Research Topics
Genomes and Genes | Diogo R LaraSummaryAffiliation: Porto Alegre Country: Brazil Publications
| Collaborators
|
Detail Information
Publications
Development and validity data of the Brazilian Internet Study on Temperament and Psychopathology (BRAINSTEP)Diogo R Lara
Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil Serviço de Psiquiatria, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil Electronic address
J Affect Disord 141:390-8. 2012..This article presents the development and preliminary data of a large web-survey created to study how temperament relates to other psychological measures, behavior and psychiatric disorders...- The Affective and Emotional Composite Temperament (AFECT) model and scale: a system-based integrative approachDiogo R Lara
Faculdade de Biociências e de Medicina, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
J Affect Disord 140:14-37. 2012..We also developed and validated a self-report scale to evaluate this construct, the Affective and Emotional Composite Temperament Scale (AFECTS)... 
Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic surveySergio Baxter Andreoli
Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
BMC Psychiatry 9:34. 2009....- The posttraumatic stress disorder project in Brazil: neuropsychological, structural and molecular neuroimaging studies in victims of urban violenceRodrigo A Bressan
Laboratório Interdisciplinar de Neurosciencias Clínicas LiNC, Sao Paulo, Brazil
BMC Psychiatry 9:30. 2009..This paper shows the research rationale and design for these three case-control studies... 
Effect of riluzole on MK-801 and amphetamine-induced hyperlocomotionAdriana Lourenço Da Silva
Laboratório de Neurobiologia Experimental, Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
Neuropsychobiology 48:27-30. 2003..Taken together, these results suggest that riluzole would not be particularly effective as a treatment for schizophrenia and the neurotoxic and behavioral effect of NMDA antagonists do not clearly correlate...- Caffeine, mental health, and psychiatric disordersDiogo R Lara
Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
J Alzheimers Dis 20:S239-48. 2010.... - Involvement of adenosine in the neurobiology of schizophrenia and its therapeutic implicationsDiogo R Lara
Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 30:617-29. 2006..Since much of the evidence for the adenosine hypothesis is preliminary and theoretical, further investigation in the field is warranted... - Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: II. Implications for neurobiology, genetics and psychopharmacological treatmentDiogo R Lara
Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga, 6681, Pd 12A, Porto Alegre, RS 90619 900, Brazil
J Affect Disord 94:89-103. 2006..This framework may lead to a better understanding of the neurobiological basis of mental health and disease, providing an integrative approach for future research... - Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implicationsDiogo R Lara
Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
J Affect Disord 94:67-87. 2006..We submit this proposed schema represented herein as a heuristic attempt to build bridges between basic and clinical science... - Allopurinol for the treatment of aggressive behaviour in patients with dementiaDiogo R Lara
Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
Int Clin Psychopharmacol 18:53-5. 2003..Controlled studies are warranted to confirm these preliminary observations... - Inhibitory deficit in schizophrenia is not necessarily a GABAergic deficitDiogo R Lara
Departamento de Ciencias Fisiologicas, Faculdade de Ciências Biológicas, PUCRS, Porto Alegre, Brazil
Cell Mol Neurobiol 22:239-47. 2002..4. It is concluded that although the GABAergic system should be further studied, especially in sensory gating model in humans, emphasis on other inhibitory mechanisms may prove useful and provide more effective treatment... - Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in miceOscar P Dall'Igna
Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
Exp Neurol 203:241-5. 2007..5 mg/kg). This provides the first direct in vivo evidence that caffeine and A(2A) receptor antagonists afford a protection against Abeta-induced amnesia, which prompts their interest for managing Alzheimer's disease... - Beta-amyloid treatment sensitizes mice to amphetamine-induced locomotion but reduces response to caffeineOscar P Dall'Igna
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Neurodegener Dis 1:38-43. 2004..Psychosis frequently occurs in Alzheimer's disease (AD), being associated with more severe cognitive decline, but the underlying mechanisms are unknown... - Emotional and affective temperaments and cigarette smoking in a large sampleLuisa W Bisol
Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
J Affect Disord 127:89-95. 2010..Tobacco use has been associated with externalized personality traits. Our aim was to evaluate the association of smoking with emotional and affective temperaments in a large sample... - Increased locomotor response to amphetamine, but not other psychostimulants, in adult mice submitted to a low-protein dietMarcelo O Dietrich
Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Physiol Behav 83:129-33. 2004..The results are discussed based on previous works, presenting theoretical hypotheses about the possible mechanisms involved in the present findings... - Guanosine selectively inhibits locomotor stimulation induced by the NMDA antagonist dizocilpineAdriano B L Tort
Departamento de Bioquimica, ICBS, Universidade Federal do Grande do Sul UFRGS, Rua Ramiro Barcellos 2600, Anexo, 90035003 Porto Alegre, Brazil
Behav Brain Res 154:417-22. 2004..Further studies are necessary to evaluate if guanosine could have clinical utility for the treatment of schizophrenia... - Is flunarizine a long-acting oral atypical antipsychotic? A randomized clinical trial versus haloperidol for the treatment of schizophreniaLuisa W Bisol
Department of Biochemistry, Universidad Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil 90619 900
J Clin Psychiatry 69:1572-9. 2008..Flunarizine also has dopamine D2 receptor blocking properties and was effective in animal models of predictive validity for antipsychotics. However, its clinical antipsychotic efficacy has never been investigated... - Caffeine modulates P50 auditory sensory gating in healthy subjectsEduardo S Ghisolfi
Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, PUCRS, Porto Alegre, Brazil
Eur Neuropsychopharmacol 16:204-10. 2006..These results reinforce the participation of adenosine in the modulation of P50 sensory gating and suggest that caffeine ingestion should be controlled for in the P50 sensory gating paradigm... - Development and validation of the Combined Emotional and Affective Temperament Scale (CEATS): towards a brief self-rated instrumentDiogo R Lara
Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
J Affect Disord 111:320-33. 2008.... - Acute restraint stress in zebrafish: behavioral parameters and purinergic signalingAngelo L Piato
Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681 Predio 12D, Sala 340, Porto Alegre, RS 90619 900, Brazil
Neurochem Res 36:1876-86. 2011..In conclusion, ARS disturbed zebrafish behavior, and we hypothesize that the augmentation in adenosine-mediated signaling may be a strategy to reestablish homeostasis and normal behavior after a stressful event... - Maternal caffeine intake affects acetylcholinesterase in hippocampus of neonate ratsRosane Souza da Silva
Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
Int J Dev Neurosci 26:339-43. 2008..These results highlight the ability of maternal caffeine intake to interfere on cholinergic neurotransmission during brain development... - A simple webcam-based approach for the measurement of rodent locomotion and other behavioural parametersAdriano B L Tort
Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Prédio Anexo Lab 26, Porto Alegre, RS, Brazil
J Neurosci Methods 157:91-7. 2006..Such a system can be easily implemented in most laboratories and can significantly reduce the time and costs involved in behavioural analysis, especially in developing countries... - P50 sensory gating in panic disorderEduardo S Ghisolfi
Departamento de Ciencias Fisiologicas, Faculdade de Biociências da, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga, 6681 Prédio 12 A, 90619 900 Porto Alegre, RS, Brazil
J Psychiatr Res 40:535-40. 2006..Further studies are still necessary to better understand the pathophysiology of this neurophysiological dysfunction and its nature as a trait or a state marker... - Enriched environment effects on behavior, memory and BDNF in low and high exploratory miceVanessa Kazlauckas
Programa de Pós Graduação em Ciências Biológicas Bioquímica, Universidade Federal do Rio Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de Bioquimica, Porto Alegre RS 90035 003, Brazil
Physiol Behav 102:475-80. 2011..These observations may contribute to investigate biological mechanisms and therapeutical interventions for individuals with internalized psychiatric disorders... - Association of temperament with subjective sleep patternsGustavo L Ottoni
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
J Affect Disord 128:120-7. 2011..This study investigates the association of temperament with subjective sleep parameters... - A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar maniaRodrigo Machado-Vieira
Bipolar Disorder Research Program, Espirita Hospital of Porto Alegre, Porto Alegre, RS, Brazil
J Clin Psychiatry 69:1237-45. 2008..This study aimed to evaluate the efficacy and tolerability of the purinergic agents allopurinol and dipyridamole combined with lithium in bipolar mania... - Decreased hyperlocomotion induced by MK-801, but not amphetamine and caffeine in mice lacking cellular prion protein (PrP(C))Adriana S Coitinho
Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
Brain Res Mol Brain Res 107:190-4. 2002..Finally, lack of PrP(C) seems not to exacerbate the response to these psychotropic drugs, which modulate neurotransmitter systems possibly involved in schizophrenia and psychotic disorders... - Distinctive effects of unpredictable subchronic stress on memory, serum corticosterone and hippocampal BDNF levels in high and low exploratory miceVanessa Kazlauckas
Programa de Pós Graduação em Ciências Biológicas Bioquímica, Universidade Federal do Rio Grande do Sul, Instituto de Ciencias Basicas da Saude, Departamento de Bioquimica, Porto Alegre RS, 90035 003, Brazil
Behav Brain Res 218:80-6. 2011..In conclusion, our results suggest that individual differences in exploratory behavior in rodents from the same strain influence cognitive and biochemical response to stress... - Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazolJean Pierre Oses
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600 Anexo, 90035 003, Porto Alegre, RS, Brazil
Brain Res Bull 64:237-42. 2004.... - Metabolic and behavioral effects of chronic olanzapine treatment and cafeteria diet in ratsAlexandre P Muller
Departamento de Bioquimica, ICBS, UFRGS, Programa de Pós Graduação em Ciências Biológicas Bioquímica, Rua Ramiro Barcelos, Brazil
Behav Pharmacol 21:668-75. 2010..The cafeteria diet also modified the effects of chronic treatment with olanzapine on cognitive tasks, which may represent an undesirable effect of poor diets in psychiatric patients... - The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosineAndré P Schmidt
Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Pharmacol Biochem Behav 91:549-53. 2009..Hyperalgesia was correlated with CSF aspartate and glutamate levels. This study provides additional evidence for the mechanism of action of MK-801, showing that MK-801 induces hyperalgesia with parallel increase in CSF EAAs levels... - Behavioral and cognitive profile of mice with high and low exploratory phenotypesVanessa Kazlauckas
, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS, Porto Alegre, Brazil
Behav Brain Res 162:272-8. 2005..The behavioral profile of low and high exploratory mice resembled the depressive and hyperthymic temperaments of patients with unipolar depression and bipolar disorders, respectively, which may be relevant for modeling mood disorders... - Chronic treatment with caffeine blunts the hyperlocomotor but not cognitive effects of the N-methyl-D-aspartate receptor antagonist MK-801 in miceAdriana L da Silva
, ICBS, UFRGS, Porto Alegre, Brazil
Psychopharmacology (Berl) 166:258-63. 2003..Finally, these findings agree with the adenosine hypofunction model of schizophrenia, since NMDA receptor antagonists are a pharmacological model for this disorder... - Validation of the combined emotional and affective temperament scale in a large sample with high prevalence of psychiatric disordersGustavo L Ottoni
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Psychopathology 43:381-8. 2010..This paper aims to validate the CEATS in a large population with high prevalence of psychiatric disorders... - Impaired P50 sensory gating in Machado-Joseph diseaseEduardo S Ghisolfi
Departamento de Bioquímica da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Clin Neurophysiol 115:2231-5. 2004..1, is a disorder with wide range of neurological findings and brain regions involved. Studies evaluating neurophysiological parameters related to sensory gating in MJD are lacking... - Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicityOscar P Dall'Igna
Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Br J Pharmacol 138:1207-9. 2003..This constitutes the first in vitro evidence to suggest that adenosine A(2A) receptors may be the molecular target responsible for the observed beneficial effects of caffeine consumption in the development of Alzheimer's disease... - Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychoticsRodrigo W Grillo
Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
J Psychiatr Res 41:31-5. 2007..These results reinforce previous findings of reduced serum BDNF levels in schizophrenic patients and suggest a differential effect of clozapine compared to typical antipsychotics on such levels... - Does caffeine change the effect of sleep deprivation on moderate to severe depressed patients?Alexandre W Schwartzhaupt
Post Graduate Program in Psychiatry, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
J Affect Disord 112:279-83. 2009..However, there are no data about its potential influence on the antidepressive effect of SD. The objective of this study is to assess the effect of caffeine on SD in non-psychotic patients with moderate to severe unipolar depression... - A clinical trial of adjuvant allopurinol therapy for moderately refractory schizophreniaMiriam G Brunstein
Department of Biochemistry, Health Basic Science Institute, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
J Clin Psychiatry 66:213-9. 2005..P50 auditory sensory gating failed to improve with allopurinol treatment. CONCLUSIONS: Allopurinol was an effective and well-tolerated adjuvant treatment for poorly responsive schizophrenia, especially for refractory positive symptoms... - Atypical antipsychotic profile of flunarizine in animal modelsAdriano B L Tort
, ICBS, UFRGS, Porto Alegre, Brazil
Psychopharmacology (Berl) 177:344-8. 2005..The low cost, good tolerability and long half-life (over 2 weeks) of flunarizine are possible advantages for its use as an atypical antipsychotic. These results warrant clinical trials with flunarizine for the treatment of schizophrenia... - Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanolDaiane L Gebauer
Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
Pharmacol Biochem Behav 99:480-6. 2011..Height in the tank and shoal cohesion seem to be useful behavioral parameters in discriminating different classes of these drugs... - Proposal of a guanine-based purinergic system in the mammalian central nervous systemAndré P Schmidt
Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Pharmacol Ther 116:401-16. 2007.... - Clozapine, but not typical antipsychotics, correct P50 suppression deficit in patients with schizophreniaJefferson Becker
Neurology Service, Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
Clin Neurophysiol 115:396-401. 2004.... - The Circadian Energy Scale (CIRENS): two simple questions for a reliable chronotype measurement based on energyGustavo L Ottoni
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Chronobiol Int 28:229-37. 2011..The CIRENS provides a simple chronotype index and a measure of absolute energy throughout the day and seems to be a reliable chronotype assessment tool that may be useful both clinically and for large-scale studies... - Maternal caffeine intake impairs MK-801-induced hyperlocomotion in young ratsRosane Souza da Silva
Laboratório de Pesquisa Bioquímica, Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900, Porto Alegre, RS, Brazil
Eur J Pharmacol 509:155-9. 2005..The permanent effect after caffeine withdrawal suggests durable or adaptive changes during neurodevelopment, mainly on adenosine receptors or neurotransmitter systems modulated by adenosine, such as the glutamatergic system... - Caffeine as a neuroprotective adenosine receptor antagonistDiogo O Souza
Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Ann Pharmacother 38:717-8. 2004 - Impaired P50 sensory gating in post-traumatic stress disorder secondary to urban violenceEduardo S Ghisolfi
Departamento de Bioquímica do Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos, 2600 Anexo, Porto Alegre, RS, 90050 003 Brazil
Int J Psychophysiol 51:209-14. 2004..The P50 paradigm may also become an objective parameter to assess the effects of new treatments for PTSD... - Increased plasma levels of brain derived neurotrophic factor (BDNF) in patients with fibromyalgiaLisete Haas
Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Av Ipiranga, 6681 Pd 12, Porto Alegre, RS, 90619 900, Brazil
Neurochem Res 35:830-4. 2010..Our results confirm previous findings of increased plasma BDNF levels in patients with FM, suggesting that BDNF may be involved in the pathophysiology of Fibromyalgia, despite high levels of depression... - Theoretical insights into the mechanism of action of atypical antipsychoticsAdriano B L Tort
Departamento de Bioquimica, ICBS, UFRGS, Avenida Ramiro Barcelos, 2600 Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 30:541-8. 2006..Together with current experimental data, we concluded that the key factors leading to an atypical profile would be adequate posology, low affinity of the drug to D2R and/or short plasma half-life... - Low-dose quetiapine for patients with dysregulation of hyperthymic and cyclothymic temperamentsLuisa W Bisol
Departamento de Bioquimica, ICBS UFRGS, Porto Alegre, Brazil
J Psychopharmacol 24:421-4. 2010.... - The adenosine antagonist theophylline impairs p50 auditory sensory gating in normal subjectsEduardo S Ghisolfi
Departamento de Bioqui;mica, , Universidade Federal do Rio Grande do Sul, UFRGS, RS, Porto Alegre, Brazil
Neuropsychopharmacology 27:629-37. 2002.... - Unpredictable chronic stress model in zebrafish (Danio rerio): behavioral and physiological responsesAngelo L Piato
Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontifícia Universidade Católica do Rio Grande do Sul Avenida Ipiranga, 6681, 90619 900, Porto Alegre, RS, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 35:561-7. 2011..These results confirm UCS in zebrafish as an adequate model to preclinical studies of stress, although further studies are warranted to determine its predictive validity... - Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patientsGustavo Pimentel Dutra
Department of Celular and Molecular Biology, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
Rev Bras Psiquiatr 32:275-8. 2010..The aim of this study was to evaluate the ADA polymorphism 22G→A (ADA1*2) in schizophrenic patients and healthy controls... - Cinnarizine has an atypical antipsychotic profile in animal models of psychosisAdriano B L Tort
, , Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
J Psychopharmacol 19:342-6. 2005..Based on these results and on the antagonist effect of cinnarizine on dopamine D2 receptors, we suggest that it has a potential antipsychotic effect with an atypical profile that should be evaluated clinically... - Y-Maze memory task in zebrafish (Danio rerio): the role of glutamatergic and cholinergic systems on the acquisition and consolidation periodsGiana de P Cognato
Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontifícia Universidade Católica do Rio Grande do Sul Avenida Ipiranga 6681, 90619 900 Porto Alegre, RS, Brazil
Neurobiol Learn Mem 98:321-8. 2012..In addition, our results highlight the implication of the glutamatergic and cholinergic systems in the memory of zebrafish... - Circadian preference is associated with emotional and affective temperamentsGustavo L Ottoni
Hospital Materno Infantil Presidente Vargas, Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil
Chronobiol Int 29:786-93. 2012..The circadian daily energy profile can be very informative about human temperament and vice versa, and their combined assessment may be useful in the evaluation of psychiatric patients... - Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticidesRosane Maria Salvi
, , , Porto Alegre, Brazil
Toxicol Sci 72:267-71. 2003.... - How emotional traits and affective temperaments relate to cocaine experimentation, abuse and dependence in a large sampleLiane V Fuscaldo
Programa de Pós Graduação em Medicina e Ciências da Saúde, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
Addict Behav 38:1859-64. 2013..Conclusions: Specific externalized and unstable traits were associated with cocaine related behavior. Addressing these traits may be important for recovery and prevention strategies... - Anticonvulsant effect of GMP depends on its conversion to guanosineFélix A Soares
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 Anexo CEP 90 035 003, Porto Alegre, RS, Brazil
Brain Res 1005:182-6. 2004..This study shows that the previously reported effect of GMP as an anticonvulsant seems to be related to its ability to generate guanosine through the action of ecto-5'-nucleotidase... - Repeated restraint stress reduces opioid receptor binding in different rat CNS structuresGiovana Dantas
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Neurochem Res 30:1-7. 2005..7 +/- 9.7 for stressed rats). These findings suggest opioid mediation of the altered responses observed in these repeatedly-stressed animals, although the participation of non-opioid mechanisms in this phenomenon cannot be ruled out... - A case series on the hypothesized connection between dementia and bipolar spectrum disorders: bipolar type VI?Bernardo Ng
International Mood Center, and Department of Psychiatry, University of California, San Diego, CA, USA
J Affect Disord 107:307-15. 2008.... - Guanosine and its modulatory effects on the glutamatergic systemAndré P Schmidt
Eur Neuropsychopharmacol 18:620-2. 2008