Research Topics
| Carlos A Mandarim-de-LacerdaSummaryAffiliation: Rio de Janeiro Country: Brazil Publications
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Detail Information
Publications
Myocardial microcirculation stereological changes in rats subjected to nitric oxide synthesis inhibitionL M Pereira
Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro, Brazil
Pathol Res Pract 195:177-81. 1999..Although these changes may be caused by NO inhibition and not by arterial hypertension, further comparative studies on different models of arterial hypertension are needed to confirm this hypothesis...- Renal cortical remodelling by NO-synthesis blockers in rats is prevented by angiotensin-converting enzyme inhibitor and calcium channel blockerC A Mandarim-de-Lacerda
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro UERJ, Brazil
J Cell Mol Med 5:276-83. 2001..The renal cortical region showed glomerular sclerosis/hypertrophy and tubular remodelling in rats with NOs blockade that was efficiently prevented with the simultaneous treatment with enalapril or verapamil... - Cardiomyocyte volume-weighted nuclear volume and spironolactone therapy in spontaneously hypertensive ratsCarlos Alberto Mandarim-de-Lacerda
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Av 28 de Setembro, 87 fds, 20551 030, Rio de Janeiro, RJ, Brazil
Anal Quant Cytol Histol 24:331-6. 2002.... - Glomerular developmental chronology in human fetusesJ R Almeida
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brasil
J Cell Mol Med 7:492-3. 2003 - The effects of spironolactone monotherapy on blood pressure and myocardial remodeling in spontaneously hypertensive rats: a stereological studyCarlos Alberto Mandarim-de-Lacerda
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
J Biomed Sci 10:50-7. 2003..Long-term spironolactone monotherapy showed a partial effect in the preservation of intramyocardial vessels and also in the attenuation of interstitial fibrosis... - Effect of telmisartan on preexistent cardiac and renal lesions in spontaneously hypertensive mature ratsC A Mandarim-de-Lacerda
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, State University of Rio de Janeiro, Brazil
Histol Histopathol 19:727-33. 2004..Telmisartan is able to attenuate SHR cardiomyocyte and glomerular hypertrophies, and myocardial reactive fibrosis as well. It also is favorable to the intramyocardial microcirculation... - Aortic wall remodeling in rats with nitric oxide deficiency treated by enalapril or verapamilLeila M M Pereira
Laboratório de Morfometria and Morfologia Cardiovascular, Universidade do Estado do Rio de Janeiro, Centro Biomedico, Av 28 de Setembro, 87 fds CEP 20551 030, Rio de Janeiro, RJ, Brazil
Pathol Res Pract 200:211-7. 2004.... - Aorta wall quantitative alterations due to different long-term high-fat diet in ratsMarcia Barbosa Aguila
Biomedical Center, Institute of Biology, State University of Rio de Janeiro, 20551 030 Rio de Janeiro, Brazil
Food Chem Toxicol 41:1391-7. 2003..These results suggest that the dietary intake of canola oil could attenuate the aorta structure aging process with a favorable BP maintenance... - Stereological tools in biomedical researchCarlos A Mandarim-de-Lacerda
Laboratorio de Morfometria e Morfologia Cardiovascular, Departamento de Anatomia, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, 20551 030 Rio de Janeiro, Brasil
An Acad Bras Cienc 75:469-86. 2003..In the present text, a short review of the main stereological tools is done as a background basis to non-expert scientists... - Myocardial stereological adaptations in wistar rats fed with different high-fat diets during 18 monthsM B Aguila
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro UERJ, Brasil
J Nutr Sci Vitaminol (Tokyo) 47:387-93. 2001..These results support the notion that the long-term use of canola oil in the diet is better to preserve the myocardium structure, including microvascularization, than soybean oil or lard and egg yolk... - Heart and blood pressure adaptations in Wistar rats fed with different high-fat diets for 18 monthsMarcia B Aguila
Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Nutrition 19:347-52. 2003..We investigated the effect of long-term administration of four different high-fat diets on systolic blood pressure (SBP), body and heart biometry, and left ventricular myocyte nuclei number (N[lvm])... - Effect of antihypertensive drugs on the myocardial microvessels in rats with nitric oxide blockadeL M Meirelles Pereira
Laboratory of Morphometry and Cardiovascular Morphology, Institute of Biology, State University of Rio de Janeiro, Brazil
Pathol Res Pract 196:305-11. 2000..These results are compatible with the occurrence of angiogenesis in the verapamil rats... - Stereology of cardiac hypertrophy induced by NO blockade in rats treated with enalapril and verapamilL M Pereira
Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil
Anal Quant Cytol Histol 23:330-8. 2001..To quantify the structural myocardial response when chronic NO blockade hypertension is treated with antihypertensive drugs... - Numerical density of cardiomyocytes in chronic nitric oxide synthesis inhibitionC A Mandarim-de-Lacerda
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Pathobiology 68:36-42. 2000..The purpose of this study was to estimate the numerical density of cardiomyocytes that is able to show cardiomyocyte loss as a consequence of NOS inhibition... - Effect of different high-fat diets on the myocardium stereology and blood pressure in ratsM B Aguila
Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro UERJ, Brazil
Pathol Res Pract 196:841-6. 2000..Comparing three high-fat diets, the data suggest that the diet canola oil had a major beneficial effect, preserving the myocardial structure and the blood pressure in rats... - Heart biometry and allometry in rats submitted to nitric oxide synthesis blockade and treatment with antihypertensive drugsC A Mandarim-de-Lacerda
Institute of Biology, State University of Rio de Janeiro, Brazil
Ann Anat 183:171-6. 2001..Cardiac hypertrophy in rats under inhibition of NO synthesis was prevented by treatment with enalapril and verapamil more efficiently than spironolactone... - Volume-weighted mean nuclear volume and numerical nuclear density in the cardiomyocyte following enalapril and verapamil treatmentC A Mandarim-de-Lacerda
Laboratory of Morphometry and Cardiovascular Morphology, Centro Biomedico, Instituto de Biologia, State University of Rio de Janeiro, Brazil
Virchows Arch 438:92-5. 2001..With respect to cardiomyocyte nuclear size, the present results suggest a beneficial effect of the angiotensin-converting enzyme inhibitor enalapril and the calcium channel blocker verapamil when NO synthesis is blockaded... 
Effects of rosiglitazone (a peroxysome proliferator-activated receptor gamma agonist) on the blood pressure and aortic structure in metabolically programmed (perinatal low protein) ratsThiago da Silva Torres
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Hypertens Res 31:965-75. 2008..00001 for TS, two-way ANOVA). We conclude that rosiglitazone has beneficial effects in reducing the BP and the aortic tunica media hypertrophy with consequent balance of the wall stress in metabolically programmed offspring...- Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat dietVanessa Souza-Mello
Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, 20551 030 Rio de Janeiro, RJ, Brazil
Clin Sci (Lond) 119:239-50. 2010..The best results were achieved using telmisartan and sitagliptin as monotherapies or as a dual treatment, combining partial PPAR-gamma agonism and PPAR-alpha activation in the liver with extended incretin action... - Enalapril attenuates cardiorenal damage in nitric-oxide-deficient spontaneously hypertensive ratsLeila M M Pereira
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Av 28 de Setembro, 20551-030 Rio de Janeiro, Brazil
Clin Sci (Lond) 106:337-43. 2004..Enalapril administration also decreases cardiac and renal structural damage caused by genetic hypertension, as well as by the interaction between genetic hypertension and NO deficiency... 
The effect of enalapril on the cardiac remodelling in ovariectomized spontaneously hypertensive ratsWellington V Santos
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Int J Exp Pathol 85:287-94. 2004..In conclusion, ovariectomy, in SHRs, causes cardiac hypertrophy and an unfavourable myocardial remodelling. Of the spectrum of changes seen, the major effect of enalapril appears to be mediated via an increase in the density of ive...- Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspringBianca M Gregorio
Institute of Biology, Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro, Biomedical Center, Rio de Janeiro, Brazil
Am J Obstet Gynecol 203:495.e1-8. 2010..This work aimed to verify the hypothesis that maternal intake of high-fat diet in critical periods of pregnancy and/or suckling period predisposes nonalcoholic fatty liver disease in adult C57BL/6 mice offspring... - Effects of high-fat diet on plasma lipids, adiposity, and inflammatory markers in ovariectomized C57BL/6 miceAntonio Ludgero-Correia
Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Nutrition 28:316-23. 2012..To test this hypothesis, ovariectomized (OVX) mice were fed a HF diet, and we investigated the lipid metabolism, adipose tissue remodeling, adipokines, and inflammatory cytokines... - Swimming training beneficial effects in a mice model of nonalcoholic fatty liver diseaseAlini Schultz
Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, RJ, Brazil
Exp Toxicol Pathol 64:273-82. 2012..These data reinforce the notion that swimming exercise can be considered an efficient nonpharmacologic therapy in the treatment of NAFLD, obesity and insulin resistance... - Maternal fish oil supplementation benefits programmed offspring from rat dams fed low-protein dietBianca Martins Gregório
Department of Anatomy, Biomedical Center, Institute of Biology, Laboratory of Morphometry and Cardiovascular Morphology Rio de Janeiro, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Am J Obstet Gynecol 199:82.e1-7. 2008..We hypothesized that maternal fish oil supplementation would prevent the programming of offspring cardiovascular alterations... - Adipose tissue, liver and pancreas structural alterations in C57BL/6 mice fed high-fat-high-sucrose diet supplemented with fish oil (n-3 fatty acid rich oil)Fernanda A M Nascimento
Laboratorio de Morfometria e Morfologia Cardiovascular, Centro Biomedico, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av 28 de Setembro 87 fds 20551 030 Rio de Janeiro, RJ, Brasil
Exp Toxicol Pathol 62:17-25. 2010..Furthermore, fish oil improves glucagon and GLUT-2 expressions when it is decreased in insulin, but in hepatocyte binucleation and hepatic steatosis where the effect is reduced... - Exercise training attenuates cardiovascular adverse remodeling in adult ovariectomized spontaneously hypertensive ratsClaudia M M Marques
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil
Menopause 13:87-95. 2006.... - Spontaneously hypertensive rats left ventricular cardiomyocyte loss attenuation through different edible oils long-term intakeMarcia B Aguila
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil
Int J Cardiol 100:461-6. 2005..The goal is to postpone the consequences of cardiomyocyte number decrease and heart failure in hypertension... - Eplerenone offsets cardiac and aortic adverse remodeling in spontaneously hypertensive ratsAdriana K Burla
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, State University of Rio de Janeiro, Av 28 de Setembro 87 fds 20551 030 Rio de Janeiro, Rio de Janeiro, Brazil
Int J Cardiol 114:64-70. 2007..Several studies have shown beneficial effects of eplerenone in hypertension and left ventricular dysfunction, but its action on cardiac and vascular changes secondary to blood pressure elevation are not clear yet... - Renal cortex remodeling in streptozotocin-induced diabetic spontaneously hypertensive rats treated with olive oil, palm oil and fish oil from MenhadenFernanda J Medeiros
Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro (UERJ, Rio de Janeiro RJ 20551-030, Brazil
Prostaglandins Leukot Essent Fatty Acids 75:357-65. 2006..The olive oil, palm oil and mainly fish oil intake retard the usual loss of glomeruli and attenuate the renal cortex adverse remodeling of Db and non-Db SHR... - Protein restriction during gestation and/or lactation causes adverse transgenerational effects on biometry and glucose metabolism in F1 and F2 progenies of ratsAlessandra R Pinheiro
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, 20551 030 Rio de Janeiro, Brazil
Clin Sci (Lond) 114:381-92. 2008..These findings suggest that low protein during gestation and/or lactation can be passed transgenerationally to the second generation... - Hepatic structural alteration in adult programmed offspring (severe maternal protein restriction) is aggravated by post-weaning high-fat dietVanessa Souza Mello
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Av 28 de setembro 87 fds, 20551 030 Rio de Janeiro, RJ, Brazil
Br J Nutr 98:1159-69. 2007..All of these serve to highlight the paramount importance of intra-uterine conditions and postnatal diet quality when it comes to the pathogenesis of chronic diseases... - Beneficial effect of simvastatin and pravastatin treatment on adverse cardiac remodelling and glomeruli loss in spontaneously hypertensive ratsDaniele G Bezerra
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil
Clin Sci (Lond) 108:349-55. 2005.... - An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in miceIsabele Bringhenti
Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, RJ, Brazil
J Nutr Biochem 22:1009-14. 2011..Early fish oil intake has beneficial effects on the programming responses that control body fat pad, glucose and lipid metabolism, and liver and adipose tissue structure in adult programmed offspring... - Insights into coronary artery development in model of maternal protein restriction in miceGeraldo O Silva-Junior
Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil
Anat Rec (Hoboken) 294:1757-64. 2011..Maternal protein restriction in mice leads to a delay in the growth of the heart in the embryonic period modifying the development of the subepicardial peritruncal plexus and the apoptosis in the future coronary orifice region... - Offspring myocardium alteration from dams submitted to nitric oxide synthesis inhibition during pregnancyVeronica C V Martini
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Int J Cardiol 100:377-82. 2005..Furthermore, the prenatal NOS inhibition apparently stimulates the cardiomyocyte proliferation that can be observed until the end of lactation, which is when the number of cardiomyocytes nuclei profiles seems to become stable... - Hypertension and kidney alterations in rat offspring from low protein pregnanciesVeronica C Villar-Martini
Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
J Hypertens Suppl 27:S47-51. 2009..Therefore, this study was undertaken to investigate early and late glomerular structural alterations in both sexes of Wistar rat offspring from dams submitted to severe low protein intake during gestation... - Weight cycling enhances adipose tissue inflammatory responses in male miceSandra Barbosa-da-Silva
Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
PLoS ONE 7:e39837. 2012..Nutritional interventions such as dieting are often accompanied by repeated bouts of weight loss and regain, a phenomenon known as weight cycling (WC)... - Alpha-tocopherol supplementation favorable effects on blood pressure, blood viscosity and cardiac remodeling of spontaneously hypertensive ratsVirginia A V Costa
Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro (UERJ, Brazil
J Nutr Biochem 16:251-6. 2005..This was observed by a reduction of both blood viscosity and BP, and a consequent cardiomyocyte hypertrophy in treated SHRs; an improvement of vessels-to-myocytes ratio in these rats was also observed... - Maternal vitamin D deficiency delays glomerular maturity in F1 and F2 offspringFernanda A M Nascimento
Laboratory of Morphometry, Metabolism and Cardiovascular Disease, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
PLoS ONE 7:e41740. 2012..There is a high prevalence of vitamin D insufficiency in women of reproductive age... - Light and confocal microscopic observations of adult Schistosoma mansoni from mice fed on a high-fat dietRenata H Neves
Laboratory of Helminthology Romero Lascasas Porto, Department of Microbiology, Immunology and Parasitology, Faculty of Medical Sciences, Biomedical Center, Rua Prof Manuel de Abreu 444 50 andar, Vila Isabel, Rio de Janeiro, Brazil
J Helminthol 81:361-8. 2007..The data presented here are the first to report the role of a cholesterol-rich diet affecting the development of S. mansoni worms... - Maternal gestational protein-calorie restriction decreases the number of glomeruli and causes glomerular hypertrophy in adult hypertensive ratsJorge R Almeida
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Am J Obstet Gynecol 192:945-51. 2005.... - Myocardial changes after spironolactone in spontaneous hypertensive rats. A laser scanning confocal microscopy studyLeila Maria Meirelles Pereira
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil
J Cell Mol Med 6:49-57. 2002..This action on the myocardium is more efficient when the spironolactone (even in medium dose) was associated with enalapril or verapamil... - Amlodipine preserves the glomerular number in spontaneously hypertensive ratsDaniele G Bezerra
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brasil
J Cell Mol Med 9:966-71. 2005..05). A possible protective effect of amlodipine against the loss of glomeruli in SHR is a major additional action of amlodipine in the treatment of hypertension mainly when the renal lesion already exists... - A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat DietJulio C Fraulob
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Av 28 de Setembro, 87 fds CEP 20551 030, Rio de Janeiro, Brazil
J Clin Biochem Nutr 46:212-23. 2010..Additionally, the importance of fat accumulation in the pancreas has been recently highlighted. Therefore, this model could help to elucidate target organ alterations associated with metabolic syndrome... - Beneficial effect of enalapril in spontaneously hypertensive rats cardiac remodeling with nitric oxide synthesis blockadeR L de Andrade Zorzi
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brasil
J Cell Mol Med 6:599-608. 2002..CONCLUSION: Enalapril administration showed a beneficial effect on vascular remodeling and myocardial hypertrophy in SHRs. In SHRs with NO blockade, however, the beneficial effect of Enalapril occurred only in vascular remodeling... - Effect of unilateral nephrectomy on renal function of diabetic ratsG S Lopes
Nephrology Division, Pedro Ernesto Hospital, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil
Histol Histopathol 19:1085-8. 2004..The present data suggest that the acceleration of glomerular lesions in DMNx animals was more closely associated to hemodynamic adaptations than to glomerular hypertrophy... - The effect of enalapril and verapamil on the left ventricular hypertrophy and the left ventricular cardiomyocyte numerical density in rats submitted to nitric oxide inhibitionL M Pereira
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil
Int J Exp Pathol 82:115-22. 2001..In conclusion, the left ventricular hypertrophy and the significant decrease of the left ventricular cardiomyocyte number caused by the NO synthesis inhibition are efficiently prevented with the use of enalapril and verapamil... - Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptorD A B Kasal
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, Rio de Janeiro, Brazil
Histol Histopathol 23:1241-8. 2008..The protective action of this drug is comparable to the results obtained with olmesartan. Antioxidative mechanisms are proposed to account for the pressure independent effects of allopurinol... - Different edible oil beneficial effects (canola oil, fish oil, palm oil, olive oil, and soybean oil) on spontaneously hypertensive rat glomerular enlargement and glomeruli numberM B Aguila
Laboratorio de Morfometria e Morfologia Cardiovascular, , Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Brazil
Prostaglandins Other Lipid Mediat 76:74-85. 2005.... - Leprosy: contribution of mast cells to epineurial collagenizationN Aparecida de Arantes Montagna
Department of Pathology, School of Medicine, State University of Rio de Janeiro, Brazil
Clin Neuropathol 24:284-90. 2005..Tryptase, the most abundant protein product of human mast cells, has been shown to be mitogenic for fibroblasts and to increase type I collagen production... - Glomerular profile numerical density per area and mean glomerular volume in rats submitted to nitric oxide synthase blockadeL M Pereira
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, State University of Rio de Janeiro, Brazil
Histol Histopathol 16:15-20. 2001..0001) and, concomitantly, L-NAME rats had the v (glom) 33% higher than the control ones (p=0.004). These results demonstrate morphological renal alterations caused by NOS inhibition and hypertension... - Stereology of the myocardium in Leontopithecus (Lesson, 1840) callitrichidae - primatesA Pissinatti
Centro de Primatologia do Rio de Janeiro (CPRJ-FEEMA, Rio de Janeiro, Brazil
J Med Primatol 32:139-47. 2003..These characteristics may explain the faster development of L. rosalia infants as compared with that of L. chrysomelas and L. c. chrysopygus kept under the same handling conditions at the CPRJ-FEEMA... - Effects of long-term intake of edible oils on hypertension and myocardial and aortic remodelling in spontaneously hypertensive ratsMarcia Barbosa Aguila
Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro, Biomedical Center, Institute of Biology, Av 28 de Setembro 87 (fds, 20551-030 Rio de Janeiro, RJ, Brazil
J Hypertens 22:921-9. 2004..Soybean oil and olive oil had mild effects on myocardial and aortic structure... - Cardiac alterations in furosemide-treated thiamine-deprived ratsSergio da Cunha
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, State University of Rio de Janeiro, Brazil
J Card Fail 13:774-84. 2007..Chronic administration of furosemide may induce thiamine deficiency and cause or aggravate myocardial dysfunction... - Lipid metabolism in rats fed diets containing different types of lipidsMarcia Barbosa Aguila
Centro Biomedico, Instituto de Biologia, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, 20551 030, Brazil
Arq Bras Cardiol 78:25-38. 2002..To assess the effect of different types of lipid diets on the lipid metabolism of aging rats... - Atorvastatin attenuates cardiomyocyte loss in adult rats from protein-restricted damsDaniele Gonçalves Bezerra
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Av 28 de Setembro, 87 fds 20551 030 Rio de Janeiro, RJ, Brasil
J Card Fail 14:151-60. 2008..Statins are cholesterol-lowering drugs that have been proved to prevent cardiac events. Their direct effects on cardiac remodeling, when administered in programmed protein restricted animals, still are unknown... - Renal cortex remodeling in nitric oxide deficient rats treated with enalaprilNoemi Barbuto
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
J Cell Mol Med 8:102-8. 2004.... - Gender determines long-lasting effects on adult offspring heart after early-life malnourishmentAnibal Sanchez Moura
Laboratory of Physiology of Nutrition and Development, Department of Physiological Sciences, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Biol Neonate 85:256-62. 2004..Also this association was observed in the animals at 60 days of age when the insulin/glucose ratio of the MM animals was 45% greater than that observed in the FM group... - Exercise training attenuates blood pressure elevation and adverse remodeling in the aorta of spontaneously hypertensive ratsPedro Paulo Horta
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil
Life Sci 77:3336-43. 2005..CONCLUSION: PA might alter the aortic wall remodeling to adapt the artery to a hyperkinetic blood flow resulting in alterations of the extracellular matrix modulation and vascular resistance... - Long-term intake of edible oils benefits blood pressure and myocardial structure in spontaneously hypertensive rat (SHR) and streptozotocin diabetic SHRFernanda Jurema Medeiros
Universidade do Estado do Rio de Janeiro, , Instituto de Biologia, , 87 (fds). Rio de Janeiro, RJ 20551-030, Brazil
Prostaglandins Other Lipid Mediat 78:231-48. 2005..Long-term edible oil supplementation showed beneficial effects decreasing BP levels and offsetting adverse myocardial remodeling in diabetic SHR... - Effects of ACE inhibition during fetal development on cardiac microvasculature in adult spontaneously hypertensive ratsAlfredo de Souza Bomfim
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Int J Cardiol 101:237-42. 2005..The positive impact on the vascular compartment came along with little or no difference in myocytes and interstitium, suggesting the involvement of a direct mechanism... - Effects of chronic high fat diets on renal function and cortical structure in ratsMarcia Barbosa Aguila
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro (UERJ, Brazil
Exp Toxicol Pathol 55:187-95. 2003..The addition of canola oil in the LE mixture normally was not efficient to alter the renal damage except in the cortical vessels... - Kidney adaptation in nitric oxide-deficient Wistar and spontaneously hypertensive ratsLeila Maria Meirelles Pereira
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Av 28 de Setembro, 87 fds. 20551-030, Rio de Janeiro, RJ, Brazil
Life Sci 74:1375-86. 2004..Administration of enalapril, but not L-NAME, changed this tendency. However, enalapril was not totally effective in preventing vascular damage in SHR NO deficient animals... - Enalapril alters the formation of the collagen matrix in spontaneously hypertensive ratsAlfredo de Souza Bomfim
Instituto de Biologia Roberto Alcantara Gomes, UERJ, Rio de Janeiro, RJ, Brazil
Arq Bras Cardiol 81:69-72, 64-8. 2003..To assess the effect of the inhibition of the angiotensin-converting enzyme on the collagen matrix (CM) of the heart of newborn spontaneously hypertensive rats (SHR) during embryonic development... - Early renal structure alteration in rat offspring from dams fed low protein dietKarla Maria Pereira Pires
Biomedical Center, Institute of Biology, Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro, Brazil
Life Sci 79:2128-34. 2006..This supports epidemiological data in humans underlying why fetuses with low birth weight carry an increased risk of mortality from chronic diseases in adulthood, including hypertension... - Beneficial effects of physical exercise on hypertension and cardiovascular adverse remodeling of diet-induced obese ratsAlessandra Rocha Pinheiro
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Nutr Metab Cardiovasc Dis 17:365-75. 2007..Obesity is present among all age groups and in all socioeconomic groups. This study on obese rats aims to quantify the beneficial effects of physical exercise on blood pressure (BP), the heart, the elasticity and resistance of arteries... - Adult cardiorenal benefits from postnatal fish oil supplement in rat offspring of low-protein pregnanciesMariana Catta-Preta
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil
Life Sci 80:219-29. 2006..In conclusion, FO supplement, which is a rich source of n-3 fatty acids (DHA and EPA), has beneficial effects on BP control and cardiac and renal adverse remodeling usually seen in offspring of the LP pregnancies... - Dietary effect of different high-fat diet on rat liver stereologyMarcia Barbosa Aguila
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro UERJ, RJ, Brazil
Liver Int 23:363-70. 2003..Dietary habits are considered to be responsible for a fatty liver. The aims of this work are to study the effects of different lipid sources on rat hepatic structure... - Long-term feeding a high-fat diet causes histological and parasitological effects on murine schistosomiasis mansoni outcomeRenata Heisler Neves
Laboratory of Helminthology Romero Lascasas Porto, Biomedical Center, Department of Pathology and Laboratories, Faculty of Medical Sciences, State University of Rio de Janeiro, Brazil
Exp Parasitol 115:324-32. 2007..The morphometric evaluation of hepatic granulomas did not reach statistical significance (p>0.05) between diets assayed. The high-fat diet for long-term produces effects on schistosomiasis mansoni outcome... - Hepatic stereology of Schistosomiasis mansoni infected-mice fed a high-fat dietRenata Heisler Neves
, Departamento de Helmintologia, Instituto Oswaldo Cruz-Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, RJ, Brazil
Mem Inst Oswaldo Cruz 101:253-60. 2006..0004), and Vv[hf] (p = 0.0007). In conclusion, schistosomiasis mansoni infection with concurrent high-fat diet promotes intensive quantitative changes in hepatic structure, contributing to an increasing on hepatic regeneration... - Cardiac and aortic structural alterations due to surgically-induced menopause associated with renovascular hypertension in ratsLeonardo de Souza Mendonca
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
Int J Exp Pathol 88:301-9. 2007..However, renovascular hypertension exerts a far greater influence than surgically-induced menopause in this parameter... - Overweight is gender-dependent in prenatal protein--calorie restricted adult rats acting on the blood pressure and the adverse cardiac remodelingJorge Reis Almeida
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Brazil
Life Sci 77:1307-18. 2005..In conclusion: hypertension and body and cardiac growth were influenced by the interaction between gender and prenatal nutritional conditions, while cardiac remodeling seems to be only programmed by the adverse intrauterine environment... - Quantitative study of the comma-shaped body, S-shaped body and vascularized glomerulus in the second and third human gestational trimestersJorge Reis Almeida
Biomedical Center, Laboratory of Morphometry and Cardiovascular Morphology, Institute of Biology, State University of Rio de Janeiro, Brazil
Early Hum Dev 69:1-13. 2002..CONCLUSION: The growth equations and the observed tendencies of these glomerular subtypes in human fetal life could be useful to assess the kidney maturity through invasive or noninvasive investigative methods in the future... - Low molecular weight heparin in the treatment of puromycin-induced nephrosisAna Maria Ribeiro Dos Santos
Nephrology Division, University of State of Rio de Janeiro, Rio de Janeiro, Brazil
Pathol Res Pract 202:157-63. 2006..In conclusion, LMWH interferes in the complications of PAN model, but not through inhibition of the proteinuria... - Stereologic study of the sinoatrial node of rats -- age related changesSilvana Regina de Melo
Department of Morphophysiological Sciences, State University of Maringa, Av Colombo, 5790, 87020 900, Maringa, Parana, Brazil
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Faculty of Medicine, Federal University of Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
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