Felipe Saldanha Araujo
Serejo T, Silva Carvalho A, Braga L, Neves F, Pereira R, Carvalho J, et al
. Assessment of the Immunosuppressive Potential of INF-γ Licensed Adipose Mesenchymal Stem Cells, Their Secretome and Extracellular Vesicles. Cells. 2019;8: pubmed publisher
..These results contribute towards the development of new strategies to control the immune response based on AMSCs or their derived products. ..
Alexandre Ramos D, Silva Carvalho A, Lacerda M, Serejo T, Franco O, Pereira R, et al
. LL-37 treatment on human peripheral blood mononuclear cells modulates immune response and promotes regulatory T-cells generation. Biomed Pharmacother. 2018;108:1584-1590 pubmed publisher
Filiú Braga L, Serejo T, Lucena Araujo A, Neves F, de Carvalho J, Rego E, et al
. Unraveling KDM4 histone demethylase expression and its association with adverse cytogenetic findings in chronic lymphocytic leukemia. Med Oncol. 2018;36:3 pubmed publisher
..The present data clearly show that the expression of KDM4 members is dysregulated in CLL and impact the prognosis of this leukemia. These findings are useful for a better understanding of the impact of epigenetics on CLL progression. ..
Alves Silva J, de Carvalho J, Rabello D, Serejo T, Rego E, Neves F, et al
. GLP overexpression is associated with poor prognosis in Chronic Lymphocytic Leukemia and its inhibition induces leukemic cell death. Invest New Drugs. 2018;36:955-960 pubmed publisher
..Altogether, the present data demonstrate that these methyltransferases can be potential markers for disease progression, as well as a promising epigenetic target for CLL treatment and the prevention of disease evolution. ..
Oliveira Santos W, Rabello D, Lucena Araujo A, de Oliveira F, Rego E, Pittella Silva F, et al
. Residual expression of SMYD2 and SMYD3 is associated with the acquisition of complex karyotype in chronic lymphocytic leukemia. Tumour Biol. 2016;37:9473-81 pubmed publisher
..These results may provide the basis for the development of new therapeutic strategies to prevent CLL progression. ..
de Oliveira Bravo M, Carvalho J, Saldanha Araujo F. Adenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression. Purinergic Signal. 2016;12:595-609 pubmed
..Finally, we mention the main challenges and hurdles to bring such molecule to clinical settings. ..
Oliveira Bravo M, Sangiorgi B, Schiavinato J, Carvalho J, Covas D, Panepucci R, et al
. LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells. Stem Cell Res Ther. 2016;7:189 pubmed publisher