T Roman

Summary

Affiliation: Porto Alegre
Country: Brazil

Publications

  1. ncbi request reprint Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene
    T Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet 105:471-8. 2001
  2. ncbi request reprint Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder
    Tatiana Roman
    Department of Morphological Sciences, Federal School of Medical Sciences of Porto Alegre, Porto Alegre, Brazil
    Am J Pharmacogenomics 4:83-92. 2004
  3. ncbi request reprint Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type
    Marcelo Schmitz
    ADHD Outpatient Clinic Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul 90035 003, Brazil
    Biol Psychiatry 60:1028-33. 2006
  4. ncbi request reprint Further evidence for the association between attention-deficit/hyperactivity disorder and the dopamine-beta-hydroxylase gene
    Tatiana Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet 114:154-8. 2002
  5. ncbi request reprint Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder?
    Tatiana Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 120:116-20. 2003
  6. doi request reprint Is there a role for rare variants in DRD4 gene in the susceptibility for ADHD? Searching for an effect of allelic heterogeneity
    L Tovo-Rodrigues
    Departament of Genetics, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Mol Psychiatry 17:520-6. 2012
  7. doi request reprint Association study of GIT1 gene with attention-deficit hyperactivity disorder in Brazilian children and adolescents
    A Salatino-Oliveira
    Genetics Department, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Genes Brain Behav 11:864-8. 2012
  8. doi request reprint Adrenergic alpha2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type
    T L da Silva
    ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil
    J Neural Transm 115:341-5. 2008
  9. ncbi request reprint Tobacco smoking and the ADRA2A C-1291G polymorphism
    A P Prestes
    Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Neural Transm 114:1503-6. 2007
  10. ncbi request reprint Dopamine D4 receptor gene and personality dimensions in Brazilian male alcoholics
    C H Bau
    Departamento de Genetica, Instituto de Biociencias, Porto Alegre, RS, Brazil
    Psychiatr Genet 9:139-43. 1999

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene
    T Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet 105:471-8. 2001
    ..68; P = 0.03). These results add to the group of studies that together suggest a small effect of these genes in the susceptibility to ADHD...
  2. ncbi request reprint Polymorphisms of the dopamine transporter gene: influence on response to methylphenidate in attention deficit-hyperactivity disorder
    Tatiana Roman
    Department of Morphological Sciences, Federal School of Medical Sciences of Porto Alegre, Porto Alegre, Brazil
    Am J Pharmacogenomics 4:83-92. 2004
    ....
  3. ncbi request reprint Association between alpha-2a-adrenergic receptor gene and ADHD inattentive type
    Marcelo Schmitz
    ADHD Outpatient Clinic Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre, Rio Grande do Sul 90035 003, Brazil
    Biol Psychiatry 60:1028-33. 2006
    ..This study aimed to investigate the association between this ADRA2A polymorphism and attention-deficit/hyperactivity disorder-inattentive type (ADHD-I) in a nonreferred sample...
  4. ncbi request reprint Further evidence for the association between attention-deficit/hyperactivity disorder and the dopamine-beta-hydroxylase gene
    Tatiana Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet 114:154-8. 2002
    ..42, one-tailed P=0.01). Our results suggest a contribution of this gene to ADHD susceptibility, partially replicating previous findings that have demonstrated an association between the DBH TaqI A2 allele and ADHD...
  5. ncbi request reprint Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder?
    Tatiana Roman
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 120:116-20. 2003
    ..They are also consistent with the noradrenergic theories of ADHD, suggesting a role for the alpha2A adrenergic receptors in the disorder...
  6. doi request reprint Is there a role for rare variants in DRD4 gene in the susceptibility for ADHD? Searching for an effect of allelic heterogeneity
    L Tovo-Rodrigues
    Departament of Genetics, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Mol Psychiatry 17:520-6. 2012
    ..Our findings suggest that not only repeat length but also DNA sequence should be assessed to better understand the role of DRD4 exon 3 VNTR in ADHD genetic susceptibility...
  7. doi request reprint Association study of GIT1 gene with attention-deficit hyperactivity disorder in Brazilian children and adolescents
    A Salatino-Oliveira
    Genetics Department, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Genes Brain Behav 11:864-8. 2012
    ..305; P = 0.761). We conclude that rs550818 is not associated with ADHD in this Brazilian sample. More studies are required before concluding that this polymorphism plays a role in ADHD susceptibility...
  8. doi request reprint Adrenergic alpha2A receptor gene and response to methylphenidate in attention-deficit/hyperactivity disorder-predominantly inattentive type
    T L da Silva
    ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil
    J Neural Transm 115:341-5. 2008
    ..14; p = 0.016). We extended to ADHD-I previous findings suggesting the influence of the G allele at the ADRA2A -1291 C > G polymorphism on the improvement of inattentive symptoms with methylphenidate in children with all ADHD subtypes...
  9. ncbi request reprint Tobacco smoking and the ADRA2A C-1291G polymorphism
    A P Prestes
    Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Neural Transm 114:1503-6. 2007
    ..The influence of the ADRA2A gene in nicotine and other substance dependencies should be more extensively assessed in future studies...
  10. ncbi request reprint Dopamine D4 receptor gene and personality dimensions in Brazilian male alcoholics
    C H Bau
    Departamento de Genetica, Instituto de Biociencias, Porto Alegre, RS, Brazil
    Psychiatr Genet 9:139-43. 1999
    ..These results could be explained by a biological connection between the personality dimensions of novelty seeking and harm avoidance...
  11. ncbi request reprint Association between DRD4 gene and performance of children with ADHD in a test of sustained attention
    Christian Kieling
    Department of Psychiatry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre 90035 003, RS, Brazil
    Biol Psychiatry 60:1163-5. 2006
    ..The adoption of neuropsychological tests as endophenotypic measures can provide an increased sensitivity to specific dimensions of attention-deficit/hyperactivity disorder (ADHD)...
  12. ncbi request reprint Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder
    Tatiana Roman
    Department of Genetics, Federal University of Rio Grande do Sul, Brazil
    Pharmacogenetics 12:497-9. 2002
    ..01). Our findings support an association between homozygosity for the 10-repeat allele at dopamine transporter gene locus and poor response to MPH...
  13. ncbi request reprint Dopamine transporter gene, response to methylphenidate and cerebral blood flow in attention-deficit/hyperactivity disorder: a pilot study
    Luis A Rohde
    ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
    Synapse 48:87-9. 2003
    ..05). These findings provide a preliminary connection between pharmacogenetics and neurobiological investigations on stimulant treatment of ADHD...
  14. ncbi request reprint Association of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorder
    Guilherme Polanczyk
    Attention Deficit Hyperactivity Disorder Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
    Arch Gen Psychiatry 64:218-24. 2007
    ..However, the effect of ADRA2A in the response to methylphenidate in humans has not been previously investigated, to our knowledge...
  15. ncbi request reprint Brain perfusion and dopaminergic genes in boys with attention-deficit/hyperactivity disorder
    Claudia Szobot
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 132:53-8. 2005
    ..05). Our findings suggest that a higher recruitment in middle temporal gyrus, an area associated to working memory and selective attention, should exist to compensate a putative effect of the interaction between these dopaminergic genes...
  16. ncbi request reprint No significant association between response to methylphenidate and genes of the dopaminergic and serotonergic systems in a sample of Brazilian children with attention-deficit/hyperactivity disorder
    Cristian Patrick Zeni
    ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:391-4. 2007
    ..Prospective multi-site controlled studies with larger sample sizes are needed in order to disentangle the role of candidate genes in response to ADHD treatment...
  17. ncbi request reprint A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children
    Julia P Genro
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:215-9. 2007
    ..004). Our results suggest a role for the promoter region of DAT1 gene in ADHD susceptibility in this Brazilian sample...
  18. ncbi request reprint Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys
    Ana Paula M Guimarães
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 144:69-73. 2007
    ..04). Our results suggest that findings from ADHD association studies for serotonin genes might be understood in the context of a gender effect, which may help to explain conflicting results in these association studies...
  19. pmc Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes
    Naomi Lowe
    Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 74:348-56. 2004
    ..The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12-1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes...
  20. ncbi request reprint Attention-deficit/hyperactivity disorder: advancing on pharmacogenomics
    Guilherme Polanczyk
    Federal University of Rio Grande do Sul, ADHD Out Patient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clinicas de Porto Alegre, Brazil
    Pharmacogenomics 6:225-34. 2005
    ..As such, multi-site collaborative efforts to obtain larger samples with standardized methodology should be encouraged...