A T Wyse


Affiliation: Porto Alegre
Country: Brazil


  1. Dos Santos T, Siebert C, de Oliveira M, Manfredini V, Wyse A. Chronic mild Hyperhomocysteinemia impairs energy metabolism, promotes DNA damage and induces a Nrf2 response to oxidative stress in rats brain. Cell Mol Neurobiol. 2019;: pubmed publisher
    ..These changes may be associated with the mechanisms by which chronic mild HHCY has been linked to the risk factor of fear, mood disorders and depression, as well as in neurodegenerative diseases. ..
  2. Wyse A, Grings M, Wajner M, Leipnitz G. The Role of Oxidative Stress and Bioenergetic Dysfunction in Sulfite Oxidase Deficiency: Insights from Animal Models. Neurotox Res. 2019;35:484-494 pubmed publisher
    ..These promising data offer new perspectives for potential therapeutic strategies for this condition, which may include the early use of appropriate antioxidants and PPAR agonists in addition to the available treatment. ..
  3. Siebert C, Bertó C, Ferreira F, Moreira D, Dos Santos T, Wyse A. Vitamin D partially reverses the increase in p-NF-κB/p65 immunocontent and interleukin-6 levels, but not in acetylcholinesterase activity in hippocampus of adult female ovariectomized rats. Int J Dev Neurosci. 2018;71:122-129 pubmed publisher
    ..Our findings may help in the understanding of the brain changes that occurs in post menopause period and open perspectives for futures research involving VIT D therapies. ..
  4. Siebert C, Dos Santos T, Bertó C, Parisi M, Coelho R, Manfredini V, et al. Vitamin D Supplementation Reverses DNA Damage and Telomeres Shortening Caused by Ovariectomy in Hippocampus of Wistar Rats. Neurotox Res. 2018;34:538-546 pubmed publisher
    ..Taken together, these results demonstrate that surgical menopause in rats causes hippocampal biochemical changes and VIT D appears, at least in part, to act in a beneficial way. ..
  5. da Cunha M, da Cunha A, Loureiro S, Machado F, Schmitz F, Kolling J, et al. Experimental Lung Injury Promotes Changes in Oxidative/Nitrative Status and Inflammatory Markers in Cerebral Cortex of Rats. Mol Neurobiol. 2015;52:1590-1600 pubmed publisher
    ..Our findings show that the lung injury alters oxidative/nitrative status and induces inflammation in the cerebral cortex of rats, which might be associated with cognitive impairments present in patients with lung injury. ..
  6. Schmitz F, Pierozan P, Rodrigues A, Biasibetti H, Coelho D, Mussulini B, et al. Chronic Treatment with a Clinically Relevant Dose of Methylphenidate Increases Glutamate Levels in Cerebrospinal Fluid and Impairs Glutamatergic Homeostasis in Prefrontal Cortex of Juvenile Rats. Mol Neurobiol. 2016;53:2384-96 pubmed publisher
  7. Longoni A, Kolling J, dos Santos T, dos Santos J, da Silva J, Pettenuzzo L, et al. 1,25-Dihydroxyvitamin D3 exerts neuroprotective effects in an ex vivo model of mild hyperhomocysteinemia. Int J Dev Neurosci. 2016;48:71-9 pubmed publisher
    ..Calcitriol (50 nM) prevented these alterations by increasing the level of the vitamin D receptor. Our findings suggest that using calcitriol may be a therapeutic strategy for treating the cerebral complications caused by Hcy. ..
  8. Ferreira F, Biasibetti Brendler H, Pierozan P, Schmitz F, Bertó C, Prezzi C, et al. Kynurenic Acid Restores Nrf2 Levels and Prevents Quinolinic Acid-Induced Toxicity in Rat Striatal Slices. Mol Neurobiol. 2018;55:8538-8549 pubmed publisher
    ..This study elucidates some of the protective effects of KYNA against the damage caused by QUIN toxicity. ..
  9. Schmitz F, Pierozan P, Rodrigues A, Biasibetti H, Grings M, Zanotto B, et al. Methylphenidate Decreases ATP Levels and Impairs Glutamate Uptake and Na+,K+-ATPase Activity in Juvenile Rat Hippocampus. Mol Neurobiol. 2017;54:7796-7807 pubmed publisher
    ..Taken together, our results suggest that chronic MPH exposure at early age impairs glutamate uptake and Na+,K+-ATPase activity probably by decreasing in ATP levels observed in rat hippocampus. ..

More Information


  1. Schmitz F, Pierozan P, Biasibetti Brendler H, Ferreira F, dos Santos Petry F, Trindade V, et al. Methylphenidate disrupts cytoskeletal homeostasis and reduces membrane-associated lipid content in juvenile rat hippocampus. Metab Brain Dis. 2018;33:693-704 pubmed publisher
  2. Longoni A, Kolling J, Siebert C, dos Santos J, da Silva J, Pettenuzzo L, et al. 1,25-Dihydroxyvitamin D3 prevents deleterious effects of homocysteine on mitochondrial function and redox status in heart slices. Nutr Res. 2017;38:52-63 pubmed publisher
    ..These findings suggest that calcitriol may be a preventive/therapeutic strategy for complications caused by Hcy. ..
  3. Dos Santos T, Kolling J, Siebert C, Biasibetti H, Bertó C, Grun L, et al. Effects of previous physical exercise to chronic stress on long-term aversive memory and oxidative stress in amygdala and hippocampus of rats. Int J Dev Neurosci. 2017;56:58-67 pubmed publisher
    ..Our findings suggest that physical exercise during the developmental period may protect against aversive memory impairment and brain oxidative damage caused by chronic stress exposure later in life. ..
  4. Schmitz F, Pierozan P, Rodrigues A, Biasibetti H, Grunevald M, Pettenuzzo L, et al. Methylphenidate Causes Behavioral Impairments and Neuron and Astrocyte Loss in the Hippocampus of Juvenile Rats. Mol Neurobiol. 2017;54:4201-4216 pubmed publisher
  5. Rodrigues A, Biasibetti H, Zanotto B, Sanches E, Schmitz F, Nunes V, et al. D-Galactose Causes Motor Coordination Impairment, and Histological and Biochemical Changes in the Cerebellum of Rats. Mol Neurobiol. 2017;54:4127-4137 pubmed publisher
    ..Our results suggest that galactose induces histological and biochemical changes in cerebellum, which can be associated with motor coordination impairment. ..
  6. Kolling J, Scherer E, Siebert C, Longoni A, Loureiro S, Weis S, et al. Severe Hyperhomocysteinemia Decreases Respiratory Enzyme and Na(+)-K(+) ATPase Activities, and Leads to Mitochondrial Alterations in Rat Amygdala. Neurotox Res. 2016;29:408-18 pubmed publisher
  7. Biasibetti H, Pierozan P, Rodrigues A, Manfredini V, Wyse A. Hypoxanthine Intrastriatal Administration Alters Neuroinflammatory Profile and Redox Status in Striatum of Infant and Young Adult Rats. Mol Neurobiol. 2017;54:2790-2800 pubmed publisher
  8. Pierozan P, Biasibetti H, Schmitz F, Ávila H, Fernandes C, Pessoa Pureur R, et al. Neurotoxicity of Methylmercury in Isolated Astrocytes and Neurons: the Cytoskeleton as a Main Target. Mol Neurobiol. 2017;54:5752-5767 pubmed publisher
    ..Otherwise, redox imbalance and glutamate-independent mechanisms disrupted the cytoskeleton and induced necrosis in MeHg-exposed astrocyte. ..
  9. Schweinberger B, Rodrigues A, Turcatel E, Pierozan P, Pettenuzzo L, Grings M, et al. Maternal Hypermethioninemia Affects Neurons Number, Neurotrophins Levels, Energy Metabolism, and Na+,K+-ATPase Expression/Content in Brain of Rat Offspring. Mol Neurobiol. 2018;55:980-988 pubmed publisher
    ..These results indicate that maternal hypermethioninemia may be a predisposing factor for damage to the brain during the intrauterine life. ..
  10. Biasibetti Brendler H, Schmitz F, Pierozan P, Zanotto B, Prezzi C, de Andrade R, et al. Hypoxanthine Induces Neuroenergetic Impairment and Cell Death in Striatum of Young Adult Wistar Rats. Mol Neurobiol. 2018;55:4098-4106 pubmed publisher
  11. Siebert C, Pierozan P, Kolling J, Dos Santos T, Sebotaio M, Marques E, et al. Vitamin D3 Reverses the Hippocampal Cytoskeleton Imbalance But Not Memory Deficits Caused by Ovariectomy in Adult Wistar Rats. Neuromolecular Med. 2017;19:345-356 pubmed publisher
    ..Vitamin D reversed the effects caused by OVX on cytoskeleton in hippocampus, but it was not able to reverse the effects on memory. ..
  12. Wyse A, Netto C. Behavioral and neurochemical effects of proline. Metab Brain Dis. 2011;26:159-72 pubmed publisher
  13. Vuaden F, Savio L, Rico E, Mussulini B, Rosemberg D, de Oliveira D, et al. Methionine Exposure Alters Glutamate Uptake and Adenine Nucleotide Hydrolysis in the Zebrafish Brain. Mol Neurobiol. 2016;53:200-209 pubmed publisher
    ..This phenomenon might explain, at least in part, the increased susceptibility of hypermethioninemic patients to neurological symptoms. ..
  14. de S Moreira D, Figueiró P, Siebert C, Prezzi C, Rohden F, Guma F, et al. Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective?. Neurotox Res. 2018;33:580-592 pubmed publisher
  15. Schweinberger B, Rodrigues A, Dos Santos T, Rohden F, Barbosa S, da Luz Soster P, et al. Methionine Administration in Pregnant Rats Causes Memory Deficit in the Offspring and Alters Ultrastructure in Brain Tissue. Neurotox Res. 2018;33:239-246 pubmed publisher
    ..Our findings suggest that the cell morphological changes caused by maternal hypermethioninemia may be, at least partially, associated to the memory deficit of rat offspring. ..
  16. Rodrigues A, Biasibetti H, Zanotto B, Sanches E, Pierozan P, Schmitz F, et al. Intracerebroventricular D-galactose administration impairs memory and alters activity and expression of acetylcholinesterase in the rat. Int J Dev Neurosci. 2016;50:1-6 pubmed publisher
    ..These findings suggest that these changes in AChE may, at least in part, to lead to memory impairment caused by galactose. Taken together, our results can help understand the etiopathology of classical galactosemia. ..
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    Schweinberger B, Wyse A. Mechanistic basis of hypermethioninemia. Amino Acids. 2016;48:2479-2489 pubmed
    ..Besides, reactive oxygen species may mediate other alterations induced by methionine, such as the reduction in brain Na+,K+-ATPase activity, and liver inflammation. ..
  18. Kolling J, Longoni A, Siebert C, Dos Santos T, Marques E, Carletti J, et al. Severe Hyperhomocysteinemia Decreases Creatine Kinase Activity and Causes Memory Impairment: Neuroprotective Role of Creatine. Neurotox Res. 2017;32:585-593 pubmed publisher
    ..This finding may be associated, at least in part, with memory improvement, suggesting that creatine might represent an effective adjuvant to protect against the effects of high homocysteine plasma levels. ..
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    Wyse A, Bavaresco C, Hagen M, Delwing D, Wannmacher C, Severo Dutra Filho C, et al. In vitro stimulation of oxidative stress in cerebral cortex of rats by the guanidino compounds accumulating in hyperargininemia. Brain Res. 2001;923:50-7 pubmed
    ..The results suggest that oxidative stress caused by guanidino compounds may be involved in the brain dysfunction amongst other potential pathophysiological mechanisms observed in hyperargininemia...
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    Wyse A, Stefanello F, Chiarani F, Delwing D, Wannmacher C, Wajner M. Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction. Neurochem Res. 2004;29:385-9 pubmed