L F Marins


Affiliation: Rio Grande
Country: Brazil


  1. Maciel F, Geihs M, Cruz B, Vargas M, Allodi S, Marins L, et al. Melatonin as a signaling molecule for metabolism regulation in response to hypoxia in the crab Neohelice granulata. Int J Mol Sci. 2014;15:22405-20 pubmed publisher
    ..granulata. This molecule inhibited the gene expression of CHH and caused an eyestalk- and receptor-dependent hyperglycemia, which suggests that melatonin may have a signaling role in metabolic regulation in this crab. ..
  2. Feijó R, Braga A, Lanes C, Figueiredo M, Romano L, Klosterhoff M, et al. Silencing of Gonad-Inhibiting Hormone Transcripts in Litopenaeus vannamei Females by use of the RNA Interference Technology. Mar Biotechnol (NY). 2016;18:117-23 pubmed publisher
    ..This is the first report of the use of RNAi technology to develop an alternative method to eyestalk ablation in captive L. vannamei shrimps. ..
  3. Dalmolin C, Almeida D, Figueiredo M, Marins L. Expression profile of glucose transport-related genes under chronic and acute exposure to growth hormone in zebrafish. Comp Biochem Physiol A Mol Integr Physiol. 2018;221:1-6 pubmed publisher
    ..This appeared to occur through downregulation of most of the analyzed GLUTs. ..
  4. Almeida D, da Silva Nornberg B, Geracitano L, Barros D, Monserrat J, Marins L. Induction of phase II enzymes and hsp70 genes by copper sulfate through the electrophile-responsive element (EpRE): insights obtained from a transgenic zebrafish model carrying an orthologous EpRE sequence of mammalian origin. Fish Physiol Biochem. 2010;36:347-353 pubmed publisher
  5. Batista C, Figueiredo M, Almeida D, Romano L, Marins L. Impairment of the immune system in GH-overexpressing transgenic zebrafish (Danio rerio). Fish Shellfish Immunol. 2014;36:519-24 pubmed publisher
  6. Nornberg B, Batista C, Almeida D, Trindade G, Marins L. ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells. Toxicol In Vitro. 2015;29:204-10 pubmed publisher
    ..These data provide useful insights for better understanding of MP detoxification mechanism in fish hepatocytes. ..
  7. Dalmolin C, Almeida D, Figueiredo M, Marins L. Food intake and appetite control in a GH-transgenic zebrafish. Fish Physiol Biochem. 2015;41:1131-41 pubmed publisher
    ..It is clear that transgenic zebrafish eat more and faster, and it seems that it occurs due to pomc down-regulation, since npy might be under regulation of the humoral factor glucose. ..
  8. Studzinski A, Barros D, Marins L. Growth hormone (GH) increases cognition and expression of ionotropic glutamate receptors (AMPA and NMDA) in transgenic zebrafish (Danio rerio). Behav Brain Res. 2015;294:36-42 pubmed publisher
    ..The transgenic strain F0104 was shown to be an interesting model for elucidating the intricate mechanisms related to the effect of the somatotropic axis on learning and memory in vertebrates. ..
  9. Figueiredo M, Boyle R, Sandrini J, Varela A, Marins L. High level of GHR nuclear translocation in skeletal muscle of a hyperplasic transgenic zebrafish. J Mol Endocrinol. 2016;56:47-54 pubmed publisher
    ..In addition, the results presented here highlight the possibility that these membrane proteins may be involved more directly than previously thought in the control of genes related to cell growth and proliferation. ..

More Information


  1. Nornberg B, Almeida D, Figueiredo M, Marins L. GH indirectly enhances the regeneration of transgenic zebrafish fins through IGF2a and IGF2b. Transgenic Res. 2016;25:743-9 pubmed publisher
    ..Overall, the results revealed that excess GH enhances fin regeneration in zebrafish through igf2a and igf2b expression, acting indirectly on this major physiological process. ..
  2. Almeida D, Vaz B, Azevedo Figueiredo M, Junior A, Marins L. Fluorescent transgenic zebrafish as a biosensor for growth-related effects of methyl parathion. Aquat Toxicol. 2014;152:147-51 pubmed publisher
    ..Therefore, this transgenic fish is a promising candidate model for sensitive, fast, and easy environmental monitoring. ..
  3. Batista C, Figueiredo M, Almeida D, Romano L, Marins L. Effects of somatotrophic axis (GH/GHR) double transgenesis on structural and molecular aspects of the zebrafish immune system. Fish Shellfish Immunol. 2015;45:725-32 pubmed publisher
    ..These results indicate that GHR overexpression does not reverse the impairments caused by GH and, in addition, could reinforce the damage to the immune functions in GH transgenic zebrafish. ..
  4. Nornberg B, Figueiredo M, Marins L. Expression profile of IGF paralog genes in liver and muscle of a GH-transgenic zebrafish. Gen Comp Endocrinol. 2016;226:36-41 pubmed publisher
    ..This group of IGFs appears to be favoring the hypertrophic intracellular pathway in muscle tissue of transgenic zebrafish. ..
  5. Silva A, Almeida D, Nornberg B, Pereira J, Pires D, Corcini C, et al. Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR). Transgenic Res. 2017;26:123-134 pubmed publisher
    ..Therefore, it is clear that GH-transgenesis technology should take into account the need to obtain adequate levels of circulating hormone in order to achieve maximum growth with minimal negative side effects. ..
  6. Riet J, Ramos L, Lewis R, Marins L. Improving the PCR protocol to amplify a repetitive DNA sequence. Genet Mol Res. 2017;16: pubmed publisher
    ..We describe the amplification of the MaSp1 gene through minor changes in the PCR program. The results show that a denaturation temperature of 98°C is the key determinant in the amplification of the MaSp1 partial gene sequence. ..