Marcelo T Bozza

Summary

Affiliation: Rio de Janeiro
Country: Brazil

Publications

  1. ncbi request reprint Characterization of heme as activator of Toll-like receptor 4
    Rodrigo T Figueiredo
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ, Brazil
    J Biol Chem 282:20221-9. 2007
  2. doi request reprint Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction
    Claudia N Paiva
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, Brazil
    J Leukoc Biol 85:855-61. 2009
  3. pmc Oxidative stress fuels Trypanosoma cruzi infection in mice
    Claudia N Paiva
    Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia Professor Paulo de Góes IMPPG, Rio de Janeiro, Brazil
    J Clin Invest 122:2531-42. 2012
  4. doi request reprint Schistosomal‐derived lysophosphatidylcholine are involved in eosinophil activation and recruitment through Toll‐like receptor-2-dependent mechanisms
    Kelly G Magalhaes
    Laboratório de Imunofarmacologia and 2Laboratório de Patologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Infect Dis 202:1369-79. 2010
  5. doi request reprint Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection
    Iranaia Assunção-Miranda
    Programa de Biologia Estrutural, Departamento de Imunologia, Instituto de Microbiologia, CCS Bloco I, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, Cidade Universitaria, Rio de Janeiro RJ, 21941 902 Brazil
    FASEB J 24:218-28. 2010
  6. pmc Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
    Fernando A Bozza
    ICU, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Av Brasil 4365, Rio de Janeiro, Brazil
    Crit Care 11:R49. 2007
  7. ncbi request reprint Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors
    Bárbara N Porto
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, RJ, 21 941 590 Brasil
    J Biol Chem 282:24430-6. 2007
  8. doi request reprint CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection
    Claudia N Paiva
    Departamento de Imunologia, Instituto de Microbiologia Prof Paulo de Goes, UFRJ, Av Carlos Chagas Filho 373, CCS Bloco I, Ilha do Fundao, Rio de Janeiro, RJ, Brazil 21941 902
    J Leukoc Biol 86:1239-46. 2009
  9. ncbi request reprint Monocyte chemoattractant protein-1/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response
    Patricia Pacheco
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Immunol 179:8500-8. 2007
  10. pmc Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation
    Patricia L Fernandez
    Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941 902 Rio de Janeiro, Brazil
    J Biol Chem 285:32844-51. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Characterization of heme as activator of Toll-like receptor 4
    Rodrigo T Figueiredo
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, RJ, Brazil
    J Biol Chem 282:20221-9. 2007
    ..Thus, our results presented here reveal a previous unrecognized role of heme as an extracellular signaling molecule that affects the innate immune response through a receptor-mediated mechanism...
  2. doi request reprint Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction
    Claudia N Paiva
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, Brazil
    J Leukoc Biol 85:855-61. 2009
    ..These results give experimental support to the proposition that blockade of MIF might constitute an adjunctive, therapeutic approach to IC disease...
  3. pmc Oxidative stress fuels Trypanosoma cruzi infection in mice
    Claudia N Paiva
    Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia Professor Paulo de Góes IMPPG, Rio de Janeiro, Brazil
    J Clin Invest 122:2531-42. 2012
    ..Our results indicate that oxidative stress contributes to parasite persistence in host tissues and open a new avenue for the development of anti-T. cruzi drugs...
  4. doi request reprint Schistosomal‐derived lysophosphatidylcholine are involved in eosinophil activation and recruitment through Toll‐like receptor-2-dependent mechanisms
    Kelly G Magalhaes
    Laboratório de Imunofarmacologia and 2Laboratório de Patologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Infect Dis 202:1369-79. 2010
    ..Moreover, our results suggest that TLR2‐dependent inflammatory reaction, cytokine production, and eosinophil recruitment and activation may contribute to the pathogenesis and lethality in the chronic phase of infection...
  5. doi request reprint Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection
    Iranaia Assunção-Miranda
    Programa de Biologia Estrutural, Departamento de Imunologia, Instituto de Microbiologia, CCS Bloco I, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, Cidade Universitaria, Rio de Janeiro RJ, 21941 902 Brazil
    FASEB J 24:218-28. 2010
    ..These results demonstrated the contribution of MIF to the pathogenesis of dengue and pointed to a possible beneficial role of neutralizing MIF as an adjunctive therapeutic approach to treat the severe forms of the disease...
  6. pmc Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
    Fernando A Bozza
    ICU, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Av Brasil 4365, Rio de Janeiro, Brazil
    Crit Care 11:R49. 2007
    ..The aim of the present study was to determine the cytokine profile in plasma of patients with severe sepsis by using a multiplex system for simultaneous detection of 17 cytokines...
  7. ncbi request reprint Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors
    Bárbara N Porto
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, RJ, 21 941 590 Brasil
    J Biol Chem 282:24430-6. 2007
    ....
  8. doi request reprint CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection
    Claudia N Paiva
    Departamento de Imunologia, Instituto de Microbiologia Prof Paulo de Goes, UFRJ, Av Carlos Chagas Filho 373, CCS Bloco I, Ilha do Fundao, Rio de Janeiro, RJ, Brazil 21941 902
    J Leukoc Biol 86:1239-46. 2009
    ..Our results demonstrate that CCL2 contributes to reduce parasite growth and indicate that it does so by controlling the distribution, cellular composition, and state of activation of inflammatory infiltrates in acute T. cruzi infection...
  9. ncbi request reprint Monocyte chemoattractant protein-1/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response
    Patricia Pacheco
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Immunol 179:8500-8. 2007
    ..Therefore, infection-elicited MCP-1, besides its known CCR2-driven chemotactic function, appears as a key activator of lipid body biogenic and functional machineries, signaling through a microtubule-dependent manner...
  10. pmc Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation
    Patricia L Fernandez
    Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941 902 Rio de Janeiro, Brazil
    J Biol Chem 285:32844-51. 2010
    ..Our results highlight a mechanism by which heme amplifies the secretion of cytokines triggered by microbial molecule activation and indicates possible pathways for therapeutic intervention during hemolytic infectious diseases...
  11. doi request reprint Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection
    Elizabeth S Magalhães
    Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    FASEB J 23:1262-71. 2009
    ..Together, these results indicate that MIF participates in IL-5-driven maturation of eosinophils and in tissue eosinophilia associated with S. mansoni infection...
  12. pmc TLR4 recognizes Pseudallescheria boydii conidia and purified rhamnomannans
    Rodrigo T Figueiredo
    Departamento de Imunologia, Laboratório de Inflamação e Imunidade, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 941 902 Brazil
    J Biol Chem 285:40714-23. 2010
    ..These results imply that TLR4 recognizes P. boydii conidia and this recognition is at least in part due to rhamnomannans expressed on the surface of P. boydii...
  13. doi request reprint Leukotriene B4 mediates neutrophil migration induced by heme
    Ana Paula T Monteiro
    Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Immunol 186:6562-7. 2011
    ....
  14. ncbi request reprint Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation
    Elizabeth S Magalhães
    Departamento de Imunologia, Instituto de Microbiologia, UFRJ, Rio de Janeiro, Brazil
    Eur J Immunol 37:1097-106. 2007
    ..The present study demonstrates that MIF is required for allergic inflammation, adding important elements to our knowledge of asthma pathogenesis and suggesting that neutralization of MIF might be of therapeutic value in asthma...
  15. pmc MIF participates in Toxoplasma gondii-induced pathology following oral infection
    Marta G Cavalcanti
    Departamento de Imunologia, Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 6:e25259. 2011
    ..Considering the critical role of MIF in the pathogenesis of IBD, we hypothesized that MIF participates in the inflammatory response induced by oral infection with T. gondii...
  16. pmc Bacterial clearance in septic mice is modulated by MCP-1/CCL2 and nitric oxide
    Rachel N Gomes
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Instituto de Pesquisa Evandro Chagas, FIOCRUZ, Brazil
    Shock 39:63-9. 2013
    ..In conclusion, we demonstrated for the first time that MCP-1/CCL2 has a crucial role in the clearance of bacteria by mechanisms involving increased expression of inducible NO synthase and production of NO by ERK signaling pathways...
  17. pmc Trypanosoma cruzi infection is enhanced by vector saliva through immunosuppressant mechanisms mediated by lysophosphatidylcholine
    Rafael D Mesquita
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, UFRJ, 21940 590, Rio de Janeiro, RJ, Brazil
    Infect Immun 76:5543-52. 2008
    ..cruzi transmission and that some of its biological effects are attributed to LPC. This is a demonstration that a vector-derived lysophospholipid may act as an enhancing factor of Chagas disease...
  18. ncbi request reprint Biochemical and biological characterization of the venoms of Bothriopsis bilineata and Bothriopsis taeniata (Serpentes: Viperidae)
    Bárbara N Porto
    Laboratório de Inflamação e Imunidade, Depto de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Av Carlos Chagas Filho, 373, CCS Bloco I, sala 059, Ilha do Fundao, 21 941 902 Rio de Janeiro RJ, Brazil
    Toxicon 50:270-7. 2007
    ..Together, these results show that B. bilineata and B. taeniata venoms induce a marked inflammatory reaction, with leukocyte recruitment, and hemorrhage, which parallels to a high proteolytic activity found in these venoms...
  19. ncbi request reprint Unraveling the lethal synergism between Trypanosoma cruzi infection and LPS: a role for increased macrophage reactivity
    Claudia N Paiva
    Departamento de Imunologia, Instituto de Microbiologia Prof Paulo de Goes, UFRJ, Rio de Janeiro, Brasil
    Eur J Immunol 37:1355-64. 2007
    ..Our results point to independent MIF and TNF/TNF-R1 lethal pathways and suggest a role for hyperactivated macrophages in T. cruzi-sensitized LPS-induced shock...
  20. pmc Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production
    Guilherme B Fortes
    Instituto de Microbiologia Universidade Federal do Rio de Janeiro, Brazil
    Blood 119:2368-75. 2012
    ..Taken together, these results revealed that heme induces macrophage necrosis through 2 synergistic mechanisms: TLR4/Myd88-dependent expression of TNF and TLR4-independent generation of ROS...
  21. pmc Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: a relevant role on viral replication
    Eduardo G Regis
    Laboratory on Thymus Research, Oswaldo Cruz Institute FIOCRUZ, Rio de Janeiro, RJ, Brazil
    Virology 399:31-8. 2010
    ..Our results show that HIV-1 induces MIF secretion and suggest that MIF influences the HIV-1 biology through activation of HIV-1 LTR...
  22. pmc Soluble factors released by Toxoplasma gondii-infected astrocytes down-modulate nitric oxide production by gamma interferon-activated microglia and prevent neuronal degeneration
    Claudia Rozenfeld
    Instituto de Biofisica Carlos Chagas Filho, Departamento de Anatomia, ICB, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21944 590, Brazil
    Infect Immun 71:2047-57. 2003
    ..This may reduce host tissue inflammation, thus avoiding neuron damage during an established Th1 protective immune response...
  23. ncbi request reprint Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis
    Fernando A Bozza
    ICU, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Shock 22:309-13. 2004
    ....
  24. pmc Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway
    Erik Svensjo
    Instituto de Biofisica Carlos Chagas Filho, UFRJ, Rio de Janeiro, Brazil
    Microvasc Res 83:185-93. 2012
    ..The data suggest that leukocyte accumulation and plasma leakage induced by maxadilan involves a mechanism related to PAC1- and CXCR1/2-receptors on leukocytes and endothelial cells...
  25. ncbi request reprint An alpha-glucan of Pseudallescheria boydii is involved in fungal phagocytosis and Toll-like receptor activation
    Vera Carolina B Bittencourt
    Departamento de Microbiologia Geral and Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
    J Biol Chem 281:22614-23. 2006
    ..These results might have relevance in the context of infections with P. boydii and other fungi, and alpha-glucan could be a target for intervention during fungal infections...
  26. pmc Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production
    Fabiane M Barbosa
    Laboratorio de Estudos Integrados em Bioquimica Microbiana, Departamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude CCS, Rio de Janeiro, Brazil
    Clin Vaccine Immunol 14:94-8. 2007
    ..In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8...
  27. pmc Macrophage migration inhibitory factor in protozoan infections
    Marcelo T Bozza
    Laboratório de Inflamação e Imunidade, Departamento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21941 902, Rio de Janeiro, RJ, Brazil
    J Parasitol Res 2012:413052. 2012
    ..As a general trend, MIF participates in the control of parasite burden at the expense of promoting tissue damage due to increased inflammation...
  28. ncbi request reprint Nod1 participates in the innate immune response to Pseudomonas aeruginosa
    Leonardo H Travassos
    Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ CEP 21 941 590, Brazil
    J Biol Chem 280:36714-8. 2005
    ..aeruginosa. Finally, we demonstrate that the cytokine secretion kinetics and bacterial killing are altered in Nod1-deficient cells infected with P. aeruginosa in the early stages of infection...
  29. ncbi request reprint Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin
    Carmen Penido
    Laboratorio de Imunofarmacologia, Departamento de Fisiologia e Farmacodinamica, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
    J Immunol 171:6788-94. 2003
    ..Moreover, by using MCP-1 neutralizing Abs and genetically deficient mice we show that LPS- and BCG-induced gammadelta T lymphocyte influx to the pleural cavity of mice is mainly orchestrated by the CC chemokine MCP-1...
  30. ncbi request reprint Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein
    Adriana R Silva
    Departamento de Fisiologia e Farmacodinamica, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Immunol 168:4112-20. 2002
    ..MCP-1 has a key role in this inflammatory response, and 5-lipoxygenase products are essential for neutrophil recruitment into the inflamed pleural cavity...