Raquel C Maia

Summary

Affiliation: Rio de Janeiro
Country: Brazil

Publications

  1. doi LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells
    Raquel C Maia
    Laboratório de Hemato Oncologia Celular e Molecular, Programa de Pesquisa em Hemato Oncologia Molecular, Instituto Nacional de Cancer INCA, Rio de Janeiro, RJ, Brazil
    Invest New Drugs 29:1143-55. 2011
  2. doi Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells
    Eduardo J S Salustiano
    Laboratório de Imunologia Tumoral, Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Invest New Drugs 28:139-44. 2010
  3. ncbi The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells
    Flaviana R de Souza Reis
    Laboratório de Hemato Oncologia Celular e Molecular, Programa de Pesquisa em Hemato Oncologia Molecular, Instituto Nacional de Cancer INCA, Rio de Janeiro, RJ, Brazil
    Anticancer Agents Med Chem 13:341-51. 2013
  4. doi Survivin and P-glycoprotein are associated and highly expressed in late phase chronic myeloid leukemia
    Flaviana R S Reis
    Laboratório de Hemato Oncologia Celular e Molecular, Programa de Pesquisa em Hemato Oncologia Molecular, Instituto Nacional de Câncer Rio de Janeiro, RJ, Brazil
    Oncol Rep 26:471-8. 2011
  5. doi Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias
    Camilla de S B Veiga
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, RJ, Brazil
    Blood Cells Mol Dis 46:230-4. 2011
  6. ncbi Contrasting features of MDR phenotype in leukemias by using two fluorochromes: implications for clinical practice
    Flavia C Vasconcelos
    Laboratório de Hematologia Celular e Molecular, Servico de Hematologia, Hospital do Câncer HC I, Instituto Nacional de Cancer INCA, Rio de Janeiro RJ, Brazil
    Leuk Res 31:445-54. 2007
  7. doi Immunodetection of caspase-3 by Western blot using glutaraldehyde
    Gabriela Nestal de Moraes
    Coordination of Clinical Research, Brazilian National Institute of Cancer, CEP 20231 050 Rio de Janeiro, RJ, Brazil
    Anal Biochem 415:203-5. 2011

Collaborators

  • Andre L Mencalha
  • Flavia C Vasconcelos
  • Flaviana R de Souza Reis
  • Carolina P Castro
  • Paulo R R Costa
  • Flaviana R S Reis
  • Gabriela Nestal de Moraes
  • Camilla de S B Veiga
  • Eduardo J S Salustiano
  • Karina L Silva
  • Vivian M Rumjanek
  • Paloma S de Souza
  • Alcides J da Silva
  • Fernanda C Casal de Faria
  • Flavia da Cunha Vasconcelos
  • Reinaldo D Bello
  • Cláudia J B P Coelho
  • Erika Carvalho
  • Eliana Abdelhay
  • Silvia M F Carvalho
  • Aline F Ferreira
  • Robson Q Monteiro
  • Cinthya Sternberg
  • Arthur Moellman-Coelho
  • Fabíola A Castro
  • Débora L Pereira
  • Tatiana C Carneiro-Lobo
  • Alcides J M da Silva
  • Renata F Fernandes
  • Chaquip D Netto
  • Thiago S Bacelar
  • Camilla D Buarque
  • Jolie K Kwee
  • Geraldo B Cavalcanti
  • Ernesto de Meis

Detail Information

Publications7

  1. doi LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells
    Raquel C Maia
    Laboratório de Hemato Oncologia Celular e Molecular, Programa de Pesquisa em Hemato Oncologia Molecular, Instituto Nacional de Cancer INCA, Rio de Janeiro, RJ, Brazil
    Invest New Drugs 29:1143-55. 2011
    ..The data suggest that LQB-118 has a potent anti-CML activity that can overcome multifactorial drug resistance mechanisms, making this compound a promising new anti-CML agent...
  2. doi Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells
    Eduardo J S Salustiano
    Laboratório de Imunologia Tumoral, Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Invest New Drugs 28:139-44. 2010
    ..In contrast, lapachol (2) and beta-lapachone (3), which cannot be bioactivated by reduction, showed little activity against the same cell lines...
  3. ncbi The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells
    Flaviana R de Souza Reis
    Laboratório de Hemato Oncologia Celular e Molecular, Programa de Pesquisa em Hemato Oncologia Molecular, Instituto Nacional de Cancer INCA, Rio de Janeiro, RJ, Brazil
    Anticancer Agents Med Chem 13:341-51. 2013
    ..Our findings suggest that LQB-118 might be a promising therapeutic approach for AML patients through survivin downregulation...
  4. doi Survivin and P-glycoprotein are associated and highly expressed in late phase chronic myeloid leukemia
    Flaviana R S Reis
    Laboratório de Hemato Oncologia Celular e Molecular, Programa de Pesquisa em Hemato Oncologia Molecular, Instituto Nacional de Câncer Rio de Janeiro, RJ, Brazil
    Oncol Rep 26:471-8. 2011
    ..018), but not in early (p=0.5) chronic phase of CML, suggests that this association may play a biological role in late CML phase and may offer an important target for the development of new therapies...
  5. doi Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias
    Camilla de S B Veiga
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, RJ, Brazil
    Blood Cells Mol Dis 46:230-4. 2011
    ..We conclude that PAR-1 might play an important biological role in aggressive leukemias and might offer additional strategies for the development of new therapies...
  6. ncbi Contrasting features of MDR phenotype in leukemias by using two fluorochromes: implications for clinical practice
    Flavia C Vasconcelos
    Laboratório de Hematologia Celular e Molecular, Servico de Hematologia, Hospital do Câncer HC I, Instituto Nacional de Cancer INCA, Rio de Janeiro RJ, Brazil
    Leuk Res 31:445-54. 2007
    ..000). Similarly, MRP1 positive cells were best detected by Rho-123 as opposed to DiOC(2) (p=0.007). Our results support the idea that Rho-123 is the substrate of choice for leukemic cells...
  7. doi Immunodetection of caspase-3 by Western blot using glutaraldehyde
    Gabriela Nestal de Moraes
    Coordination of Clinical Research, Brazilian National Institute of Cancer, CEP 20231 050 Rio de Janeiro, RJ, Brazil
    Anal Biochem 415:203-5. 2011
    ..Here we present a modification of the Western blot protocol to improve sensitivity of caspase-3 detection, providing a valuable tool to access its activation in biological specimens...