Wiliam A Prado

Summary

Country: Brazil

Publications

  1. pmc The antinociceptive effect of electroacupuncture at different depths of acupoints and under the needling surface
    Marcelo L Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Avenue Bandeirantes 3900, CEP 14049 900 Ribeirao Preto, SP, Brazil
    Chin Med 7:3. 2012
  2. doi request reprint Postoperative analgesia induced by intrathecal neostigmine or bethanechol in rats
    W A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 36:648-54. 2009
  3. ncbi request reprint Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Brain Res 1018:272-82. 2004
  4. ncbi request reprint Antinociceptive potency of intrathecal morphine in the rat tail flick test: a comparative study using acute lumbar catheter in rats with or without a chronic atlanto-occipital catheter
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    J Neurosci Methods 129:33-9. 2003
  5. ncbi request reprint Microinjection of renin-angiotensin system peptides in discrete sites within the rat periaqueductal gray matter elicits antinociception
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, USP, Ribeirao Preto, SP 14049 900, Brazil
    Brain Res 972:207-15. 2003
  6. ncbi request reprint Antinociceptive potency of aminoglycoside antibiotics and magnesium chloride: a comparative study on models of phasic and incisional pain in rats
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 35:395-403. 2002
  7. ncbi request reprint Presurgical ketoprofen, but not morphine, dipyrone, diclofenac or tenoxicam, preempts post-incisional mechanical allodynia in rats
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 35:111-9. 2002
  8. ncbi request reprint Involvement of calcium in pain and antinociception
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes, 3900, 14040 900 Ribeirão Preto, SP, Brazil
    Braz J Med Biol Res 34:449-61. 2001
  9. ncbi request reprint Antinociceptive effect of intrathecal neostigmine evaluated in rats by two different pain models
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 30:1225-31. 1997
  10. ncbi request reprint The anterior pretectal nucleus participates as a relay station in the glutamate-, but not morphine-induced antinociception from the dorsal raphe nucleus in rats
    W A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    Pain 88:169-76. 2000

Collaborators

  • Adriana Pelegrini-da-Silva
  • Elaine A Del Bel
  • Fernando Q Cunha
  • Gabriela Rocha Lauretti
  • Marcelo L Silva
  • Glaucia Melo Reis
  • João Walter S Silveira
  • Cristiane F Villarreal
  • Josie R T Silva
  • Quintino M Dias
  • Ana Carolina Rossaneis
  • Vania Aparecida V Kina
  • Ariane Petronilho
  • Quintino Moura Dias
  • A F Gaspar
  • Raquel de Oliveira
  • A M Sousa
  • Josie Rt Silva
  • M A Oliveira
  • Rafael S Fais
  • Gláucia M Reis
  • Norberto Garcia-Cairasco
  • Flavio Del Vecchio
  • Simone F Crespilho
  • M L Mamede Rosa
  • Marlene P dos Reis
  • Vania A V Kina

Detail Information

Publications33

  1. pmc The antinociceptive effect of electroacupuncture at different depths of acupoints and under the needling surface
    Marcelo L Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Avenue Bandeirantes 3900, CEP 14049 900 Ribeirao Preto, SP, Brazil
    Chin Med 7:3. 2012
    ..abstract:..
  2. doi request reprint Postoperative analgesia induced by intrathecal neostigmine or bethanechol in rats
    W A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 36:648-54. 2009
    ..However, the similar behaviour of bethanechol in the same model points to an additional mechanism involving intrinsic changes in spinal muscarinic receptors...
  3. ncbi request reprint Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Brain Res 1018:272-82. 2004
    ..The acetylcholine released by DM in turn induces antinociception via activation of muscarinic receptors...
  4. ncbi request reprint Antinociceptive potency of intrathecal morphine in the rat tail flick test: a comparative study using acute lumbar catheter in rats with or without a chronic atlanto-occipital catheter
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    J Neurosci Methods 129:33-9. 2003
    ..The use of an AL catheter minimizes such spinal changes and permits acute experimental protocols in which more than one spinal injection is necessary...
  5. ncbi request reprint Microinjection of renin-angiotensin system peptides in discrete sites within the rat periaqueductal gray matter elicits antinociception
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, USP, Ribeirao Preto, SP 14049 900, Brazil
    Brain Res 972:207-15. 2003
    ..This study shows for the first time the antinociceptive effect of RS, AI, AII and III in well-defined PAG regions, an effect that is receptor mediated for AII...
  6. ncbi request reprint Antinociceptive potency of aminoglycoside antibiotics and magnesium chloride: a comparative study on models of phasic and incisional pain in rats
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 35:395-403. 2002
    ..Magnesium was less potent than the antibiotics and effective in the tail-flick test only...
  7. ncbi request reprint Presurgical ketoprofen, but not morphine, dipyrone, diclofenac or tenoxicam, preempts post-incisional mechanical allodynia in rats
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 35:111-9. 2002
    ..It is concluded that stimuli generated in the inflamed tissue, rather than changes in the central nervous system are relevant for the persistence of pain in the model of post-incisional pain...
  8. ncbi request reprint Involvement of calcium in pain and antinociception
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes, 3900, 14040 900 Ribeirão Preto, SP, Brazil
    Braz J Med Biol Res 34:449-61. 2001
    ..This article reviews the manners by which calcium ions penetrate cell membranes and the changes in these mechanisms caused by opioids and calcium antagonists regarding nociceptive and antinociceptive events...
  9. ncbi request reprint Antinociceptive effect of intrathecal neostigmine evaluated in rats by two different pain models
    W A Prado
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 30:1225-31. 1997
    ..In addition, we show that inhibition by a lower dose of neostigmine of the formalin-induced phasic pain did not prevent the subsequent occurrence of tonic pain produced by the irritant...
  10. ncbi request reprint The anterior pretectal nucleus participates as a relay station in the glutamate-, but not morphine-induced antinociception from the dorsal raphe nucleus in rats
    W A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    Pain 88:169-76. 2000
    ..The study also further supports the notion that the DRN is involved in both descending and ascending pain inhibitory systems...
  11. ncbi request reprint The effects of intraspinal L-NOARG or SIN-1 on the control by descending pathways of incisional pain in rats
    Vania Aparecida V Kina
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Ribeirao Preto, SP, 14049 900, Brazil
    Life Sci 76:1939-51. 2005
    ....
  12. doi request reprint Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the activation of different descending pain inhibitory mechanisms
    Josie R T Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Avenida Bandeirantes 3900, Ribeirao Preto, SP, Brazil
    J Pain 12:51-60. 2011
    ..In contrast, the intensity of 100-Hz EAIA involves spinal muscarinic, opioid, and GABA(B) mechanisms, while the duration of the effects depends on spinal serotonergic, muscarinic, opioid, and GABA(A) mechanisms...
  13. doi request reprint Stimulation-produced analgesia from the occipital or retrosplenial cortex of rats involves serotonergic and opioid mechanisms in the anterior pretectal nucleus
    Glaucia Melo Reis
    Department of Pharmacology, University of Sao Paulo, Ribeirao Preto, Brazil
    J Pain 12:523-30. 2011
    ..We conclude that the APtN acts as an intermediary for separate descending pain inhibitory pathways activated from the OC and RSC, utilizing at least serotonin and endogenous opioid as mediators in the nucleus...
  14. doi request reprint Antinociceptive effect of stimulating the zona incerta with glutamate in rats
    Ariane Petronilho
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
    Pharmacol Biochem Behav 101:360-8. 2012
    ..This profile resembles the reported effects of these antagonists on the antinociception caused by stimulating the periaqueductal gray or the pedunculopontine tegmental nucleus...
  15. doi request reprint Retrosplenial cortex is involved in analgesia induced by 2- but not 100-Hz electroacupuncture in the rat tail-flick test
    Marcelo L Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Av Bandeirantes 3900, CEP 14049 900, Ribeirao Preto, SP, Brazil
    J Acupunct Meridian Stud 5:42-5. 2012
    ..The integrity of the RSC is implicated in the duration of analgesia induced by low-frequency EA but is not essential for the analgesic effects evoked by high-frequency EA...
  16. pmc Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats
    João Walter S Silveira
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
    Mol Pain 6:17. 2010
    ..The number of spinal c-Fos positive neurons of rats treated intrathecally with serotonin, noradrenaline or acetylcholine antagonists where evaluated to study the descending pathways activated by a surgical paw incision...
  17. ncbi request reprint Antinociception induced by stimulating the anterior pretectal nucleus in two models of pain in rats
    Cristiane F Villarreal
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Ribeirao Preto, SP, Brazil
    Clin Exp Pharmacol Physiol 31:608-13. 2004
    ..The noxious stimulation produced during the tail flick test may be not enough to activate the same circuitry, but electrical stimulation at the dorsal APtN is very effective in inhibiting brief thermal noxious inputs at the spinal level...
  18. doi request reprint Stimulation of the occipital or retrosplenial cortex reduces incision pain in rats
    Ana Carolina Rossaneis
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
    Pharmacol Biochem Behav 100:220-7. 2011
    ..The pathway activated from the RSC utilizes serotonergic and opioid mediation in the APtN, whereas stimulation of the OC utilizes a non-serotonergic, non-cholinergic and non-opioid mediation in the same nucleus...
  19. doi request reprint The integrity of the anterior pretectal nucleus and dorsolateral funiculus is necessary for electroacupuncture-induced analgesia in the rat tail-flick test
    Marcelo L Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Av Bandeirantes 3900, CEP 14049 900, Ribeirao Preto, SP, Brazil
    Eur J Pain 14:249-54. 2010
    ..We thus conclude that the integrity of the APtN and DLF is necessary for EA-induced analgesia in the rat tail-flick test. In addition, the integrity of the dorsal APtN is necessary for the analgesic effect of 2 but not 100 Hz EA...
  20. doi request reprint Antinociceptive effect of stimulating the occipital or retrosplenial cortex in rats
    Glaucia Melo Reis
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Pain 11:1015-26. 2010
    ..These findings enhance our understanding of the role of the cerebral cortex in control of pain...
  21. ncbi request reprint Role of PAG in the antinociception evoked from the medial or central amygdala in rats
    M A Oliveira
    Department of Pharmacology, , , , Brazil
    Brain Res Bull 54:55-63. 2001
    ..The circuitry activated from the CE, but not the ME, utilises opioid mediation in the PAG. The effect from the CE depends at least on mu-opioid, serotonergic, and probably beta-adrenergic mediation in the PAG...
  22. ncbi request reprint Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat
    Cristiane F Villarreal
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Pain 103:163-74. 2003
    ..The results also are in agreement with the current notion that persistent noxious inputs to the APtN tonically activate a descending mechanism that excites superficial cells and inhibits deep cells in the spinal dorsal horn...
  23. doi request reprint Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter
    A Pelegrini-da-Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, ZIP 14049 900 Ribeirão Preto, Sao Paulo, Brazil
    Neuroscience 164:1263-73. 2009
    ....
  24. doi request reprint Muscarinic and alpha(1)-adrenergic mechanisms contribute to the spinal mediation of stimulation-induced antinociception from the pedunculopontine tegmental nucleus in the rat
    Quintino M Dias
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Ribeirao Preto, SP, Brazil
    Pharmacol Biochem Behav 92:488-94. 2009
    ..Serotonergic, endogenous opioid and alpha(2)-adrenergic mechanisms are involved in the duration but not in the intensity of the effect...
  25. ncbi request reprint Participation of brainstem nuclei in the pronociceptive effect of lesion or neural block of the anterior pretectal nucleus in a rat model of incisional pain
    Cristiane F Villarreal
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, USP, Rebeirao Preto, 14049 900 SP, Brazil
    Neuropharmacology 47:117-27. 2004
    ....
  26. ncbi request reprint The dual effect of a nitric oxide donor in nociception
    A M Sousa
    Department of Pharmacology, , USP, Av. Bandeirantes 3900, 149049-900, SP, , Brazil
    Brain Res 897:9-19. 2001
    ..The effects of SIN-1 vary depending on the dose and pain model utilized, but its most sensitive effect seems to be antinociception. However, high doses of the NO-donor can intensify ongoing pain...
  27. ncbi request reprint The effects of early or late neurolytic sympathetic plexus block on the management of abdominal or pelvic cancer pain
    Raquel de Oliveira
    Department of Biomechanic, Medicine and Rehabilitation of the Locomotor Apparatus, Faculty of Medicine of Ribeirao Preto, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Pain 110:400-8. 2004
    ..05). The occasional neurolysis-related complications were transitory. The results suggest NSPB for the management of cancer pain should be considered earlier in the disease...
  28. ncbi request reprint Oral ketamine and transdermal nitroglycerin as analgesic adjuvants to oral morphine therapy for cancer pain management
    G R Lauretti
    Department of Surgery, Orthopedics and Traumatology, Center for Pain Treatment, Hospital das Clinicas, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Anesthesiology 90:1528-33. 1999
    ..This study was designed to evaluate the role of oral ketamine or transdermal nitroglycerin polymer, a nitric oxide donor, as coadjuvants to oral morphine in cancer pain therapy...
  29. ncbi request reprint A new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociception
    A Pelegrini-da-Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Neuroscience 132:453-63. 2005
    ....
  30. ncbi request reprint Dual effect of local application of nitric oxide donors in a model of incision pain in rats
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Av Bandeirantes 3900, CEP 14049 900, Ribeirao Preto, Sao Paolo, Brazil
    Eur J Pharmacol 441:57-65. 2002
    ..Drugs generating high NO concentrations, however, intensify pain via a guanylate cyclase-independent mechanism...
  31. ncbi request reprint Comparison of pre- versus post-incision administration of intraplantar indomethacin and MK886 in a rat model of postoperative pain
    A F Gaspar
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Braz J Med Biol Res 40:1141-7. 2007
    ..In conclusion, preoperative inhibition of the local generation of both prostaglandins and leukotrienes by surgical incision may be an alternative to provide preemptive analgesia...
  32. ncbi request reprint Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat
    M L Mamede Rosa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Brain Res 757:133-8. 1997
    ..These results indicate that the antinociceptive effects of opioid or serotonergic agonists microinjected into the APtN depend on drug interaction with local mu or 5-HT1B receptors, respectively...
  33. ncbi request reprint High-performance liquid chromatographic separation of renin-angiotensin system peptides and most of their metabolic fragments
    Adriana Pelegrini-da-Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    J Chromatogr B Analyt Technol Biomed Life Sci 780:301-7. 2002
    ....