Research Topics
Genomes and GenesSpecies | Tatiana RomanSummaryAffiliation: Porto Alegre Country: Brazil Publications
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Detail Information
Publications
Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorderTatiana Roman
Department of Morphological Sciences, Federal School of Medical Sciences of Porto Alegre, Porto Alegre, Brazil
Am J Pharmacogenomics 4:83-92. 2004....
A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorderJulia P Genro
Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Am J Med Genet B Neuropsychiatr Genet 147:1568-75. 2008....- Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHDAngélica Salatino-Oliveira
Departamento de Genetica, Instituto de Biociencias, UFRGS, Caixa Postal 15053, Porto Alegre, RS 91501 970, Brazil
J Neural Transm 119:729-33. 2012..762; p = 0.016; OR = 1.58; CI(95%) = 1.07-2.35). Our findings replicate previous results and suggest a role for COMT in the etiology of DBD in children and adolescents with ADHD... - Further evidence for the association between attention deficit/hyperactivity disorder and the serotonin receptor 1B geneAna P Guimarães
Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Caixa Postal 15053, Porto Alegre, RS 91501 970, Brazil
J Neural Transm 116:1675-80. 2009..Our results provide additional evidence that HRT1B gene may be an important risk factor for the development of ADHD, but this effect seems not to be attributable to inattentive cases... - Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder?Tatiana Roman
Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Am J Med Genet B Neuropsychiatr Genet 120:116-20. 2003..They are also consistent with the noradrenergic theories of ADHD, suggesting a role for the alpha2A adrenergic receptors in the disorder... - A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian childrenJulia P Genro
Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Am J Med Genet B Neuropsychiatr Genet 144:215-9. 2007..004). Our results suggest a role for the promoter region of DAT1 gene in ADHD susceptibility in this Brazilian sample... - Association between alpha-2a-adrenergic receptor gene and ADHD inattentive typeMarcelo Schmitz
ADHD Outpatient Clinic Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul 90035 003, Brazil
Biol Psychiatry 60:1028-33. 2006..This study aimed to investigate the association between this ADRA2A polymorphism and attention-deficit/hyperactivity disorder-inattentive type (ADHD-I) in a nonreferred sample... - MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorderAna P Guimarães
Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Int J Neuropsychopharmacol 12:709-14. 2009..83, p=0.009). These results suggest an effect of the MAOA-uVNTR high-activity genotype on the improvement of oppositional symptoms with MPH treatment... - Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boysAna Paula M Guimarães
Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Am J Med Genet B Neuropsychiatr Genet 144:69-73. 2007..04). Our results suggest that findings from ADHD association studies for serotonin genes might be understood in the context of a gender effect, which may help to explain conflicting results in these association studies... - Further evidence for the association between attention-deficit/hyperactivity disorder and the dopamine-beta-hydroxylase geneTatiana Roman
Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Am J Med Genet 114:154-8. 2002..42, one-tailed P=0.01). Our results suggest a contribution of this gene to ADHD susceptibility, partially replicating previous findings that have demonstrated an association between the DBH TaqI A2 allele and ADHD... - 22q11.2 deletion syndrome in patients admitted to a cardiac pediatric intensive care unit in BrazilRafael F M Rosa
Clinical Genetics, Universidade Federal de Ciências da Saúde de Porto Alegre UFCSPA and Complexo Hospitalar Santa Casa de Porto Alegre CHSCPA, Porto Alegre, RS, Brazil
Am J Med Genet A 146:1655-61. 2008..It is possible that 22q11DS patients with a severe CHD could have died before having a chance to access a tertiary hospital, leading to an underestimate of its frequency... - Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorderTatiana Roman
Department of Genetics, Federal University of Rio Grande do Sul, Brazil
Pharmacogenetics 12:497-9. 2002..01). Our findings support an association between homozygosity for the 10-repeat allele at dopamine transporter gene locus and poor response to MPH... - Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot studyLuis A Rohde
ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
Synapse 48:87-9. 2003..05). These findings provide a preliminary connection between pharmacogenetics and neurobiological investigations on stimulant treatment of ADHD... - Attention-deficit/hyperactivity disorder: advancing on pharmacogenomicsGuilherme Polanczyk
Federal University of Rio Grande do Sul, ADHD Out-Patient Clinic, Child and Adolescent Psychiatric Division, , Brazil
Pharmacogenomics 6:225-34. 2005..As such, multi-site collaborative efforts to obtain larger samples with standardized methodology should be encouraged... - No significant association between response to methylphenidate and genes of the dopaminergic and serotonergic systems in a sample of Brazilian children with attention-deficit/hyperactivity disorderCristian Patrick Zeni
ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil
Am J Med Genet B Neuropsychiatr Genet 144:391-4. 2007..Prospective multi-site controlled studies with larger sample sizes are needed in order to disentangle the role of candidate genes in response to ADHD treatment... - Brain perfusion and dopaminergic genes in boys with attention-deficit/hyperactivity disorderClaudia Szobot
Division of Child and Adolescent Psychiatry, Department of Psychiatry, , Federal University of Rio Grande do Sul, Brazil
Am J Med Genet B Neuropsychiatr Genet 132:53-8. 2005..05). Our findings suggest that a higher recruitment in middle temporal gyrus, an area associated to working memory and selective attention, should exist to compensate a putative effect of the interaction between these dopaminergic genes... 
Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypesNaomi Lowe
Department of Genetics, Trinity College, Dublin 2, Ireland
Am J Hum Genet 74:348-56. 2004..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes...- Association between DRD4 gene and performance of children with ADHD in a test of sustained attentionChristian Kieling
Department of Psychiatry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre 90035 003, RS, Brazil
Biol Psychiatry 60:1163-5. 2006..The adoption of neuropsychological tests as endophenotypic measures can provide an increased sensitivity to specific dimensions of attention-deficit/hyperactivity disorder (ADHD)... - Association of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorderGuilherme Polanczyk
Attention Deficit Hyperactivity Disorder Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
Arch Gen Psychiatry 64:218-24. 2007..However, the effect of ADRA2A in the response to methylphenidate in humans has not been previously investigated, to our knowledge...