Carlos A Mandarim-de-Lacerda

Summary

Affiliation: Rio de Janeiro
Country: Brazil

Publications

  1. Bargut T, Souza Mello V, Mandarim de Lacerda C, Aguila M. Fish oil diet modulates epididymal and inguinal adipocyte metabolism in mice. Food Funct. 2016;7:1468-76 pubmed publisher
  2. Karise I, Bargut T, del Sol M, Aguila M, Mandarim de Lacerda C. Metformin enhances mitochondrial biogenesis and thermogenesis in brown adipocytes of mice. Biomed Pharmacother. 2019;111:1156-1165 pubmed publisher
    ..Metformin effects are not linked to body mass changes, but affect BAT thermogenesis, mitochondrial biogenesis, and fatty acid uptake. Therefore, BAT may be a metformin adjuvant target for the treatment of metabolic disorders. ..
  3. Guimarães J, Bargut T, Mandarim de Lacerda C, Aguila M. Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice. Prostaglandins Leukot Essent Fatty Acids. 2019;140:64-71 pubmed publisher
    ..The MCT oil groups also presented increased beta-oxidation and mitochondrial biogenesis. In conclusion, MCT oil showed detrimental hepatic effects and should be used with caution, especially in the presence of hepatic alterations. ..
  4. Bargut T, Martins F, Santos L, Aguila M, Mandarim de Lacerda C. Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice. Mol Cell Endocrinol. 2019;482:18-27 pubmed publisher
    ..Importantly, EPA and DHA administrated alone showed stronger results than the combination of EPA + DHA. The results suggest that EPA and DHA might be useful as adjuvant strategies to treat metabolic-associated disorders. ..
  5. Borges C, Bringhenti I, Mandarim de Lacerda C, Aguila M. Vitamin D deficiency aggravates the liver metabolism and inflammation in ovariectomized mice. Biomed Pharmacother. 2018;107:878-888 pubmed publisher
    ..The treatment of vitamin D deficiency is simple and not costly and can reduce the impact of menopause on metabolism and especially the liver. ..
  6. Schultz A, Neil D, Aguila M, Mandarim de Lacerda C. Hepatic adverse effects of fructose consumption independent of overweight/obesity. Int J Mol Sci. 2013;14:21873-86 pubmed publisher
    ..These conditions are associated with a poor prognosis. ..
  7. Magliano D, Penna de Carvalho A, Vázquez Carrera M, Mandarim de Lacerda C, Aguila M. Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. Endocrine. 2015;50:355-67 pubmed publisher
    ..We conclude that GW501516 may serve as a therapeutic option for the treatment of a highly activated ACE/AT1r axis in WAT and liver. ..
  8. Bargut T, Mandarim de Lacerda C, Aguila M. A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice. J Nutr Biochem. 2015;26:960-9 pubmed publisher
    ..In summary, fish oil activates PPAR (the three isoforms) and AMPK, decreases WAT insulin resistance and inflammation, and inhibits MAPK and RAS pathways activation. ..
  9. Aguila M, Mandarim de Lacerda C. Heart and blood pressure adaptations in Wistar rats fed with different high-fat diets for 18 months. Nutrition. 2003;19:347-52 pubmed
    ..The CA + LE diet resulted in balanced levels of SBP and N(lvm) in rats, suggesting that canola oil reduces cardiovascular injury caused by intake of lard and egg yolk. ..

More Information

Publications26

  1. Bargut T, Silva e Silva A, Souza Mello V, Mandarim de Lacerda C, Aguila M. Mice fed fish oil diet and upregulation of brown adipose tissue thermogenic markers. Eur J Nutr. 2016;55:159-69 pubmed publisher
    ..Both groups exhibited elevated PPAR and thermogenic markers expression in a dose-dependent way. FO improves metabolic profile and upregulates thermogenic markers, suggesting an elevated thermogenesis that leads to reduced BM gain. ..
  2. Motta V, Aguila M, Mandarim de Lacerda C. High-intensity interval training (swimming) significantly improves the adverse metabolism and comorbidities in diet-induced obese mice. J Sports Med Phys Fitness. 2015;: pubmed
    ..In skeletal muscle, HIIT improves PPAR--alpha and glucose transporter-4 and reduces PPAR--gamma levels. HIIT leads to attenuate the adverse effects caused by a chronic ingestion of a high-fat diet. ..
  3. Barbosa da Silva S, Souza Mello V, Magliano D, Marinho T, Aguila M, Mandarim de Lacerda C. Singular effects of PPAR agonists on nonalcoholic fatty liver disease of diet-induced obese mice. Life Sci. 2015;127:73-81 pubmed publisher
    ..The results reinforce the central role of PPARalpha, as well as its contrary relationship to PPARgamma in the regulation of metabolic homeostasis and lipolytic pathways in the liver. ..
  4. Ornellas F, Souza Mello V, Mandarim de Lacerda C, Aguila M. Combined parental obesity augments single-parent obesity effects on hypothalamus inflammation, leptin signaling (JAK/STAT), hyperphagia, and obesity in the adult mice offspring. Physiol Behav. 2016;153:47-55 pubmed publisher
  5. Pimenta M, Bringhenti I, Souza Mello V, Dos Santos Mendes I, Aguila M, Mandarim de Lacerda C. High-intensity interval training beneficial effects on body mass, blood pressure, and oxidative stress in diet-induced obesity in ovariectomized mice. Life Sci. 2015;139:75-82 pubmed publisher
    ..The HIIT protocol significantly reduced BM, SBP and oxidative stress in the skeletal muscle indicating that HIIT diminishes the cardiovascular and metabolic risk that is inherent to obesity and menopause. ..
  6. Schultz A, Barbosa da Silva S, Aguila M, Mandarim de Lacerda C. Differences and similarities in hepatic lipogenesis, gluconeogenesis and oxidative imbalance in mice fed diets rich in fructose or sucrose. Food Funct. 2015;6:1684-91 pubmed publisher
    ..In conclusion, current findings demonstrate comparable adverse effects on carbohydrate metabolism, inflammatory profile, antioxidant imbalance and NAFLD in the mice of the C57BL/6 strain fed a diet rich in sucrose or rich in fructose. ..
  7. Motta V, Aguila M, Mandarim de Lacerda C. High-intensity interval training (swimming) significantly improves the adverse metabolism and comorbidities in diet-induced obese mice. J Sports Med Phys Fitness. 2016;56:655-63 pubmed
    ..In skeletal muscle, HIIT improves PPAR-alpha and glucose transporter-4 and reduces PPAR-gamma levels. HIIT leads to attenuate the adverse effects caused by a chronic ingestion of a high-fat diet. ..
  8. Bargut T, Aguila M, Mandarim de Lacerda C. Brown adipose tissue: Updates in cellular and molecular biology. Tissue Cell. 2016;48:452-60 pubmed publisher
    ..This bound leads to the initialization of the many pathways that may activate thermogenesis in acute and/or chronic ways. In summary, this mini-review aims to demonstrate the latest advances in the knowledge of BAT. ..
  9. Martins F, Bargut T, Aguila M, Mandarim de Lacerda C. Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Ann Anat. 2017;210:44-51 pubmed publisher
    ..The findings suggest that the lack of substrate for thermogenesis and the local inflammation negatively regulated thermogenic signaling in the ob/ob mice. ..
  10. Motta V, Bargut T, Aguila M, Mandarim de Lacerda C. Treating fructose-induced metabolic changes in mice with high-intensity interval training: insights in the liver, white adipose tissue, and skeletal muscle. J Appl Physiol (1985). 2017;123:699-709 pubmed publisher
    ..Because HIIT may block these adverse effects in all of these three tissues, it might be suggested that it functions as a coadjutant treatment in combatting the alterations caused by high-fructose intake. ..
  11. Ornellas F, Bringhenti I, Mattos B, Mandarim de Lacerda C, Aguila M. Father's obesity programs the adipose tissue in the offspring via the local renin-angiotensin system and MAPKs pathways, especially in adult male mice. Eur J Nutr. 2018;57:1901-1912 pubmed publisher
    ..The activation of local RAS and ERK1/2, a concomitant PPAR diminishing, and impairment in phosphorylation of AKT and IRS-1 could explain at least in part the findings regardless of the increase in body mass in the offspring. ..
  12. Maia Ceciliano T, Barreto Vianna A, Barbosa da Silva S, Aguila M, Faria T, Mandarim de Lacerda C. Maternal vitamin D-restricted diet has consequences in the formation of pancreatic islet/insulin-signaling in the adult offspring of mice. Endocrine. 2016;54:60-69 pubmed
    ..The decrease of PDX-1 is probably significant to the changes in the beta-cell mass and insulin secretion in adulthood. ..
  13. Martins F, Aguila M, Mandarim de Lacerda C. Impaired steroidogenesis in the testis of leptin-deficient mice (ob/ob -/-). Acta Histochem. 2017;119:508-515 pubmed publisher
    ..The study provides new evidence and contributes to the understanding of how the lack of leptin and obesity might negatively modulate the testicular function leading to infertility. ..
  14. Barreto Vianna A, Aguila M, Mandarim de Lacerda C. Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation. Metab Brain Dis. 2017;32:1735-1745 pubmed publisher
  15. Ornellas F, Carapeto P, Mandarim de Lacerda C, Aguila M. Obese fathers lead to an altered metabolism and obesity in their children in adulthood: review of experimental and human studies. J Pediatr (Rio J). 2017;93:551-559 pubmed publisher
    ..Paternal obesity can induce programmed phenotypes in offspring through epigenetics. Therefore, it can be considered a public health problem, affecting the children's future life. ..
  16. Bargut T, Santos L, Machado D, Aguila M, Mandarim de Lacerda C. Eicosapentaenoic acid (EPA) vs. Docosahexaenoic acid (DHA): Effects in epididymal white adipose tissue of mice fed a high-fructose diet. Prostaglandins Leukot Essent Fatty Acids. 2017;123:14-24 pubmed publisher
    ..Therefore, when considering fructose-induced adverse effects in WAT, the most prominent actions were observed with DHA. ..
  17. Borges C, Penna de Carvalho A, Medeiros Junior J, Aguila M, Mandarim de Lacerda C. Ovariectomy modify local renin-angiotensin-aldosterone system gene expressions in the heart of ApoE (-/-) mice. Life Sci. 2017;191:1-8 pubmed publisher
    ..The evaluation of the local Renin-Angiotensin-Aldosterone system (RAAS) gene expressions in the heart of ovariectomized (OVX) apolipoprotein E deficient mice (ApoE)...