Genomes and Genes
Affiliation: Rio de Janeiro
- Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infectionAndre Bafica
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 177:3515-9. 2006..Our results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and that TLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-gamma synthesis during infection with T. cruzi...
- Role of the Toll/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasitesRicardo T Gazzinelli
Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Immunol Rev 201:9-25. 2004....
- Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88Marco A Campos
Department of Biochemistry and Immunology, Instituto de Ciencias Biologicas, and School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
J Immunol 172:1711-8. 2004..This pathway is partially dependent on MyD88 and necessary for mounting optimal inflammatory and RNI responses that control T. cruzi replication during the early stages of infection...
- Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and functionBernardo S Franklin
Immunopathology Laboratory, René Rachou Institute, Fundacao Oswaldo Cruz, Avenue Augusto de Lima 1715, MG 30190, Belo Horizonte, Brazil
Proc Natl Acad Sci U S A 106:5789-94. 2009....
- Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruziCatherine Ropert
Laboratory of Immunopathology, Centro de Pesquisas Rene Rachou, FIOCRUZ, Av Augusto de Lima 1715, Barro Preto, 30190 002 Belo Horizonte, MG, Brazil
J Endotoxin Res 10:425-30. 2004..cruzi parasites...
- The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplicationAnderson A Andrade
, , Universidade Federal de Minas Gerais, , 6627, Campus Pampulha, 31270-901, Belo Horizonte, Minas Gerais, Brazil
Biochem J 381:437-46. 2004..e. post-penetration, but is also crucial to define the fate of virus progeny...
- Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cureAlvaro J Romanha
Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
J Infect Dis 186:823-8. 2002..These results suggest that activation of the immune system by the parasite and endogenous interferon-gamma play a major role in the efficacy of benznidazole against infection with T. cruzi...
- Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruziDaniella C Bartholomeu
Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
J Immunol 181:1333-44. 2008..cruzi genome are likely to be main parasite targets and probably become available to TLR9 when parasites are destroyed in the lysosome-fused vacuoles during parasite invasion/uptake by phagocytes...
- Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malariaCatherine Ropert
Laboratory of Immunopathology, René Rachou Institute, FIOCRUZ, Av Augusto de Lima, 1715, Belo Horizonte, MG, Brazil
Semin Immunopathol 30:41-51. 2008..These findings suggest that MyD88 may represent an Achilles' heel during Plasmodium infection...
- MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malariaBernardo S Franklin
Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil
Microbes Infect 9:881-90. 2007..chabaudi...
- Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotesCatherine Ropert
Laboratory of Immunopathology, CPqRR-FIOCRUZ, Av. Augusto de Lima 1715, MG, Belo Horizonte, Brazil
Microbes Infect 4:1015-25. 2002..We discuss the possible implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease...
- The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas diseaseCaroline Junqueira
Laboratorio de Immunopatologia, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, MG, Brazil
Expert Rev Mol Med 12:e29. 2010..cruzi strain as a vaccine shuttle that elicits potent T cell responses specific to a tumour antigen and protective immunity against a syngeneic melanoma cell line...
- Changes in cellular contractility and cytokines profile during Trypanosoma cruzi infection in miceDanilo Roman-Campos
Dept of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
Basic Res Cardiol 104:238-46. 2009..Indeed, we propose a role for IFN-gamma, TNF-alpha and MCP-1/CCL2 in the mechanical heart remodeling during experimental Chagas' disease...
- Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33Marcus V Andrade
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760, USA
Eur J Immunol 41:760-72. 2011..IL-33 may retune mast cell responses to Ag toward enhanced cytokine production and thus determine the symptoms and severity of Ag-dependent allergic and autoimmune diseases...
- Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccineCaroline Junqueira
Laboratorio de Imunopatologia, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Brazil
PLoS ONE 7:e36245. 2012..Finally, the level of protective immunity against the NY-ESO-1 expressing melanoma was associated with the magnitude of both CD4(+) T and CD8(+) T cell responses elicited by a specific immunological adjuvant...
- Inhibition of ERK1/2 and CREB phosphorylation by caspase-dependent mechanism enhances apoptosis in a fibrosarcoma cell line treated with butyrateFlávia L A Rabelo
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Caixa Postal 486, CEP 30 161 970, Belo Horizonte, Minas Gerais, Brazil
Biochem Biophys Res Commun 303:968-72. 2003..In conclusion, butyrate induced apoptosis in 2C4 cells is regulated by the levels of ERK1/2 and CREB phosphorylation in a caspase dependent mechanism...
- Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophagesCatherine Ropert
Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Brazil
J Immunol 171:1456-65. 2003..These results indicate a critical role of p38/stress-activated protein kinase-2 and NF-kappaB-dependent phosphatase in macrophage hyporesponsiveness induced by microbial products that activate TLR2 and TLR4...
- Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell lineFlávia L A Rabelo
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
Biochem Biophys Res Commun 301:968-73. 2003....