Marcio Nucci


Affiliation: Rio de Janeiro
Country: Brazil


  1. Nucci M, Anaissie E, Betts R, Dupont B, Wu C, Buell D, et al. Early removal of central venous catheter in patients with candidemia does not improve outcome: analysis of 842 patients from 2 randomized clinical trials. Clin Infect Dis. 2010;51:295-303 pubmed publisher
    ..In this cohort of 842 adults with candidemia followed up prospectively, early CVC removal was not associated with any clinical benefit. These findings suggest an evidence-based re-evaluation of current treatment recommendations. ..
  2. Nucci M, Braga P, Nouér S, Anaissie E. Time of catheter removal in candidemia and mortality. Braz J Infect Dis. 2018;: pubmed publisher
    ..parapsilosis infection (OR 0.247, 95% CI 0.103-0.590) retained significance. The impact of CVC removal is dependent on whether the optimal analysis strategy is deployed and should be taken into consideration in future analyses. ..
  3. Braga P, Cruz I, Ortiz I, Barreiros G, Nouér S, Nucci M. Secular trends of candidemia at a Brazilian tertiary care teaching hospital. Braz J Infect Dis. 2018;22:273-277 pubmed publisher
  4. Nucci F, Nouer S, Capone D, Nucci M. Invasive mould disease in haematologic patients: comparison between fusariosis and aspergillosis. Clin Microbiol Infect. 2018;24:1105.e1-1105.e4 pubmed publisher
    ..However, a substantial proportion of patients with IF present with a clinical picture similar to IA, with fever, lung infiltrates, and positive serum galactomannan. ..
  5. Nucci M, Queiroz Telles F, Tobón A, Restrepo A, Colombo A. Epidemiology of opportunistic fungal infections in Latin America. Clin Infect Dis. 2010;51:561-70 pubmed publisher
    ..Species distribution also differs: in Latin America, the most common Candida species (other than Candida albicans) causing bloodstream infections are Candida parapsilosis or Candida tropicalis, rather than Candida glabrata. ..
  6. Nucci M, Queiroz Telles F, Alvarado Matute T, Tiraboschi I, Cortes J, Zurita J, et al. Epidemiology of candidemia in Latin America: a laboratory-based survey. PLoS ONE. 2013;8:e59373 pubmed publisher
    ..albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates. ..
  7. Souto Filho J, Loureiro M, Pulcheri W, Morais J, Nucci M, Portugal R. Evaluation of bone marrow aspirates in patients with acute myeloid leukemia at day 14 of induction therapy. Diagn Pathol. 2015;10:122 pubmed publisher
    ..Patients who attained higher grades of cytoreduction on D14 had better OS. Evaluation of D14 BMA using both methods had a significant agreement with BMB and between observers, identifying a population of patients with poor outcome. ..
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    Nucci M. Emerging moulds: Fusarium, Scedosporium and Zygomycetes in transplant recipients. Curr Opin Infect Dis. 2003;16:607-12 pubmed
    ..The understanding of the changing epidemiology of fungal infections and their implications for the prognosis of transplant recipients are important to better evaluate the impact of new transplant procedures. ..
  9. Beteille E, Guarana M, Nucci M. Infective endocarditis in neutropenic patients with viridans streptococci bacteraemia. Clin Microbiol Infect. 2018;: pubmed publisher
    ..Given the rarity of IE in neutropenic patients, routine investigation with echocardiography is not indicated. However, the presence of a new significant murmur should prompt appropriate investigation to rule out IE. ..

More Information


  1. Nucci M, Garnica M, Gloria A, Lehugeur D, Dias V, Palma L, et al. Invasive fungal diseases in haematopoietic cell transplant recipients and in patients with acute myeloid leukaemia or myelodysplasia in Brazil. Clin Microbiol Infect. 2013;19:745-51 pubmed publisher
    ..We observed a high burden of IFD and a high incidence and mortality for fusariosis in this first multicentre epidemiological study of IFD in haematological patients in Brazil. ..
  2. Garnica M, Sinhorelo A, Madeira L, Portugal R, Nucci M. Diagnostic-driven antifungal therapy in neutropenic patients using the D-index and serial serum galactomannan testing. Braz J Infect Dis. 2016;20:354-9 pubmed publisher
  3. Varon A, Nouér S, Barreiros G, Trope B, Akiti T, Nucci M. Antimold Prophylaxis May Reduce the Risk of Invasive Fusariosis in Hematologic Patients with Superficial Skin Lesions with Positive Culture for Fusarium. Antimicrob Agents Chemother. 2016;60:7290-7294 pubmed
    ..Primary antifungal prophylaxis with an antimold azole may prevent the occurrence of invasive fusariosis in high-risk hematologic patients with superficial skin lesions on admission growing Fusarium spp. ..
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    Nucci M, Colombo A. Candidemia due to Candida tropicalis: clinical, epidemiologic, and microbiologic characteristics of 188 episodes occurring in tertiary care hospitals. Diagn Microbiol Infect Dis. 2007;58:77-82 pubmed
    ..tropicalis and C. albicans candidemia was a higher proportion of neutropenic patients in C. tropicalis candidemia. C. tropicalis is a leading cause of candidemia in Brazil, and its epidemiology is similar to that of C. albicans...
  5. Nucci M, Nouér S, Esteves P, Guimarães T, Breda G, de Miranda B, et al. Discontinuation of empirical antifungal therapy in ICU patients using 1,3-?-d-glucan. J Antimicrob Chemother. 2016;71:2628-33 pubmed publisher
    ..Prospective studies with a higher number of patients are needed. ..
  6. Guarana M, Nucci M. Acute disseminated candidiasis with skin lesions: a systematic review. Clin Microbiol Infect. 2018;24:246-250 pubmed publisher
    ..krusei in patients receiving fluconazole prophylaxis, occurring less frequently. ..