Diogo R Lara

Summary

Affiliation: Porto Alegre
Country: Brazil

Publications

  1. doi request reprint Development and validity data of the Brazilian Internet Study on Temperament and Psychopathology (BRAINSTEP)
    Diogo R Lara
    Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 141:390-8. 2012
  2. doi request reprint The Affective and Emotional Composite Temperament (AFECT) model and scale: a system-based integrative approach
    Diogo R Lara
    Faculdade de Biociências e de Medicina, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 140:14-37. 2012
  3. pmc Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic survey
    Sergio Baxter Andreoli
    Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    BMC Psychiatry 9:34. 2009
  4. pmc The posttraumatic stress disorder project in Brazil: neuropsychological, structural and molecular neuroimaging studies in victims of urban violence
    Rodrigo A Bressan
    Laboratório Interdisciplinar de Neurosciencias Clínicas LiNC, Sao Paulo, Brazil
    BMC Psychiatry 9:30. 2009
  5. doi request reprint Caffeine, mental health, and psychiatric disorders
    Diogo R Lara
    Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
    J Alzheimers Dis 20:S239-48. 2010
  6. ncbi request reprint Involvement of adenosine in the neurobiology of schizophrenia and its therapeutic implications
    Diogo R Lara
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:617-29. 2006
  7. ncbi request reprint Effect of riluzole on MK-801 and amphetamine-induced hyperlocomotion
    Adriana Lourenço Da Silva
    Laboratório de Neurobiologia Experimental, Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
    Neuropsychobiology 48:27-30. 2003
  8. ncbi request reprint Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: II. Implications for neurobiology, genetics and psychopharmacological treatment
    Diogo R Lara
    Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga, 6681, Pd 12A, Porto Alegre, RS 90619 900, Brazil
    J Affect Disord 94:89-103. 2006
  9. ncbi request reprint Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implications
    Diogo R Lara
    Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Affect Disord 94:67-87. 2006
  10. ncbi request reprint Allopurinol for the treatment of aggressive behaviour in patients with dementia
    Diogo R Lara
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
    Int Clin Psychopharmacol 18:53-5. 2003

Collaborators

Detail Information

Publications66

  1. doi request reprint Development and validity data of the Brazilian Internet Study on Temperament and Psychopathology (BRAINSTEP)
    Diogo R Lara
    Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 141:390-8. 2012
    ..This article presents the development and preliminary data of a large web-survey created to study how temperament relates to other psychological measures, behavior and psychiatric disorders...
  2. doi request reprint The Affective and Emotional Composite Temperament (AFECT) model and scale: a system-based integrative approach
    Diogo R Lara
    Faculdade de Biociências e de Medicina, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 140:14-37. 2012
    ..We also developed and validated a self-report scale to evaluate this construct, the Affective and Emotional Composite Temperament Scale (AFECTS)...
  3. pmc Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic survey
    Sergio Baxter Andreoli
    Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    BMC Psychiatry 9:34. 2009
    ....
  4. pmc The posttraumatic stress disorder project in Brazil: neuropsychological, structural and molecular neuroimaging studies in victims of urban violence
    Rodrigo A Bressan
    Laboratório Interdisciplinar de Neurosciencias Clínicas LiNC, Sao Paulo, Brazil
    BMC Psychiatry 9:30. 2009
    ..This paper shows the research rationale and design for these three case-control studies...
  5. doi request reprint Caffeine, mental health, and psychiatric disorders
    Diogo R Lara
    Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
    J Alzheimers Dis 20:S239-48. 2010
    ....
  6. ncbi request reprint Involvement of adenosine in the neurobiology of schizophrenia and its therapeutic implications
    Diogo R Lara
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:617-29. 2006
    ..Since much of the evidence for the adenosine hypothesis is preliminary and theoretical, further investigation in the field is warranted...
  7. ncbi request reprint Effect of riluzole on MK-801 and amphetamine-induced hyperlocomotion
    Adriana Lourenço Da Silva
    Laboratório de Neurobiologia Experimental, Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
    Neuropsychobiology 48:27-30. 2003
    ..Taken together, these results suggest that riluzole would not be particularly effective as a treatment for schizophrenia and the neurotoxic and behavioral effect of NMDA antagonists do not clearly correlate...
  8. ncbi request reprint Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: II. Implications for neurobiology, genetics and psychopharmacological treatment
    Diogo R Lara
    Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga, 6681, Pd 12A, Porto Alegre, RS 90619 900, Brazil
    J Affect Disord 94:89-103. 2006
    ..This framework may lead to a better understanding of the neurobiological basis of mental health and disease, providing an integrative approach for future research...
  9. ncbi request reprint Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implications
    Diogo R Lara
    Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Affect Disord 94:67-87. 2006
    ..We submit this proposed schema represented herein as a heuristic attempt to build bridges between basic and clinical science...
  10. ncbi request reprint Allopurinol for the treatment of aggressive behaviour in patients with dementia
    Diogo R Lara
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
    Int Clin Psychopharmacol 18:53-5. 2003
    ..Controlled studies are warranted to confirm these preliminary observations...
  11. ncbi request reprint Inhibitory deficit in schizophrenia is not necessarily a GABAergic deficit
    Diogo R Lara
    Departamento de Ciencias Fisiologicas, Faculdade de Ciências Biológicas, PUCRS, Porto Alegre, Brazil
    Cell Mol Neurobiol 22:239-47. 2002
    ..4. It is concluded that although the GABAergic system should be further studied, especially in sensory gating model in humans, emphasis on other inhibitory mechanisms may prove useful and provide more effective treatment...
  12. ncbi request reprint Beta-amyloid treatment sensitizes mice to amphetamine-induced locomotion but reduces response to caffeine
    Oscar P Dall'Igna
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Neurodegener Dis 1:38-43. 2004
    ..Psychosis frequently occurs in Alzheimer's disease (AD), being associated with more severe cognitive decline, but the underlying mechanisms are unknown...
  13. ncbi request reprint Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice
    Oscar P Dall'Igna
    Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
    Exp Neurol 203:241-5. 2007
    ..5 mg/kg). This provides the first direct in vivo evidence that caffeine and A(2A) receptor antagonists afford a protection against Abeta-induced amnesia, which prompts their interest for managing Alzheimer's disease...
  14. doi request reprint Emotional and affective temperaments and cigarette smoking in a large sample
    Luisa W Bisol
    Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 127:89-95. 2010
    ..Tobacco use has been associated with externalized personality traits. Our aim was to evaluate the association of smoking with emotional and affective temperaments in a large sample...
  15. ncbi request reprint Increased locomotor response to amphetamine, but not other psychostimulants, in adult mice submitted to a low-protein diet
    Marcelo O Dietrich
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Physiol Behav 83:129-33. 2004
    ..The results are discussed based on previous works, presenting theoretical hypotheses about the possible mechanisms involved in the present findings...
  16. ncbi request reprint Guanosine selectively inhibits locomotor stimulation induced by the NMDA antagonist dizocilpine
    Adriano B L Tort
    Departamento de Bioquimica, ICBS, Universidade Federal do Grande do Sul UFRGS, Rua Ramiro Barcellos 2600, Anexo, 90035003 Porto Alegre, Brazil
    Behav Brain Res 154:417-22. 2004
    ..Further studies are necessary to evaluate if guanosine could have clinical utility for the treatment of schizophrenia...
  17. ncbi request reprint Cinnarizine has an atypical antipsychotic profile in animal models of psychosis
    Oscar P Dall'Igna
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
    J Psychopharmacol 19:342-6. 2005
    ..Based on these results and on the antagonist effect of cinnarizine on dopamine D2 receptors, we suggest that it has a potential antipsychotic effect with an atypical profile that should be evaluated clinically...
  18. ncbi request reprint Is flunarizine a long-acting oral atypical antipsychotic? A randomized clinical trial versus haloperidol for the treatment of schizophrenia
    Luisa W Bisol
    Department of Biochemistry, Universidad Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil 90619 900
    J Clin Psychiatry 69:1572-9. 2008
    ..Flunarizine also has dopamine D2 receptor blocking properties and was effective in animal models of predictive validity for antipsychotics. However, its clinical antipsychotic efficacy has never been investigated...
  19. ncbi request reprint Caffeine modulates P50 auditory sensory gating in healthy subjects
    Eduardo S Ghisolfi
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
    Eur Neuropsychopharmacol 16:204-10. 2006
    ..These results reinforce the participation of adenosine in the modulation of P50 sensory gating and suggest that caffeine ingestion should be controlled for in the P50 sensory gating paradigm...
  20. doi request reprint Development and validation of the Combined Emotional and Affective Temperament Scale (CEATS): towards a brief self-rated instrument
    Diogo R Lara
    Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 111:320-33. 2008
    ....
  21. doi request reprint Acute restraint stress in zebrafish: behavioral parameters and purinergic signaling
    Angelo L Piato
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681 Predio 12D, Sala 340, Porto Alegre, RS 90619 900, Brazil
    Neurochem Res 36:1876-86. 2011
    ..In conclusion, ARS disturbed zebrafish behavior, and we hypothesize that the augmentation in adenosine-mediated signaling may be a strategy to reestablish homeostasis and normal behavior after a stressful event...
  22. ncbi request reprint A simple webcam-based approach for the measurement of rodent locomotion and other behavioural parameters
    Adriano B L Tort
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Prédio Anexo Lab 26, Porto Alegre, RS, Brazil
    J Neurosci Methods 157:91-7. 2006
    ..Such a system can be easily implemented in most laboratories and can significantly reduce the time and costs involved in behavioural analysis, especially in developing countries...
  23. ncbi request reprint P50 sensory gating in panic disorder
    Eduardo S Ghisolfi
    Departamento de Ciencias Fisiologicas, Faculdade de Biociências da, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga, 6681 Prédio 12 A, 90619 900 Porto Alegre, RS, Brazil
    J Psychiatr Res 40:535-40. 2006
    ..Further studies are still necessary to better understand the pathophysiology of this neurophysiological dysfunction and its nature as a trait or a state marker...
  24. doi request reprint Maternal caffeine intake affects acetylcholinesterase in hippocampus of neonate rats
    Rosane Souza da Silva
    Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
    Int J Dev Neurosci 26:339-43. 2008
    ..These results highlight the ability of maternal caffeine intake to interfere on cholinergic neurotransmission during brain development...
  25. doi request reprint Enriched environment effects on behavior, memory and BDNF in low and high exploratory mice
    Vanessa Kazlauckas
    Programa de Pós Graduação em Ciências Biológicas Bioquímica, Universidade Federal do Rio Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de Bioquimica, Porto Alegre RS 90035 003, Brazil
    Physiol Behav 102:475-80. 2011
    ..These observations may contribute to investigate biological mechanisms and therapeutical interventions for individuals with internalized psychiatric disorders...
  26. doi request reprint Association of temperament with subjective sleep patterns
    Gustavo L Ottoni
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Affect Disord 128:120-7. 2011
    ..This study investigates the association of temperament with subjective sleep parameters...
  27. ncbi request reprint Behavioral and cognitive profile of mice with high and low exploratory phenotypes
    Vanessa Kazlauckas
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Behav Brain Res 162:272-8. 2005
    ..The behavioral profile of low and high exploratory mice resembled the depressive and hyperthymic temperaments of patients with unipolar depression and bipolar disorders, respectively, which may be relevant for modeling mood disorders...
  28. ncbi request reprint Chronic treatment with caffeine blunts the hyperlocomotor but not cognitive effects of the N-methyl-D-aspartate receptor antagonist MK-801 in mice
    Oscar P Dall'Igna
    Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
    Psychopharmacology (Berl) 166:258-63. 2003
    ..We hypothesized that if NMDA receptor antagonists require adenosine to produce behavioral effects, mice tolerant to the adenosine receptor antagonist caffeine would have a diminished response to NMDA receptor antagonists...
  29. pmc A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania
    Rodrigo Machado-Vieira
    Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, RS, Brazil
    J Clin Psychiatry 69:1237-45. 2008
    ..This study aimed to evaluate the efficacy and tolerability of the purinergic agents allopurinol and dipyridamole combined with lithium in bipolar mania...
  30. ncbi request reprint Decreased hyperlocomotion induced by MK-801, but not amphetamine and caffeine in mice lacking cellular prion protein (PrP(C))
    Adriana S Coitinho
    Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
    Brain Res Mol Brain Res 107:190-4. 2002
    ..Finally, lack of PrP(C) seems not to exacerbate the response to these psychotropic drugs, which modulate neurotransmitter systems possibly involved in schizophrenia and psychotic disorders...
  31. ncbi request reprint One for all and all for one: the importance of shoaling on behavioral and stress responses in zebrafish
    Natalia Pagnussat
    Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Zebrafish 10:338-42. 2013
    ..These features can be beneficial or detrimental depending on study aims and should be considered when designing, analyzing, and interpreting zebrafish behavioral data...
  32. doi request reprint Y-Maze memory task in zebrafish (Danio rerio): the role of glutamatergic and cholinergic systems on the acquisition and consolidation periods
    Giana de P Cognato
    Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontifícia Universidade Católica do Rio Grande do Sul Avenida Ipiranga 6681, 90619 900 Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 98:321-8. 2012
    ..In addition, our results highlight the implication of the glutamatergic and cholinergic systems in the memory of zebrafish...
  33. ncbi request reprint Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol
    Jean Pierre Oses
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
    Brain Res Bull 64:237-42. 2004
    ....
  34. doi request reprint Distinctive effects of unpredictable subchronic stress on memory, serum corticosterone and hippocampal BDNF levels in high and low exploratory mice
    Vanessa Kazlauckas
    Programa de Pós Graduação em Ciências Biológicas Bioquímica, Universidade Federal do Rio Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de Bioquimica, Porto Alegre RS, 90035 003, Brazil
    Behav Brain Res 218:80-6. 2011
    ..In conclusion, our results suggest that individual differences in exploratory behavior in rodents from the same strain influence cognitive and biochemical response to stress...
  35. doi request reprint The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine
    André P Schmidt
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 91:549-53. 2009
    ..Hyperalgesia was correlated with CSF aspartate and glutamate levels. This study provides additional evidence for the mechanism of action of MK-801, showing that MK-801 induces hyperalgesia with parallel increase in CSF EAAs levels...
  36. doi request reprint Metabolic and behavioral effects of chronic olanzapine treatment and cafeteria diet in rats
    Alexandre P Muller
    Departamento de Bioquimica, ICBS, UFRGS, Programa de Pós Graduação em Ciências Biológicas Bioquímica, Rua Ramiro Barcelos, Brazil
    Behav Pharmacol 21:668-75. 2010
    ..The cafeteria diet also modified the effects of chronic treatment with olanzapine on cognitive tasks, which may represent an undesirable effect of poor diets in psychiatric patients...
  37. ncbi request reprint Atypical antipsychotic profile of flunarizine in animal models
    Adriano B L Tort
    Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
    Psychopharmacology (Berl) 177:344-8. 2005
    ..Parkinsonism has been described as one of its side-effects in the elderly, which is in agreement with its recently characterized moderate D2 receptor antagonism...
  38. doi request reprint Validation of the combined emotional and affective temperament scale in a large sample with high prevalence of psychiatric disorders
    Gustavo L Ottoni
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Psychopathology 43:381-8. 2010
    ..This paper aims to validate the CEATS in a large population with high prevalence of psychiatric disorders...
  39. ncbi request reprint Impaired P50 sensory gating in Machado-Joseph disease
    Eduardo S Ghisolfi
    Departamento de Bioquímica da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Clin Neurophysiol 115:2231-5. 2004
    ..1, is a disorder with wide range of neurological findings and brain regions involved. Studies evaluating neurophysiological parameters related to sensory gating in MJD are lacking...
  40. pmc Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity
    Oscar P Dall'Igna
    Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Br J Pharmacol 138:1207-9. 2003
    ..This constitutes the first in vitro evidence to suggest that adenosine A(2A) receptors may be the molecular target responsible for the observed beneficial effects of caffeine consumption in the development of Alzheimer's disease...
  41. ncbi request reprint Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics
    Rodrigo W Grillo
    Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
    J Psychiatr Res 41:31-5. 2007
    ..These results reinforce previous findings of reduced serum BDNF levels in schizophrenic patients and suggest a differential effect of clozapine compared to typical antipsychotics on such levels...
  42. ncbi request reprint A clinical trial of adjuvant allopurinol therapy for moderately refractory schizophrenia
    Miriam G Brunstein
    Department of Biochemistry, Health Basic Science Institute, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    J Clin Psychiatry 66:213-9. 2005
    ..To evaluate the xanthine oxidase inhibitor allopurinol as an adjuvant treatment for patients with moderately refractory schizophrenia, with the objective of increasing the endogenous pool of purines, including the neuro-modulator adenosine...
  43. doi request reprint Does caffeine change the effect of sleep deprivation on moderate to severe depressed patients?
    Alexandre W Schwartzhaupt
    Post Graduate Program in Psychiatry, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    J Affect Disord 112:279-83. 2009
    ..However, there are no data about its potential influence on the antidepressive effect of SD. The objective of this study is to assess the effect of caffeine on SD in non-psychotic patients with moderate to severe unipolar depression...
  44. ncbi request reprint Caffeine as a neuroprotective adenosine receptor antagonist
    Oscar P Dall'Igna
    Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Ann Pharmacother 38:717-8. 2004
  45. doi request reprint Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol
    Daiane L Gebauer
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 99:480-6. 2011
    ..Height in the tank and shoal cohesion seem to be useful behavioral parameters in discriminating different classes of these drugs...
  46. ncbi request reprint Proposal of a guanine-based purinergic system in the mammalian central nervous system
    André P Schmidt
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Pharmacol Ther 116:401-16. 2007
    ....
  47. ncbi request reprint Clozapine, but not typical antipsychotics, correct P50 suppression deficit in patients with schizophrenia
    Jefferson Becker
    Neurology Service, Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Clin Neurophysiol 115:396-401. 2004
    ....
  48. ncbi request reprint Maternal caffeine intake impairs MK-801-induced hyperlocomotion in young rats
    Rosane Souza da Silva
    Laboratório de Pesquisa Bioquímica, Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900, Porto Alegre, RS, Brazil
    Eur J Pharmacol 509:155-9. 2005
    ..The permanent effect after caffeine withdrawal suggests durable or adaptive changes during neurodevelopment, mainly on adenosine receptors or neurotransmitter systems modulated by adenosine, such as the glutamatergic system...
  49. doi request reprint The Circadian Energy Scale (CIRENS): two simple questions for a reliable chronotype measurement based on energy
    Gustavo L Ottoni
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Chronobiol Int 28:229-37. 2011
    ..The CIRENS provides a simple chronotype index and a measure of absolute energy throughout the day and seems to be a reliable chronotype assessment tool that may be useful both clinically and for large-scale studies...
  50. doi request reprint Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression
    Diogo R Lara
    Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Neuropsychopharmacol 16:2111-7. 2013
    ..Thus, VLDS ketamine may have broad spectrum effects beyond its antidepressant properties, with rapid onset of action, high efficacy, good tolerability and low cost, allowing extended treatment as needed...
  51. doi request reprint How emotional traits and affective temperaments relate to cocaine experimentation, abuse and dependence in a large sample
    Liane V Fuscaldo
    Programa de Pós Graduação em Medicina e Ciências da Saúde, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Addict Behav 38:1859-64. 2013
    ..Conclusions: Specific externalized and unstable traits were associated with cocaine related behavior. Addressing these traits may be important for recovery and prevention strategies...
  52. ncbi request reprint Impaired P50 sensory gating in post-traumatic stress disorder secondary to urban violence
    Eduardo S Ghisolfi
    Departamento de Bioquímica do Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos, 2600 Anexo, Porto Alegre, RS, 90050 003 Brazil
    Int J Psychophysiol 51:209-14. 2004
    ..The P50 paradigm may also become an objective parameter to assess the effects of new treatments for PTSD...
  53. doi request reprint Increased plasma levels of brain derived neurotrophic factor (BDNF) in patients with fibromyalgia
    Lisete Haas
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga, 6681 Pd 12, Porto Alegre, RS, 90619 900, Brazil
    Neurochem Res 35:830-4. 2010
    ..Our results confirm previous findings of increased plasma BDNF levels in patients with FM, suggesting that BDNF may be involved in the pathophysiology of Fibromyalgia, despite high levels of depression...
  54. doi request reprint Low-dose quetiapine for patients with dysregulation of hyperthymic and cyclothymic temperaments
    Luisa W Bisol
    Departamento de Bioquimica, ICBS UFRGS, Porto Alegre, Brazil
    J Psychopharmacol 24:421-4. 2010
    ....
  55. ncbi request reprint The adenosine antagonist theophylline impairs p50 auditory sensory gating in normal subjects
    Eduardo S Ghisolfi
    Departamento de Bioqui mica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, UFRGS, RS, Porto Alegre, Brazil
    Neuropsychopharmacology 27:629-37. 2002
    ....
  56. ncbi request reprint Theoretical insights into the mechanism of action of atypical antipsychotics
    Adriano B L Tort
    Departamento de Bioquimica, ICBS, UFRGS, Avenida Ramiro Barcelos, 2600 Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:541-8. 2006
    ..Together with current experimental data, we concluded that the key factors leading to an atypical profile would be adequate posology, low affinity of the drug to D2R and/or short plasma half-life...
  57. ncbi request reprint Structural validity and reliability of the Positive and Negative Affect Schedule (PANAS): evidence from a large Brazilian community sample
    Hudson W de Carvalho
    Department of Psychology, Universidade Federal de Pelotas UFPel, Pelotas, RS, Brazil
    Rev Bras Psiquiatr 35:169-72. 2013
    ..This study aimed to validate a Brazilian interview-version of the PANAS by means of factor and internal consistency analysis...
  58. doi request reprint Unpredictable chronic stress model in zebrafish (Danio rerio): behavioral and physiological responses
    Angelo L Piato
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontifícia Universidade Católica do Rio Grande do Sul Avenida Ipiranga, 6681, 90619 900, Porto Alegre, RS, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 35:561-7. 2011
    ..These results confirm UCS in zebrafish as an adequate model to preclinical studies of stress, although further studies are warranted to determine its predictive validity...
  59. ncbi request reprint Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
    Gustavo Pimentel Dutra
    Department of Celular and Molecular Biology, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 32:275-8. 2010
    ..The aim of this study was to evaluate the ADA polymorphism 22G→A (ADA1*2) in schizophrenic patients and healthy controls...
  60. ncbi request reprint Anticonvulsant effect of GMP depends on its conversion to guanosine
    Félix A Soares
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 Anexo CEP 90 035 003, Porto Alegre, RS, Brazil
    Brain Res 1005:182-6. 2004
    ..This study shows that the previously reported effect of GMP as an anticonvulsant seems to be related to its ability to generate guanosine through the action of ecto-5'-nucleotidase...
  61. doi request reprint The spinning task: a new protocol to easily assess motor coordination and resistance in zebrafish
    Ana R Blazina
    1 Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Zebrafish 10:480-5. 2013
    ..These results suggest that the Spinning Task is a useful protocol to add information to the assessment of zebrafish motor behavior...
  62. doi request reprint Circadian preference is associated with emotional and affective temperaments
    Gustavo L Ottoni
    Hospital Materno Infantil Presidente Vargas, Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil
    Chronobiol Int 29:786-93. 2012
    ..The circadian daily energy profile can be very informative about human temperament and vice versa, and their combined assessment may be useful in the evaluation of psychiatric patients...
  63. ncbi request reprint Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticides
    Rosane Maria Salvi
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, Brazil
    Toxicol Sci 72:267-71. 2003
    ....
  64. ncbi request reprint Repeated restraint stress reduces opioid receptor binding in different rat CNS structures
    Giovana Dantas
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurochem Res 30:1-7. 2005
    ..7 +/- 9.7 for stressed rats). These findings suggest opioid mediation of the altered responses observed in these repeatedly-stressed animals, although the participation of non-opioid mechanisms in this phenomenon cannot be ruled out...
  65. ncbi request reprint A case series on the hypothesized connection between dementia and bipolar spectrum disorders: bipolar type VI?
    Bernardo Ng
    International Mood Center, and Department of Psychiatry, University of California, San Diego, CA, USA
    J Affect Disord 107:307-15. 2008
    ....
  66. doi request reprint Guanosine and its modulatory effects on the glutamatergic system
    André P Schmidt
    Eur Neuropsychopharmacol 18:620-2. 2008