed tomography angiography
    Henrique L Staniak
    Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 233:381-6. 2014
    ..Nevertheless the relationship between less severe atherosclerosis plaque burden and postprandial TG is less established...
  35. ncbi request reprint Phosphate binder impact on bone remodeling and coronary calcification--results from the BRiC study
    Daniela Veit Barreto
    Division of Nephrology, Department of Internal Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil
    Nephron Clin Pract 110:c273-83. 2008
    ..This is a prospective study that compares the effects of calcium acetate and sevelamer on coronary calcification (CAC) and bone histology...
  36. ncbi request reprint Cardiovascular and metabolic syndrome risk among men with and without erectile dysfunction: case-control study
    João Paulo Zambon
    Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Sao Paulo Med J 128:137-40. 2010
    ....
  37. doi request reprint Lipid transfers to HDL are predictors of precocious clinical coronary heart disease
    Raul C Maranhão
    Heart Institute InCor of the Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Clin Chim Acta 413:502-5. 2012
    ..The aim was to investigate whether precocious CAD patients show abnormalities in lipid transfers to HDL, a fundamental step in HDL metabolism and function...
  38. ncbi request reprint Obesity and its association with other cardiovascular risk factors in school children in Itapetininga, Brazil
    Abel Pereira
    Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Rua Expedicionários 1700, Sao Paulo, SP, Brazil
    Arq Bras Cardiol 93:253-60. 2009
    ..Paucity of data on childhood obesity and cardiovascular risk in Brazil...
  39. ncbi request reprint Pulse wave velocity--a useful tool for cardiovascular surveillance in pre-dialysis patients
    Marcelo M Lemos
    Department of Internal Medicine, Division of Nephrology, Hospital do Rim e Hipertensao, Federal University of Sao Paulo, Sao Paulo, Brazil
    Nephrol Dial Transplant 22:3527-32. 2007
    ..Few data are available concerning PWV in pre-dialysis patients. The aim of this study was to evaluate the association between PWV and cardiovascular disease in pre-dialysis...
  40. ncbi request reprint What is new in familial hypercholesterolemia?
    Raul D Santos
    Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Curr Opin Lipidol 25:183-8. 2014
    ..The purpose of this review is to describe advances in the diagnosis, cause, metabolism, risk factors for atherosclerosis, and treatment of familial hypercholesterolemia...
  41. doi request reprint Statin restores cardiac autonomic response to acute hypoxia in hypercholesterolaemia
    Maria S Brasileiro-Santos
    Instituto do Coração InCor, Universidade de Sao Paulo, Sao Paulo, Brazil Universidade Federal de São Paulo UNIFESP, Sao Paulo, Brazil Universidade Federal da Paraíba, Joao Pessoa, Brazil
    Eur J Clin Invest 43:1291-8. 2013
    ..Hypercholesterolaemia may alter cardiovascular autonomic function. We investigated the autonomic cardiovascular regulation during normoxia and hypoxia in familial isolated HC patients with or without statin treatment...
  42. pmc Pre-historic eating patterns in Latin America and protective effects of plant-based diets on cardiovascular risk factors
    Julio C Acosta Navarro
    Heart Institute, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 65:1049-54. 2010
    ....
  43. ncbi request reprint Combined effect of high low-density lipoprotein cholesterol and metabolic syndrome on subclinical coronary atherosclerosis in white men without clinical evidence of myocardial ischemia
    Catherine Y Campbell
    The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 100:840-3. 2007
    ..In conclusion, these results suggest that the risk of CAC in asymptomatic men with moderate or high LDL cholesterol is magnified in persons with MS...