Eduardo Magalhães Rego

Summary

Country: Brazil

Publications

  1. pmc Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia
    Sarah Cristina Bassi
    Hematology and Oncology Division, Medical School of Ribeirao Preto, Universidade de Sao Paulo USP, Ribeirao Preto, SP, Brazil
    Rev Bras Hematol Hemoter 34:134-9. 2012
  2. pmc Epidemiology and treatment of acute promyelocytic leukemia in latin america
    E M Rego
    National Institute of Science and Technology in Stem Cell and Cell Therapy, Division of Oncology Hematology, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo
    Mediterr J Hematol Infect Dis 3:e2011049. 2011
  3. pmc Differentiation syndrome in promyelocytic leukemia: clinical presentation, pathogenesis and treatment
    E M Rego
    National Institute of Science and Technology in Stem Cell and Cell Therapy, Division of Oncology Hematology, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo
    Mediterr J Hematol Infect Dis 3:e2011048. 2011
  4. pmc Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway
    Lorena L de Figueiredo-Pontes
    Hematology Division of the Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    PLoS ONE 6:e26713. 2011
  5. pmc Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia
    Hamilton L Gimenes-Teixeira
    Department of Internal Medicine, Division of Hematology Oncology, University of Sao Paulo, Ribeirao Preto, Brazil
    Exp Hematol Oncol 2:10. 2013
  6. doi Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL
    Eduardo M Rego
    Hematology Oncology Division, Department of Internal Medicine, Medical School of Ribeirão Preto and Center for Cell Based Therapy, University of Sao Paulo, Ribeirao Preto, Brazil
    Blood 121:1935-43. 2013
  7. doi The impact of medical education and networking on the outcome of leukemia treatment in developing countries. The experience of International Consortium on Acute Promyelocytic Leukemia (IC-APL)
    Eduardo M Rego
    Hematology Service, Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Hematology 17:S36-8. 2012
  8. pmc The CEBPA gene is down-regulated in acute promyelocytic leukemia and its upstream promoter, but not the core promoter, is highly methylated
    Bárbara Amélia Santana-Lemos
    Hematology Oncology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, CEP 14049 900, Ribeirao Preto, SP, Brazil
    Haematologica 96:617-20. 2011
  9. doi Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodysplastic syndrome: correlation with G-banding analysis and FISH
    Fábio Morato de Oliveira
    Department of Internal Medicine, Division of Hematology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Sao Paulo, Brazil
    Exp Hematol 41:198-208. 2013
  10. doi Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells
    Rosana Aparecida Freitas
    Hematology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, CEP 14049 900, Ribeirao Preto, SP, Brazil
    Leuk Res 33:958-63. 2009

Collaborators

  • Evandro M Fagundes
  • Maria Cristina Roque-Barreira
  • Arnon Nagler
  • Raul C Ribeiro
  • Arnold Ganser
  • David Grimwade
  • Fábio Morato de Oliveira
  • Francesco Lo-Coco
  • David Gomez-Almaguer
  • Guillermo J Ruiz-Arguelles
  • Alceu Afonso Jordao
  • Fabio Morato de Oliveira
  • Roberto Passetto Falcao
  • Antônio Roberto Lucena-Araújo
  • Gil Cunha De Santis
  • Antonio R Lucena-Araujo
  • Alexandre Krause
  • Hamilton L Gimenes-Teixeira
  • Roberto P Falcão
  • Sarah Cristina Bassi
  • Bárbara Amélia Santana-Lemos
  • Fernanda Caroline Carvalho
  • Lorena L de Figueiredo-Pontes
  • Sabrina Dias Leite-Cueva
  • Belinda Pinto Simões
  • Lorena Lobo de Figueiredo-Pontes
  • Rosana Aparecida Freitas
  • Aglair Bergamo Garcia
  • Rafael Henriques Jácomo
  • Ana Sílvia Gouveia Lima
  • Lorena Lobo de Figueiredo
  • Priscila S Scheucher
  • Luciana C Oliveira
  • Dalila L Zanette
  • Carlos Eduardo Miguel
  • Leandro F Dalmazzo
  • Wilson A Silva-Junior
  • Guilherme A Dos Santos
  • Ana Silvia Gouvêa de Lima
  • Maria De Lourdes Chauffaille
  • Rodrigo A Panepucci
  • Guilherme Augusto Dos Santos
  • Sandro Gomes Soares
  • Aglair B Garcia
  • Luciana Correa Oliveira de Oliveira
  • Ana Sílvia G Lima
  • Carolina H Thomé
  • Amélia G Araújo
  • Marco A Zago
  • Mirela Barros Tamarozzi
  • Barbara A A Santana-Lemos
  • Rafael H Jacomo
  • Ana Paula Alencar de Lima Lange
  • Carolina Hassibe Thomé
  • Lucas Gabriel Maltoni Romano
  • Roberto Passeto Falcao
  • Benedito de Pina Almeida Prado
  • Dimas Tadeu Covas
  • Patricia A Assis
  • Mariana Tereza de Lira Benício
  • Thiago Donizete da Silva José
  • Francisco de Paula Careta
  • Renata Amorim Brandão
  • Fontanari Krause
  • M Luciana
  • Helio Vannucchi
  • Priscila Santos Scheucher
  • Guilherme Augusto Silva dos Santos
  • Rodrigo Siqueira Abreu e Lima
  • Hamilton Luiz Gimenes Teixeira
  • Daniela Secco
  • Lucia Helena Faccioli
  • Mirela de Barros Tamarozzi
  • Fernando Queirós Cunha
  • Romualdo Barroso Sousa
  • Susana Elisa Moreno
  • Rodrigo Siqueira de Abreu e Lima

Detail Information

Publications21

  1. pmc Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia
    Sarah Cristina Bassi
    Hematology and Oncology Division, Medical School of Ribeirao Preto, Universidade de Sao Paulo USP, Ribeirao Preto, SP, Brazil
    Rev Bras Hematol Hemoter 34:134-9. 2012
    ..However, early mortality is still an important limitation and hematologists must be aware of the importance of treating newly diagnosed acute promyelocytic leukemia as a medical emergency...
  2. pmc Epidemiology and treatment of acute promyelocytic leukemia in latin america
    E M Rego
    National Institute of Science and Technology in Stem Cell and Cell Therapy, Division of Oncology Hematology, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo
    Mediterr J Hematol Infect Dis 3:e2011049. 2011
    ..Here, we review the main differences in APL epidemilogy in Latin America as well as treatment outcomes...
  3. pmc Differentiation syndrome in promyelocytic leukemia: clinical presentation, pathogenesis and treatment
    E M Rego
    National Institute of Science and Technology in Stem Cell and Cell Therapy, Division of Oncology Hematology, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo
    Mediterr J Hematol Infect Dis 3:e2011048. 2011
    ..In severe cases (respiratory or acute renal failure) it is recommended the discontinuation of ATRA or ATO until recovery...
  4. pmc Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway
    Lorena L de Figueiredo-Pontes
    Hematology Division of the Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    PLoS ONE 6:e26713. 2011
    ..Since loss of the TGFβ response in leukemic cells may be an important second oncogenic hit, modulation of TGFβ signaling may be of therapeutic interest...
  5. pmc Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia
    Hamilton L Gimenes-Teixeira
    Department of Internal Medicine, Division of Hematology Oncology, University of Sao Paulo, Ribeirao Preto, Brazil
    Exp Hematol Oncol 2:10. 2013
    ..Here, we evaluated miRNA expression profiles in normal thymocytes, mature T-cells, and T-ALL samples with and without CD56 expression and correlated microRNA expression with treatment outcome...
  6. doi Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL
    Eduardo M Rego
    Hematology Oncology Division, Department of Internal Medicine, Medical School of Ribeirão Preto and Center for Cell Based Therapy, University of Sao Paulo, Ribeirao Preto, Brazil
    Blood 121:1935-43. 2013
    ....
  7. doi The impact of medical education and networking on the outcome of leukemia treatment in developing countries. The experience of International Consortium on Acute Promyelocytic Leukemia (IC-APL)
    Eduardo M Rego
    Hematology Service, Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Hematology 17:S36-8. 2012
    ....
  8. pmc The CEBPA gene is down-regulated in acute promyelocytic leukemia and its upstream promoter, but not the core promoter, is highly methylated
    Bárbara Amélia Santana-Lemos
    Hematology Oncology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, CEP 14049 900, Ribeirao Preto, SP, Brazil
    Haematologica 96:617-20. 2011
    ..Our results corroborate data obtained in animal models showing that CEBPA is down-regulated in acute promyelocytic leukemia stem cells and suggest that epigenetic mechanisms may be involved...
  9. doi Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodysplastic syndrome: correlation with G-banding analysis and FISH
    Fábio Morato de Oliveira
    Department of Internal Medicine, Division of Hematology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Sao Paulo, Brazil
    Exp Hematol 41:198-208. 2013
    ....
  10. doi Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells
    Rosana Aparecida Freitas
    Hematology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, CEP 14049 900, Ribeirao Preto, SP, Brazil
    Leuk Res 33:958-63. 2009
    ..Our results support the concept of alpha-TOS as an anti-leukemic compound which spares normal hematopoiesis...
  11. doi High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia
    Antonio R Lucena-Araujo
    Department of Internal Medicine, Hematology Division, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14048 900 Ribeirao Preto, Brazil
    Leuk Res 35:260-4. 2011
    ..001). In conclusion, we described a significant association between overexpression of AURKA/B and cytogenetics findings in AML, which may be relevant to new therapeutic approaches, based on Aurora kinase inhibitors...
  12. doi FISH analysis for TET2 deletion in a cohort of 362 Brazilian myeloid malignancies: correlation with karyotype abnormalities
    Fabio Morato de Oliveira
    Department of Internal Medicine, Division of Hematology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Med Oncol 30:483. 2013
    ..The search for alterations in TET2 gene may be important for the prediction of prognosis in normal/altered AML patients' karyotype or in the disease evolution of patients with MNP and MDS...
  13. ncbi Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia
    Gil Cunha De Santis
    Center for Cell Based Therapy, Medical School of Ribeirao Preto, University of Sao Paulo, Brazil
    J Clin Apher 26:181-5. 2011
    ..Other forms of treatment must be found to reduce the high mortality rate related to leukostasis...
  14. doi Identification of a new translocation that disrupts the RUNX1 gene in a patient with de novo acute myeloid leukemia
    Antônio Roberto Lucena-Araújo
    Department of Internal Medicine, Hematology Division, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, Ribeirao Preto, São Paulo 14048 900, Brazil
    Med Oncol 29:1114-8. 2012
    ....
  15. pmc The recognition of N-glycans by the lectin ArtinM mediates cell death of a human myeloid leukemia cell line
    Fernanda Caroline Carvalho
    Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brasil
    PLoS ONE 6:e27892. 2011
    ..Our results provide new insights into the potential of N-glycans containing a β1,6-GlcNAc branch linked to α1,6-mannose as a novel target for anti-leukemia treatment...
  16. pmc Granulocyte colony-stimulating factor and leukemogenesis
    Lorena Lobo de Figueiredo
    Division of Hematology, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Campus USP, 14049 900, Ribeirao Preto, Sao Paulo, Brazil
    Mediators Inflamm 13:145-50. 2004
    ..Finally, in the PLZF-RARalpha acute promyelocytic leukemia transgenic model, G-CSF deficiency suppressed leukemia development. Altogether, these data suggest that the G-CSF signaling pathway may play a role in leukemogenesis...
  17. ncbi Adhesion molecules and Differentiation Syndrome: phenotypic and functional analysis of the effect of ATRA, As2O3, phenylbutyrate, and G-CSF in acute promyelocytic leukemia
    Gil Cunha De Santis
    Hematology Division and Center for Cell Based Therapy, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Brazil
    Haematologica 92:1615-22. 2007
    ..As(2)O(3), Phenylbutyrate (PB) and G-CSF are known to potentiate ATRA effects. Our aim was to analyze the changes in expression and function of adhesion molecules induced by ATRA, As(2)O(3), G-CSF and PB, and their association...
  18. ncbi [From the molecular model to the impact on prognosis: an overview on acute promyelocytic leukemia]
    Rafael Henriques Jácomo
    Laboratorio de Hematologia, Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, SP, Brazil
    Rev Assoc Med Bras 54:82-9. 2008
    ..Differing from excellent results observed in developed countries, APL mortality in Brazil is still high, despite the wide availability of drugs...
  19. doi Tetrasomy 8 in a patient with chronic lymphocytic leukemia
    Fabio Morato de Oliveira
    Department of Internal Medicine, Division of Hematology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, SP, Brazil
    Cancer Genet Cytogenet 198:166-9. 2010
    ..The prognostic significance of tetrasomy 8 in CLL remains to be elucidated. However, the patient has been followed up in the outpatient hospital since 2004 without any therapeutic intervention and has so far remained stable...
  20. ncbi Targeting the acute myeloid leukemia stem cells
    Alexandre Krause
    Hematology Division, Department of Internal Medicine, Medical School of Ribeirão Preto and National Institute of Science and Technology on Cell Based Therapy, University of Sao Paulo, Campus USP, Ribeirao Preto, SP, Brazil
    Anticancer Agents Med Chem 10:104-10. 2010
    ..The aim of this review is, by taking acute myeloid leukemia (AML) as a bona fide example, to discuss some of the mechanisms used by the LSCs to survive and the strategies which could be used to eradicate these cells...