Catherine Ropert

Summary

Affiliation: Rio de Janeiro
Country: Brazil

Publications

  1. doi request reprint Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men
    Ricardo T Gazzinelli
    Immunopathology Laboratory, René Rachou Institute, Oswaldo Cruz Foundation Minas Gerais, 30190 002, Belo Horizonte, MG, Brazil Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605 02324, USA Electronic address
    Cell Host Microbe 15:132-8. 2014
  2. ncbi request reprint Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:3515-9. 2006
  3. ncbi request reprint Role of the Toll/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites
    Ricardo T Gazzinelli
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Immunol Rev 201:9-25. 2004
  4. ncbi request reprint Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88
    Marco A Campos
    Department of Biochemistry and Immunology, Instituto de Ciencias Biologicas, and School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    J Immunol 172:1711-8. 2004
  5. pmc Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function
    Bernardo S Franklin
    Immunopathology Laboratory, René Rachou Institute, Fundacao Oswaldo Cruz, Avenue Augusto de Lima 1715, MG 30190, Belo Horizonte, Brazil
    Proc Natl Acad Sci U S A 106:5789-94. 2009
  6. pmc Differential use of TLR2 and TLR9 in the regulation of immune responses during the infection with Trypanosoma cruzi
    Humberto D Gravina
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 8:e63100. 2013
  7. ncbi request reprint Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi
    Catherine Ropert
    Laboratory of Immunopathology, Centro de Pesquisas Rene Rachou, FIOCRUZ, Av Augusto de Lima 1715, Barro Preto, 30190 002 Belo Horizonte, MG, Brazil
    J Endotoxin Res 10:425-30. 2004
  8. pmc The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication
    Anderson A Andrade
    Grupo de Transdução de Sinal, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Campus Pampulha, 31270 901, Belo Horizonte, Minas Gerais, Brazil
    Biochem J 381:437-46. 2004
  9. ncbi request reprint Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure
    Alvaro J Romanha
    Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
    J Infect Dis 186:823-8. 2002
  10. ncbi request reprint Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi
    Daniella C Bartholomeu
    Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    J Immunol 181:1333-44. 2008

Collaborators

  • Marco A Campos
  • Douglas T Golenbock
  • Alan Sher
  • Daniella C Bartholomeu
  • Harry Bjorkbacka
  • Rodrigo R Resende
  • Thiago M Cunha
  • Lucia Mendonca-Previato
  • Mauricio M Rodrigues
  • Silvane M F Murta
  • Luiz R Travassos
  • Joao S Silva
  • Eicke Latz
  • Michael A Beaven
  • M M Teixeira
  • S Akira
  • Andre Bafica
  • Ricardo T Gazzinelli
  • Danilo Roman-Campos
  • Caroline Junqueira
  • Bernardo S Franklin
  • Flávia L A Rabelo
  • Humberto D Gravina
  • Policarpo Sales-Júnior
  • Silvia Guatimosim
  • Jacqueline I Alvarez-Leite
  • Jader S Cruz
  • Marcus V Andrade
  • Claudio A Bonjardim
  • Anderson A Andrade
  • Mariana G Ramos
  • Jingtao Lilue
  • Rondon Mendonça-Neto
  • Alvaro J Romanha
  • Jonathan Howard
  • Nazareth N Rocha
  • Jader Santos Cruz
  • Paula Campos
  • Hugo L Duarte
  • Aline Lara
  • Ricardo Tostes Gazzinelli
  • Hugo Leonardo Duarte
  • Enéas Ricardo Gomes
  • Enéas R Gomes
  • Lis Antonelli
  • Anderson Ferreira
  • Marcus L O Penido
  • Bruno Galvão-Filho
  • Fernando Q Cunha
  • Gerd Ritter
  • José Oswaldo Previato
  • Warrison A Andrade
  • Ana Paula C Salgado
  • Ana Tereza Guerrero
  • Shoko Iwaki
  • Jose R Cunha-Melo
  • Braulia Caetano
  • Mariane B Melo
  • Policarpo A Sales
  • Marco Antônio Ataíde
  • Peggy Parroche
  • Fanny Lauw
  • Paulo Nogueira
  • Luiz Hildebrando Pereira da Silva
  • Hugo Leonardo L Duarte
  • Rosane B de Oliveira
  • Antonio J Natali
  • Mauro Shugiro Tada
  • Dhelio Pereira
  • Policarpo A Sales-Junior
  • Soraia O Rodrigues
  • Lis R Antonelli
  • Arthur M Goncalves
  • Eneida P Valente
  • Roberta V Oliveira
  • Erna G Kroon
  • Lirlândia P de Sousa
  • Paulo C P Ferreira
  • Patrícia N G Silva
  • Anna C T C Pereira
  • Gustavo P Amarante-Mendes
  • Gabriela Brumatti
  • Rosana O Alves

Detail Information

Publications22

  1. doi request reprint Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men
    Ricardo T Gazzinelli
    Immunopathology Laboratory, René Rachou Institute, Oswaldo Cruz Foundation Minas Gerais, 30190 002, Belo Horizonte, MG, Brazil Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, 31270 901, Belo Horizonte, MG, Brazil Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605 02324, USA Electronic address
    Cell Host Microbe 15:132-8. 2014
    ..The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed. ..
  2. ncbi request reprint Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:3515-9. 2006
    ..Our results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and that TLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-gamma synthesis during infection with T. cruzi...
  3. ncbi request reprint Role of the Toll/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites
    Ricardo T Gazzinelli
    Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Immunol Rev 201:9-25. 2004
    ....
  4. ncbi request reprint Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88
    Marco A Campos
    Department of Biochemistry and Immunology, Instituto de Ciencias Biologicas, and School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    J Immunol 172:1711-8. 2004
    ..This pathway is partially dependent on MyD88 and necessary for mounting optimal inflammatory and RNI responses that control T. cruzi replication during the early stages of infection...
  5. pmc Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function
    Bernardo S Franklin
    Immunopathology Laboratory, René Rachou Institute, Fundacao Oswaldo Cruz, Avenue Augusto de Lima 1715, MG 30190, Belo Horizonte, Brazil
    Proc Natl Acad Sci U S A 106:5789-94. 2009
    ....
  6. pmc Differential use of TLR2 and TLR9 in the regulation of immune responses during the infection with Trypanosoma cruzi
    Humberto D Gravina
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS ONE 8:e63100. 2013
    ..The differential use of TLR2 and TLR9 by the immune cells during the acute phase of the infection explains why TLR9- but not TLR2-deficient mice are susceptible to T. cruzi infection...
  7. ncbi request reprint Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi
    Catherine Ropert
    Laboratory of Immunopathology, Centro de Pesquisas Rene Rachou, FIOCRUZ, Av Augusto de Lima 1715, Barro Preto, 30190 002 Belo Horizonte, MG, Brazil
    J Endotoxin Res 10:425-30. 2004
    ..cruzi parasites...
  8. pmc The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication
    Anderson A Andrade
    Grupo de Transdução de Sinal, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Campus Pampulha, 31270 901, Belo Horizonte, Minas Gerais, Brazil
    Biochem J 381:437-46. 2004
    ..e. post-penetration, but is also crucial to define the fate of virus progeny...
  9. ncbi request reprint Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure
    Alvaro J Romanha
    Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
    J Infect Dis 186:823-8. 2002
    ..These results suggest that activation of the immune system by the parasite and endogenous interferon-gamma play a major role in the efficacy of benznidazole against infection with T. cruzi...
  10. ncbi request reprint Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi
    Daniella C Bartholomeu
    Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    J Immunol 181:1333-44. 2008
    ..cruzi genome are likely to be main parasite targets and probably become available to TLR9 when parasites are destroyed in the lysosome-fused vacuoles during parasite invasion/uptake by phagocytes...
  11. ncbi request reprint Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria
    Catherine Ropert
    Laboratory of Immunopathology, René Rachou Institute, FIOCRUZ, Av Augusto de Lima, 1715, Belo Horizonte, MG, Brazil
    Semin Immunopathol 30:41-51. 2008
    ..These findings suggest that MyD88 may represent an Achilles' heel during Plasmodium infection...
  12. ncbi request reprint MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria
    Bernardo S Franklin
    Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil
    Microbes Infect 9:881-90. 2007
    ..chabaudi...
  13. ncbi request reprint Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes
    Catherine Ropert
    Laboratory of Immunopathology, CPqRR FIOCRUZ, Av Augusto de Lima 1715, MG, Belo Horizonte, Brazil
    Microbes Infect 4:1015-25. 2002
    ..We discuss the possible implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease...
  14. doi request reprint The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease
    Caroline Junqueira
    Laboratorio de Immunopatologia, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, MG, Brazil
    Expert Rev Mol Med 12:e29. 2010
    ..cruzi strain as a vaccine shuttle that elicits potent T cell responses specific to a tumour antigen and protective immunity against a syngeneic melanoma cell line...
  15. doi request reprint Changes in cellular contractility and cytokines profile during Trypanosoma cruzi infection in mice
    Danilo Roman-Campos
    Dept of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Basic Res Cardiol 104:238-46. 2009
    ..Indeed, we propose a role for IFN-gamma, TNF-alpha and MCP-1/CCL2 in the mechanical heart remodeling during experimental Chagas' disease...
  16. ncbi request reprint Cardiomyocyte dysfunction during the chronic phase of Chagas disease
    Danilo Roman-Campos
    Laboratório de Membranas Excitáveis e Biologia Cardiovascular, Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 108:243-5. 2013
    ..Thus, the chronic phase of Chagas disease is characterised by cardiomyocyte dysfunction, which could lead to heart failure...
  17. pmc Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33
    Marcus V Andrade
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1760, USA
    Eur J Immunol 41:760-72. 2011
    ..IL-33 may retune mast cell responses to Ag toward enhanced cytokine production and thus determine the symptoms and severity of Ag-dependent allergic and autoimmune diseases...
  18. doi request reprint Novel insights into the development of chagasic cardiomyopathy: role of PI3Kinase/NO axis
    Danilo Roman-Campos
    Laboratórios de Membranas Excitáveis e de Biologia Cardiovascular, Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Int J Cardiol 167:3011-20. 2013
    ..Therefore, the main objective of the study was to investigate the development of the Chagas' disease towards its chronic phase and correlate with modifications in the cellular electrophysiological characteristics of the infected heart...
  19. pmc Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine
    Caroline Junqueira
    Laboratorio de Imunopatologia, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Brazil
    PLoS ONE 7:e36245. 2012
    ..Finally, the level of protective immunity against the NY-ESO-1 expressing melanoma was associated with the magnitude of both CD4(+) T and CD8(+) T cell responses elicited by a specific immunological adjuvant...
  20. ncbi request reprint Inhibition of ERK1/2 and CREB phosphorylation by caspase-dependent mechanism enhances apoptosis in a fibrosarcoma cell line treated with butyrate
    Flávia L A Rabelo
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Caixa Postal 486, CEP 30 161 970, Belo Horizonte, Minas Gerais, Brazil
    Biochem Biophys Res Commun 303:968-72. 2003
    ..In conclusion, butyrate induced apoptosis in 2C4 cells is regulated by the levels of ERK1/2 and CREB phosphorylation in a caspase dependent mechanism...
  21. ncbi request reprint Inhibition of a p38/stress-activated protein kinase-2-dependent phosphatase restores function of IL-1 receptor-associate kinase-1 and reverses Toll-like receptor 2- and 4-dependent tolerance of macrophages
    Catherine Ropert
    Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Brazil
    J Immunol 171:1456-65. 2003
    ..These results indicate a critical role of p38/stress-activated protein kinase-2 and NF-kappaB-dependent phosphatase in macrophage hyporesponsiveness induced by microbial products that activate TLR2 and TLR4...
  22. ncbi request reprint Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line
    Flávia L A Rabelo
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
    Biochem Biophys Res Commun 301:968-73. 2003
    ....