Tatiana Roman

Summary

Affiliation: Porto Alegre
Country: Brazil

Publications

  1. ncbi request reprint Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder
    Tatiana Roman
    Department of Morphological Sciences, Federal School of Medical Sciences of Porto Alegre, Porto Alegre, Brazil
    Am J Pharmacogenomics 4:83-92. 2004
  2. doi request reprint A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder
    Julia P Genro
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 147:1568-75. 2008
  3. doi request reprint Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD
    Angélica Salatino-Oliveira
    Departamento de Genetica, Instituto de Biociencias, UFRGS, Caixa Postal 15053, Porto Alegre, RS 91501 970, Brazil
    J Neural Transm 119:729-33. 2012
  4. doi request reprint Further evidence for the association between attention deficit/hyperactivity disorder and the serotonin receptor 1B gene
    Ana P Guimarães
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Caixa Postal 15053, Porto Alegre, RS 91501 970, Brazil
    J Neural Transm 116:1675-80. 2009
  5. ncbi request reprint Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder?
    Tatiana Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 120:116-20. 2003
  6. ncbi request reprint A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children
    Julia P Genro
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:215-9. 2007
  7. ncbi request reprint Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type
    Marcelo Schmitz
    ADHD Outpatient Clinic Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul 90035 003, Brazil
    Biol Psychiatry 60:1028-33. 2006
  8. doi request reprint MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder
    Ana P Guimarães
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Neuropsychopharmacol 12:709-14. 2009
  9. ncbi request reprint Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys
    Ana Paula M Guimarães
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:69-73. 2007
  10. pmc The Brazilian contribution to Attention-Deficit/Hyperactivity Disorder molecular genetics in children and adolescents
    Julia Pasqualini Genro
    Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil
    Genet Mol Biol 35:932-8. 2012

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder
    Tatiana Roman
    Department of Morphological Sciences, Federal School of Medical Sciences of Porto Alegre, Porto Alegre, Brazil
    Am J Pharmacogenomics 4:83-92. 2004
    ....
  2. doi request reprint A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder
    Julia P Genro
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 147:1568-75. 2008
    ....
  3. doi request reprint Cathechol-O-methyltransferase Val(158)Met polymorphism is associated with disruptive behavior disorders among children and adolescents with ADHD
    Angélica Salatino-Oliveira
    Departamento de Genetica, Instituto de Biociencias, UFRGS, Caixa Postal 15053, Porto Alegre, RS 91501 970, Brazil
    J Neural Transm 119:729-33. 2012
    ..762; p = 0.016; OR = 1.58; CI(95%) = 1.07-2.35). Our findings replicate previous results and suggest a role for COMT in the etiology of DBD in children and adolescents with ADHD...
  4. doi request reprint Further evidence for the association between attention deficit/hyperactivity disorder and the serotonin receptor 1B gene
    Ana P Guimarães
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Caixa Postal 15053, Porto Alegre, RS 91501 970, Brazil
    J Neural Transm 116:1675-80. 2009
    ..Our results provide additional evidence that HRT1B gene may be an important risk factor for the development of ADHD, but this effect seems not to be attributable to inattentive cases...
  5. ncbi request reprint Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder?
    Tatiana Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 120:116-20. 2003
    ..They are also consistent with the noradrenergic theories of ADHD, suggesting a role for the alpha2A adrenergic receptors in the disorder...
  6. ncbi request reprint A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children
    Julia P Genro
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:215-9. 2007
    ..004). Our results suggest a role for the promoter region of DAT1 gene in ADHD susceptibility in this Brazilian sample...
  7. ncbi request reprint Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type
    Marcelo Schmitz
    ADHD Outpatient Clinic Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul 90035 003, Brazil
    Biol Psychiatry 60:1028-33. 2006
    ..This study aimed to investigate the association between this ADRA2A polymorphism and attention-deficit/hyperactivity disorder-inattentive type (ADHD-I) in a nonreferred sample...
  8. doi request reprint MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder
    Ana P Guimarães
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Neuropsychopharmacol 12:709-14. 2009
    ..83, p=0.009). These results suggest an effect of the MAOA-uVNTR high-activity genotype on the improvement of oppositional symptoms with MPH treatment...
  9. ncbi request reprint Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys
    Ana Paula M Guimarães
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:69-73. 2007
    ..04). Our results suggest that findings from ADHD association studies for serotonin genes might be understood in the context of a gender effect, which may help to explain conflicting results in these association studies...
  10. pmc The Brazilian contribution to Attention-Deficit/Hyperactivity Disorder molecular genetics in children and adolescents
    Julia Pasqualini Genro
    Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil
    Genet Mol Biol 35:932-8. 2012
    ..New plausible biological hypotheses linked to neurotransmission and neurodevelopment, as well as new analytic approaches are needed to fully disclose the genetic component of the disorder...
  11. ncbi request reprint Further evidence for the association between attention-deficit/hyperactivity disorder and the dopamine-beta-hydroxylase gene
    Tatiana Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet 114:154-8. 2002
    ..42, one-tailed P=0.01). Our results suggest a contribution of this gene to ADHD susceptibility, partially replicating previous findings that have demonstrated an association between the DBH TaqI A2 allele and ADHD...
  12. doi request reprint 22q11.2 deletion syndrome in patients admitted to a cardiac pediatric intensive care unit in Brazil
    Rafael F M Rosa
    Clinical Genetics, Universidade Federal de Ciências da Saúde de Porto Alegre UFCSPA and Complexo Hospitalar Santa Casa de Porto Alegre CHSCPA, Porto Alegre, RS, Brazil
    Am J Med Genet A 146:1655-61. 2008
    ..It is possible that 22q11DS patients with a severe CHD could have died before having a chance to access a tertiary hospital, leading to an underestimate of its frequency...
  13. ncbi request reprint Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder
    Tatiana Roman
    Department of Genetics, Federal University of Rio Grande do Sul, Brazil
    Pharmacogenetics 12:497-9. 2002
    ..01). Our findings support an association between homozygosity for the 10-repeat allele at dopamine transporter gene locus and poor response to MPH...
  14. ncbi request reprint Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot study
    Luis A Rohde
    ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
    Synapse 48:87-9. 2003
    ..05). These findings provide a preliminary connection between pharmacogenetics and neurobiological investigations on stimulant treatment of ADHD...
  15. ncbi request reprint Brain perfusion and dopaminergic genes in boys with attention-deficit/hyperactivity disorder
    Claudia Szobot
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 132:53-8. 2005
    ..05). Our findings suggest that a higher recruitment in middle temporal gyrus, an area associated to working memory and selective attention, should exist to compensate a putative effect of the interaction between these dopaminergic genes...
  16. ncbi request reprint No significant association between response to methylphenidate and genes of the dopaminergic and serotonergic systems in a sample of Brazilian children with attention-deficit/hyperactivity disorder
    Cristian Patrick Zeni
    ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:391-4. 2007
    ..Prospective multi-site controlled studies with larger sample sizes are needed in order to disentangle the role of candidate genes in response to ADHD treatment...
  17. ncbi request reprint Attention-deficit/hyperactivity disorder: advancing on pharmacogenomics
    Guilherme Polanczyk
    Federal University of Rio Grande do Sul, ADHD Out Patient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Brazil
    Pharmacogenomics 6:225-34. 2005
    ..As such, multi-site collaborative efforts to obtain larger samples with standardized methodology should be encouraged...
  18. ncbi request reprint Association of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorder
    Guilherme Polanczyk
    Attention Deficit Hyperactivity Disorder Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
    Arch Gen Psychiatry 64:218-24. 2007
    ..However, the effect of ADRA2A in the response to methylphenidate in humans has not been previously investigated, to our knowledge...
  19. pmc Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes
    Naomi Lowe
    Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 74:348-56. 2004
    ..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes...
  20. ncbi request reprint Association between DRD4 gene and performance of children with ADHD in a test of sustained attention
    Christian Kieling
    Department of Psychiatry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre 90035 003, RS, Brazil
    Biol Psychiatry 60:1163-5. 2006
    ..The adoption of neuropsychological tests as endophenotypic measures can provide an increased sensitivity to specific dimensions of attention-deficit/hyperactivity disorder (ADHD)...