Pedro W Rosario

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..We conclude that further studies are needed to define in which patients undetectable basal Tg (negative TgAb) combined with negative US is sufficient, and no additional tests are required...

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..We propose that screening based on phenotypic alterations is cost-effective since these changes occur early and almost universally in acromegaly and are uncommon in the general population...

..To evaluate the efficacy of recombinant human thyroid stimulating hormone [rhTSH (versus hypothyroidism)] in thyroid ablation with an activity of 1.1 GBq (30 mCi) (131)I...

..The TSH levels achieved and the safety of 24 cycles of rhTSH administration (ablation and control assessment) are reported...

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..To evaluate the contribution of (131)I scintigraphy and ultrasonography to the prediction of malignancy in thyroid nodules with indeterminate cytology in euthyroid patients...

..To report the results of cytology and histology obtained for a series of systematically resected thyroid nodules >or= 4 cm...

..The objective of this study was to compare the area under the curve (AUC) of TSH obtained after L-T4 withdrawal versus administration of rhTSH...

..SCH is not completely asymptomatic in women aged < 65 years, and is associated with heart abnormalities and with increased bone turnover and reduced BMD even before menopause...

..14 microg/L for the GH IRMA DSL and GH IFMA AutoDelfia kits and 0.25 microg/L for the GH ICMA Immulite kit; for women, 0.25 microg/L, 0.40 microg/L and 0.70 microg/L, respectively...

..Therefore, we sought to evaluate the natural history of this milder form of SCH (TSH < or =10 mIU/L with normal thyroid hormone levels) in adult women patients...

..One important aspect in the decision to treat or not elderly patients with subclinical hyperthyroidism (SCH) is the risk of progression to overt hyperthyroidism (OH)...

..To evaluate the frequency of elevated TSH in pregnant women of low risk for thyroid dysfunction...

..To determine the normal values of serum IGF-1 (Immulite 2000) in a Brazilian adult (21-70 years) population...

..To evaluate the frequency of subclinical acromegaly (in the absence of clinical phenotype but biochemically uncontrolled) in patients with prolactinoma during treatment with dopaminergic agonists...

..This study compared the efficacies of rhTSH and thyroid hormone withdrawal (THW) to prepare patients at high risk of relapse for RA...

..To establish limits of normal serum TSH for the adult (18 to 60 years) Brazilian population according to recommendations of the National Academy of Clinical Biochemistry...

..The present results suggest that the prevalence of acromegaly is underestimated and further studies are needed to evaluate the cost-effectiveness of biochemical screening in certain groups of patients...

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..The objective of this prospective study was to compare the damage caused by 131I (3.7 GBq) when these 2 preparations are used...

..In cases with lung metastases, the persistence of micronodules on CT was associated with the persistence of detectable Tg in patients presenting negative post-therapy WBS...

..The purpose of this study was to evaluate the ultrasonographic characteristics of metastatic lymph nodes in patients with papillary thyroid carcinoma...

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..Elevated Tg levels suggest the presence of metastases, indicating the need for ablative therapy with posttreatment scanning, which might reveal non-apparent metastases...

..To determine the usefulness of thyroglobulin (Tg) before ablation and the correlation with posttreatment scanning in patients with thyroid carcinoma...

..To determine the usefulness of thyroglobulin (Tg) stimulation in low-risk patients with undetectable Tg on T4 and negative neck ultrasound (US) after initial therapy of thyroid carcinoma...

..To determine the success of ablative treatment using fixed high doses of 131I in patients with thyroid cancer...

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..In contrast, the routine use of posttherapy scanning is questioned...

..Our data suggest that ablative therapy employing a dose of 100 to 300 mCi is safe in young individuals, but persistent complications such as salivary dysfunction and conjunctivitis may occur...

..Patients with a positive post-therapy scan may show a significant reduction in Tg, with even complete remission in some cases after radioiodine, but the impact of this treatment on mortality remains controversial...

..The studies also show that the administration of recombinant TSH is safe, with few mild or moderate adverse effects...

..To evaluate a highly sensitive thyroglobulin (Tg) assay [functional sensitivity (FS): 0.1 ng/ml] (Tg-ICMA) in low-risk patients with known Tg on T4 < or = 1 ng/ml measured by a traditional assay (FS: 1 ng/ml) (Tg-IRMA)...

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..The present study evaluated the evolution of these pregnancies and the consequences for the offspring...

..Recurrence after 5 years was only 1.3% in patients without apparent disease (negative US and DxWBS) and stimulated Tg <1 ng/ml. An algorithm for the follow-up of high-risk patients after initial therapy is presented in this study...

..The T4 dose reduction protocol proved to be useful for Tg stimulation and ablative therapy, without the complication of severe hypothyroidism or the cost of recombinant TSH...

..To determine the stunning effect of a tracer dose of 5 mCi iodine-131...

..All committee members further revised and refined the document. The guidelines were developed based on the expert opinion of the committee participants, as well as on previously published information...

..In conclusion, plasma FVIII levels are elevated in women with type 2 diabetes and macrovascular disease. It also appears that this is not mediated by inflammation or endothelial injury and is likely to be due to an alternate mechanism...